Motif ID: Lhx3

Z-value: 0.903


Transcription factors associated with Lhx3:

Gene SymbolEntrez IDGene Name
Lhx3 ENSMUSG00000026934.9 Lhx3



Activity profile for motif Lhx3.

activity profile for motif Lhx3


Sorted Z-values histogram for motif Lhx3

Sorted Z-values for motif Lhx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_14621805 8.698 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr7_-_103827922 8.442 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr7_-_45103747 6.645 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr4_-_14621494 5.192 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr17_-_67950908 4.780 ENSMUST00000164647.1
 Arhgap28
Rho GTPase activating protein 28
chr19_+_26623419 4.692 ENSMUST00000176584.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr4_+_102589687 4.554 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr4_-_14621669 4.553 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr10_-_64090265 4.474 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr2_-_33087169 3.873 ENSMUST00000102810.3
 Garnl3
GTPase activating RANGAP domain-like 3
chr4_+_136143497 3.796 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr10_-_33624587 3.643 ENSMUST00000160299.1
ENSMUST00000019920.6
 Clvs2

clavesin 2

chr2_-_33086366 3.577 ENSMUST00000049618.2
 Garnl3
GTPase activating RANGAP domain-like 3
chr2_+_125136692 3.535 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr1_-_38821215 3.529 ENSMUST00000039612.4
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr5_+_66968961 3.518 ENSMUST00000132991.1
 Limch1
LIM and calponin homology domains 1
chr2_-_164171113 3.372 ENSMUST00000045196.3
 Kcns1
K+ voltage-gated channel, subfamily S, 1
chr13_-_101692624 3.241 ENSMUST00000035532.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr6_+_96115249 3.189 ENSMUST00000075080.5
 Fam19a1
family with sequence similarity 19, member A1
chr15_+_16778101 2.691 ENSMUST00000026432.6
 Cdh9
cadherin 9
chr13_+_93304799 2.560 ENSMUST00000080127.5
 Homer1
homer homolog 1 (Drosophila)
chr1_+_177444653 2.442 ENSMUST00000094276.3
 Zbtb18
zinc finger and BTB domain containing 18
chr10_-_64090241 2.436 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr10_+_36506814 2.387 ENSMUST00000167191.1
ENSMUST00000058738.4
 Hs3st5

heparan sulfate (glucosamine) 3-O-sulfotransferase 5

chr18_+_37477768 2.363 ENSMUST00000051442.5
 Pcdhb16
protocadherin beta 16
chr2_+_36230426 2.312 ENSMUST00000062069.5
 Ptgs1
prostaglandin-endoperoxide synthase 1
chr14_+_80000292 2.142 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr5_-_118244861 2.049 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
 Rnft2



ring finger protein, transmembrane 2



chr10_+_102158858 1.984 ENSMUST00000138522.1
ENSMUST00000163753.1
ENSMUST00000138016.1
 Mgat4c


mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)


chr6_+_34780412 1.944 ENSMUST00000115016.1
ENSMUST00000115017.1
 Agbl3

ATP/GTP binding protein-like 3

chr11_-_30198232 1.900 ENSMUST00000102838.3
 Sptbn1
spectrin beta, non-erythrocytic 1
chr10_+_116143881 1.842 ENSMUST00000105271.2
 Ptprr
protein tyrosine phosphatase, receptor type, R
chr3_+_151437887 1.817 ENSMUST00000046977.7
 Eltd1
EGF, latrophilin seven transmembrane domain containing 1
chr2_+_82053222 1.783 ENSMUST00000047527.7
 Zfp804a
zinc finger protein 804A
chr3_+_84952146 1.767 ENSMUST00000029727.7
 Fbxw7
F-box and WD-40 domain protein 7
chrX_-_139871637 1.748 ENSMUST00000033811.7
ENSMUST00000087401.5
 Morc4

microrchidia 4

chr7_-_45830776 1.644 ENSMUST00000107723.2
ENSMUST00000131384.1
 Grwd1

glutamate-rich WD repeat containing 1

chr3_+_136670076 1.520 ENSMUST00000070198.7
 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr13_+_93304066 1.505 ENSMUST00000109493.1
 Homer1
homer homolog 1 (Drosophila)
chr1_-_158356258 1.424 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr10_-_35711891 1.365 ENSMUST00000080898.2
 Amd2
S-adenosylmethionine decarboxylase 2
chr13_+_49608030 1.354 ENSMUST00000021822.5
 Ogn
osteoglycin
chr14_+_69347587 1.315 ENSMUST00000064831.5
 Entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chr8_-_109251698 1.277 ENSMUST00000079189.3
 4922502B01Rik
RIKEN cDNA 4922502B01 gene
chr10_-_62507737 1.217 ENSMUST00000020271.6
 Srgn
serglycin
chr3_-_57294880 1.049 ENSMUST00000171384.1
 Tm4sf1
transmembrane 4 superfamily member 1
chrX_+_66653003 1.044 ENSMUST00000036043.4
 Slitrk2
SLIT and NTRK-like family, member 2
chr5_-_70842617 0.982 ENSMUST00000031119.1
 Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr3_+_122419772 0.975 ENSMUST00000029766.4
 Bcar3
breast cancer anti-estrogen resistance 3
chrX_-_143933089 0.956 ENSMUST00000087313.3
 Dcx
doublecortin
chr3_+_142620596 0.955 ENSMUST00000165774.1
 Gbp2
guanylate binding protein 2
chr7_-_30534180 0.821 ENSMUST00000044338.4
 Arhgap33
Rho GTPase activating protein 33
chr16_+_11406618 0.786 ENSMUST00000122168.1
 Snx29
sorting nexin 29
chr4_-_147809788 0.762 ENSMUST00000105734.3
ENSMUST00000176201.1
 Gm13157
Gm20707
predicted gene 13157
predicted gene 20707
chr4_+_145585166 0.735 ENSMUST00000105739.1
ENSMUST00000119718.1
 Gm13212

predicted gene 13212

chrX_-_143933204 0.724 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr9_+_113812547 0.717 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
 Clasp2


CLIP associating protein 2


chr5_-_51553896 0.717 ENSMUST00000132734.1
 Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chr10_+_5593718 0.647 ENSMUST00000051809.8
 Myct1
myc target 1
chr17_-_78684262 0.637 ENSMUST00000145480.1
 Strn
striatin, calmodulin binding protein
chr2_-_72986716 0.616 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr6_+_124304646 0.613 ENSMUST00000112541.2
ENSMUST00000032234.2
 Cd163

CD163 antigen

chr3_+_66985647 0.555 ENSMUST00000162362.1
ENSMUST00000065074.7
 Rsrc1

arginine/serine-rich coiled-coil 1

chr8_-_106573461 0.525 ENSMUST00000073722.5
 Gm10073
predicted pseudogene 10073
chr14_-_108914237 0.515 ENSMUST00000100322.2
 Slitrk1
SLIT and NTRK-like family, member 1
chr7_+_100159241 0.427 ENSMUST00000032967.3
 Lipt2
lipoyl(octanoyl) transferase 2 (putative)
chr5_-_62765618 0.372 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr8_-_21906412 0.362 ENSMUST00000051965.4
 Defb11
defensin beta 11
chr4_+_146610961 0.329 ENSMUST00000130825.1
 Gm13248
predicted gene 13248
chr4_+_105789869 0.307 ENSMUST00000184254.1
 Gm12728
predicted gene 12728
chr4_+_147492417 0.201 ENSMUST00000105721.2
 Gm13152
predicted gene 13152
chr4_+_147132038 0.191 ENSMUST00000084149.3
 Gm13139
predicted gene 13139
chr2_+_3114220 0.191 ENSMUST00000072955.5
 Fam171a1
family with sequence similarity 171, member A1
chr2_-_84425258 0.174 ENSMUST00000074262.2
 Calcrl
calcitonin receptor-like
chr11_+_59306920 0.159 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr11_+_109543694 0.080 ENSMUST00000106696.1
 Arsg
arylsulfatase G
chr11_-_4095344 0.076 ENSMUST00000004868.5
 Mtfp1
mitochondrial fission process 1
chr3_+_66985680 0.061 ENSMUST00000065047.6
 Rsrc1
arginine/serine-rich coiled-coil 1
chr1_-_36273425 0.057 ENSMUST00000056946.6
 Neurl3
neuralized homolog 3 homolog (Drosophila)
chr4_+_145510759 0.037 ENSMUST00000105742.1
ENSMUST00000136309.1
 Gm13225

predicted gene 13225

chr14_-_96519067 0.026 ENSMUST00000022666.7
 Klhl1
kelch-like 1
chr3_-_116712644 0.003 ENSMUST00000029569.2
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 18.4 GO:0019532 oxalate transport(GO:0019532)
1.2 4.8 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.6 2.3 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.5 4.7 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.5 1.5 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203)
0.5 6.9 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.5 1.8 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.5 1.4 GO:0006597 spermine biosynthetic process(GO:0006597)
0.4 1.2 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.4 2.4 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.4 1.8 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.4 4.6 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.3 3.2 GO:0010459 negative regulation of heart rate(GO:0010459)
0.3 1.9 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.3 4.1 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.3 1.9 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.2 0.7 GO:2000182 regulation of progesterone biosynthetic process(GO:2000182)
0.1 3.8 GO:0030903 notochord development(GO:0030903)
0.1 0.4 GO:0009106 lipoate metabolic process(GO:0009106)
0.1 3.4 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.1 1.6 GO:0006337 nucleosome disassembly(GO:0006337)
0.1 1.7 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 2.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 0.7 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 1.0 GO:0044406 adhesion of symbiont to host(GO:0044406)
0.0 3.6 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 2.1 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.2 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.0 1.0 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 2.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 3.5 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 1.4 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.6 GO:0006953 acute-phase response(GO:0006953)
0.0 7.4 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.0 3.5 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 1.9 GO:0021766 hippocampus development(GO:0021766)
0.0 1.6 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.6 GO:0046677 response to antibiotic(GO:0046677)
0.0 1.0 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 8.4 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.4 1.8 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.4 1.3 GO:0097637 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.4 1.9 GO:0032437 cuticular plate(GO:0032437)
0.3 1.5 GO:0005955 calcineurin complex(GO:0005955)
0.2 4.7 GO:0071564 npBAF complex(GO:0071564)
0.2 0.7 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.2 4.6 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 2.1 GO:0042581 specific granule(GO:0042581)
0.2 1.2 GO:0042629 mast cell granule(GO:0042629)
0.1 3.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 4.1 GO:0043034 costamere(GO:0043034)
0.1 1.0 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.1 4.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 15.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 3.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 3.6 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 8.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 0.7 GO:0097440 apical dendrite(GO:0097440)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 8.4 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
1.7 18.4 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
1.3 6.6 GO:0019770 IgG receptor activity(GO:0019770)
0.8 3.2 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.4 2.4 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.4 2.0 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.4 4.1 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.4 1.8 GO:0050816 phosphothreonine binding(GO:0050816)
0.3 1.4 GO:0019808 polyamine binding(GO:0019808)
0.3 1.5 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.2 1.3 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.2 3.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 3.6 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 4.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 1.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 1.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 3.7 GO:0005504 fatty acid binding(GO:0005504)
0.1 3.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 4.7 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 1.9 GO:0030506 ankyrin binding(GO:0030506)
0.1 6.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 1.0 GO:0050811 GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811)
0.1 2.3 GO:0004601 peroxidase activity(GO:0004601)
0.1 0.7 GO:0002162 dystroglycan binding(GO:0002162)
0.0 11.2 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.6 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.7 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.6 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 1.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.2 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.0 1.2 GO:0005518 collagen binding(GO:0005518)
0.0 1.4 GO:0008083 growth factor activity(GO:0008083)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.2 PID_IL5_PATHWAY IL5-mediated signaling events
0.1 2.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.8 PID_MYC_PATHWAY C-MYC pathway
0.1 6.2 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.7 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.6 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.2 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.2 18.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 6.1 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 1.4 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.1 2.0 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 3.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.9 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 2.4 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.8 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.7 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.7 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.9 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 4.4 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.0 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.2 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.7 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions