Motif ID: Lhx8

Z-value: 0.554


Transcription factors associated with Lhx8:

Gene SymbolEntrez IDGene Name
Lhx8 ENSMUSG00000096225.2 Lhx8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx8mm10_v2_chr3_-_154330543_1543305760.212.0e-01Click!


Activity profile for motif Lhx8.

activity profile for motif Lhx8


Sorted Z-values histogram for motif Lhx8

Sorted Z-values for motif Lhx8



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_44617310 1.756 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
 Ebf1


early B cell factor 1


chr12_+_38783503 1.565 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr12_+_38783455 1.469 ENSMUST00000161980.1
ENSMUST00000160701.1
 Etv1

ets variant gene 1

chr2_-_72986716 1.393 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr13_+_65512678 1.289 ENSMUST00000081471.2
 Gm10139
predicted gene 10139
chr1_+_6487231 1.283 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr2_-_67433181 1.131 ENSMUST00000180773.1
 Gm26727
predicted gene, 26727
chr8_+_104831572 1.054 ENSMUST00000059449.6
 Ces2b
carboxyesterase 2B
chr4_-_155645408 0.985 ENSMUST00000115821.2
 Gm10563
predicted gene 10563
chr13_+_62129894 0.941 ENSMUST00000099449.3
 Zfp808
zinc finger protein 80
chr8_+_45627709 0.914 ENSMUST00000134321.1
ENSMUST00000135336.1
 Sorbs2

sorbin and SH3 domain containing 2

chr13_+_5861489 0.835 ENSMUST00000000080.6
 Klf6
Kruppel-like factor 6
chr8_+_34054622 0.772 ENSMUST00000149618.1
 Gm9951
predicted gene 9951
chr4_+_126556935 0.765 ENSMUST00000048391.8
 Clspn
claspin
chr14_+_60768120 0.764 ENSMUST00000025940.6
 C1qtnf9
C1q and tumor necrosis factor related protein 9
chr17_-_90088343 0.759 ENSMUST00000173917.1
 Nrxn1
neurexin I
chr1_-_127677923 0.729 ENSMUST00000160616.1
 Tmem163
transmembrane protein 163
chr8_-_69373383 0.686 ENSMUST00000072427.4
 Gm10033
predicted gene 10033
chr19_+_11469353 0.685 ENSMUST00000165310.1
 Ms4a6c
membrane-spanning 4-domains, subfamily A, member 6C
chr1_-_44218952 0.673 ENSMUST00000054801.3
 Mettl21e
methyltransferase like 21E
chr13_-_62466709 0.654 ENSMUST00000076195.5
 Zfp935
zinc finger protein 935
chr4_+_126556994 0.633 ENSMUST00000147675.1
 Clspn
claspin
chr18_+_12972225 0.604 ENSMUST00000025290.5
 Impact
imprinted and ancient
chr10_+_58497918 0.568 ENSMUST00000036576.8
 Ccdc138
coiled-coil domain containing 138
chr2_-_114013619 0.559 ENSMUST00000090275.4
 Gjd2
gap junction protein, delta 2
chr3_+_54361103 0.550 ENSMUST00000107985.3
ENSMUST00000117373.1
ENSMUST00000073012.6
ENSMUST00000081564.6
 Postn



periostin, osteoblast specific factor



chr3_+_107291215 0.543 ENSMUST00000029502.7
 Slc16a4
solute carrier family 16 (monocarboxylic acid transporters), member 4
chr15_+_21111452 0.538 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr2_-_52558539 0.520 ENSMUST00000102760.3
ENSMUST00000102761.2
 Cacnb4

calcium channel, voltage-dependent, beta 4 subunit

chr8_-_57653023 0.515 ENSMUST00000034021.5
 Galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr14_+_54625305 0.489 ENSMUST00000097177.4
 Psmb11
proteasome (prosome, macropain) subunit, beta type, 11
chr4_-_118489755 0.478 ENSMUST00000184261.1
 Tie1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr14_-_46831984 0.469 ENSMUST00000181311.1
ENSMUST00000074862.2
 Gm10101

predicted gene 10101

chr3_+_76075583 0.460 ENSMUST00000160261.1
 Fstl5
follistatin-like 5
chr1_+_33908172 0.459 ENSMUST00000182513.1
ENSMUST00000183034.1
 Dst

dystonin

chr13_-_66851513 0.394 ENSMUST00000169322.1
 Gm17404
predicted gene, 17404
chr15_-_98221056 0.393 ENSMUST00000170618.1
ENSMUST00000141911.1
 Olfr287

olfactory receptor 287

chr8_-_57652993 0.391 ENSMUST00000110316.2
 Galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr12_-_20900867 0.385 ENSMUST00000079237.5
 Zfp125
zinc finger protein 125
chr11_-_109995775 0.372 ENSMUST00000020948.8
 Abca8b
ATP-binding cassette, sub-family A (ABC1), member 8b
chr17_-_21908092 0.365 ENSMUST00000106026.2
 2210404O09Rik
RIKEN cDNA 2210404O09 gene
chr2_+_65620829 0.357 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr6_-_136173492 0.355 ENSMUST00000111905.1
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr13_-_49652714 0.333 ENSMUST00000021818.7
 Cenpp
centromere protein P
chr11_-_102579071 0.331 ENSMUST00000107080.1
 Gm11627
predicted gene 11627
chr3_-_144760841 0.317 ENSMUST00000059091.5
 Clca1
chloride channel calcium activated 1
chr10_-_4432312 0.315 ENSMUST00000126102.1
ENSMUST00000131853.1
ENSMUST00000042251.4
 Rmnd1


required for meiotic nuclear division 1 homolog (S. cerevisiae)


chr6_+_11926758 0.313 ENSMUST00000133776.1
 Phf14
PHD finger protein 14
chr2_-_175131864 0.305 ENSMUST00000108929.2
 Gm14399
predicted gene 14399
chr2_+_177508570 0.282 ENSMUST00000108940.2
 Gm14403
predicted gene 14403
chr6_-_71440623 0.273 ENSMUST00000002292.8
 Rmnd5a
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr18_-_43687695 0.252 ENSMUST00000082254.6
 Jakmip2
janus kinase and microtubule interacting protein 2
chr3_-_100685431 0.250 ENSMUST00000008907.7
 Man1a2
mannosidase, alpha, class 1A, member 2
chrX_+_101640056 0.233 ENSMUST00000119299.1
ENSMUST00000044475.4
 Ogt

O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)

chr1_+_164048214 0.217 ENSMUST00000027874.5
 Sele
selectin, endothelial cell
chr5_+_123930675 0.214 ENSMUST00000094320.3
ENSMUST00000165148.1
 Ccdc62

coiled-coil domain containing 62

chr10_-_4432285 0.214 ENSMUST00000155172.1
 Rmnd1
required for meiotic nuclear division 1 homolog (S. cerevisiae)
chr3_-_116712644 0.209 ENSMUST00000029569.2
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr17_+_8182247 0.190 ENSMUST00000161898.1
 Fgfr1op
Fgfr1 oncogene partner
chr10_-_67912620 0.189 ENSMUST00000064656.7
 Zfp365
zinc finger protein 365
chr16_+_24721842 0.180 ENSMUST00000115314.2
 Lpp
LIM domain containing preferred translocation partner in lipoma
chr5_-_100820929 0.180 ENSMUST00000117364.1
ENSMUST00000055245.6
 Fam175a

family with sequence similarity 175, member A

chr2_+_73312601 0.175 ENSMUST00000090811.4
ENSMUST00000112050.1
 Scrn3

secernin 3

chr17_-_35027909 0.167 ENSMUST00000040151.2
 Sapcd1
suppressor APC domain containing 1
chr11_-_102579461 0.165 ENSMUST00000107081.1
 Gm11627
predicted gene 11627
chr17_+_17374332 0.163 ENSMUST00000024620.6
 Riok2
RIO kinase 2 (yeast)
chrM_+_7759 0.160 ENSMUST00000082407.1
ENSMUST00000082408.1
 mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr1_+_17145357 0.160 ENSMUST00000026879.7
 Gdap1
ganglioside-induced differentiation-associated-protein 1
chr6_+_15185203 0.155 ENSMUST00000154448.1
 Foxp2
forkhead box P2
chr1_-_74588117 0.155 ENSMUST00000066986.6
 Zfp142
zinc finger protein 142
chr8_+_110079758 0.151 ENSMUST00000058804.8
 Zfp612
zinc finger protein 612
chrX_-_157415286 0.138 ENSMUST00000079945.4
ENSMUST00000138396.1
 Phex

phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)

chr14_+_48446340 0.130 ENSMUST00000111735.2
 Tmem260
transmembrane protein 260
chr5_-_98566762 0.126 ENSMUST00000086912.4
 1700010H22Rik
RIKEN cDNA 1700010H22 gene
chr14_+_46832127 0.112 ENSMUST00000068532.8
 Cgrrf1
cell growth regulator with ring finger domain 1
chr5_+_121795034 0.103 ENSMUST00000162327.1
 Atxn2
ataxin 2
chr5_+_67306941 0.088 ENSMUST00000162372.1
ENSMUST00000113676.2
 Slc30a9

solute carrier family 30 (zinc transporter), member 9

chr9_-_78378725 0.085 ENSMUST00000034900.7
 Ooep
oocyte expressed protein
chr5_-_76905463 0.081 ENSMUST00000146570.1
ENSMUST00000142450.1
ENSMUST00000120963.1
 Aasdh


aminoadipate-semialdehyde dehydrogenase


chr7_-_28372597 0.071 ENSMUST00000144700.1
 Plekhg2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr16_-_16829276 0.062 ENSMUST00000023468.5
 Spag6
sperm associated antigen 6
chr2_-_114175321 0.057 ENSMUST00000043160.6
 Aqr
aquarius
chr18_+_23415400 0.048 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr15_-_99370427 0.047 ENSMUST00000081224.7
ENSMUST00000120633.1
ENSMUST00000088233.6
 Fmnl3


formin-like 3


chr5_+_34336289 0.032 ENSMUST00000182709.1
ENSMUST00000030992.6
 Rnf4

ring finger protein 4

chr11_+_45852031 0.019 ENSMUST00000109261.3
ENSMUST00000109260.1
 Clint1

clathrin interactor 1

chr11_+_98798653 0.018 ENSMUST00000037930.6
 Msl1
male-specific lethal 1 homolog (Drosophila)
chr1_+_161969179 0.017 ENSMUST00000111594.2
ENSMUST00000028021.6
 Pigc

phosphatidylinositol glycan anchor biosynthesis, class C

chr1_+_86064619 0.009 ENSMUST00000027432.8
 Psmd1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr3_-_116712696 0.009 ENSMUST00000169530.1
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr15_-_99820072 0.005 ENSMUST00000109024.2
 Lima1
LIM domain and actin binding 1
chr19_-_24961545 0.004 ENSMUST00000025815.8
 Cbwd1
COBW domain containing 1
chr2_+_21205719 0.002 ENSMUST00000054591.3
ENSMUST00000102952.1
ENSMUST00000138965.1
ENSMUST00000138914.1
ENSMUST00000102951.1
 Thnsl1




threonine synthase-like 1 (bacterial)





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.0 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.2 0.6 GO:0032058 positive regulation of translational initiation in response to stress(GO:0032058)
0.2 0.8 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.2 0.6 GO:1904207 chemokine (C-C motif) ligand 2 secretion(GO:0035926) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.1 1.4 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.1 1.3 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.1 0.3 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.1 0.4 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 0.2 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.1 0.2 GO:0033566 gamma-tubulin complex localization(GO:0033566)
0.1 0.5 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.1 0.3 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.2 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.0 0.5 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.0 0.5 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.2 GO:0090070 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.0 0.5 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.9 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.9 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.5 GO:0045026 plasma membrane fusion(GO:0045026)
0.0 0.2 GO:0007202 activation of phospholipase C activity(GO:0007202)
0.0 0.2 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0 0.2 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.4 GO:0007608 sensory perception of smell(GO:0007608)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0031673 H zone(GO:0031673)
0.1 0.3 GO:0034657 GID complex(GO:0034657)
0.1 0.8 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.6 GO:0005922 connexon complex(GO:0005922)
0.0 0.3 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.2 GO:0042588 zymogen granule(GO:0042588)
0.0 0.4 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.5 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.2 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.1 1.8 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.1 0.2 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.1 0.4 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 0.8 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 0.9 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.2 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.4 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 0.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.2 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.3 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.5 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.5 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.8 GO:0005179 hormone activity(GO:0005179)
0.0 0.2 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.0 GO:0033142 progesterone receptor binding(GO:0033142)
0.0 3.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.4 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.8 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.9 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.8 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.4 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.5 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions