Motif ID: Mecom

Z-value: 0.688


Transcription factors associated with Mecom:

Gene SymbolEntrez IDGene Name
Mecom ENSMUSG00000027684.10 Mecom



Activity profile for motif Mecom.

activity profile for motif Mecom


Sorted Z-values histogram for motif Mecom

Sorted Z-values for motif Mecom



Network of associatons between targets according to the STRING database.



First level regulatory network of Mecom

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrY_+_897782 11.680 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr1_+_185454803 4.692 ENSMUST00000061093.6
 Slc30a10
solute carrier family 30, member 10
chr14_-_52020698 4.667 ENSMUST00000067549.7
 Zfp219
zinc finger protein 219
chr6_+_138140298 4.436 ENSMUST00000008684.4
 Mgst1
microsomal glutathione S-transferase 1
chrX_-_145505136 3.736 ENSMUST00000112835.1
 Amot
angiomotin
chrX_-_145505175 3.521 ENSMUST00000143610.1
 Amot
angiomotin
chr9_+_65890237 2.504 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr5_-_120467296 2.445 ENSMUST00000132916.1
 Sdsl
serine dehydratase-like
chr11_-_115367667 1.947 ENSMUST00000123428.1
ENSMUST00000044152.6
ENSMUST00000106542.2
 Hid1


HID1 domain containing


chr1_+_107511489 1.811 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_107511416 1.787 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr7_-_103853199 1.656 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr10_-_6980376 1.650 ENSMUST00000105617.1
 Ipcef1
interaction protein for cytohesin exchange factors 1
chr4_+_11704439 1.634 ENSMUST00000108304.2
 Gem
GTP binding protein (gene overexpressed in skeletal muscle)
chr1_+_120006980 1.515 ENSMUST00000072886.4
 Sctr
secretin receptor
chr3_+_41742615 1.506 ENSMUST00000146165.1
ENSMUST00000119572.1
ENSMUST00000108065.2
ENSMUST00000120167.1
ENSMUST00000026867.7
ENSMUST00000026868.7
 D3Ertd751e





DNA segment, Chr 3, ERATO Doi 751, expressed





chr4_+_128846163 1.501 ENSMUST00000138291.1
 Gm12968
predicted gene 12968
chr14_+_55854115 1.417 ENSMUST00000168479.1
 Nynrin
NYN domain and retroviral integrase containing
chr4_-_110292719 1.408 ENSMUST00000106601.1
 Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr14_+_55853997 1.395 ENSMUST00000100529.3
 Nynrin
NYN domain and retroviral integrase containing
chr10_+_5593718 1.388 ENSMUST00000051809.8
 Myct1
myc target 1
chrX_+_9885622 1.387 ENSMUST00000067529.2
ENSMUST00000086165.3
 Sytl5

synaptotagmin-like 5

chr11_-_88718078 1.372 ENSMUST00000092794.5
 Msi2
musashi RNA-binding protein 2
chr7_+_82337218 1.192 ENSMUST00000173828.1
 Adamtsl3
ADAMTS-like 3
chr2_+_103970115 1.146 ENSMUST00000111143.1
ENSMUST00000138815.1
 Lmo2

LIM domain only 2

chr13_+_49544443 1.135 ENSMUST00000177948.1
ENSMUST00000021820.6
 Aspn

asporin

chr2_+_103969528 1.035 ENSMUST00000123437.1
ENSMUST00000163256.1
 Lmo2

LIM domain only 2

chr13_+_104287855 1.032 ENSMUST00000065766.6
 Adamts6
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
chr2_+_103970221 0.892 ENSMUST00000111140.2
ENSMUST00000111139.2
 Lmo2

LIM domain only 2

chr14_+_115042752 0.867 ENSMUST00000134140.2
 Mir17hg
Mir17 host gene 1 (non-protein coding)
chr2_+_71786923 0.767 ENSMUST00000112101.1
ENSMUST00000028522.3
 Itga6

integrin alpha 6

chr18_+_4994600 0.709 ENSMUST00000140448.1
 Svil
supervillin
chr13_-_103764502 0.684 ENSMUST00000074616.5
 Srek1
splicing regulatory glutamine/lysine-rich protein 1
chrX_+_169879596 0.680 ENSMUST00000112105.1
ENSMUST00000078947.5
 Mid1

midline 1

chr1_-_69685937 0.648 ENSMUST00000027146.2
 Ikzf2
IKAROS family zinc finger 2
chr1_+_156838915 0.640 ENSMUST00000111720.1
 Angptl1
angiopoietin-like 1
chr11_-_116027961 0.605 ENSMUST00000106454.1
 H3f3b
H3 histone, family 3B
chr13_+_89540636 0.517 ENSMUST00000022108.7
 Hapln1
hyaluronan and proteoglycan link protein 1
chr14_+_34375504 0.514 ENSMUST00000111908.1
 Mmrn2
multimerin 2
chr2_-_149798701 0.439 ENSMUST00000148202.1
ENSMUST00000139471.1
 Gm14133

predicted gene 14133

chr2_-_152830266 0.429 ENSMUST00000140436.1
 Bcl2l1
BCL2-like 1
chr12_-_86079019 0.357 ENSMUST00000003687.6
 Tgfb3
transforming growth factor, beta 3
chr9_+_115909455 0.348 ENSMUST00000119291.1
ENSMUST00000069651.6
 Gadl1

glutamate decarboxylase-like 1

chr16_-_38713235 0.295 ENSMUST00000023487.4
 Arhgap31
Rho GTPase activating protein 31
chr9_-_13245741 0.275 ENSMUST00000110582.2
 Jrkl
jerky homolog-like (mouse)
chr9_+_105053239 0.274 ENSMUST00000035177.8
ENSMUST00000149243.1
 Mrpl3

mitochondrial ribosomal protein L3

chrX_-_113185485 0.267 ENSMUST00000026607.8
ENSMUST00000113388.2
 Chm

choroidermia

chrX_+_112604274 0.259 ENSMUST00000071814.6
 Zfp711
zinc finger protein 711
chr8_-_18741542 0.255 ENSMUST00000033846.6
 Angpt2
angiopoietin 2
chr10_+_3740348 0.111 ENSMUST00000120274.1
 Plekhg1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr18_+_80206887 0.065 ENSMUST00000127234.1
 Gm16286
predicted gene 16286
chr5_+_134582690 0.062 ENSMUST00000023867.6
 Rfc2
replication factor C (activator 1) 2
chr9_+_72806874 0.043 ENSMUST00000055535.8
 Prtg
protogenin homolog (Gallus gallus)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 11.7 GO:0002457 T cell antigen processing and presentation(GO:0002457)
1.8 7.3 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
1.6 4.7 GO:0071579 regulation of zinc ion transport(GO:0071579)
1.1 4.4 GO:0006982 response to lipid hydroperoxide(GO:0006982) cellular response to lipid hydroperoxide(GO:0071449)
0.4 2.8 GO:0015074 DNA integration(GO:0015074)
0.3 1.7 GO:0015671 oxygen transport(GO:0015671)
0.2 3.1 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.2 1.1 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.2 1.6 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.2 0.6 GO:1902340 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.1 0.8 GO:0035878 nail development(GO:0035878)
0.1 0.4 GO:0003032 detection of oxygen(GO:0003032)
0.1 0.4 GO:0046898 response to cycloheximide(GO:0046898)
0.1 0.3 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 0.7 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 1.4 GO:0048864 stem cell development(GO:0048864)
0.0 1.9 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.5 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0 1.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.3 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 1.5 GO:0030819 positive regulation of cAMP biosynthetic process(GO:0030819)
0.0 3.6 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 0.1 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.0 0.7 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.0 0.7 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 1.0 GO:0035904 aorta development(GO:0035904)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.9 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.2 1.7 GO:0005833 hemoglobin complex(GO:0005833)
0.2 7.3 GO:0008180 COP9 signalosome(GO:0008180)
0.1 1.4 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.8 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.3 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 1.6 GO:0051233 spindle midzone(GO:0051233)
0.0 0.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 3.1 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 2.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 4.7 GO:0055037 recycling endosome(GO:0055037)
0.0 1.4 GO:0005844 polysome(GO:0005844)
0.0 0.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.7 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 11.7 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
1.5 7.3 GO:0043532 angiostatin binding(GO:0043532)
0.6 2.4 GO:0003941 L-serine ammonia-lyase activity(GO:0003941)
0.4 1.7 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.2 4.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.2 4.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 0.8 GO:0038132 neuregulin binding(GO:0038132)
0.1 0.4 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 3.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 3.1 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 1.4 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.4 GO:0051434 BH3 domain binding(GO:0051434)
0.0 1.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.6 GO:0019003 GDP binding(GO:0019003)
0.0 4.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.8 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.3 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 1.1 GO:0005518 collagen binding(GO:0005518)
0.0 0.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.3 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.7 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.8 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 5.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.4 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.4 PID_GLYPICAN_1PATHWAY Glypican 1 network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 7.3 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.2 4.4 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 1.5 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.4 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.6 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.3 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling