Motif ID: Meox1
Z-value: 1.093
Transcription factors associated with Meox1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Meox1 | ENSMUSG00000001493.9 | Meox1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.8 | 19.0 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 3.4 | 23.8 | GO:0019532 | oxalate transport(GO:0019532) |
| 3.0 | 8.9 | GO:1904395 | positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) |
| 2.8 | 8.3 | GO:1904139 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
| 1.5 | 4.5 | GO:0014826 | vein smooth muscle contraction(GO:0014826) |
| 1.2 | 3.6 | GO:0001193 | maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193) |
| 0.9 | 3.6 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
| 0.9 | 4.3 | GO:0002121 | inter-male aggressive behavior(GO:0002121) |
| 0.8 | 3.0 | GO:1900533 | medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535) |
| 0.6 | 4.6 | GO:0097118 | neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) |
| 0.5 | 3.1 | GO:0000707 | meiotic DNA recombinase assembly(GO:0000707) |
| 0.4 | 2.6 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
| 0.4 | 1.7 | GO:0044268 | multicellular organismal protein metabolic process(GO:0044268) |
| 0.4 | 3.8 | GO:0046541 | saliva secretion(GO:0046541) |
| 0.4 | 1.1 | GO:0006059 | hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401) |
| 0.3 | 1.7 | GO:0098706 | ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) |
| 0.2 | 0.7 | GO:0019676 | ammonia assimilation cycle(GO:0019676) |
| 0.2 | 4.6 | GO:0002495 | antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) |
| 0.2 | 4.2 | GO:0042541 | hemoglobin biosynthetic process(GO:0042541) |
| 0.2 | 2.3 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.2 | 0.7 | GO:0033364 | mast cell secretory granule organization(GO:0033364) |
| 0.2 | 1.3 | GO:0016185 | synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185) |
| 0.2 | 1.4 | GO:0031848 | protection from non-homologous end joining at telomere(GO:0031848) |
| 0.2 | 3.0 | GO:0048240 | sperm capacitation(GO:0048240) |
| 0.2 | 1.7 | GO:1990253 | cellular response to leucine starvation(GO:1990253) |
| 0.2 | 0.6 | GO:0061743 | motor learning(GO:0061743) |
| 0.2 | 1.2 | GO:0070317 | negative regulation of G0 to G1 transition(GO:0070317) |
| 0.1 | 0.6 | GO:0046947 | hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947) |
| 0.1 | 12.7 | GO:0003073 | regulation of systemic arterial blood pressure(GO:0003073) |
| 0.1 | 0.4 | GO:1901856 | negative regulation of cellular respiration(GO:1901856) |
| 0.1 | 0.7 | GO:0021993 | initiation of neural tube closure(GO:0021993) |
| 0.1 | 1.3 | GO:0033572 | transferrin transport(GO:0033572) |
| 0.1 | 1.9 | GO:0031987 | locomotion involved in locomotory behavior(GO:0031987) |
| 0.1 | 0.9 | GO:1904781 | positive regulation of protein localization to centrosome(GO:1904781) |
| 0.1 | 1.2 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.1 | 0.4 | GO:2000774 | positive regulation of cellular senescence(GO:2000774) |
| 0.1 | 1.2 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.1 | 0.4 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 0.1 | 0.1 | GO:1904956 | regulation of midbrain dopaminergic neuron differentiation(GO:1904956) |
| 0.1 | 8.0 | GO:0043149 | contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149) |
| 0.1 | 1.5 | GO:0006907 | pinocytosis(GO:0006907) |
| 0.1 | 0.2 | GO:0034285 | response to sucrose(GO:0009744) response to disaccharide(GO:0034285) |
| 0.0 | 0.2 | GO:0002553 | histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553) |
| 0.0 | 0.3 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.0 | 0.9 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
| 0.0 | 2.0 | GO:0006418 | tRNA aminoacylation for protein translation(GO:0006418) |
| 0.0 | 1.8 | GO:0006506 | GPI anchor biosynthetic process(GO:0006506) |
| 0.0 | 0.6 | GO:0001916 | positive regulation of T cell mediated cytotoxicity(GO:0001916) |
| 0.0 | 0.9 | GO:0090036 | regulation of protein kinase C signaling(GO:0090036) |
| 0.0 | 1.9 | GO:0030490 | maturation of SSU-rRNA(GO:0030490) |
| 0.0 | 0.5 | GO:0060707 | trophoblast giant cell differentiation(GO:0060707) |
| 0.0 | 4.5 | GO:0007416 | synapse assembly(GO:0007416) |
| 0.0 | 1.3 | GO:0006687 | glycosphingolipid metabolic process(GO:0006687) |
| 0.0 | 0.1 | GO:0010593 | negative regulation of lamellipodium assembly(GO:0010593) |
| 0.0 | 0.9 | GO:0030901 | midbrain development(GO:0030901) |
| 0.0 | 0.3 | GO:0034982 | mitochondrial protein processing(GO:0034982) |
| 0.0 | 6.4 | GO:1902593 | protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593) |
| 0.0 | 2.8 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.0 | 0.7 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.0 | 1.3 | GO:0016052 | carbohydrate catabolic process(GO:0016052) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 7.3 | GO:0071953 | elastic fiber(GO:0071953) |
| 1.0 | 1.0 | GO:0097524 | sperm plasma membrane(GO:0097524) |
| 0.6 | 3.1 | GO:0033063 | Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) |
| 0.5 | 4.6 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.4 | 1.3 | GO:0098835 | presynaptic endosome(GO:0098830) presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) |
| 0.3 | 1.7 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.3 | 1.7 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.3 | 1.1 | GO:0097454 | Schwann cell microvillus(GO:0097454) |
| 0.2 | 54.9 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.2 | 1.3 | GO:0005638 | lamin filament(GO:0005638) |
| 0.2 | 3.6 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.2 | 1.9 | GO:0005688 | U6 snRNP(GO:0005688) |
| 0.2 | 4.6 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.1 | 2.0 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.1 | 1.2 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.1 | 8.9 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.1 | 4.5 | GO:0031672 | A band(GO:0031672) |
| 0.1 | 0.7 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.1 | 0.3 | GO:0005745 | m-AAA complex(GO:0005745) |
| 0.1 | 0.4 | GO:0070187 | telosome(GO:0070187) |
| 0.1 | 0.7 | GO:0097386 | glial cell projection(GO:0097386) |
| 0.1 | 6.3 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 1.5 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 2.0 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 4.3 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 0.9 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.0 | 1.6 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 0.9 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 2.7 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 1.6 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 1.1 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 0.4 | GO:0044291 | cell-cell contact zone(GO:0044291) |
| 0.0 | 1.7 | GO:0005770 | late endosome(GO:0005770) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 19.0 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 3.0 | 8.9 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
| 2.2 | 23.8 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
| 1.5 | 4.5 | GO:0004962 | endothelin receptor activity(GO:0004962) |
| 1.4 | 4.2 | GO:0016748 | succinyltransferase activity(GO:0016748) |
| 1.2 | 8.3 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.8 | 4.6 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.6 | 1.7 | GO:0003989 | acetyl-CoA carboxylase activity(GO:0003989) |
| 0.4 | 1.3 | GO:0016160 | alpha-amylase activity(GO:0004556) amylase activity(GO:0016160) |
| 0.4 | 3.1 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.4 | 12.7 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.3 | 3.8 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.3 | 1.9 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.3 | 1.5 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.3 | 2.3 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.3 | 3.0 | GO:0036042 | long-chain fatty acyl-CoA binding(GO:0036042) |
| 0.2 | 0.7 | GO:0016880 | acid-ammonia (or amide) ligase activity(GO:0016880) |
| 0.2 | 1.1 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
| 0.2 | 4.0 | GO:0042287 | MHC protein binding(GO:0042287) |
| 0.2 | 6.1 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 0.6 | GO:0008475 | procollagen-lysine 5-dioxygenase activity(GO:0008475) |
| 0.1 | 2.0 | GO:0002161 | aminoacyl-tRNA editing activity(GO:0002161) |
| 0.1 | 1.0 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
| 0.1 | 1.3 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.1 | 0.5 | GO:0050694 | galactose 3-O-sulfotransferase activity(GO:0050694) |
| 0.1 | 3.6 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
| 0.1 | 1.0 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.1 | 2.6 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.1 | 1.1 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.1 | 1.3 | GO:0005521 | lamin binding(GO:0005521) |
| 0.1 | 0.2 | GO:1990460 | leptin receptor binding(GO:1990460) |
| 0.0 | 0.3 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.0 | 0.7 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 0.0 | 0.7 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.0 | 0.2 | GO:0097642 | calcitonin family receptor activity(GO:0097642) |
| 0.0 | 0.4 | GO:0005522 | profilin binding(GO:0005522) |
| 0.0 | 1.3 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 3.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 3.6 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.0 | 4.3 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 0.9 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.0 | 1.2 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 0.9 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.0 | 0.4 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 0.0 | 0.1 | GO:0051022 | Rho GDP-dissociation inhibitor binding(GO:0051022) |
| 0.0 | 1.2 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.0 | 2.3 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 1.2 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.0 | 0.7 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 5.2 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 0.7 | GO:0005080 | protein kinase C binding(GO:0005080) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 8.9 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 3.2 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 4.5 | PID_ARF6_TRAFFICKING_PATHWAY | Arf6 trafficking events |
| 0.1 | 4.2 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.1 | 1.7 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.0 | 7.3 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 1.5 | PID_MAPK_TRK_PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 0.9 | PID_RHOA_PATHWAY | RhoA signaling pathway |
| 0.0 | 0.7 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.7 | PID_MTOR_4PATHWAY | mTOR signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 8.3 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.7 | 12.7 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.4 | 44.7 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.3 | 8.9 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
| 0.2 | 3.6 | REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.2 | 4.2 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.1 | 1.9 | REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.1 | 1.7 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 2.0 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.1 | 2.0 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.1 | 4.5 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 1.7 | REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 0.0 | 3.6 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 0.9 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 0.4 | REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.0 | 2.2 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 1.6 | REACTOME_PEPTIDE_CHAIN_ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 0.7 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
