Motif ID: Msx2_Hoxd4

Z-value: 0.977

Transcription factors associated with Msx2_Hoxd4:

Gene SymbolEntrez IDGene Name
Msx2 ENSMUSG00000021469.8 Msx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Msx2mm10_v2_chr13_-_53473074_53473074-0.371.9e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Msx2_Hoxd4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_36811361 9.439 ENSMUST00000101534.1
Ptn
pleiotrophin
chr2_+_4017727 7.069 ENSMUST00000177457.1
Frmd4a
FERM domain containing 4A
chr15_+_21111452 6.949 ENSMUST00000075132.6
Cdh12
cadherin 12
chr3_+_62419668 6.072 ENSMUST00000161057.1
Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr15_-_79285502 5.907 ENSMUST00000165408.1
Baiap2l2
BAI1-associated protein 2-like 2
chr1_+_159737510 5.748 ENSMUST00000111669.3
Tnr
tenascin R
chr5_-_62766153 5.540 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_-_152625212 4.093 ENSMUST00000027760.7
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr14_-_88471396 3.638 ENSMUST00000061628.5
Pcdh20
protocadherin 20
chr1_-_190170671 3.535 ENSMUST00000175916.1
Prox1
prospero-related homeobox 1
chr3_-_49757257 3.189 ENSMUST00000035931.7
Pcdh18
protocadherin 18
chr5_-_62765618 3.123 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr6_-_136171722 2.923 ENSMUST00000053880.6
Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr11_+_103133333 2.865 ENSMUST00000124928.1
ENSMUST00000062530.4
Hexim2

hexamethylene bis-acetamide inducible 2

chr2_-_63184253 2.851 ENSMUST00000075052.3
ENSMUST00000112454.1
Kcnh7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr1_-_190170178 2.848 ENSMUST00000177288.1
Prox1
prospero-related homeobox 1
chr3_+_68869563 2.835 ENSMUST00000054551.2
1110032F04Rik
RIKEN cDNA 1110032F04 gene
chr3_+_138065052 2.764 ENSMUST00000163080.2
1110002E22Rik
RIKEN cDNA 1110002E22 gene
chr12_+_74297474 2.691 ENSMUST00000072100.3
Dbpht2
DNA binding protein with his-thr domain
chr10_-_33624587 2.655 ENSMUST00000160299.1
ENSMUST00000019920.6
Clvs2

clavesin 2

chr3_-_85741389 2.554 ENSMUST00000094148.4
Fam160a1
family with sequence similarity 160, member A1
chr11_+_103133303 2.532 ENSMUST00000107037.1
Hexim2
hexamethylene bis-acetamide inducible 2
chr15_+_92597104 2.484 ENSMUST00000035399.8
Pdzrn4
PDZ domain containing RING finger 4
chr15_-_37459327 2.457 ENSMUST00000119730.1
ENSMUST00000120746.1
Ncald

neurocalcin delta

chr12_+_36314160 2.428 ENSMUST00000041407.5
Sostdc1
sclerostin domain containing 1
chr17_-_90088343 2.084 ENSMUST00000173917.1
Nrxn1
neurexin I
chr4_+_136143497 2.030 ENSMUST00000008016.2
Id3
inhibitor of DNA binding 3
chr4_+_124657646 2.002 ENSMUST00000053491.7
Pou3f1
POU domain, class 3, transcription factor 1
chr2_-_33086366 1.920 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr2_-_63184170 1.836 ENSMUST00000112452.1
Kcnh7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr19_+_26749726 1.729 ENSMUST00000175842.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr2_-_45110336 1.658 ENSMUST00000028229.6
ENSMUST00000152232.1
Zeb2

zinc finger E-box binding homeobox 2

chr18_+_37513652 1.643 ENSMUST00000061405.4
Pcdhb21
protocadherin beta 21
chrX_+_159708593 1.629 ENSMUST00000080394.6
Sh3kbp1
SH3-domain kinase binding protein 1
chr2_+_125136692 1.506 ENSMUST00000099452.2
Ctxn2
cortexin 2
chr4_-_129121889 1.479 ENSMUST00000139450.1
ENSMUST00000125931.1
ENSMUST00000116444.2
Hpca


hippocalcin


chrX_+_150547375 1.465 ENSMUST00000066337.6
ENSMUST00000112715.1
Alas2

aminolevulinic acid synthase 2, erythroid

chr9_+_32116040 1.436 ENSMUST00000174641.1
Arhgap32
Rho GTPase activating protein 32
chr18_+_37518341 1.419 ENSMUST00000097609.1
Pcdhb22
protocadherin beta 22
chr2_-_45112890 1.352 ENSMUST00000076836.6
Zeb2
zinc finger E-box binding homeobox 2
chr13_+_75967704 1.296 ENSMUST00000022081.1
Spata9
spermatogenesis associated 9
chr1_-_72284248 1.245 ENSMUST00000097698.4
ENSMUST00000027381.6
Pecr

peroxisomal trans-2-enoyl-CoA reductase

chr15_-_37458523 1.199 ENSMUST00000116445.2
Ncald
neurocalcin delta
chr9_-_114390633 1.186 ENSMUST00000084881.4
Crtap
cartilage associated protein
chr13_+_51408618 1.147 ENSMUST00000087978.3
S1pr3
sphingosine-1-phosphate receptor 3
chr1_-_168432270 1.140 ENSMUST00000072863.4
Pbx1
pre B cell leukemia homeobox 1
chr3_+_52268337 1.127 ENSMUST00000053764.5
Foxo1
forkhead box O1
chr10_+_39612934 1.102 ENSMUST00000019987.6
Traf3ip2
TRAF3 interacting protein 2
chr5_-_23616528 1.077 ENSMUST00000088392.4
Srpk2
serine/arginine-rich protein specific kinase 2
chr1_-_133921393 1.067 ENSMUST00000048432.5
Prelp
proline arginine-rich end leucine-rich repeat
chr18_-_43477764 1.026 ENSMUST00000057110.9
Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr18_+_52767994 1.009 ENSMUST00000025413.7
ENSMUST00000163742.2
ENSMUST00000178011.1
Sncaip


synuclein, alpha interacting protein (synphilin)


chr2_-_144527341 0.996 ENSMUST00000163701.1
ENSMUST00000081982.5
Dzank1

double zinc ribbon and ankyrin repeat domains 1

chr9_+_22454290 0.977 ENSMUST00000168332.1
Gm17545
predicted gene, 17545
chr17_-_14694223 0.974 ENSMUST00000170872.1
Thbs2
thrombospondin 2
chrX_-_8132770 0.970 ENSMUST00000130832.1
ENSMUST00000033506.6
ENSMUST00000115623.1
ENSMUST00000153839.1
Wdr13



WD repeat domain 13



chr3_+_84952146 0.948 ENSMUST00000029727.7
Fbxw7
F-box and WD-40 domain protein 7
chr9_-_112187766 0.941 ENSMUST00000111872.2
ENSMUST00000164754.2
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr12_-_27160311 0.929 ENSMUST00000182473.1
ENSMUST00000177636.1
ENSMUST00000183238.1
Gm9866


predicted gene 9866


chr2_+_72054598 0.880 ENSMUST00000028525.5
Rapgef4
Rap guanine nucleotide exchange factor (GEF) 4
chr6_-_136941887 0.878 ENSMUST00000111891.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr18_-_37969742 0.866 ENSMUST00000166148.1
ENSMUST00000163131.1
ENSMUST00000043437.7
Fchsd1


FCH and double SH3 domains 1


chr18_+_37320374 0.843 ENSMUST00000078271.2
Pcdhb5
protocadherin beta 5
chr1_+_165788681 0.815 ENSMUST00000161971.1
ENSMUST00000178336.1
ENSMUST00000005907.5
ENSMUST00000027849.4
Cd247



CD247 antigen



chr4_+_102570065 0.813 ENSMUST00000097950.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr16_-_44016387 0.803 ENSMUST00000036174.3
Gramd1c
GRAM domain containing 1C
chr6_+_136518820 0.793 ENSMUST00000032335.6
Atf7ip
activating transcription factor 7 interacting protein
chr7_-_73537621 0.745 ENSMUST00000172704.1
Chd2
chromodomain helicase DNA binding protein 2
chr7_-_114117761 0.731 ENSMUST00000069449.5
Rras2
related RAS viral (r-ras) oncogene homolog 2
chr13_+_93304799 0.731 ENSMUST00000080127.5
Homer1
homer homolog 1 (Drosophila)
chr6_+_29853746 0.729 ENSMUST00000064872.6
ENSMUST00000152581.1
ENSMUST00000176265.1
ENSMUST00000154079.1
Ahcyl2



S-adenosylhomocysteine hydrolase-like 2



chr1_+_180109192 0.729 ENSMUST00000143176.1
ENSMUST00000135056.1
Cdc42bpa

CDC42 binding protein kinase alpha

chrX_+_101640056 0.716 ENSMUST00000119299.1
ENSMUST00000044475.4
Ogt

O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)

chr9_-_55919605 0.669 ENSMUST00000037408.8
Scaper
S phase cyclin A-associated protein in the ER
chr3_-_66296807 0.665 ENSMUST00000029419.7
Veph1
ventricular zone expressed PH domain-containing 1
chr5_-_146220901 0.648 ENSMUST00000169407.2
ENSMUST00000161331.1
ENSMUST00000159074.2
ENSMUST00000067837.3
Rnf6



ring finger protein (C3H2C3 type) 6



chr5_-_107875035 0.637 ENSMUST00000138111.1
ENSMUST00000112642.1
Evi5

ecotropic viral integration site 5

chr7_-_101845300 0.618 ENSMUST00000094141.5
Folr2
folate receptor 2 (fetal)
chr4_-_40722307 0.614 ENSMUST00000181475.1
Gm6297
predicted gene 6297
chr7_-_38019505 0.589 ENSMUST00000085513.4
Uri1
URI1, prefoldin-like chaperone
chr9_-_89705017 0.586 ENSMUST00000058488.6
Tmed3
transmembrane emp24 domain containing 3
chr4_-_149126688 0.575 ENSMUST00000030815.2
Cort
cortistatin
chr1_+_165788746 0.556 ENSMUST00000161559.2
Cd247
CD247 antigen
chr1_-_186749304 0.526 ENSMUST00000001339.5
Rrp15
ribosomal RNA processing 15 homolog (S. cerevisiae)
chr1_+_63176818 0.521 ENSMUST00000129339.1
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr4_-_62519885 0.498 ENSMUST00000107444.1
ENSMUST00000030090.3
Alad

aminolevulinate, delta-, dehydratase

chr14_-_36919314 0.490 ENSMUST00000182797.1
Ccser2
coiled-coil serine rich 2
chr4_-_141078302 0.478 ENSMUST00000030760.8
Necap2
NECAP endocytosis associated 2
chr8_+_70527724 0.467 ENSMUST00000119353.2
ENSMUST00000075491.7
Fkbp8

FK506 binding protein 8

chr11_-_109472611 0.458 ENSMUST00000168740.1
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr13_-_95250166 0.446 ENSMUST00000162153.1
ENSMUST00000160957.2
ENSMUST00000159598.1
ENSMUST00000162412.1
Pde8b



phosphodiesterase 8B



chr6_+_124304646 0.446 ENSMUST00000112541.2
ENSMUST00000032234.2
Cd163

CD163 antigen

chr12_-_85374696 0.418 ENSMUST00000040766.7
Tmed10
transmembrane emp24-like trafficking protein 10 (yeast)
chr6_-_106800051 0.416 ENSMUST00000013882.7
ENSMUST00000049675.4
ENSMUST00000113239.3
Crbn


cereblon


chr7_+_126950518 0.413 ENSMUST00000106335.1
ENSMUST00000146017.1
Sez6l2

seizure related 6 homolog like 2

chr2_+_132847719 0.413 ENSMUST00000124836.1
ENSMUST00000154160.1
Crls1

cardiolipin synthase 1

chr7_-_121074501 0.411 ENSMUST00000047194.2
Igsf6
immunoglobulin superfamily, member 6
chr7_-_29906524 0.410 ENSMUST00000159920.1
ENSMUST00000162592.1
Zfp27

zinc finger protein 27

chr13_+_76098734 0.399 ENSMUST00000091466.3
Ttc37
tetratricopeptide repeat domain 37
chr13_+_93304066 0.374 ENSMUST00000109493.1
Homer1
homer homolog 1 (Drosophila)
chr7_+_96522342 0.373 ENSMUST00000129737.1
Tenm4
teneurin transmembrane protein 4
chr1_+_191025350 0.368 ENSMUST00000181050.1
A230020J21Rik
RIKEN cDNA A230020J21 gene
chr9_+_64235201 0.359 ENSMUST00000039011.3
Uchl4
ubiquitin carboxyl-terminal esterase L4
chr1_+_33908172 0.354 ENSMUST00000182513.1
ENSMUST00000183034.1
Dst

dystonin

chr15_-_50890396 0.353 ENSMUST00000185183.1
Trps1
trichorhinophalangeal syndrome I (human)
chr1_-_163289214 0.340 ENSMUST00000183691.1
Prrx1
paired related homeobox 1
chr1_-_163725123 0.326 ENSMUST00000159679.1
Mettl11b
methyltransferase like 11B
chr5_-_84417359 0.304 ENSMUST00000113401.1
Epha5
Eph receptor A5
chr9_+_30942541 0.300 ENSMUST00000068135.6
Adamts8
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8
chr7_-_45921418 0.289 ENSMUST00000038876.5
Emp3
epithelial membrane protein 3
chr3_-_110143937 0.278 ENSMUST00000051253.3
Ntng1
netrin G1
chrX_-_143933089 0.273 ENSMUST00000087313.3
Dcx
doublecortin
chr6_-_13871477 0.268 ENSMUST00000139231.1
2610001J05Rik
RIKEN cDNA 2610001J05 gene
chr7_-_45920830 0.232 ENSMUST00000164119.1
Emp3
epithelial membrane protein 3
chr1_-_132390301 0.232 ENSMUST00000132435.1
Tmcc2
transmembrane and coiled-coil domains 2
chrX_-_150814265 0.221 ENSMUST00000026302.6
ENSMUST00000129768.1
ENSMUST00000112699.2
Maged2


melanoma antigen, family D, 2


chrX_-_143933204 0.221 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
Dcx


doublecortin


chr13_+_49544443 0.216 ENSMUST00000177948.1
ENSMUST00000021820.6
Aspn

asporin

chr13_+_40859768 0.214 ENSMUST00000110191.2
Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr2_-_164389095 0.185 ENSMUST00000167427.1
Slpi
secretory leukocyte peptidase inhibitor
chr3_-_144570136 0.169 ENSMUST00000043325.7
Hs2st1
heparan sulfate 2-O-sulfotransferase 1
chr11_-_74724670 0.161 ENSMUST00000021091.8
Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr17_+_46161021 0.161 ENSMUST00000024748.7
ENSMUST00000172170.1
Gtpbp2

GTP binding protein 2

chr1_-_133661318 0.157 ENSMUST00000027736.6
ENSMUST00000179598.1
Zc3h11a
Zbed6
zinc finger CCCH type containing 11A
zinc finger, BED domain containing 6
chr11_+_78465697 0.156 ENSMUST00000001126.3
Slc46a1
solute carrier family 46, member 1
chr3_-_146495115 0.156 ENSMUST00000093951.2
Spata1
spermatogenesis associated 1
chr5_-_72168142 0.148 ENSMUST00000013693.6
Commd8
COMM domain containing 8
chr18_+_23752333 0.147 ENSMUST00000170802.1
ENSMUST00000155708.1
ENSMUST00000118826.2
Mapre2


microtubule-associated protein, RP/EB family, member 2


chr7_+_126950687 0.122 ENSMUST00000106333.1
Sez6l2
seizure related 6 homolog like 2
chr2_+_180710117 0.089 ENSMUST00000029090.2
Gid8
GID complex subunit 8 homolog (S. cerevisiae)
chrX_-_103981242 0.088 ENSMUST00000121153.1
ENSMUST00000070705.4
Rlim

ring finger protein, LIM domain interacting

chr17_-_24073479 0.081 ENSMUST00000017090.5
Kctd5
potassium channel tetramerisation domain containing 5
chr10_+_5593718 0.072 ENSMUST00000051809.8
Myct1
myc target 1
chr17_-_25785324 0.065 ENSMUST00000150324.1
Haghl
hydroxyacylglutathione hydrolase-like
chr18_+_34840575 0.053 ENSMUST00000043484.7
Reep2
receptor accessory protein 2
chr18_-_3281712 0.052 ENSMUST00000182204.1
ENSMUST00000154705.1
ENSMUST00000182833.1
ENSMUST00000151084.1
Crem



cAMP responsive element modulator



chrM_+_10167 0.046 ENSMUST00000082414.1
mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr7_+_126950837 0.043 ENSMUST00000106332.1
Sez6l2
seizure related 6 homolog like 2
chr17_+_45506825 0.031 ENSMUST00000024733.7
Aars2
alanyl-tRNA synthetase 2, mitochondrial (putative)
chr17_-_46327949 0.026 ENSMUST00000047970.7
Abcc10
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr6_+_37870786 0.019 ENSMUST00000120428.1
ENSMUST00000031859.7
Trim24

tripartite motif-containing 24


Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 9.4 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
2.1 6.4 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
1.4 5.7 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.8 2.4 GO:2000016 negative regulation of determination of dorsal identity(GO:2000016)
0.7 2.9 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.5 2.1 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.5 3.0 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.5 1.5 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.4 5.9 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.3 6.1 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.2 0.7 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.2 0.9 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.2 1.1 GO:0035063 nuclear speck organization(GO:0035063)
0.2 1.7 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.2 0.9 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.2 5.4 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.2 3.2 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 7.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 0.4 GO:0035106 operant conditioning(GO:0035106)
0.1 0.9 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.1 0.4 GO:0035964 COPI-coated vesicle budding(GO:0035964)
0.1 10.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 0.6 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.1 1.2 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.1 1.1 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.1 1.1 GO:0071455 cellular response to hyperoxia(GO:0071455)
0.1 0.4 GO:0032289 central nervous system myelin formation(GO:0032289) cardiac cell fate specification(GO:0060912)
0.1 0.7 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 1.2 GO:0030497 fatty acid elongation(GO:0030497)
0.1 1.0 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.1 2.0 GO:0030903 notochord development(GO:0030903)
0.1 1.1 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 0.8 GO:0015884 folic acid transport(GO:0015884)
0.1 1.1 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.1 2.0 GO:0032292 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.1 0.8 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 2.0 GO:0006783 heme biosynthetic process(GO:0006783)
0.1 0.6 GO:0045187 regulation of circadian sleep/wake cycle(GO:0042749) regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.1 0.4 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.0 1.4 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.8 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 1.1 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.0 3.7 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 0.2 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.0 0.2 GO:0030202 heparin metabolic process(GO:0030202)
0.0 0.4 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.2 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.0 1.0 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.0 0.2 GO:0070294 renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294)
0.0 0.5 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.9 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.2 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.5 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 2.7 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 4.9 GO:0007416 synapse assembly(GO:0007416)
0.0 0.3 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 0.5 GO:0032060 bleb assembly(GO:0032060)
0.0 0.7 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.3 GO:0048664 neuron fate determination(GO:0048664)
0.0 5.0 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 0.6 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.0 0.4 GO:0006953 acute-phase response(GO:0006953)
0.0 0.9 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.1 GO:1900095 regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.0 0.5 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 0.3 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 1.1 GO:0007569 cell aging(GO:0007569)
0.0 0.5 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.5 GO:0045471 response to ethanol(GO:0045471)
0.0 6.3 GO:0007264 small GTPase mediated signal transduction(GO:0007264)
0.0 1.6 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.2 GO:0019731 antibacterial humoral response(GO:0019731)
0.0 0.6 GO:0031338 regulation of vesicle fusion(GO:0031338) activation of GTPase activity(GO:0090630)
0.0 0.0 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.0 0.3 GO:0031365 N-terminal protein amino acid modification(GO:0031365)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.7 GO:0072534 perineuronal net(GO:0072534)
0.6 5.9 GO:0071439 clathrin complex(GO:0071439)
0.3 1.4 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.2 0.9 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.2 2.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 2.9 GO:0043083 synaptic cleft(GO:0043083)
0.2 0.9 GO:0044316 cone cell pedicle(GO:0044316)
0.1 0.4 GO:0055087 Ski complex(GO:0055087)
0.1 1.5 GO:0044327 dendritic spine head(GO:0044327)
0.1 10.3 GO:0031594 neuromuscular junction(GO:0031594)
0.1 1.7 GO:0071564 npBAF complex(GO:0071564)
0.1 0.4 GO:0031673 H zone(GO:0031673)
0.1 0.5 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 1.0 GO:0031091 platelet alpha granule(GO:0031091)
0.1 1.1 GO:0042588 zymogen granule(GO:0042588)
0.1 1.0 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 0.6 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 7.0 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.6 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 1.4 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.8 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 3.1 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 0.4 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.6 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.2 GO:0000235 astral microtubule(GO:0000235)
0.0 0.2 GO:0000346 transcription export complex(GO:0000346)
0.0 0.5 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 1.2 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 5.4 GO:0016607 nuclear speck(GO:0016607)
0.0 0.3 GO:0046658 anchored component of plasma membrane(GO:0046658)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 9.4 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.7 4.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.7 5.4 GO:0097322 7SK snRNA binding(GO:0097322)
0.5 6.4 GO:0050693 LBD domain binding(GO:0050693)
0.5 1.5 GO:0016748 succinyltransferase activity(GO:0016748)
0.4 1.2 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.4 2.9 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.3 2.4 GO:0098821 BMP receptor activity(GO:0098821)
0.3 5.7 GO:0046625 sphingolipid binding(GO:0046625)
0.2 0.7 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.2 4.7 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.2 0.6 GO:0051870 methotrexate binding(GO:0051870)
0.2 0.9 GO:0050816 phosphothreonine binding(GO:0050816)
0.2 8.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 2.1 GO:0097109 neuroligin family protein binding(GO:0097109)
0.2 1.1 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 2.7 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 0.9 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 3.7 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 0.7 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 1.1 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 3.0 GO:0070412 R-SMAD binding(GO:0070412)
0.1 4.1 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 0.2 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 0.2 GO:0015232 heme transporter activity(GO:0015232)
0.1 2.0 GO:0005504 fatty acid binding(GO:0005504)
0.0 7.1 GO:0030674 protein binding, bridging(GO:0030674)
0.0 1.1 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 1.7 GO:0030552 cAMP binding(GO:0030552)
0.0 0.3 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 1.1 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 1.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.5 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 16.2 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.4 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.0 0.4 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 6.1 GO:0005543 phospholipid binding(GO:0005543)
0.0 0.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.6 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.4 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 1.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.5 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.0 GO:0004813 alanine-tRNA ligase activity(GO:0004813)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 9.4 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.2 8.7 PID_ARF6_PATHWAY Arf6 signaling events
0.1 1.1 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 3.1 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 2.4 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 6.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.1 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.9 PID_MYC_PATHWAY C-MYC pathway
0.0 1.0 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.6 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.4 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.7 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.1 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 0.3 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.7 PID_CDC42_PATHWAY CDC42 signaling events
0.0 0.5 PID_NFAT_3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2 3.7 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 6.9 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 2.9 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 4.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.1 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.1 2.0 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 9.5 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.6 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 1.1 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.4 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.0 0.9 REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.0 0.9 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation