Motif ID: Msx3

Z-value: 0.514


Transcription factors associated with Msx3:

Gene SymbolEntrez IDGene Name
Msx3 ENSMUSG00000025469.9 Msx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Msx3mm10_v2_chr7_-_140049083_1400490890.481.5e-03Click!


Activity profile for motif Msx3.

activity profile for motif Msx3


Sorted Z-values histogram for motif Msx3

Sorted Z-values for motif Msx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Msx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_14621805 4.456 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr15_+_44787746 2.965 ENSMUST00000181839.1
 2310069G16Rik
RIKEN cDNA 2310069G16 gene
chr4_+_102254739 2.637 ENSMUST00000106907.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr4_-_14621494 2.583 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr2_-_45117349 2.371 ENSMUST00000176438.2
 Zeb2
zinc finger E-box binding homeobox 2
chr4_-_14621669 2.040 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr9_-_53975246 1.657 ENSMUST00000048409.7
 Elmod1
ELMO/CED-12 domain containing 1
chr10_+_39612934 1.603 ENSMUST00000019987.6
 Traf3ip2
TRAF3 interacting protein 2
chr10_+_81257277 1.589 ENSMUST00000117488.1
ENSMUST00000105328.3
ENSMUST00000121205.1
 Matk


megakaryocyte-associated tyrosine kinase


chr2_-_33087169 1.446 ENSMUST00000102810.3
 Garnl3
GTPase activating RANGAP domain-like 3
chr10_+_88379217 1.299 ENSMUST00000130301.1
ENSMUST00000020251.8
 Gnptab

N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits

chr1_-_52190901 1.191 ENSMUST00000156887.1
ENSMUST00000129107.1
 Gls

glutaminase

chr2_-_33086366 1.164 ENSMUST00000049618.2
 Garnl3
GTPase activating RANGAP domain-like 3
chr5_+_14514918 1.117 ENSMUST00000030691.10
ENSMUST00000182407.1
 Pclo

piccolo (presynaptic cytomatrix protein)

chr10_+_88379127 1.109 ENSMUST00000127615.1
 Gnptab
N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
chr15_+_82252397 0.974 ENSMUST00000136948.1
 1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr12_+_72441852 0.944 ENSMUST00000162159.1
 Lrrc9
leucine rich repeat containing 9
chrX_-_143933089 0.824 ENSMUST00000087313.3
 Dcx
doublecortin
chrX_-_143933204 0.804 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr12_+_72441933 0.758 ENSMUST00000161284.1
 Lrrc9
leucine rich repeat containing 9
chr13_-_102958084 0.677 ENSMUST00000099202.3
ENSMUST00000172264.1
 Mast4

microtubule associated serine/threonine kinase family member 4

chr5_+_88583527 0.614 ENSMUST00000031229.6
 Rufy3
RUN and FYVE domain containing 3
chr13_+_83732438 0.608 ENSMUST00000182701.1
 C130071C03Rik
RIKEN cDNA C130071C03 gene
chr17_-_24527830 0.574 ENSMUST00000176353.1
ENSMUST00000176237.1
 Traf7

TNF receptor-associated factor 7

chr2_+_125136692 0.534 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr3_-_116253467 0.517 ENSMUST00000090473.5
 Gpr88
G-protein coupled receptor 88
chr7_+_103550368 0.500 ENSMUST00000106888.1
 Olfr613
olfactory receptor 613
chr17_-_24527925 0.482 ENSMUST00000176652.1
 Traf7
TNF receptor-associated factor 7
chr7_-_127895578 0.461 ENSMUST00000033074.6
 Vkorc1
vitamin K epoxide reductase complex, subunit 1
chr11_+_70018421 0.458 ENSMUST00000108588.1
 Dlg4
discs, large homolog 4 (Drosophila)
chr2_+_121956651 0.432 ENSMUST00000110574.1
 Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr3_+_66985947 0.429 ENSMUST00000161726.1
ENSMUST00000160504.1
 Rsrc1

arginine/serine-rich coiled-coil 1

chr13_-_58354862 0.401 ENSMUST00000043605.5
 Kif27
kinesin family member 27
chr17_+_21383725 0.401 ENSMUST00000056107.4
ENSMUST00000162659.1
 Zfp677

zinc finger protein 677

chr16_+_49699198 0.385 ENSMUST00000046777.4
ENSMUST00000142682.1
 Ift57

intraflagellar transport 57

chr12_+_102128718 0.382 ENSMUST00000159329.1
 Slc24a4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr7_+_3645267 0.370 ENSMUST00000038913.9
 Cnot3
CCR4-NOT transcription complex, subunit 3
chr2_+_121956411 0.367 ENSMUST00000110578.1
 Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr1_-_158356258 0.351 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr3_-_41742471 0.347 ENSMUST00000026866.8
 Sclt1
sodium channel and clathrin linker 1
chr18_+_37819543 0.318 ENSMUST00000055935.5
 Pcdhga9
protocadherin gamma subfamily A, 9
chr8_+_107031218 0.318 ENSMUST00000034388.9
 Vps4a
vacuolar protein sorting 4a (yeast)
chr12_-_71136611 0.318 ENSMUST00000021486.8
ENSMUST00000166120.1
 Timm9

translocase of inner mitochondrial membrane 9

chrM_+_7005 0.303 ENSMUST00000082405.1
 mt-Co2
mitochondrially encoded cytochrome c oxidase II
chrX_+_107255878 0.302 ENSMUST00000101294.2
ENSMUST00000118820.1
ENSMUST00000120971.1
 Gpr174


G protein-coupled receptor 174


chr7_-_99141068 0.289 ENSMUST00000037968.8
 Uvrag
UV radiation resistance associated gene
chr9_-_15301555 0.255 ENSMUST00000034414.8
 4931406C07Rik
RIKEN cDNA 4931406C07 gene
chr3_+_94837533 0.237 ENSMUST00000107270.2
 Pogz
pogo transposable element with ZNF domain
chr16_-_75766758 0.229 ENSMUST00000114244.1
ENSMUST00000046283.8
 Hspa13

heat shock protein 70 family, member 13

chr3_+_66985680 0.226 ENSMUST00000065047.6
 Rsrc1
arginine/serine-rich coiled-coil 1
chr11_+_53433299 0.222 ENSMUST00000018382.6
 Gdf9
growth differentiation factor 9
chr3_+_66985647 0.217 ENSMUST00000162362.1
ENSMUST00000065074.7
 Rsrc1

arginine/serine-rich coiled-coil 1

chr7_+_101896817 0.190 ENSMUST00000143835.1
 Anapc15
anaphase prompoting complex C subunit 15
chrX_-_75578188 0.186 ENSMUST00000033545.5
 Rab39b
RAB39B, member RAS oncogene family
chrM_+_9870 0.184 ENSMUST00000084013.1
 mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr3_+_106034661 0.172 ENSMUST00000170669.2
 Gm4540
predicted gene 4540
chr15_+_38661904 0.172 ENSMUST00000022904.6
 Atp6v1c1
ATPase, H+ transporting, lysosomal V1 subunit C1
chr9_+_44398176 0.170 ENSMUST00000165839.1
 Slc37a4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr3_+_66985700 0.165 ENSMUST00000046542.6
ENSMUST00000162693.1
 Rsrc1

arginine/serine-rich coiled-coil 1

chr6_+_145934113 0.160 ENSMUST00000032383.7
 Sspn
sarcospan
chr8_+_69659263 0.146 ENSMUST00000169125.1
 Zfp964
zinc finger protein 964
chr19_+_5474681 0.098 ENSMUST00000165485.1
ENSMUST00000166253.1
ENSMUST00000167371.1
ENSMUST00000167855.1
ENSMUST00000070118.7
 Efemp2




epidermal growth factor-containing fibulin-like extracellular matrix protein 2




chrX_+_101449078 0.087 ENSMUST00000033674.5
 Itgb1bp2
integrin beta 1 binding protein 2
chr8_+_72219726 0.051 ENSMUST00000003123.8
 Fam32a
family with sequence similarity 32, member A
chr1_-_34439672 0.035 ENSMUST00000042493.8
 Ccdc115
coiled-coil domain containing 115
chr3_+_83055516 0.025 ENSMUST00000150268.1
ENSMUST00000122128.1
 Plrg1

pleiotropic regulator 1, PRL1 homolog (Arabidopsis)

chr4_-_58912678 0.018 ENSMUST00000144512.1
ENSMUST00000102889.3
ENSMUST00000055822.8
 AI314180


expressed sequence AI314180


chr3_+_32515295 0.003 ENSMUST00000029203.7
 Zfp639
zinc finger protein 639

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 9.1 GO:0019532 oxalate transport(GO:0019532)
0.8 2.4 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.4 2.4 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.4 1.1 GO:0098928 presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526)
0.2 1.2 GO:0006543 glutamine catabolic process(GO:0006543)
0.2 2.6 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 0.3 GO:0009838 abscission(GO:0009838)
0.2 0.5 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.1 0.5 GO:0061743 motor learning(GO:0061743)
0.1 1.6 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 1.6 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.1 1.1 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 0.3 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 0.3 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 0.2 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.3 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0 0.2 GO:0042701 progesterone secretion(GO:0042701)
0.0 0.5 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.0 0.4 GO:0097186 amelogenesis(GO:0097186)
0.0 0.6 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 1.0 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.8 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 1.6 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.4 GO:0044458 motile cilium assembly(GO:0044458)
0.0 1.7 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 0.4 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 0.5 GO:0007608 sensory perception of smell(GO:0007608)
0.0 0.4 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.2 GO:0051382 kinetochore assembly(GO:0051382)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0099569 presynaptic cytoskeleton(GO:0099569)
0.1 2.6 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.3 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.6 GO:0071437 invadopodium(GO:0071437)
0.0 0.4 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.3 GO:0071439 clathrin complex(GO:0071439)
0.0 0.3 GO:0090543 ESCRT III complex(GO:0000815) Flemming body(GO:0090543)
0.0 7.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.4 GO:0044292 dendrite terminus(GO:0044292)
0.0 0.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 1.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 9.1 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.6 2.4 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.2 1.2 GO:0004359 glutaminase activity(GO:0004359)
0.1 1.1 GO:0005522 profilin binding(GO:0005522)
0.1 0.5 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 2.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 0.4 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 2.4 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.5 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.5 GO:0048038 quinone binding(GO:0048038)
0.0 1.6 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.3 GO:0045125 bioactive lipid receptor activity(GO:0045125)
0.0 0.2 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.3 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.6 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.5 ST_GA12_PATHWAY G alpha 12 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 9.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.2 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 2.6 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 0.5 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.4 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 1.6 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.0 1.6 REACTOME_SIGNALING_BY_ERBB2 Genes involved in Signaling by ERBB2
0.0 0.3 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)