Motif ID: Mtf1

Z-value: 0.607


Transcription factors associated with Mtf1:

Gene SymbolEntrez IDGene Name
Mtf1 ENSMUSG00000028890.7 Mtf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mtf1mm10_v2_chr4_+_124802543_124802678-0.462.5e-03Click!


Activity profile for motif Mtf1.

activity profile for motif Mtf1


Sorted Z-values histogram for motif Mtf1

Sorted Z-values for motif Mtf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Mtf1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_94172618 8.902 ENSMUST00000034214.6
 Mt2
metallothionein 2
chr8_+_94179089 4.713 ENSMUST00000034215.6
 Mt1
metallothionein 1
chr9_-_56635624 2.370 ENSMUST00000114256.1
 Lingo1
leucine rich repeat and Ig domain containing 1
chr11_-_32222233 2.321 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
 Rhbdf1


rhomboid family 1 (Drosophila)


chr4_+_103619580 2.220 ENSMUST00000106827.1
 Dab1
disabled 1
chr7_+_5056856 2.010 ENSMUST00000131368.1
ENSMUST00000123956.1
 Ccdc106

coiled-coil domain containing 106

chr9_-_14381242 1.974 ENSMUST00000167549.1
 Endod1
endonuclease domain containing 1
chr9_-_112187898 1.762 ENSMUST00000178410.1
ENSMUST00000172380.3
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr4_+_129985098 1.673 ENSMUST00000106017.1
ENSMUST00000121049.1
 Bai2

brain-specific angiogenesis inhibitor 2

chr7_+_132610620 1.666 ENSMUST00000033241.5
 Lhpp
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
chr4_+_129984833 1.426 ENSMUST00000120204.1
 Bai2
brain-specific angiogenesis inhibitor 2
chr1_+_75400070 1.415 ENSMUST00000113589.1
 Speg
SPEG complex locus
chr11_+_63133068 1.352 ENSMUST00000108700.1
 Pmp22
peripheral myelin protein 22
chr11_+_63132569 1.191 ENSMUST00000108701.1
 Pmp22
peripheral myelin protein 22
chr7_-_15922361 1.152 ENSMUST00000044355.7
 Sepw1
selenoprotein W, muscle 1
chr6_-_39118211 1.151 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr2_-_91236967 1.131 ENSMUST00000028696.4
 Ddb2
damage specific DNA binding protein 2
chr8_+_106211016 1.101 ENSMUST00000109297.1
 Prmt7
protein arginine N-methyltransferase 7
chr4_-_93335510 1.092 ENSMUST00000066774.4
 Tusc1
tumor suppressor candidate 1
chr8_+_106210936 1.060 ENSMUST00000071592.5
 Prmt7
protein arginine N-methyltransferase 7
chr4_+_134496996 1.059 ENSMUST00000095074.3
 Paqr7
progestin and adipoQ receptor family member VII
chr8_+_123373778 1.027 ENSMUST00000057934.3
ENSMUST00000108840.2
 Tcf25

transcription factor 25 (basic helix-loop-helix)

chr5_-_125341043 0.985 ENSMUST00000111390.1
ENSMUST00000086075.6
 Scarb1

scavenger receptor class B, member 1

chr1_-_167393826 0.972 ENSMUST00000028005.2
 Mgst3
microsomal glutathione S-transferase 3
chr12_-_4592927 0.946 ENSMUST00000170816.1
 Gm3625
predicted gene 3625
chr1_+_179668202 0.902 ENSMUST00000040538.3
 Sccpdh
saccharopine dehydrogenase (putative)
chr17_+_47688992 0.887 ENSMUST00000156118.1
 Frs3
fibroblast growth factor receptor substrate 3
chr8_+_13159135 0.866 ENSMUST00000033824.6
 Lamp1
lysosomal-associated membrane protein 1
chr9_+_57940104 0.843 ENSMUST00000043059.7
 Sema7a
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr3_-_58692391 0.834 ENSMUST00000070368.7
 Siah2
seven in absentia 2
chr8_-_70776650 0.825 ENSMUST00000034296.8
 Pik3r2
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)
chr2_-_91236877 0.805 ENSMUST00000111352.1
 Ddb2
damage specific DNA binding protein 2
chr10_+_70245083 0.771 ENSMUST00000046807.6
 Slc16a9
solute carrier family 16 (monocarboxylic acid transporters), member 9
chr18_+_14424821 0.766 ENSMUST00000069552.5
 Gm5160
predicted gene 5160
chr17_-_83631892 0.731 ENSMUST00000051482.1
 Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr16_+_22857845 0.689 ENSMUST00000004574.7
ENSMUST00000178320.1
ENSMUST00000166487.2
 Dnajb11


DnaJ (Hsp40) homolog, subfamily B, member 11


chr14_-_26170283 0.673 ENSMUST00000100809.4
 Plac9b
placenta specific 9b
chr10_-_81001338 0.606 ENSMUST00000099462.1
ENSMUST00000118233.1
 Gng7

guanine nucleotide binding protein (G protein), gamma 7

chr6_-_56923927 0.553 ENSMUST00000031793.5
 Nt5c3
5'-nucleotidase, cytosolic III
chr1_+_131867224 0.539 ENSMUST00000112386.1
ENSMUST00000027693.7
 Rab7l1

RAB7, member RAS oncogene family-like 1

chr15_-_93519499 0.498 ENSMUST00000109255.2
 Prickle1
prickle homolog 1 (Drosophila)
chr1_+_167618246 0.491 ENSMUST00000111380.1
 Rxrg
retinoid X receptor gamma
chr7_-_141539784 0.473 ENSMUST00000118694.1
ENSMUST00000153191.1
ENSMUST00000166082.1
ENSMUST00000026586.6
 Chid1



chitinase domain containing 1



chr19_-_4201591 0.467 ENSMUST00000025740.6
 Rad9a
RAD9 homolog A
chr16_-_22857514 0.445 ENSMUST00000004576.6
 Tbccd1
TBCC domain containing 1
chr17_-_56716788 0.440 ENSMUST00000067931.5
 Vmac
vimentin-type intermediate filament associated coiled-coil protein
chr15_-_83149307 0.426 ENSMUST00000100375.4
 Poldip3
polymerase (DNA-directed), delta interacting protein 3
chr12_+_33957645 0.419 ENSMUST00000049089.5
 Twist1
twist basic helix-loop-helix transcription factor 1
chr12_+_111758848 0.388 ENSMUST00000084941.5
 Klc1
kinesin light chain 1
chr3_+_107895916 0.387 ENSMUST00000172247.1
ENSMUST00000167387.1
 Gstm5

glutathione S-transferase, mu 5

chr16_-_91597636 0.385 ENSMUST00000023686.8
 Tmem50b
transmembrane protein 50B
chr15_+_100469034 0.385 ENSMUST00000037001.8
 Letmd1
LETM1 domain containing 1
chr12_+_111758923 0.378 ENSMUST00000118471.1
ENSMUST00000122300.1
 Klc1

kinesin light chain 1

chr8_+_92827273 0.350 ENSMUST00000034187.7
 Mmp2
matrix metallopeptidase 2
chr5_+_129787390 0.343 ENSMUST00000031402.8
 Cct6a
chaperonin containing Tcp1, subunit 6a (zeta)
chr5_-_34637203 0.320 ENSMUST00000114331.3
 Mfsd10
major facilitator superfamily domain containing 10
chr3_-_94412883 0.313 ENSMUST00000181305.1
 1700040D17Rik
RIKEN cDNA 1700040D17 gene
chr13_-_45964964 0.295 ENSMUST00000180110.1
ENSMUST00000091628.3
ENSMUST00000167708.2
 Atxn1


ataxin 1


chr3_+_107895821 0.282 ENSMUST00000004134.4
 Gstm5
glutathione S-transferase, mu 5
chr8_+_70905970 0.278 ENSMUST00000019405.2
 Map1s
microtubule-associated protein 1S
chr6_+_90619241 0.256 ENSMUST00000032177.8
 Slc41a3
solute carrier family 41, member 3
chr10_+_20952547 0.240 ENSMUST00000105525.4
 Ahi1
Abelson helper integration site 1
chr2_-_130664565 0.233 ENSMUST00000089559.4
 Ddrgk1
DDRGK domain containing 1
chr16_+_57121705 0.217 ENSMUST00000166897.1
 Tomm70a
translocase of outer mitochondrial membrane 70 homolog A (yeast)
chr2_+_150323702 0.216 ENSMUST00000133235.2
 Gm10130
predicted gene 10130
chr7_-_43313233 0.206 ENSMUST00000012796.7
ENSMUST00000107986.2
 Zfp715

zinc finger protein 715

chr17_-_56626872 0.205 ENSMUST00000047226.8
 Lonp1
lon peptidase 1, mitochondrial
chr13_+_23934434 0.190 ENSMUST00000072391.1
 Hist1h2aa
histone cluster 1, H2aa
chr3_-_121815212 0.168 ENSMUST00000029770.5
 Abcd3
ATP-binding cassette, sub-family D (ALD), member 3
chr5_+_142401484 0.163 ENSMUST00000072837.5
 Foxk1
forkhead box K1
chr18_+_11839220 0.156 ENSMUST00000171109.1
ENSMUST00000046948.8
 Cables1

CDK5 and Abl enzyme substrate 1

chr10_-_39899238 0.155 ENSMUST00000178563.1
 AA474331
expressed sequence AA474331
chr4_+_133574728 0.149 ENSMUST00000030662.2
 Gpatch3
G patch domain containing 3
chr9_+_78175898 0.148 ENSMUST00000180974.1
 C920006O11Rik
RIKEN cDNA C920006O11 gene
chr4_-_43040279 0.142 ENSMUST00000107958.1
ENSMUST00000107959.1
ENSMUST00000152846.1
 Fam214b


family with sequence similarity 214, member B


chr9_+_109832998 0.119 ENSMUST00000119376.1
ENSMUST00000122343.1
 Nme6

NME/NM23 nucleoside diphosphate kinase 6

chr3_+_107896247 0.118 ENSMUST00000169365.1
 Gstm5
glutathione S-transferase, mu 5
chr1_+_191906743 0.115 ENSMUST00000044954.6
 Slc30a1
solute carrier family 30 (zinc transporter), member 1
chr10_+_77606044 0.114 ENSMUST00000020501.8
 Sumo3
SMT3 suppressor of mif two 3 homolog 3 (yeast)
chr5_-_34637107 0.111 ENSMUST00000124668.1
ENSMUST00000001109.4
ENSMUST00000155577.1
ENSMUST00000114329.1
 Mfsd10



major facilitator superfamily domain containing 10



chr12_-_36156781 0.082 ENSMUST00000020856.4
 Bzw2
basic leucine zipper and W2 domains 2
chr10_+_77606217 0.055 ENSMUST00000129492.1
ENSMUST00000141228.2
 Sumo3

SMT3 suppressor of mif two 3 homolog 3 (yeast)

chr12_+_103532435 0.018 ENSMUST00000021631.5
 Ppp4r4
protein phosphatase 4, regulatory subunit 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 13.6 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.7 2.2 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.4 2.2 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.3 1.0 GO:0015920 regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920)
0.3 0.9 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626) positive regulation of natural killer cell degranulation(GO:0043323)
0.2 1.9 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.2 0.2 GO:0035844 cloaca development(GO:0035844)
0.2 0.5 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.2 0.5 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.2 0.8 GO:0035617 stress granule disassembly(GO:0035617)
0.1 0.4 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) regulation of oxidative phosphorylation uncoupler activity(GO:2000275) cell proliferation involved in heart valve development(GO:2000793)
0.1 2.4 GO:0048715 negative regulation of oligodendrocyte differentiation(GO:0048715)
0.1 2.5 GO:0032060 bleb assembly(GO:0032060)
0.1 0.1 GO:0061687 detoxification of inorganic compound(GO:0061687)
0.1 0.8 GO:0070458 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.1 0.8 GO:0046415 urate metabolic process(GO:0046415)
0.1 0.8 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.1 0.4 GO:0051661 maintenance of centrosome location(GO:0051661) maintenance of Golgi location(GO:0051684)
0.1 0.3 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.1 0.4 GO:0042891 antibiotic transport(GO:0042891)
0.1 0.6 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.2 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.1 0.6 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.3 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.2 GO:1990564 regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721) protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.5 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 1.8 GO:0034605 cellular response to heat(GO:0034605)
0.0 2.3 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.0 0.3 GO:1990173 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
0.0 0.7 GO:0016556 mRNA modification(GO:0016556)
0.0 0.3 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.4 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.8 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 1.4 GO:0055013 cardiac muscle cell development(GO:0055013)
0.0 1.1 GO:0048477 oogenesis(GO:0048477)
0.0 0.5 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.4 GO:0006875 cellular metal ion homeostasis(GO:0006875)
0.0 0.9 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.0 0.1 GO:0006228 UTP biosynthetic process(GO:0006228)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0044194 cytolytic granule(GO:0044194)
0.3 1.9 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 0.4 GO:0045098 type III intermediate filament(GO:0045098)
0.1 2.5 GO:0043218 compact myelin(GO:0043218)
0.1 0.5 GO:0030896 checkpoint clamp complex(GO:0030896)
0.1 0.8 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 1.0 GO:0031528 microvillus membrane(GO:0031528)
0.1 0.7 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.8 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.3 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.4 GO:0000346 transcription export complex(GO:0000346)
0.0 0.4 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.3 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 2.7 GO:0005903 brush border(GO:0005903)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)
0.0 0.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.2 GO:0001650 fibrillar center(GO:0001650)
0.0 0.9 GO:0005811 lipid particle(GO:0005811)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.2 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.4 1.7 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.3 1.0 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.2 0.5 GO:0004568 chitinase activity(GO:0004568)
0.1 0.8 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 0.5 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 0.4 GO:0042895 antibiotic transporter activity(GO:0042895)
0.1 0.3 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.1 4.2 GO:0005507 copper ion binding(GO:0005507)
0.1 0.8 GO:0038191 neuropilin binding(GO:0038191)
0.1 1.2 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 0.2 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.5 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 1.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 1.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 2.2 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.0 0.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.9 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.6 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 2.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.2 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.3 GO:0034046 poly(G) binding(GO:0034046)
0.0 1.9 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.4 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.8 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.8 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 1.1 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.4 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 7.3 GO:0008270 zinc ion binding(GO:0008270)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.2 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 3.0 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.8 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 2.4 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.9 PID_SHP2_PATHWAY SHP2 signaling
0.0 2.3 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 0.8 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER
0.1 1.0 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 0.8 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.8 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 0.6 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.8 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.8 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.3 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.9 REACTOME_FRS2_MEDIATED_CASCADE Genes involved in FRS2-mediated cascade
0.0 0.6 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 2.4 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.3 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.8 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 0.5 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.0 0.7 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)