Motif ID: Nfatc4

Z-value: 0.531


Transcription factors associated with Nfatc4:

Gene SymbolEntrez IDGene Name
Nfatc4 ENSMUSG00000023411.5 Nfatc4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc4mm10_v2_chr14_+_55824795_55824889-0.699.8e-07Click!


Activity profile for motif Nfatc4.

activity profile for motif Nfatc4


Sorted Z-values histogram for motif Nfatc4

Sorted Z-values for motif Nfatc4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_83504032 5.410 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr1_-_56978534 3.672 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr15_+_92051153 3.287 ENSMUST00000169825.1
 Cntn1
contactin 1
chr19_+_26623419 2.886 ENSMUST00000176584.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr1_-_56969864 2.818 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr15_+_3270767 2.338 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr11_+_97415527 2.208 ENSMUST00000121799.1
 Arhgap23
Rho GTPase activating protein 23
chr12_+_91400990 1.951 ENSMUST00000021346.7
ENSMUST00000021343.6
 Tshr

thyroid stimulating hormone receptor

chr4_+_48049080 1.692 ENSMUST00000153369.1
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr19_-_4943049 1.532 ENSMUST00000133254.1
ENSMUST00000120475.1
ENSMUST00000025834.7
 Peli3


pellino 3


chr6_-_59024470 1.450 ENSMUST00000089860.5
 Fam13a
family with sequence similarity 13, member A
chr1_-_193370225 1.443 ENSMUST00000169907.1
 Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr1_-_193370260 1.422 ENSMUST00000016323.4
 Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr2_+_55435918 1.389 ENSMUST00000067101.3
 Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chr2_+_125136692 1.373 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr13_+_31806627 1.335 ENSMUST00000062292.2
 Foxc1
forkhead box C1
chr14_-_25927672 1.322 ENSMUST00000185006.1
 Tmem254a
transmembrane protein 254a
chr14_+_70555900 1.317 ENSMUST00000163060.1
 Hr
hairless
chr6_-_59024340 1.234 ENSMUST00000173193.1
 Fam13a
family with sequence similarity 13, member A
chr14_-_26067355 1.216 ENSMUST00000100819.5
 Tmem254c
transmembrane protein 254c
chr1_-_126830632 1.209 ENSMUST00000112583.1
ENSMUST00000094609.3
 Nckap5

NCK-associated protein 5

chr14_-_25927250 1.202 ENSMUST00000100811.5
 Tmem254a
transmembrane protein 254a
chr10_+_21993890 1.165 ENSMUST00000092673.4
 Sgk1
serum/glucocorticoid regulated kinase 1
chr5_+_117363513 1.137 ENSMUST00000111959.1
 Wsb2
WD repeat and SOCS box-containing 2
chr3_+_84925476 1.081 ENSMUST00000107675.1
 Fbxw7
F-box and WD-40 domain protein 7
chr1_+_34005872 1.052 ENSMUST00000182296.1
 Dst
dystonin
chr19_+_29101375 0.922 ENSMUST00000064393.5
 Rcl1
RNA terminal phosphate cyclase-like 1
chr1_-_126830786 0.886 ENSMUST00000162646.1
 Nckap5
NCK-associated protein 5
chr13_-_52981027 0.810 ENSMUST00000071065.7
 Nfil3
nuclear factor, interleukin 3, regulated
chr11_+_29692937 0.751 ENSMUST00000102843.3
ENSMUST00000102842.3
ENSMUST00000078830.4
ENSMUST00000170731.1
 Rtn4



reticulon 4



chr3_-_152193803 0.683 ENSMUST00000050073.6
 Dnajb4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr9_+_113812547 0.479 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
 Clasp2


CLIP associating protein 2


chr12_-_84450944 0.466 ENSMUST00000085192.5
 Aldh6a1
aldehyde dehydrogenase family 6, subfamily A1
chr10_+_4611971 0.387 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr2_-_66410064 0.375 ENSMUST00000112366.1
 Scn1a
sodium channel, voltage-gated, type I, alpha
chr11_+_75468040 0.321 ENSMUST00000043598.7
ENSMUST00000108435.1
 Tlcd2

TLC domain containing 2

chr14_+_47663756 0.314 ENSMUST00000022391.7
 Ktn1
kinectin 1
chr17_-_49564262 0.281 ENSMUST00000057610.6
 Daam2
dishevelled associated activator of morphogenesis 2
chr1_-_64121389 0.279 ENSMUST00000055001.3
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr15_-_79062866 0.274 ENSMUST00000151889.1
ENSMUST00000040676.4
 Ankrd54

ankyrin repeat domain 54

chr5_+_145114280 0.258 ENSMUST00000141602.1
 Arpc1b
actin related protein 2/3 complex, subunit 1B
chr18_+_73863672 0.238 ENSMUST00000134847.1
 Mro
maestro
chr12_+_84451485 0.238 ENSMUST00000137170.1
 Lin52
lin-52 homolog (C. elegans)
chr18_-_62741387 0.217 ENSMUST00000097557.3
 Spink13
serine peptidase inhibitor, Kazal type 13
chr9_-_13446753 0.215 ENSMUST00000167906.2
 Gm17571
predicted gene, 17571
chr2_+_3114220 0.199 ENSMUST00000072955.5
 Fam171a1
family with sequence similarity 171, member A1
chr1_-_64121456 0.197 ENSMUST00000142009.1
ENSMUST00000114086.1
 Klf7

Kruppel-like factor 7 (ubiquitous)

chr7_-_79920599 0.149 ENSMUST00000075657.6
 Ap3s2
adaptor-related protein complex 3, sigma 2 subunit
chr19_-_24477356 0.115 ENSMUST00000099556.1
 Fam122a
family with sequence similarity 122, member A
chr2_-_73660351 0.109 ENSMUST00000154258.1
 Chn1
chimerin (chimaerin) 1
chr11_-_47379405 0.104 ENSMUST00000077221.5
 Sgcd
sarcoglycan, delta (dystrophin-associated glycoprotein)
chr19_-_8839181 0.098 ENSMUST00000096259.4
 Gng3
guanine nucleotide binding protein (G protein), gamma 3
chr2_-_165884636 0.076 ENSMUST00000177633.1
ENSMUST00000018050.7
ENSMUST00000088113.4
 Zmynd8


zinc finger, MYND-type containing 8


chr19_+_8839298 0.064 ENSMUST00000160556.1
 Bscl2
Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)
chr3_-_116662643 0.055 ENSMUST00000029570.5
 Hiat1
hippocampus abundant gene transcript 1
chr3_+_94837533 0.037 ENSMUST00000107270.2
 Pogz
pogo transposable element with ZNF domain

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.4 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.6 1.7 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.5 1.5 GO:0070428 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070432)
0.4 1.3 GO:1902256 apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.4 6.5 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.3 2.0 GO:1904587 response to glycoprotein(GO:1904587)
0.3 2.9 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.2 1.1 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.2 1.4 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.2 0.9 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.2 0.5 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.1 0.8 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.1 0.4 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.1 1.2 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 1.3 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.1 0.5 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 1.1 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.2 GO:0060467 negative regulation of fertilization(GO:0060467)
0.0 3.0 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.0 0.4 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.8 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.0 0.1 GO:1903756 regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.0 2.9 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.3 1.1 GO:0031673 H zone(GO:0031673)
0.2 2.9 GO:0071564 npBAF complex(GO:0071564)
0.1 0.5 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 0.2 GO:0090568 nuclear transcriptional repressor complex(GO:0090568) RNA polymerase II transcription repressor complex(GO:0090571)
0.1 7.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 0.4 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.8 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 5.8 GO:0030017 sarcomere(GO:0030017)
0.0 0.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 3.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.1 GO:0030315 T-tubule(GO:0030315)
0.0 0.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 1.3 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.1 GO:0030123 AP-3 adaptor complex(GO:0030123)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.4 GO:0003680 AT DNA binding(GO:0003680)
0.3 0.9 GO:0003963 RNA-3'-phosphate cyclase activity(GO:0003963)
0.3 1.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 1.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.2 2.0 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 1.2 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 0.4 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 1.3 GO:0008301 DNA binding, bending(GO:0008301)
0.1 1.3 GO:0042809 vitamin D receptor binding(GO:0042809)
0.1 2.9 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 1.7 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 2.9 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.5 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.8 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.4 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.7 GO:0001671 ATPase activator activity(GO:0001671)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.4 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 1.7 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 1.4 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.9 PID_ARF6_PATHWAY Arf6 signaling events
0.0 2.9 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 1.1 PID_MYC_PATHWAY C-MYC pathway
0.0 1.2 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 1.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.4 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.8 PID_NOTCH_PATHWAY Notch signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.2 5.4 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.1 1.5 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 3.3 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.5 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 2.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.1 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.5 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.8 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 2.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases