Motif ID: Nfe2l2

Z-value: 0.680


Transcription factors associated with Nfe2l2:

Gene SymbolEntrez IDGene Name
Nfe2l2 ENSMUSG00000015839.6 Nfe2l2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfe2l2mm10_v2_chr2_-_75704535_757046410.038.6e-01Click!


Activity profile for motif Nfe2l2.

activity profile for motif Nfe2l2


Sorted Z-values histogram for motif Nfe2l2

Sorted Z-values for motif Nfe2l2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfe2l2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_24644933 2.603 ENSMUST00000019684.5
Slc9a3r2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr4_+_118961578 2.390 ENSMUST00000058651.4
Lao1
L-amino acid oxidase 1
chr6_+_5725639 2.091 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr9_-_58313189 1.951 ENSMUST00000061799.8
Loxl1
lysyl oxidase-like 1
chr17_-_25570678 1.691 ENSMUST00000025003.3
ENSMUST00000173447.1
Sox8

SRY-box containing gene 8

chr1_-_172219715 1.689 ENSMUST00000170700.1
ENSMUST00000003554.4
Casq1

calsequestrin 1

chr2_+_155775333 1.666 ENSMUST00000029141.5
Mmp24
matrix metallopeptidase 24
chr7_-_105482197 1.663 ENSMUST00000047040.2
Prkcdbp
protein kinase C, delta binding protein
chr5_-_139484420 1.634 ENSMUST00000150992.1
Zfand2a
zinc finger, AN1-type domain 2A
chr19_-_4037910 1.497 ENSMUST00000169613.1
Gstp1
glutathione S-transferase, pi 1
chr3_-_116968827 1.423 ENSMUST00000119557.1
Palmd
palmdelphin
chr2_+_164948219 1.412 ENSMUST00000017881.2
Mmp9
matrix metallopeptidase 9
chr5_-_139484475 1.408 ENSMUST00000110851.1
ENSMUST00000079996.6
Zfand2a

zinc finger, AN1-type domain 2A

chr6_+_17463927 1.390 ENSMUST00000115442.1
Met
met proto-oncogene
chr14_-_20393473 1.382 ENSMUST00000061444.3
Mrps16
mitochondrial ribosomal protein S16
chr1_-_155146755 1.315 ENSMUST00000027744.8
Mr1
major histocompatibility complex, class I-related
chr4_-_126321669 1.292 ENSMUST00000102617.4
Adprhl2
ADP-ribosylhydrolase like 2
chr9_-_116175318 1.251 ENSMUST00000061101.4
ENSMUST00000035014.6
Tgfbr2

transforming growth factor, beta receptor II

chr1_+_165769392 1.230 ENSMUST00000040298.4
Creg1
cellular repressor of E1A-stimulated genes 1
chr3_-_116968969 1.219 ENSMUST00000143611.1
ENSMUST00000040097.7
Palmd

palmdelphin

chr13_-_54611332 1.215 ENSMUST00000091609.4
Cltb
clathrin, light polypeptide (Lcb)
chr13_-_54611274 1.103 ENSMUST00000049575.7
Cltb
clathrin, light polypeptide (Lcb)
chr16_+_90220742 1.100 ENSMUST00000023707.9
Sod1
superoxide dismutase 1, soluble
chr17_-_25868727 1.087 ENSMUST00000026828.5
Fam195a
family with sequence similarity 195, member A
chr5_+_128601106 1.076 ENSMUST00000117102.2
Fzd10
frizzled homolog 10 (Drosophila)
chr1_+_136018062 1.063 ENSMUST00000117950.1
Tmem9
transmembrane protein 9
chr2_+_25395866 1.049 ENSMUST00000028328.2
Entpd2
ectonucleoside triphosphate diphosphohydrolase 2
chr18_+_61045139 1.047 ENSMUST00000025522.4
ENSMUST00000115274.1
Pdgfrb

platelet derived growth factor receptor, beta polypeptide

chr5_+_66676098 1.014 ENSMUST00000031131.9
Uchl1
ubiquitin carboxy-terminal hydrolase L1
chr1_+_136017967 1.014 ENSMUST00000063719.8
ENSMUST00000118832.1
Tmem9

transmembrane protein 9

chr5_-_92348871 0.975 ENSMUST00000038816.6
ENSMUST00000118006.1
Cxcl10

chemokine (C-X-C motif) ligand 10

chr2_+_112261926 0.972 ENSMUST00000028553.3
Nop10
NOP10 ribonucleoprotein
chr5_+_19907502 0.960 ENSMUST00000101558.3
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr16_+_17144600 0.958 ENSMUST00000115702.1
Ydjc
YdjC homolog (bacterial)
chr19_+_8929628 0.919 ENSMUST00000096241.4
Eml3
echinoderm microtubule associated protein like 3
chrX_-_51681856 0.895 ENSMUST00000114871.1
Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr1_-_136260873 0.889 ENSMUST00000086395.5
Gpr25
G protein-coupled receptor 25
chr7_+_4460687 0.884 ENSMUST00000167298.1
ENSMUST00000171445.1
Eps8l1

EPS8-like 1

chr8_+_65967157 0.879 ENSMUST00000072482.6
March1
membrane-associated ring finger (C3HC4) 1
chr10_+_116143881 0.878 ENSMUST00000105271.2
Ptprr
protein tyrosine phosphatase, receptor type, R
chr2_-_25272380 0.863 ENSMUST00000028342.6
Ssna1
Sjogren's syndrome nuclear autoantigen 1
chr17_-_47834682 0.862 ENSMUST00000066368.6
Mdfi
MyoD family inhibitor
chrX_-_51681703 0.858 ENSMUST00000088172.5
Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr18_+_73863672 0.848 ENSMUST00000134847.1
Mro
maestro
chr2_-_130397525 0.838 ENSMUST00000028897.7
Cpxm1
carboxypeptidase X 1 (M14 family)
chr7_+_141468776 0.829 ENSMUST00000058746.5
Cd151
CD151 antigen
chr11_-_98438941 0.817 ENSMUST00000002655.7
Mien1
migration and invasion enhancer 1
chr7_+_19181159 0.784 ENSMUST00000120595.1
ENSMUST00000048502.8
Eml2

echinoderm microtubule associated protein like 2

chr7_-_102250086 0.698 ENSMUST00000106923.1
ENSMUST00000098230.4
Rhog

ras homolog gene family, member G

chr2_+_25272475 0.680 ENSMUST00000028341.4
Anapc2
anaphase promoting complex subunit 2
chr11_+_120673359 0.656 ENSMUST00000135346.1
ENSMUST00000127269.1
ENSMUST00000131727.2
ENSMUST00000149389.1
ENSMUST00000153346.1
Aspscr1




alveolar soft part sarcoma chromosome region, candidate 1 (human)




chr9_-_21239310 0.650 ENSMUST00000164812.1
ENSMUST00000049567.4
Keap1

kelch-like ECH-associated protein 1

chr11_+_120673018 0.641 ENSMUST00000106158.2
ENSMUST00000103016.1
ENSMUST00000168714.1
Aspscr1


alveolar soft part sarcoma chromosome region, candidate 1 (human)


chr11_-_7213897 0.625 ENSMUST00000020702.4
ENSMUST00000135887.2
Igfbp3

insulin-like growth factor binding protein 3

chr8_+_105326354 0.619 ENSMUST00000015000.5
ENSMUST00000098453.2
Tmem208

transmembrane protein 208

chr7_-_44849075 0.615 ENSMUST00000047085.8
Tbc1d17
TBC1 domain family, member 17
chr19_-_4042165 0.601 ENSMUST00000042700.9
Gstp2
glutathione S-transferase, pi 2
chr3_+_28805436 0.600 ENSMUST00000043867.5
Rpl22l1
ribosomal protein L22 like 1
chr17_-_70998010 0.561 ENSMUST00000024846.6
Myl12a
myosin, light chain 12A, regulatory, non-sarcomeric
chr3_+_108256926 0.559 ENSMUST00000090569.5
Psma5
proteasome (prosome, macropain) subunit, alpha type 5
chr7_-_141429433 0.553 ENSMUST00000124444.1
Cend1
cell cycle exit and neuronal differentiation 1
chr5_-_45450121 0.551 ENSMUST00000127562.1
Qdpr
quinoid dihydropteridine reductase
chr5_-_108675569 0.551 ENSMUST00000051757.7
Slc26a1
solute carrier family 26 (sulfate transporter), member 1
chr17_+_55952623 0.548 ENSMUST00000003274.6
Ebi3
Epstein-Barr virus induced gene 3
chr5_+_19907774 0.543 ENSMUST00000115267.2
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr14_-_54617993 0.542 ENSMUST00000022803.4
Psmb5
proteasome (prosome, macropain) subunit, beta type 5
chr14_+_30825580 0.538 ENSMUST00000006701.5
Tmem110
transmembrane protein 110
chr2_-_44927161 0.534 ENSMUST00000130991.1
Gtdc1
glycosyltransferase-like domain containing 1
chr5_-_45450221 0.533 ENSMUST00000015950.5
Qdpr
quinoid dihydropteridine reductase
chrX_-_167209149 0.529 ENSMUST00000112176.1
Tmsb4x
thymosin, beta 4, X chromosome
chr16_+_18812286 0.528 ENSMUST00000005394.6
Ufd1l
ubiquitin fusion degradation 1 like
chr9_+_65214690 0.525 ENSMUST00000069000.7
Parp16
poly (ADP-ribose) polymerase family, member 16
chr1_-_121332545 0.518 ENSMUST00000161068.1
Insig2
insulin induced gene 2
chr13_+_14613242 0.517 ENSMUST00000170836.2
Psma2
proteasome (prosome, macropain) subunit, alpha type 2
chr5_-_45450143 0.515 ENSMUST00000154962.1
Qdpr
quinoid dihydropteridine reductase
chr4_+_117251951 0.509 ENSMUST00000062824.5
Tmem53
transmembrane protein 53
chr10_+_60277627 0.508 ENSMUST00000105465.1
ENSMUST00000177779.1
ENSMUST00000179238.1
ENSMUST00000004316.8
Psap



prosaposin



chr19_-_8929323 0.505 ENSMUST00000096242.3
Rom1
rod outer segment membrane protein 1
chr7_-_29180699 0.488 ENSMUST00000059642.10
Psmd8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr4_+_5644084 0.487 ENSMUST00000054857.6
Fam110b
family with sequence similarity 110, member B
chr5_+_31698050 0.485 ENSMUST00000114507.3
ENSMUST00000063813.4
ENSMUST00000071531.5
ENSMUST00000131995.1
Bre



brain and reproductive organ-expressed protein



chr7_+_139834148 0.483 ENSMUST00000026548.7
Gpr123
G protein-coupled receptor 123
chr2_-_26910569 0.475 ENSMUST00000015920.5
ENSMUST00000139815.1
ENSMUST00000102899.3
Med22


mediator complex subunit 22


chr16_-_17531019 0.462 ENSMUST00000142666.1
ENSMUST00000100125.3
Thap7

THAP domain containing 7

chr18_+_37320374 0.457 ENSMUST00000078271.2
Pcdhb5
protocadherin beta 5
chr2_-_181691771 0.457 ENSMUST00000108778.1
ENSMUST00000165416.1
Rgs19

regulator of G-protein signaling 19

chr2_+_91054054 0.457 ENSMUST00000002171.7
ENSMUST00000111441.3
Psmc3

proteasome (prosome, macropain) 26S subunit, ATPase 3

chr16_+_20694908 0.447 ENSMUST00000056518.6
Fam131a
family with sequence similarity 131, member A
chr11_-_109473598 0.446 ENSMUST00000070152.5
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr4_+_116685859 0.442 ENSMUST00000129315.1
ENSMUST00000106470.1
Prdx1

peroxiredoxin 1

chr7_+_44468051 0.441 ENSMUST00000118493.1
Josd2
Josephin domain containing 2
chr7_-_29180454 0.438 ENSMUST00000182328.1
Psmd8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr5_+_31697960 0.431 ENSMUST00000114515.2
Bre
brain and reproductive organ-expressed protein
chr16_-_17144415 0.427 ENSMUST00000115709.1
Ccdc116
coiled-coil domain containing 116
chr1_-_121332571 0.426 ENSMUST00000071064.6
Insig2
insulin induced gene 2
chr12_+_55398775 0.416 ENSMUST00000021412.8
Psma6
proteasome (prosome, macropain) subunit, alpha type 6
chr3_-_141982224 0.412 ENSMUST00000029948.8
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr9_+_86695542 0.412 ENSMUST00000150367.2
A330041J22Rik
RIKEN cDNA A330041J22 gene
chr8_+_33653238 0.408 ENSMUST00000033992.8
Gsr
glutathione reductase
chr3_-_146781351 0.408 ENSMUST00000005164.7
Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr16_-_18343882 0.404 ENSMUST00000130752.1
ENSMUST00000115628.2
Tango2

transport and golgi organization 2

chr17_-_26939464 0.404 ENSMUST00000025027.8
ENSMUST00000114935.1
Cuta

cutA divalent cation tolerance homolog (E. coli)

chr6_-_129533267 0.398 ENSMUST00000181594.1
1700101I11Rik
RIKEN cDNA 1700101I11 gene
chr14_-_37135310 0.398 ENSMUST00000165649.2
Ghitm
growth hormone inducible transmembrane protein
chr4_+_116685544 0.385 ENSMUST00000135573.1
ENSMUST00000151129.1
Prdx1

peroxiredoxin 1

chr11_+_97362396 0.379 ENSMUST00000045540.3
Socs7
suppressor of cytokine signaling 7
chr7_+_44468020 0.378 ENSMUST00000117324.1
ENSMUST00000120852.1
ENSMUST00000118628.1
Josd2


Josephin domain containing 2


chr2_-_163419508 0.376 ENSMUST00000046908.3
Oser1
oxidative stress responsive serine rich 1
chr4_+_117252010 0.372 ENSMUST00000125943.1
ENSMUST00000106434.1
Tmem53

transmembrane protein 53

chr16_+_20548577 0.369 ENSMUST00000003319.5
Abcf3
ATP-binding cassette, sub-family F (GCN20), member 3
chr8_-_107588392 0.368 ENSMUST00000044106.4
Psmd7
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
chr3_+_133338936 0.367 ENSMUST00000150386.1
ENSMUST00000125858.1
Ppa2

pyrophosphatase (inorganic) 2

chr2_+_91054009 0.359 ENSMUST00000067663.7
Psmc3
proteasome (prosome, macropain) 26S subunit, ATPase 3
chr7_+_45639964 0.357 ENSMUST00000148532.1
Mamstr
MEF2 activating motif and SAP domain containing transcriptional regulator
chr17_+_34032348 0.343 ENSMUST00000173354.1
ENSMUST00000116612.2
Rxrb

retinoid X receptor beta

chr11_-_30649510 0.317 ENSMUST00000074613.3
Acyp2
acylphosphatase 2, muscle type
chr7_+_44848991 0.315 ENSMUST00000107885.1
Akt1s1
AKT1 substrate 1 (proline-rich)
chr7_-_104315455 0.305 ENSMUST00000106837.1
ENSMUST00000106839.2
ENSMUST00000070943.6
Trim12a


tripartite motif-containing 12A


chr11_-_50210765 0.298 ENSMUST00000143379.1
ENSMUST00000015981.5
ENSMUST00000102774.4
Sqstm1


sequestosome 1


chr5_+_30013141 0.296 ENSMUST00000026845.7
Il6
interleukin 6
chr19_+_8839298 0.296 ENSMUST00000160556.1
Bscl2
Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)
chr1_-_168431695 0.294 ENSMUST00000176790.1
Pbx1
pre B cell leukemia homeobox 1
chr5_+_100798627 0.294 ENSMUST00000016977.8
ENSMUST00000112898.1
ENSMUST00000112901.1
Mrps18c


mitochondrial ribosomal protein S18C


chr4_+_102421518 0.289 ENSMUST00000106904.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr13_-_12461432 0.276 ENSMUST00000143693.1
ENSMUST00000144283.1
ENSMUST00000099820.3
ENSMUST00000135166.1
Lgals8



lectin, galactose binding, soluble 8



chr9_-_27030010 0.260 ENSMUST00000034470.9
Vps26b
vacuolar protein sorting 26 homolog B (yeast)
chr14_-_18239053 0.252 ENSMUST00000090543.5
Nr1d2
nuclear receptor subfamily 1, group D, member 2
chr11_+_60537978 0.248 ENSMUST00000044250.3
Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chr19_-_6080311 0.233 ENSMUST00000159832.1
Vps51
vacuolar protein sorting 51 homolog (S. cerevisiae)
chr11_-_59809774 0.229 ENSMUST00000047706.2
ENSMUST00000102697.3
Flcn

folliculin

chr12_+_80518990 0.228 ENSMUST00000021558.6
Galnt16
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16
chr12_+_17544873 0.226 ENSMUST00000171737.1
Odc1
ornithine decarboxylase, structural 1
chr2_+_180171485 0.224 ENSMUST00000061437.4
Adrm1
adhesion regulating molecule 1
chr2_-_167043494 0.217 ENSMUST00000067584.6
Znfx1
zinc finger, NFX1-type containing 1
chr12_-_85288419 0.216 ENSMUST00000121930.1
Acyp1
acylphosphatase 1, erythrocyte (common) type
chr7_+_28881656 0.216 ENSMUST00000066880.4
Capn12
calpain 12
chr1_-_120074023 0.201 ENSMUST00000056089.7
Tmem37
transmembrane protein 37
chr4_+_123016590 0.194 ENSMUST00000102649.3
Trit1
tRNA isopentenyltransferase 1
chr4_-_41569502 0.173 ENSMUST00000108049.2
ENSMUST00000108052.3
ENSMUST00000108050.1
Fam219a


family with sequence similarity 219, member A


chr17_-_45573253 0.169 ENSMUST00000165127.1
ENSMUST00000166469.1
ENSMUST00000024739.7
Hsp90ab1


heat shock protein 90 alpha (cytosolic), class B member 1


chr14_-_37135126 0.166 ENSMUST00000042564.9
Ghitm
growth hormone inducible transmembrane protein
chr6_-_8259098 0.166 ENSMUST00000012627.4
Rpa3
replication protein A3
chr7_+_24271568 0.160 ENSMUST00000032696.6
Zfp93
zinc finger protein 93
chr18_-_53418004 0.158 ENSMUST00000025419.7
Ppic
peptidylprolyl isomerase C
chr4_-_133874682 0.147 ENSMUST00000168974.2
Rps6ka1
ribosomal protein S6 kinase polypeptide 1
chr4_-_57956283 0.144 ENSMUST00000030051.5
Txn1
thioredoxin 1
chr11_+_78178105 0.137 ENSMUST00000147819.1
Tlcd1
TLC domain containing 1
chrX_+_153498202 0.135 ENSMUST00000060714.8
Ubqln2
ubiquilin 2
chr11_+_78178651 0.127 ENSMUST00000092880.7
ENSMUST00000127587.1
ENSMUST00000108338.1
Tlcd1


TLC domain containing 1


chr19_-_8839181 0.126 ENSMUST00000096259.4
Gng3
guanine nucleotide binding protein (G protein), gamma 3
chr15_-_79834224 0.119 ENSMUST00000109623.1
ENSMUST00000109625.1
ENSMUST00000023060.6
ENSMUST00000089299.5
Cbx6

Npcd

chromobox 6

neuronal pentraxin chromo domain

chr17_+_28951950 0.119 ENSMUST00000153462.1
Kctd20
potassium channel tetramerisation domain containing 20
chr16_+_17561885 0.109 ENSMUST00000171002.1
ENSMUST00000023441.4
P2rx6

purinergic receptor P2X, ligand-gated ion channel, 6

chr3_+_27182994 0.107 ENSMUST00000091284.4
Nceh1
neutral cholesterol ester hydrolase 1
chr4_-_122885965 0.106 ENSMUST00000128485.1
Cap1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr1_-_33907721 0.092 ENSMUST00000115161.1
ENSMUST00000062289.8
Bend6

BEN domain containing 6

chr2_-_44927206 0.079 ENSMUST00000100127.2
Gtdc1
glycosyltransferase-like domain containing 1
chr13_-_52929640 0.065 ENSMUST00000120535.1
ENSMUST00000119311.1
ENSMUST00000021913.9
ENSMUST00000110031.3
Auh



AU RNA binding protein/enoyl-coenzyme A hydratase



chr2_+_25428699 0.061 ENSMUST00000102919.3
Abca2
ATP-binding cassette, sub-family A (ABC1), member 2
chr17_-_45572495 0.056 ENSMUST00000130406.1
Hsp90ab1
heat shock protein 90 alpha (cytosolic), class B member 1
chr1_-_167285110 0.052 ENSMUST00000027839.8
Uck2
uridine-cytidine kinase 2
chr16_+_20651652 0.052 ENSMUST00000007212.8
Psmd2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr9_+_107578887 0.046 ENSMUST00000149638.1
ENSMUST00000139274.1
ENSMUST00000130053.1
ENSMUST00000122985.1
ENSMUST00000127380.1
ENSMUST00000139581.1
Nat6





N-acetyltransferase 6





chr11_+_80428598 0.044 ENSMUST00000173938.1
ENSMUST00000017572.7
Psmd11

proteasome (prosome, macropain) 26S subunit, non-ATPase, 11

chr4_-_122885905 0.040 ENSMUST00000069533.5
Cap1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr17_+_26933070 0.038 ENSMUST00000073724.5
Phf1
PHD finger protein 1
chr16_+_58727910 0.025 ENSMUST00000023426.5
ENSMUST00000162057.1
ENSMUST00000162191.1
Cldn25


claudin 25


chr15_+_89253035 0.022 ENSMUST00000088788.3
Ppp6r2
protein phosphatase 6, regulatory subunit 2
chr2_-_120609500 0.021 ENSMUST00000133612.1
ENSMUST00000102498.1
ENSMUST00000102499.1
Lrrc57


leucine rich repeat containing 57


chr4_+_42035113 0.016 ENSMUST00000098127.1
Gm10597
predicted gene 10597
chr2_+_156475844 0.015 ENSMUST00000103135.1
Epb4.1l1
erythrocyte protein band 4.1-like 1
chr19_-_4839286 0.014 ENSMUST00000037246.5
Ccs
copper chaperone for superoxide dismutase
chr12_+_111758848 0.014 ENSMUST00000084941.5
Klc1
kinesin light chain 1
chr10_+_128058947 0.013 ENSMUST00000052798.7
Ptges3
prostaglandin E synthase 3 (cytosolic)
chr2_-_120609319 0.010 ENSMUST00000102497.3
Lrrc57
leucine rich repeat containing 57
chr10_+_18845071 0.005 ENSMUST00000019998.7
Perp
PERP, TP53 apoptosis effector
chr11_+_100619217 0.005 ENSMUST00000107376.1
Nkiras2
NFKB inhibitor interacting Ras-like protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0072034 renal vesicle induction(GO:0072034)
0.6 1.7 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.5 1.5 GO:0070488 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771) neutrophil aggregation(GO:0070488)
0.4 1.3 GO:0003274 endocardial cushion fusion(GO:0003274)
0.3 1.0 GO:0035441 cell migration involved in vasculogenesis(GO:0035441) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.3 1.0 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.3 1.8 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.3 1.4 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.3 1.0 GO:0007412 axon target recognition(GO:0007412)
0.2 0.9 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.2 3.0 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.2 0.9 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.2 0.6 GO:1902512 positive regulation of apoptotic DNA fragmentation(GO:1902512)
0.2 1.6 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.2 1.4 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.2 1.0 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.2 2.1 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.2 1.5 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.2 0.6 GO:0021933 radial glia guided migration of cerebellar granule cell(GO:0021933)
0.2 1.1 GO:0038030 non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030) non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.2 0.6 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.2 0.6 GO:0006624 vacuolar protein processing(GO:0006624)
0.1 1.7 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
0.1 1.1 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.1 0.5 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.1 1.0 GO:0009181 purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
0.1 0.9 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.1 0.8 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.1 2.6 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.1 0.4 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 0.3 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.1 2.1 GO:0071451 cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451)
0.1 0.6 GO:0019532 oxalate transport(GO:0019532)
0.1 0.2 GO:2001170 negative regulation of cellular respiration(GO:1901856) negative regulation of ATP biosynthetic process(GO:2001170)
0.1 0.2 GO:0009446 putrescine biosynthetic process(GO:0009446)
0.1 0.2 GO:0097278 transforming growth factor beta activation(GO:0036363) complement-dependent cytotoxicity(GO:0097278)
0.1 1.2 GO:0043248 proteasome assembly(GO:0043248)
0.1 0.9 GO:0045717 negative regulation of fatty acid biosynthetic process(GO:0045717)
0.1 0.8 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.1 0.2 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)
0.1 0.7 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.1 1.3 GO:0032620 interleukin-17 production(GO:0032620)
0.1 0.5 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.9 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.0 0.9 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 0.3 GO:0002317 plasma cell differentiation(GO:0002317)
0.0 0.1 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020)
0.0 0.3 GO:0044130 negative regulation of growth of symbiont in host(GO:0044130) negative regulation of growth of symbiont involved in interaction with host(GO:0044146)
0.0 0.5 GO:0060736 prostate gland growth(GO:0060736)
0.0 0.4 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0 0.7 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.0 0.4 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.0 0.5 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 2.0 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.0 1.7 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.1 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.0 0.3 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.1 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.0 0.3 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 1.8 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.0 0.1 GO:0009174 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0 0.3 GO:0050995 negative regulation of lipid catabolic process(GO:0050995)
0.0 0.4 GO:0010831 positive regulation of myotube differentiation(GO:0010831)
0.0 0.3 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.0 0.4 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 1.1 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.3 GO:0055012 ventricular cardiac muscle cell differentiation(GO:0055012)
0.0 0.3 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.7 2.1 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.4 1.7 GO:0014802 terminal cisterna(GO:0014802)
0.2 1.0 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.2 2.3 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.2 1.5 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 0.6 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.1 0.9 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 1.2 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 1.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 0.3 GO:0044753 amphisome(GO:0044753)
0.1 0.3 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 2.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 2.0 GO:0005838 proteasome regulatory particle(GO:0005838)
0.1 1.1 GO:0031045 dense core granule(GO:0031045)
0.1 3.5 GO:0000502 proteasome complex(GO:0000502)
0.1 0.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 1.7 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 1.0 GO:0005605 basal lamina(GO:0005605)
0.0 0.2 GO:1990745 EARP complex(GO:1990745)
0.0 0.2 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.5 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.2 GO:0005662 DNA replication factor A complex(GO:0005662) replisome(GO:0030894) nuclear replisome(GO:0043601)
0.0 0.8 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 2.8 GO:0005604 basement membrane(GO:0005604)
0.0 0.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 1.4 GO:0032420 stereocilium(GO:0032420)
0.0 0.6 GO:0016460 myosin II complex(GO:0016460)
0.0 0.3 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 1.4 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.5 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 2.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 2.3 GO:0005770 late endosome(GO:0005770)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)
0.0 0.3 GO:0000930 gamma-tubulin complex(GO:0000930)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.5 1.6 GO:0004155 6,7-dihydropteridine reductase activity(GO:0004155)
0.4 1.8 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.3 1.4 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.3 1.3 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.3 1.1 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.3 1.0 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.3 1.5 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 1.0 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.2 1.0 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.2 2.3 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.2 2.0 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.1 1.0 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.1 0.4 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.1 0.5 GO:0003998 acylphosphatase activity(GO:0003998)
0.1 0.6 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.1 0.8 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.1 1.9 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 1.0 GO:0043262 adenosine-diphosphatase activity(GO:0043262)
0.1 0.5 GO:0004565 beta-galactosidase activity(GO:0004565)
0.1 0.4 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.1 2.1 GO:1900750 glutathione peroxidase activity(GO:0004602) glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 0.8 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 2.6 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 1.7 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.2 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.1 0.5 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.1 1.4 GO:0001968 fibronectin binding(GO:0001968)
0.0 1.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.4 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.9 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.3 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.3 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.4 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.9 GO:0042287 MHC protein binding(GO:0042287)
0.0 0.2 GO:0002135 CTP binding(GO:0002135)
0.0 0.3 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.1 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.2 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.2 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.1 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 1.7 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 1.3 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 0.2 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.0 2.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.4 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.5 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 0.4 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.1 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.4 GO:0005507 copper ion binding(GO:0005507)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 PID_ARF_3PATHWAY Arf1 pathway
0.1 2.5 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.3 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 1.4 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.0 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 2.7 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 3.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.0 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.0 0.8 ST_B_CELL_ANTIGEN_RECEPTOR B Cell Antigen Receptor
0.0 1.1 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.9 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.7 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.1 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.3 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.1 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 2.3 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 3.5 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 1.3 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 2.1 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 1.5 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 1.7 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.7 REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0 0.6 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.0 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.9 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.2 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.2 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.3 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.5 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 0.4 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.4 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.2 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 1.7 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.5 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.4 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.4 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 1.2 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.4 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.0 1.7 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.3 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events