Motif ID: Nr2e1

Z-value: 0.293


Transcription factors associated with Nr2e1:

Gene SymbolEntrez IDGene Name
Nr2e1 ENSMUSG00000019803.5 Nr2e1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr2e1mm10_v2_chr10_-_42583628_425836390.086.0e-01Click!


Activity profile for motif Nr2e1.

activity profile for motif Nr2e1


Sorted Z-values histogram for motif Nr2e1

Sorted Z-values for motif Nr2e1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2e1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_33924632 1.264 ENSMUST00000057188.6
 Cnr1
cannabinoid receptor 1 (brain)
chrX_-_143827391 1.208 ENSMUST00000087316.5
 Capn6
calpain 6
chrX_-_139998519 1.036 ENSMUST00000113007.1
ENSMUST00000033810.7
ENSMUST00000113011.2
ENSMUST00000087400.5
 Rbm41



RNA binding motif protein 41



chr4_-_63403330 0.911 ENSMUST00000035724.4
 Akna
AT-hook transcription factor
chr5_-_88527841 0.783 ENSMUST00000087033.3
 Igj
immunoglobulin joining chain
chr8_-_61902669 0.701 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr4_+_28813152 0.685 ENSMUST00000108194.2
ENSMUST00000108191.1
 Epha7

Eph receptor A7

chr4_+_28813125 0.661 ENSMUST00000029964.5
ENSMUST00000080934.4
 Epha7

Eph receptor A7

chr15_-_10485385 0.599 ENSMUST00000168690.1
 Brix1
BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)
chr15_-_10485890 0.532 ENSMUST00000169050.1
ENSMUST00000022855.5
 Brix1

BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)

chr2_-_73386396 0.516 ENSMUST00000112044.1
ENSMUST00000112043.1
ENSMUST00000076463.5
 Gpr155


G protein-coupled receptor 155


chr4_+_32238950 0.483 ENSMUST00000037416.6
 Bach2
BTB and CNC homology 2
chr4_-_119415494 0.412 ENSMUST00000063642.2
 Ccdc30
coiled-coil domain containing 30
chr4_-_35845204 0.382 ENSMUST00000164772.1
ENSMUST00000065173.2
 Lingo2

leucine rich repeat and Ig domain containing 2

chr12_+_111166485 0.348 ENSMUST00000139162.1
 Traf3
TNF receptor-associated factor 3
chr12_+_111166413 0.329 ENSMUST00000021706.4
 Traf3
TNF receptor-associated factor 3
chrM_+_7005 0.284 ENSMUST00000082405.1
 mt-Co2
mitochondrially encoded cytochrome c oxidase II
chr6_-_126939524 0.268 ENSMUST00000144954.1
ENSMUST00000112221.1
ENSMUST00000112220.1
 Rad51ap1


RAD51 associated protein 1


chr12_+_111166349 0.265 ENSMUST00000117269.1
 Traf3
TNF receptor-associated factor 3
chr2_-_23040137 0.259 ENSMUST00000091394.6
ENSMUST00000093171.6
 Abi1

abl-interactor 1

chr2_-_23040177 0.244 ENSMUST00000114544.3
ENSMUST00000139038.1
ENSMUST00000126112.1
ENSMUST00000178908.1
ENSMUST00000078977.7
ENSMUST00000140164.1
ENSMUST00000149719.1
 Abi1






abl-interactor 1






chr12_+_111166536 0.230 ENSMUST00000060274.6
 Traf3
TNF receptor-associated factor 3
chr10_+_18469958 0.222 ENSMUST00000162891.1
ENSMUST00000100054.3
 Nhsl1

NHS-like 1

chr1_-_53785214 0.205 ENSMUST00000027263.7
 Stk17b
serine/threonine kinase 17b (apoptosis-inducing)
chr3_+_14578609 0.203 ENSMUST00000029069.6
ENSMUST00000165922.2
 E2f5

E2F transcription factor 5

chr17_+_32685655 0.189 ENSMUST00000008801.6
 Cyp4f15
cytochrome P450, family 4, subfamily f, polypeptide 15
chr2_-_23040092 0.168 ENSMUST00000153931.1
ENSMUST00000123948.1
 Abi1

abl-interactor 1

chr15_-_97705787 0.113 ENSMUST00000023104.5
 Rpap3
RNA polymerase II associated protein 3
chr9_-_42457594 0.111 ENSMUST00000125995.1
 Tbcel
tubulin folding cofactor E-like
chr15_+_41830921 0.105 ENSMUST00000166917.1
 Oxr1
oxidation resistance 1
chrX_-_95658392 0.084 ENSMUST00000120620.1
 Zc4h2
zinc finger, C4H2 domain containing
chr17_+_32685610 0.072 ENSMUST00000168171.1
 Cyp4f15
cytochrome P450, family 4, subfamily f, polypeptide 15
chrX_-_95658416 0.061 ENSMUST00000044382.6
 Zc4h2
zinc finger, C4H2 domain containing
chrX_-_95658379 0.046 ENSMUST00000119640.1
 Zc4h2
zinc finger, C4H2 domain containing
chr10_-_61784014 0.045 ENSMUST00000020283.4
 H2afy2
H2A histone family, member Y2
chr6_+_126939957 0.024 ENSMUST00000032497.3
 D6Wsu163e
DNA segment, Chr 6, Wayne State University 163, expressed

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0031622 positive regulation of fever generation(GO:0031622) trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
0.2 1.3 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.1 1.2 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.7 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 1.1 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.2 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.7 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.2 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.3 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 1.2 GO:0001578 microtubule bundle formation(GO:0001578)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0035631 CD40 receptor complex(GO:0035631)
0.1 0.7 GO:0031209 SCAR complex(GO:0031209)
0.0 1.0 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 1.2 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.1 GO:0097255 R2TP complex(GO:0097255)
0.0 0.7 GO:0002102 podosome(GO:0002102)
0.0 1.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.3 GO:0042734 presynaptic membrane(GO:0042734)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 1.2 GO:0031996 thioesterase binding(GO:0031996)
0.1 1.0 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.1 1.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.7 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.5 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.3 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.3 GO:0008144 drug binding(GO:0008144)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.3 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.2 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 0.7 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon