Motif ID: Nr2e3

Z-value: 0.944


Transcription factors associated with Nr2e3:

Gene SymbolEntrez IDGene Name
Nr2e3 ENSMUSG00000032292.2 Nr2e3



Activity profile for motif Nr2e3.

activity profile for motif Nr2e3


Sorted Z-values histogram for motif Nr2e3

Sorted Z-values for motif Nr2e3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2e3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_-_35215008 8.186 ENSMUST00000091636.3
Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr1_+_143640664 6.063 ENSMUST00000038252.2
B3galt2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr3_+_54156039 4.664 ENSMUST00000029311.6
Trpc4
transient receptor potential cation channel, subfamily C, member 4
chr2_+_65620829 4.520 ENSMUST00000028377.7
Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr10_-_109010955 4.389 ENSMUST00000105276.1
ENSMUST00000064054.7
Syt1

synaptotagmin I

chr11_-_42182924 4.277 ENSMUST00000020707.5
ENSMUST00000132971.1
Gabra1

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1

chr6_-_13839916 4.254 ENSMUST00000060442.7
Gpr85
G protein-coupled receptor 85
chr4_-_138396438 4.198 ENSMUST00000105032.2
Fam43b
family with sequence similarity 43, member B
chr2_-_45112890 3.890 ENSMUST00000076836.6
Zeb2
zinc finger E-box binding homeobox 2
chr11_+_111066154 3.767 ENSMUST00000042970.2
Kcnj2
potassium inwardly-rectifying channel, subfamily J, member 2
chr16_-_22439719 3.520 ENSMUST00000079601.6
Etv5
ets variant gene 5
chr18_+_32938955 3.423 ENSMUST00000042868.4
Camk4
calcium/calmodulin-dependent protein kinase IV
chr10_-_109764840 3.373 ENSMUST00000163071.1
Nav3
neuron navigator 3
chr10_+_90576570 3.259 ENSMUST00000182786.1
ENSMUST00000182600.1
Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr10_-_109009055 3.142 ENSMUST00000156979.1
Syt1
synaptotagmin I
chr12_+_95695350 3.119 ENSMUST00000110117.1
Flrt2
fibronectin leucine rich transmembrane protein 2
chr7_-_110862944 3.078 ENSMUST00000033050.3
Lyve1
lymphatic vessel endothelial hyaluronan receptor 1
chr12_+_69963452 3.031 ENSMUST00000110560.1
Gm3086
predicted gene 3086
chr16_-_52454074 2.913 ENSMUST00000023312.7
Alcam
activated leukocyte cell adhesion molecule
chr16_-_22439570 2.906 ENSMUST00000170393.1
Etv5
ets variant gene 5
chr2_+_96318014 2.839 ENSMUST00000135431.1
ENSMUST00000162807.2
Lrrc4c

leucine rich repeat containing 4C

chr4_-_151861762 2.718 ENSMUST00000097774.2
Camta1
calmodulin binding transcription activator 1
chr4_-_151861698 2.709 ENSMUST00000049790.7
Camta1
calmodulin binding transcription activator 1
chr10_+_90576678 2.639 ENSMUST00000182284.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr9_-_77347816 2.531 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
Mlip



muscular LMNA-interacting protein



chr10_-_29144194 2.430 ENSMUST00000070359.2
Gm9996
predicted gene 9996
chr4_-_151861667 2.363 ENSMUST00000169423.2
Camta1
calmodulin binding transcription activator 1
chr11_-_42182163 2.358 ENSMUST00000153147.1
Gabra1
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1
chr1_-_58424042 2.337 ENSMUST00000034868.7
Clk1
CDC-like kinase 1
chr5_+_19227046 2.319 ENSMUST00000088516.3
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr14_+_101840602 2.283 ENSMUST00000159314.1
Lmo7
LIM domain only 7
chr7_+_36698002 2.272 ENSMUST00000021641.6
Tshz3
teashirt zinc finger family member 3
chr10_+_90576777 2.257 ENSMUST00000183136.1
ENSMUST00000182595.1
Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr10_+_90576708 2.188 ENSMUST00000182430.1
ENSMUST00000182960.1
ENSMUST00000182045.1
ENSMUST00000182083.1
Anks1b



ankyrin repeat and sterile alpha motif domain containing 1B



chr10_+_90576252 2.130 ENSMUST00000182427.1
ENSMUST00000182053.1
ENSMUST00000182113.1
Anks1b


ankyrin repeat and sterile alpha motif domain containing 1B


chr14_+_101840501 2.095 ENSMUST00000159026.1
Lmo7
LIM domain only 7
chr3_+_68468162 2.044 ENSMUST00000182532.1
Schip1
schwannomin interacting protein 1
chr13_-_91388079 2.042 ENSMUST00000181054.1
A830009L08Rik
RIKEN cDNA A830009L08 gene
chr14_+_123659971 2.034 ENSMUST00000049681.7
Itgbl1
integrin, beta-like 1
chr13_-_51701041 1.976 ENSMUST00000110042.1
Gm15440
predicted gene 15440
chr10_+_107271827 1.962 ENSMUST00000020057.8
ENSMUST00000105280.3
Lin7a

lin-7 homolog A (C. elegans)

chr9_-_77347787 1.930 ENSMUST00000184848.1
ENSMUST00000184415.1
Mlip

muscular LMNA-interacting protein

chr5_-_65335597 1.826 ENSMUST00000172660.1
ENSMUST00000172732.1
ENSMUST00000031092.8
Rfc1


replication factor C (activator 1) 1


chr8_+_125995102 1.821 ENSMUST00000046765.8
Kcnk1
potassium channel, subfamily K, member 1
chr5_-_65335564 1.807 ENSMUST00000172780.1
Rfc1
replication factor C (activator 1) 1
chr14_-_26442824 1.806 ENSMUST00000136635.1
ENSMUST00000125437.1
Slmap

sarcolemma associated protein

chr8_-_54718664 1.793 ENSMUST00000144711.2
ENSMUST00000093510.2
Wdr17

WD repeat domain 17

chr17_-_71475285 1.719 ENSMUST00000127430.1
Smchd1
SMC hinge domain containing 1
chrX_-_143933204 1.659 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
Dcx


doublecortin


chrX_-_143933089 1.632 ENSMUST00000087313.3
Dcx
doublecortin
chr5_+_19907502 1.566 ENSMUST00000101558.3
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr5_+_19907774 1.561 ENSMUST00000115267.2
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr6_+_141524379 1.477 ENSMUST00000032362.9
Slco1c1
solute carrier organic anion transporter family, member 1c1
chr19_-_29753600 1.456 ENSMUST00000175764.1
9930021J03Rik
RIKEN cDNA 9930021J03 gene
chr1_+_151755339 1.456 ENSMUST00000059498.5
Edem3
ER degradation enhancer, mannosidase alpha-like 3
chr4_+_102760294 1.437 ENSMUST00000072481.5
ENSMUST00000156596.1
ENSMUST00000080728.6
ENSMUST00000106882.2
Sgip1



SH3-domain GRB2-like (endophilin) interacting protein 1



chr9_-_77347889 1.353 ENSMUST00000185039.1
Mlip
muscular LMNA-interacting protein
chr4_+_102760135 1.276 ENSMUST00000066824.7
Sgip1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr9_-_16378231 1.276 ENSMUST00000082170.5
Fat3
FAT tumor suppressor homolog 3 (Drosophila)
chr1_-_40790642 1.268 ENSMUST00000039672.5
Mfsd9
major facilitator superfamily domain containing 9
chr9_+_113812547 1.264 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
Clasp2


CLIP associating protein 2


chr16_+_43510267 1.234 ENSMUST00000114695.2
Zbtb20
zinc finger and BTB domain containing 20
chr5_-_104021919 1.219 ENSMUST00000031251.9
Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr17_-_17624458 1.208 ENSMUST00000041047.2
Lnpep
leucyl/cystinyl aminopeptidase
chr9_-_13245741 1.208 ENSMUST00000110582.2
Jrkl
jerky homolog-like (mouse)
chr1_+_177445660 1.184 ENSMUST00000077225.6
Zbtb18
zinc finger and BTB domain containing 18
chr7_+_27731398 1.135 ENSMUST00000130997.1
Zfp60
zinc finger protein 60
chr19_-_31664356 1.133 ENSMUST00000073581.5
Prkg1
protein kinase, cGMP-dependent, type I
chr11_+_19924403 1.127 ENSMUST00000093298.5
Spred2
sprouty-related, EVH1 domain containing 2
chr3_+_103279293 1.121 ENSMUST00000029444.6
ENSMUST00000106860.1
Trim33

tripartite motif-containing 33

chr2_+_69647208 1.070 ENSMUST00000074963.2
ENSMUST00000112286.2
Bbs5

Bardet-Biedl syndrome 5 (human)

chr5_-_104021799 1.068 ENSMUST00000119025.1
Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr7_+_27731445 1.053 ENSMUST00000042641.7
Zfp60
zinc finger protein 60
chr11_+_19924354 1.049 ENSMUST00000093299.6
Spred2
sprouty-related, EVH1 domain containing 2
chr11_-_65162904 1.039 ENSMUST00000093002.5
ENSMUST00000047463.8
Arhgap44

Rho GTPase activating protein 44

chr11_-_76571527 1.022 ENSMUST00000072740.6
Abr
active BCR-related gene
chr5_-_51553896 1.018 ENSMUST00000132734.1
Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chrY_-_10643315 1.012 ENSMUST00000100115.1
Gm20775
predicted gene, 20775
chrX_+_42149288 1.008 ENSMUST00000115073.2
ENSMUST00000115072.1
Stag2

stromal antigen 2

chr7_+_27731373 0.986 ENSMUST00000108336.1
Zfp60
zinc finger protein 60
chr2_-_136387929 0.976 ENSMUST00000035264.2
ENSMUST00000077200.3
Pak7

p21 protein (Cdc42/Rac)-activated kinase 7

chr16_+_23107754 0.961 ENSMUST00000077605.5
ENSMUST00000115341.3
Eif4a2

eukaryotic translation initiation factor 4A2

chr11_-_28584260 0.958 ENSMUST00000093253.3
ENSMUST00000109502.2
ENSMUST00000042534.8
Ccdc85a


coiled-coil domain containing 85A


chr1_+_180111339 0.952 ENSMUST00000145181.1
Cdc42bpa
CDC42 binding protein kinase alpha
chr17_-_24689901 0.940 ENSMUST00000007236.4
Syngr3
synaptogyrin 3
chr16_+_43508118 0.919 ENSMUST00000114690.1
Zbtb20
zinc finger and BTB domain containing 20
chr2_-_161109017 0.910 ENSMUST00000039782.7
ENSMUST00000134178.1
Chd6

chromodomain helicase DNA binding protein 6

chr5_+_88583527 0.895 ENSMUST00000031229.6
Rufy3
RUN and FYVE domain containing 3
chrX_-_59166080 0.884 ENSMUST00000119306.1
Fgf13
fibroblast growth factor 13
chr5_+_76809964 0.848 ENSMUST00000120818.1
C530008M17Rik
RIKEN cDNA C530008M17 gene
chr2_-_140671400 0.845 ENSMUST00000056760.3
Flrt3
fibronectin leucine rich transmembrane protein 3
chr10_+_119992962 0.834 ENSMUST00000154238.1
Grip1
glutamate receptor interacting protein 1
chrX_-_108834303 0.827 ENSMUST00000101283.3
ENSMUST00000150434.1
Brwd3

bromodomain and WD repeat domain containing 3

chr18_+_61555258 0.791 ENSMUST00000165123.1
Csnk1a1
casein kinase 1, alpha 1
chr12_+_88953399 0.772 ENSMUST00000057634.7
Nrxn3
neurexin III
chr4_+_49521176 0.756 ENSMUST00000042964.6
ENSMUST00000107696.1
Zfp189

zinc finger protein 189

chr2_+_143546144 0.754 ENSMUST00000028905.9
Pcsk2
proprotein convertase subtilisin/kexin type 2
chr13_+_21478907 0.745 ENSMUST00000062609.5
Zkscan4
zinc finger with KRAB and SCAN domains 4
chr16_-_16560201 0.736 ENSMUST00000162045.1
ENSMUST00000162124.1
ENSMUST00000161861.1
Fgd4


FYVE, RhoGEF and PH domain containing 4


chr6_+_104492790 0.728 ENSMUST00000161446.1
ENSMUST00000161070.1
ENSMUST00000089215.5
Cntn6


contactin 6


chr11_-_3774706 0.721 ENSMUST00000155197.1
Osbp2
oxysterol binding protein 2
chr5_-_123140135 0.686 ENSMUST00000160099.1
AI480526
expressed sequence AI480526
chr11_+_94044111 0.683 ENSMUST00000132079.1
Spag9
sperm associated antigen 9
chr2_-_27027909 0.672 ENSMUST00000102890.4
ENSMUST00000153388.1
ENSMUST00000045702.5
Slc2a6


solute carrier family 2 (facilitated glucose transporter), member 6


chr15_+_6299781 0.665 ENSMUST00000078019.6
Dab2
disabled 2, mitogen-responsive phosphoprotein
chr18_+_61555308 0.644 ENSMUST00000165721.1
ENSMUST00000115246.2
ENSMUST00000166990.1
ENSMUST00000163205.1
ENSMUST00000170862.1
Csnk1a1




casein kinase 1, alpha 1




chr2_-_140671440 0.643 ENSMUST00000099301.1
Flrt3
fibronectin leucine rich transmembrane protein 3
chr8_-_60954726 0.642 ENSMUST00000110302.1
Clcn3
chloride channel 3
chr5_-_5266038 0.608 ENSMUST00000115451.1
ENSMUST00000115452.1
ENSMUST00000131392.1
Cdk14


cyclin-dependent kinase 14


chr3_-_137981523 0.592 ENSMUST00000136613.1
ENSMUST00000029806.6
Dapp1

dual adaptor for phosphotyrosine and 3-phosphoinositides 1

chr10_-_11080956 0.588 ENSMUST00000105560.1
Grm1
glutamate receptor, metabotropic 1
chr7_-_65371210 0.579 ENSMUST00000102592.3
Tjp1
tight junction protein 1
chr2_-_80129458 0.577 ENSMUST00000102653.1
Pde1a
phosphodiesterase 1A, calmodulin-dependent
chrX_+_42149534 0.565 ENSMUST00000127618.1
Stag2
stromal antigen 2
chr2_+_24949747 0.555 ENSMUST00000028350.3
Zmynd19
zinc finger, MYND domain containing 19
chr2_-_140671462 0.554 ENSMUST00000110057.2
Flrt3
fibronectin leucine rich transmembrane protein 3
chr5_-_24447587 0.517 ENSMUST00000127194.1
ENSMUST00000115033.1
ENSMUST00000123167.1
ENSMUST00000030799.8
Tmub1



transmembrane and ubiquitin-like domain containing 1



chr9_-_122903102 0.502 ENSMUST00000180877.1
ENSMUST00000180486.1
A530083I20Rik

RIKEN cDNA A530083I20 gene

chr18_-_22850738 0.490 ENSMUST00000092015.4
ENSMUST00000069215.6
Nol4

nucleolar protein 4

chr4_-_25281752 0.478 ENSMUST00000038705.7
Ufl1
UFM1 specific ligase 1
chrX_+_166344692 0.474 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
Gpm6b





glycoprotein m6b





chrX_+_120290259 0.462 ENSMUST00000113358.3
ENSMUST00000050239.9
ENSMUST00000113364.3
Pcdh11x


protocadherin 11 X-linked


chr13_-_12464925 0.438 ENSMUST00000124888.1
Lgals8
lectin, galactose binding, soluble 8
chr3_+_40540751 0.435 ENSMUST00000091186.3
Intu
inturned planar cell polarity effector homolog (Drosophila)
chr10_+_62071014 0.432 ENSMUST00000053865.5
Gm5424
predicted gene 5424
chrX_-_134111852 0.416 ENSMUST00000033610.6
Nox1
NADPH oxidase 1
chr11_-_109472611 0.398 ENSMUST00000168740.1
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr15_+_6299797 0.388 ENSMUST00000159046.1
ENSMUST00000161040.1
Dab2

disabled 2, mitogen-responsive phosphoprotein

chr11_+_21239279 0.377 ENSMUST00000006221.7
ENSMUST00000109578.1
Vps54

vacuolar protein sorting 54 (yeast)

chr8_+_106510853 0.374 ENSMUST00000080797.6
Cdh3
cadherin 3
chr7_-_65370908 0.358 ENSMUST00000032729.6
Tjp1
tight junction protein 1
chr3_-_79145875 0.333 ENSMUST00000118340.1
Rapgef2
Rap guanine nucleotide exchange factor (GEF) 2
chr3_-_88503331 0.328 ENSMUST00000029699.6
Lmna
lamin A
chr3_+_118430299 0.321 ENSMUST00000180774.1
Gm26871
predicted gene, 26871
chr18_+_37819543 0.316 ENSMUST00000055935.5
Pcdhga9
protocadherin gamma subfamily A, 9
chr11_+_33963013 0.316 ENSMUST00000020362.2
Kcnmb1
potassium large conductance calcium-activated channel, subfamily M, beta member 1
chr14_+_20674311 0.309 ENSMUST00000048657.8
Sec24c
Sec24 related gene family, member C (S. cerevisiae)
chr9_-_83146601 0.299 ENSMUST00000162246.2
ENSMUST00000161796.2
Hmgn3

high mobility group nucleosomal binding domain 3

chr16_-_16560046 0.292 ENSMUST00000172181.2
Fgd4
FYVE, RhoGEF and PH domain containing 4
chr3_-_123690806 0.289 ENSMUST00000154668.1
Ndst3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr4_-_120951664 0.276 ENSMUST00000106280.1
Zfp69
zinc finger protein 69
chr6_-_30693676 0.242 ENSMUST00000169422.1
ENSMUST00000115131.1
ENSMUST00000115130.2
ENSMUST00000031810.8
Cep41



centrosomal protein 41



chr7_-_4522427 0.238 ENSMUST00000098859.3
Tnni3
troponin I, cardiac 3
chr13_-_28953690 0.236 ENSMUST00000067230.5
Sox4
SRY-box containing gene 4
chrX_+_163911401 0.235 ENSMUST00000140845.1
Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr13_+_80883403 0.235 ENSMUST00000099356.2
Arrdc3
arrestin domain containing 3
chr1_+_97770158 0.232 ENSMUST00000112844.3
ENSMUST00000112842.1
ENSMUST00000027571.6
Gin1


gypsy retrotransposon integrase 1


chr9_-_20952838 0.209 ENSMUST00000004202.9
Dnmt1
DNA methyltransferase (cytosine-5) 1
chr1_-_165934900 0.181 ENSMUST00000069609.5
ENSMUST00000111427.2
ENSMUST00000111426.4
Pou2f1


POU domain, class 2, transcription factor 1


chrM_+_11734 0.177 ENSMUST00000082418.1
mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr4_+_143412920 0.144 ENSMUST00000132915.1
ENSMUST00000037356.7
Pramef8

PRAME family member 8

chr18_-_66022580 0.098 ENSMUST00000143990.1
Lman1
lectin, mannose-binding, 1
chr3_-_88503187 0.095 ENSMUST00000120377.1
Lmna
lamin A
chr13_+_24943144 0.093 ENSMUST00000021773.5
Gpld1
glycosylphosphatidylinositol specific phospholipase D1
chr3_-_144202300 0.083 ENSMUST00000121796.1
ENSMUST00000121112.1
Lmo4

LIM domain only 4

chr7_+_49759100 0.067 ENSMUST00000085272.5
Htatip2
HIV-1 tat interactive protein 2, homolog (human)
chr4_-_43040279 0.057 ENSMUST00000107958.1
ENSMUST00000107959.1
ENSMUST00000152846.1
Fam214b


family with sequence similarity 214, member B


chr8_-_13200576 0.039 ENSMUST00000165605.2
Grtp1
GH regulated TBC protein 1
chr6_+_82402475 0.039 ENSMUST00000032122.8
Tacr1
tachykinin receptor 1
chr2_+_83724397 0.034 ENSMUST00000028499.4
ENSMUST00000141725.1
ENSMUST00000111740.2
Itgav


integrin alpha V


chr7_+_83584910 0.034 ENSMUST00000039317.7
ENSMUST00000164944.1
Tmc3

transmembrane channel-like gene family 3

chr2_-_73660401 0.033 ENSMUST00000102677.4
Chn1
chimerin (chimaerin) 1
chr19_-_7341433 0.021 ENSMUST00000165965.1
ENSMUST00000051711.9
ENSMUST00000169541.1
ENSMUST00000165989.1
Mark2



MAP/microtubule affinity-regulating kinase 2



chr16_+_32271468 0.008 ENSMUST00000093183.3
Smco1
single-pass membrane protein with coiled-coil domains 1
chr17_+_44777294 0.004 ENSMUST00000127798.1
Supt3
suppressor of Ty 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 6.4 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
1.0 12.5 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
1.0 7.8 GO:0005513 detection of calcium ion(GO:0005513)
0.8 2.3 GO:0050975 sensory perception of touch(GO:0050975)
0.7 6.6 GO:0071420 cellular response to histamine(GO:0071420)
0.7 5.4 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.7 2.0 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.7 6.1 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.6 3.9 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.6 1.7 GO:0060821 inactivation of X chromosome by DNA methylation(GO:0060821)
0.6 2.3 GO:0006710 androgen catabolic process(GO:0006710)
0.5 3.8 GO:0014819 regulation of skeletal muscle contraction(GO:0014819)
0.4 2.0 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.4 1.1 GO:2000224 testosterone biosynthetic process(GO:0061370) regulation of testosterone biosynthetic process(GO:2000224)
0.4 1.8 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.3 1.0 GO:0098886 modification of dendritic spine(GO:0098886)
0.3 3.7 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
0.3 3.1 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.3 1.8 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.3 8.0 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.3 1.5 GO:0036508 protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) protein demannosylation(GO:0036507) protein alpha-1,2-demannosylation(GO:0036508) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.3 0.8 GO:0030070 insulin processing(GO:0030070)
0.2 3.4 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.2 0.2 GO:0003289 atrial septum primum morphogenesis(GO:0003289)
0.2 4.7 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.2 0.9 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.2 3.3 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.2 0.6 GO:0097401 synaptic vesicle lumen acidification(GO:0097401)
0.2 1.1 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.2 1.0 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
0.2 1.3 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.2 1.6 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.2 2.2 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.1 0.6 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 5.8 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.1 0.8 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.1 1.5 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 0.9 GO:0098909 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.1 0.4 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.1 1.0 GO:0030035 microspike assembly(GO:0030035)
0.1 0.3 GO:2000481 positive regulation of cAMP-dependent protein kinase activity(GO:2000481) positive regulation of dendritic cell apoptotic process(GO:2000670)
0.1 2.0 GO:0001553 luteinization(GO:0001553)
0.1 0.4 GO:0072592 oxygen metabolic process(GO:0072592)
0.1 1.4 GO:1904424 regulation of GTP binding(GO:1904424)
0.1 0.7 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.1 0.9 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 0.4 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 7.3 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.1 0.5 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 2.7 GO:0008045 motor neuron axon guidance(GO:0008045)
0.1 0.2 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.1 0.7 GO:0035428 hexose transmembrane transport(GO:0035428)
0.1 0.4 GO:0002317 plasma cell differentiation(GO:0002317)
0.1 0.5 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1 2.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 0.2 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 0.8 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 0.3 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.4 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.0 0.1 GO:0010040 response to iron(II) ion(GO:0010040)
0.0 1.0 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.9 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 1.3 GO:0010842 retina layer formation(GO:0010842)
0.0 1.2 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.2 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.0 0.4 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.0 0.0 GO:0035106 operant conditioning(GO:0035106)
0.0 0.6 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.2 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0 0.2 GO:0015074 DNA integration(GO:0015074)
0.0 0.1 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0 0.3 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 1.1 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 0.7 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 1.2 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 2.3 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 0.0 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.0 1.0 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway(GO:2001237)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.6 GO:0005663 DNA replication factor C complex(GO:0005663)
0.6 5.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.5 1.8 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.4 7.5 GO:0031045 dense core granule(GO:0031045)
0.4 6.6 GO:1902711 GABA-A receptor complex(GO:1902711)
0.3 1.3 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.3 2.0 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.3 1.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.2 1.7 GO:0001740 Barr body(GO:0001740)
0.2 2.9 GO:0042101 T cell receptor complex(GO:0042101)
0.2 2.7 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 0.9 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.6 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 1.0 GO:0030175 filopodium(GO:0030175)
0.1 1.4 GO:0045095 keratin filament(GO:0045095)
0.1 0.4 GO:0071438 invadopodium membrane(GO:0071438)
0.1 0.9 GO:0071437 invadopodium(GO:0071437)
0.1 1.1 GO:0034464 BBSome(GO:0034464)
0.1 3.8 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.1 4.7 GO:0034704 calcium channel complex(GO:0034704)
0.1 25.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 0.4 GO:0000938 GARP complex(GO:0000938)
0.1 0.4 GO:0005638 lamin filament(GO:0005638)
0.1 0.2 GO:0097512 cardiac myofibril(GO:0097512) cardiac Troponin complex(GO:1990584)
0.1 5.6 GO:0016605 PML body(GO:0016605)
0.0 0.6 GO:0042581 specific granule(GO:0042581)
0.0 4.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 2.0 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.9 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.8 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.4 GO:0097440 apical dendrite(GO:0097440)
0.0 1.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 2.3 GO:0005811 lipid particle(GO:0005811)
0.0 5.0 GO:0030426 growth cone(GO:0030426)
0.0 1.0 GO:0048786 presynaptic active zone(GO:0048786)
0.0 3.4 GO:0001650 fibrillar center(GO:0001650)
0.0 1.2 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 1.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.0 GO:0034684 integrin alphav-beta5 complex(GO:0034684)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.5 GO:0030348 syntaxin-3 binding(GO:0030348)
1.5 6.1 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
1.1 6.6 GO:1904315 GABA-gated chloride ion channel activity(GO:0022851) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.9 5.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.5 3.8 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.4 8.0 GO:0042043 neurexin family protein binding(GO:0042043)
0.4 1.5 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.4 2.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.3 0.3 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.3 3.6 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.3 2.0 GO:0097016 L27 domain binding(GO:0097016)
0.3 2.3 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.3 3.9 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.3 5.2 GO:0045499 chemorepellent activity(GO:0045499)
0.3 3.4 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.3 1.1 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.2 12.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 3.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 1.8 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.2 1.5 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.2 0.6 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.2 0.5 GO:0071568 UFM1 transferase activity(GO:0071568)
0.1 0.6 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.1 0.4 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.1 0.9 GO:0071253 connexin binding(GO:0071253)
0.1 5.0 GO:0070412 R-SMAD binding(GO:0070412)
0.1 1.3 GO:0002162 dystroglycan binding(GO:0002162)
0.1 3.3 GO:0042805 actinin binding(GO:0042805)
0.1 1.5 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.1 0.6 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 1.1 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 0.2 GO:0030172 troponin C binding(GO:0030172)
0.1 0.3 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.0 0.7 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 2.3 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 1.0 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 3.9 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 1.1 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.9 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 0.6 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.9 GO:0042169 SH2 domain binding(GO:0042169)
0.0 2.0 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 3.5 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.0 12.0 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.2 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 1.0 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.8 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 4.1 GO:0008017 microtubule binding(GO:0008017)
0.0 0.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 1.4 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 0.7 GO:0032934 cholesterol binding(GO:0015485) sterol binding(GO:0032934)
0.0 1.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.6 GO:0030332 cyclin binding(GO:0030332)
0.0 0.2 GO:0031690 adrenergic receptor binding(GO:0031690)
0.0 0.4 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.2 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 7.5 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.1 3.6 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.1 3.4 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 3.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 1.4 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.1 2.2 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.1 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.4 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 1.0 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.6 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.6 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.0 1.0 SIG_CHEMOTAXIS Genes related to chemotaxis
0.0 1.6 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.9 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.0 PID_CDC42_PATHWAY CDC42 signaling events
0.0 0.7 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 1.1 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 0.8 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 7.5 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.4 4.7 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.4 6.6 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.4 1.2 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.3 3.1 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.3 1.8 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.2 5.4 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.2 1.5 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.1 0.9 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 1.5 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 4.0 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.1 3.7 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 1.4 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.1 1.0 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 0.6 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 1.4 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 0.7 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 6.7 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 1.1 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 1.0 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.8 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.1 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 1.0 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 2.0 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS Genes involved in G alpha (12/13) signalling events
0.0 0.3 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 1.4 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.2 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions