Motif ID: Nr5a2
Z-value: 0.904
Transcription factors associated with Nr5a2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nr5a2 | ENSMUSG00000026398.8 | Nr5a2 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2.7 | GO:0021933 | radial glia guided migration of cerebellar granule cell(GO:0021933) |
| 0.8 | 2.3 | GO:0097212 | lysosomal membrane organization(GO:0097212) |
| 0.8 | 2.3 | GO:0002014 | vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014) |
| 0.7 | 4.3 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 0.7 | 3.3 | GO:0070305 | response to cGMP(GO:0070305) cellular response to cGMP(GO:0071321) |
| 0.7 | 2.0 | GO:0042560 | 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560) |
| 0.6 | 1.9 | GO:0017055 | negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055) |
| 0.6 | 1.7 | GO:0032241 | positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256) |
| 0.6 | 1.7 | GO:0019043 | establishment of viral latency(GO:0019043) |
| 0.5 | 4.6 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.5 | 0.9 | GO:0033159 | negative regulation of protein import into nucleus, translocation(GO:0033159) |
| 0.5 | 2.3 | GO:0019244 | lactate biosynthetic process from pyruvate(GO:0019244) |
| 0.4 | 1.3 | GO:0002447 | eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308) |
| 0.4 | 1.2 | GO:0042823 | pyridoxal phosphate biosynthetic process(GO:0042823) |
| 0.4 | 3.8 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 0.4 | 1.1 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) |
| 0.4 | 1.8 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.4 | 1.1 | GO:0019401 | alditol biosynthetic process(GO:0019401) |
| 0.3 | 1.0 | GO:0033364 | mast cell secretory granule organization(GO:0033364) |
| 0.3 | 1.0 | GO:0071544 | diphosphoinositol polyphosphate catabolic process(GO:0071544) |
| 0.3 | 1.0 | GO:0035672 | regulation of cellular pH reduction(GO:0032847) oligopeptide transmembrane transport(GO:0035672) |
| 0.3 | 1.0 | GO:0045041 | protein import into mitochondrial intermembrane space(GO:0045041) |
| 0.3 | 0.9 | GO:0014826 | vein smooth muscle contraction(GO:0014826) |
| 0.3 | 0.6 | GO:0006106 | fumarate metabolic process(GO:0006106) |
| 0.3 | 1.2 | GO:0006121 | mitochondrial electron transport, succinate to ubiquinone(GO:0006121) |
| 0.3 | 2.7 | GO:0002536 | respiratory burst involved in inflammatory response(GO:0002536) negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665) |
| 0.3 | 0.8 | GO:1903538 | meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538) |
| 0.3 | 1.6 | GO:1901552 | positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142) |
| 0.3 | 0.8 | GO:0072076 | nephrogenic mesenchyme development(GO:0072076) |
| 0.3 | 2.4 | GO:1990845 | adaptive thermogenesis(GO:1990845) |
| 0.2 | 6.0 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.2 | 0.7 | GO:0071649 | regulation of chemokine (C-C motif) ligand 5 production(GO:0071649) |
| 0.2 | 0.7 | GO:0030200 | heparan sulfate proteoglycan catabolic process(GO:0030200) |
| 0.2 | 0.7 | GO:0046133 | pyrimidine ribonucleoside catabolic process(GO:0046133) |
| 0.2 | 0.7 | GO:1902445 | regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445) |
| 0.2 | 0.7 | GO:2000823 | regulation of androgen receptor activity(GO:2000823) |
| 0.2 | 1.3 | GO:0006172 | ADP biosynthetic process(GO:0006172) |
| 0.2 | 8.6 | GO:0010614 | negative regulation of cardiac muscle hypertrophy(GO:0010614) |
| 0.2 | 0.4 | GO:0009814 | defense response, incompatible interaction(GO:0009814) |
| 0.2 | 1.8 | GO:0006027 | glycosaminoglycan catabolic process(GO:0006027) |
| 0.2 | 2.6 | GO:0097067 | cellular response to thyroid hormone stimulus(GO:0097067) |
| 0.2 | 0.8 | GO:0010756 | positive regulation of plasminogen activation(GO:0010756) |
| 0.2 | 1.0 | GO:0018171 | peptidyl-cysteine oxidation(GO:0018171) |
| 0.2 | 1.5 | GO:0006390 | transcription from mitochondrial promoter(GO:0006390) |
| 0.2 | 0.9 | GO:0015817 | glutamine transport(GO:0006868) histidine transport(GO:0015817) cellular response to potassium ion starvation(GO:0051365) |
| 0.2 | 1.8 | GO:0046051 | UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051) |
| 0.2 | 1.3 | GO:0016576 | histone dephosphorylation(GO:0016576) |
| 0.2 | 2.5 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 0.2 | 1.2 | GO:0009249 | protein lipoylation(GO:0009249) |
| 0.1 | 0.4 | GO:1901856 | negative regulation of cellular respiration(GO:1901856) |
| 0.1 | 0.4 | GO:0010360 | negative regulation of anion channel activity(GO:0010360) |
| 0.1 | 0.4 | GO:0015772 | disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772) |
| 0.1 | 0.7 | GO:0045578 | negative regulation of B cell differentiation(GO:0045578) |
| 0.1 | 2.4 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.1 | 0.3 | GO:0003100 | regulation of systemic arterial blood pressure by endothelin(GO:0003100) |
| 0.1 | 5.1 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.1 | 1.0 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.1 | 0.4 | GO:0032237 | activation of store-operated calcium channel activity(GO:0032237) |
| 0.1 | 0.5 | GO:0046604 | positive regulation of mitotic centrosome separation(GO:0046604) |
| 0.1 | 1.2 | GO:0006105 | succinate metabolic process(GO:0006105) |
| 0.1 | 0.5 | GO:1902202 | regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202) |
| 0.1 | 0.7 | GO:0061622 | glycolytic process through glucose-1-phosphate(GO:0061622) |
| 0.1 | 0.9 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 0.1 | 0.8 | GO:0032790 | ribosome disassembly(GO:0032790) |
| 0.1 | 0.6 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
| 0.1 | 5.8 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.1 | 0.3 | GO:0098528 | skeletal muscle fiber differentiation(GO:0098528) |
| 0.1 | 0.6 | GO:1903300 | negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300) |
| 0.1 | 0.8 | GO:1904781 | positive regulation of protein localization to centrosome(GO:1904781) |
| 0.1 | 0.6 | GO:0071394 | cellular response to testosterone stimulus(GO:0071394) |
| 0.1 | 0.7 | GO:0006627 | protein processing involved in protein targeting to mitochondrion(GO:0006627) |
| 0.1 | 0.3 | GO:0030210 | heparin biosynthetic process(GO:0030210) |
| 0.1 | 1.8 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.1 | 0.5 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 0.1 | 0.3 | GO:0001980 | regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980) |
| 0.1 | 0.5 | GO:0043137 | DNA replication, removal of RNA primer(GO:0043137) |
| 0.1 | 2.3 | GO:2000060 | positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060) |
| 0.1 | 0.4 | GO:0015803 | branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820) |
| 0.1 | 4.3 | GO:0009060 | aerobic respiration(GO:0009060) |
| 0.1 | 1.5 | GO:0009081 | branched-chain amino acid metabolic process(GO:0009081) branched-chain amino acid catabolic process(GO:0009083) |
| 0.1 | 0.8 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.1 | 0.3 | GO:0006741 | NADP biosynthetic process(GO:0006741) |
| 0.1 | 0.7 | GO:0016198 | axon choice point recognition(GO:0016198) |
| 0.1 | 0.4 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
| 0.1 | 0.2 | GO:0003162 | atrioventricular node development(GO:0003162) |
| 0.1 | 3.1 | GO:0014003 | oligodendrocyte development(GO:0014003) |
| 0.1 | 0.4 | GO:0046684 | response to pyrethroid(GO:0046684) |
| 0.1 | 0.9 | GO:0003214 | cardiac left ventricle morphogenesis(GO:0003214) male sex determination(GO:0030238) lung-associated mesenchyme development(GO:0060484) |
| 0.1 | 0.8 | GO:2000653 | regulation of genetic imprinting(GO:2000653) |
| 0.1 | 0.4 | GO:2000672 | negative regulation of motor neuron apoptotic process(GO:2000672) |
| 0.1 | 0.8 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.1 | 0.5 | GO:0048742 | regulation of skeletal muscle fiber development(GO:0048742) |
| 0.1 | 0.8 | GO:0006654 | phosphatidic acid biosynthetic process(GO:0006654) |
| 0.1 | 0.2 | GO:1903279 | regulation of calcium:sodium antiporter activity(GO:1903279) |
| 0.1 | 0.1 | GO:0097168 | mesenchymal stem cell proliferation(GO:0097168) |
| 0.1 | 0.7 | GO:0033211 | adiponectin-activated signaling pathway(GO:0033211) long-chain fatty acid import(GO:0044539) |
| 0.1 | 1.0 | GO:0006662 | glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904) |
| 0.1 | 0.7 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.1 | 0.2 | GO:2000705 | positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) regulation of dense core granule biogenesis(GO:2000705) |
| 0.1 | 0.2 | GO:1901475 | pyruvate transmembrane transport(GO:1901475) |
| 0.1 | 1.0 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.1 | 0.4 | GO:0035507 | regulation of myosin-light-chain-phosphatase activity(GO:0035507) |
| 0.0 | 0.2 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.0 | 1.2 | GO:2000398 | regulation of T cell differentiation in thymus(GO:0033081) regulation of thymocyte aggregation(GO:2000398) |
| 0.0 | 1.1 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
| 0.0 | 0.4 | GO:0098937 | dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) |
| 0.0 | 1.4 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.0 | 0.3 | GO:0031293 | membrane protein intracellular domain proteolysis(GO:0031293) |
| 0.0 | 0.9 | GO:0042775 | mitochondrial ATP synthesis coupled electron transport(GO:0042775) |
| 0.0 | 0.5 | GO:0021860 | pyramidal neuron development(GO:0021860) |
| 0.0 | 0.3 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.0 | 4.8 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.0 | 1.8 | GO:0042168 | heme metabolic process(GO:0042168) |
| 0.0 | 0.2 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 0.7 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
| 0.0 | 0.2 | GO:0060334 | regulation of interferon-gamma-mediated signaling pathway(GO:0060334) |
| 0.0 | 1.0 | GO:0030262 | apoptotic nuclear changes(GO:0030262) |
| 0.0 | 0.3 | GO:0009644 | response to high light intensity(GO:0009644) |
| 0.0 | 1.1 | GO:0000038 | very long-chain fatty acid metabolic process(GO:0000038) |
| 0.0 | 0.2 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.0 | 0.7 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
| 0.0 | 0.2 | GO:0046459 | short-chain fatty acid metabolic process(GO:0046459) |
| 0.0 | 0.9 | GO:0045739 | positive regulation of DNA repair(GO:0045739) |
| 0.0 | 0.9 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 0.0 | 1.4 | GO:0032418 | lysosome localization(GO:0032418) |
| 0.0 | 0.0 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033) |
| 0.0 | 0.2 | GO:0051683 | establishment of Golgi localization(GO:0051683) |
| 0.0 | 1.4 | GO:0061077 | chaperone-mediated protein folding(GO:0061077) |
| 0.0 | 1.9 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.0 | 0.5 | GO:0000002 | mitochondrial genome maintenance(GO:0000002) |
| 0.0 | 0.1 | GO:0072615 | regulation of gamma-delta T cell differentiation(GO:0045586) regulation of gamma-delta T cell activation(GO:0046643) negative regulation of thymocyte apoptotic process(GO:0070244) interleukin-17 secretion(GO:0072615) |
| 0.0 | 0.4 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
| 0.0 | 2.0 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
| 0.0 | 0.4 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.0 | 0.3 | GO:0098743 | cartilage condensation(GO:0001502) cell aggregation(GO:0098743) |
| 0.0 | 0.3 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
| 0.0 | 1.5 | GO:0032091 | negative regulation of protein binding(GO:0032091) |
| 0.0 | 1.0 | GO:0009062 | fatty acid catabolic process(GO:0009062) |
| 0.0 | 0.3 | GO:0045116 | protein neddylation(GO:0045116) |
| 0.0 | 0.5 | GO:0033209 | tumor necrosis factor-mediated signaling pathway(GO:0033209) |
| 0.0 | 0.5 | GO:0006506 | GPI anchor biosynthetic process(GO:0006506) |
| 0.0 | 0.3 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 3.3 | GO:0098855 | HCN channel complex(GO:0098855) |
| 0.6 | 2.4 | GO:0045283 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 0.6 | 5.6 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) |
| 0.4 | 5.3 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.4 | 5.8 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.4 | 3.6 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.4 | 3.6 | GO:0005753 | mitochondrial proton-transporting ATP synthase complex(GO:0005753) |
| 0.3 | 1.3 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) |
| 0.2 | 1.3 | GO:0031314 | extrinsic component of mitochondrial inner membrane(GO:0031314) |
| 0.2 | 2.8 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.2 | 0.9 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.2 | 0.9 | GO:1990761 | growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812) |
| 0.2 | 0.7 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.2 | 0.8 | GO:0001652 | granular component(GO:0001652) |
| 0.2 | 0.8 | GO:0097226 | sperm mitochondrial sheath(GO:0097226) |
| 0.1 | 0.4 | GO:1990075 | periciliary membrane compartment(GO:1990075) |
| 0.1 | 0.7 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 0.1 | 1.0 | GO:1990726 | Lsm1-7-Pat1 complex(GO:1990726) |
| 0.1 | 0.4 | GO:0031680 | G-protein beta/gamma-subunit complex(GO:0031680) |
| 0.1 | 1.0 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.1 | 1.6 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.1 | 5.1 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 1.1 | GO:0045239 | tricarboxylic acid cycle enzyme complex(GO:0045239) |
| 0.1 | 1.3 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.1 | 1.6 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
| 0.1 | 0.5 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.1 | 0.3 | GO:0072534 | perineuronal net(GO:0072534) |
| 0.1 | 0.3 | GO:0005746 | mitochondrial respiratory chain(GO:0005746) |
| 0.1 | 1.4 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.1 | 4.5 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.1 | 5.4 | GO:0000786 | nucleosome(GO:0000786) |
| 0.1 | 8.1 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 0.9 | GO:0005687 | U4 snRNP(GO:0005687) |
| 0.1 | 0.7 | GO:0046930 | pore complex(GO:0046930) |
| 0.1 | 0.7 | GO:0071439 | clathrin complex(GO:0071439) |
| 0.1 | 0.3 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 0.1 | 0.4 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.1 | 0.5 | GO:0001520 | outer dense fiber(GO:0001520) |
| 0.1 | 0.5 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
| 0.1 | 1.0 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 0.7 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 0.5 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
| 0.1 | 1.9 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.1 | 1.1 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.1 | 2.4 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.1 | 5.3 | GO:0044455 | mitochondrial membrane part(GO:0044455) |
| 0.1 | 0.4 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.0 | 1.7 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 0.8 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.0 | 0.2 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.0 | 0.4 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.0 | 11.9 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 0.5 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.0 | 0.4 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.0 | 0.2 | GO:0090533 | cation-transporting ATPase complex(GO:0090533) |
| 0.0 | 0.7 | GO:0000145 | exocyst(GO:0000145) |
| 0.0 | 3.5 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 0.6 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 0.5 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.0 | 0.8 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 0.2 | GO:0042583 | chromaffin granule(GO:0042583) |
| 0.0 | 0.3 | GO:0031105 | septin complex(GO:0031105) |
| 0.0 | 0.4 | GO:0034706 | voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706) |
| 0.0 | 0.2 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.0 | 2.4 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 0.4 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 4.4 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 0.6 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.0 | 0.7 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 0.2 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 1.0 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 0.2 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.0 | 0.7 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 4.6 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.8 | 3.3 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) |
| 0.8 | 2.4 | GO:0008177 | succinate dehydrogenase (ubiquinone) activity(GO:0008177) |
| 0.7 | 2.0 | GO:0016155 | formyltetrahydrofolate dehydrogenase activity(GO:0016155) |
| 0.6 | 1.9 | GO:0002153 | steroid receptor RNA activator RNA binding(GO:0002153) |
| 0.6 | 2.4 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 0.6 | 2.3 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 0.5 | 10.6 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.5 | 3.8 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.5 | 7.9 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.4 | 1.2 | GO:0031403 | lithium ion binding(GO:0031403) |
| 0.4 | 3.7 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 0.4 | 2.5 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.4 | 3.6 | GO:0015266 | protein channel activity(GO:0015266) |
| 0.3 | 1.3 | GO:0001847 | opsonin receptor activity(GO:0001847) |
| 0.3 | 1.0 | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity(GO:0008113) |
| 0.3 | 0.9 | GO:0015182 | L-asparagine transmembrane transporter activity(GO:0015182) |
| 0.3 | 0.9 | GO:0004962 | endothelin receptor activity(GO:0004962) |
| 0.2 | 1.0 | GO:0004064 | arylesterase activity(GO:0004064) |
| 0.2 | 0.7 | GO:0070052 | collagen V binding(GO:0070052) |
| 0.2 | 0.7 | GO:0043758 | acetate-CoA ligase (ADP-forming) activity(GO:0043758) |
| 0.2 | 1.7 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795) |
| 0.2 | 0.7 | GO:0035939 | microsatellite binding(GO:0035939) |
| 0.2 | 0.6 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.2 | 0.8 | GO:0000832 | inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724) |
| 0.2 | 0.7 | GO:0008967 | phosphoglycolate phosphatase activity(GO:0008967) |
| 0.2 | 0.7 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
| 0.2 | 1.0 | GO:0000298 | endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) |
| 0.2 | 3.5 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.2 | 1.8 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.1 | 0.6 | GO:2001069 | glycogen binding(GO:2001069) |
| 0.1 | 0.4 | GO:0008515 | sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157) |
| 0.1 | 0.7 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
| 0.1 | 3.8 | GO:0009055 | electron carrier activity(GO:0009055) |
| 0.1 | 1.3 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.1 | 1.5 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.1 | 1.5 | GO:0004300 | enoyl-CoA hydratase activity(GO:0004300) |
| 0.1 | 0.3 | GO:0004069 | L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069) |
| 0.1 | 0.4 | GO:0004703 | G-protein coupled receptor kinase activity(GO:0004703) |
| 0.1 | 0.6 | GO:0033142 | progesterone receptor binding(GO:0033142) |
| 0.1 | 0.9 | GO:1990446 | U1 snRNP binding(GO:1990446) |
| 0.1 | 1.0 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
| 0.1 | 1.1 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.1 | 0.3 | GO:0030158 | protein xylosyltransferase activity(GO:0030158) |
| 0.1 | 1.0 | GO:0070181 | small ribosomal subunit rRNA binding(GO:0070181) |
| 0.1 | 0.3 | GO:0030172 | troponin C binding(GO:0030172) |
| 0.1 | 1.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 0.3 | GO:0004517 | nitric-oxide synthase activity(GO:0004517) |
| 0.1 | 0.3 | GO:0005171 | hepatocyte growth factor receptor binding(GO:0005171) |
| 0.1 | 0.8 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.1 | 0.5 | GO:0004591 | oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591) |
| 0.1 | 0.5 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.1 | 0.3 | GO:0070012 | oligopeptidase activity(GO:0070012) |
| 0.1 | 1.4 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 0.8 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
| 0.1 | 0.9 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.1 | 1.6 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.1 | 2.9 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.1 | 1.1 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.1 | 0.5 | GO:0003847 | 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) |
| 0.1 | 0.3 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 0.1 | 0.8 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.1 | 0.2 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 0.0 | 3.2 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 1.4 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.0 | 0.3 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
| 0.0 | 1.1 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.9 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.0 | 0.9 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.0 | 0.1 | GO:0052658 | inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) |
| 0.0 | 0.8 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.0 | 0.3 | GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving(GO:0042500) |
| 0.0 | 0.2 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.0 | 0.3 | GO:0019788 | NEDD8 transferase activity(GO:0019788) |
| 0.0 | 0.7 | GO:0019789 | SUMO transferase activity(GO:0019789) |
| 0.0 | 0.2 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.0 | 1.3 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.0 | 0.1 | GO:0008142 | oxysterol binding(GO:0008142) |
| 0.0 | 0.4 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.0 | 0.4 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.0 | 1.7 | GO:0020037 | heme binding(GO:0020037) |
| 0.0 | 1.3 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 0.5 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.0 | 0.4 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
| 0.0 | 0.6 | GO:0042165 | neurotransmitter binding(GO:0042165) |
| 0.0 | 1.1 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.0 | 0.8 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.0 | 0.3 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.0 | 0.2 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.0 | 4.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 2.5 | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191) |
| 0.0 | 0.9 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 5.7 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.0 | 0.8 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 0.9 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.0 | 0.6 | GO:0008198 | ferrous iron binding(GO:0008198) |
| 0.0 | 0.4 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.7 | GO:0016763 | transferase activity, transferring pentosyl groups(GO:0016763) |
| 0.0 | 0.6 | GO:0016836 | hydro-lyase activity(GO:0016836) |
| 0.0 | 0.2 | GO:0003951 | NAD+ kinase activity(GO:0003951) |
| 0.0 | 0.4 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.0 | 0.0 | GO:0032052 | bile acid binding(GO:0032052) |
| 0.0 | 0.2 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
| 0.0 | 1.5 | GO:0047485 | protein N-terminus binding(GO:0047485) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.3 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.2 | 7.2 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.1 | 1.9 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.9 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.4 | ST_INTERFERON_GAMMA_PATHWAY | Interferon gamma pathway. |
| 0.0 | 3.2 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 1.0 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 2.1 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.8 | PID_INSULIN_PATHWAY | Insulin Pathway |
| 0.0 | 0.7 | PID_EPHB_FWD_PATHWAY | EPHB forward signaling |
| 0.0 | 1.1 | PID_ENDOTHELIN_PATHWAY | Endothelins |
| 0.0 | 0.3 | PID_VEGFR1_PATHWAY | VEGFR1 specific signals |
| 0.0 | 1.2 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 0.4 | PID_P38_ALPHA_BETA_PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.0 | 0.9 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 0.4 | PID_CD8_TCR_PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.0 | 0.5 | PID_HIV_NEF_PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.0 | 0.6 | PID_FGF_PATHWAY | FGF signaling pathway |
| 0.0 | 0.4 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.0 | 0.8 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 1.3 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.5 | REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.3 | 26.6 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.2 | 7.0 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.2 | 2.0 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 1.3 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.1 | 1.7 | REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
| 0.1 | 0.9 | REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.1 | 5.2 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 3.2 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 0.7 | REACTOME_PYRIMIDINE_CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.1 | 2.4 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 0.9 | REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 0.1 | 1.5 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.1 | 1.5 | REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.1 | 0.4 | REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.1 | 1.6 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 4.5 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 1.3 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 0.8 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 0.7 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.0 | 1.1 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.4 | REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 0.8 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 0.9 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.0 | 0.3 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 0.5 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 0.3 | REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 1.8 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.9 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.8 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.0 | 0.5 | REACTOME_PYRUVATE_METABOLISM | Genes involved in Pyruvate metabolism |
| 0.0 | 0.6 | REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.0 | 1.6 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 1.2 | REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 2.0 | REACTOME_POTASSIUM_CHANNELS | Genes involved in Potassium Channels |
| 0.0 | 0.3 | REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.0 | 0.6 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 0.3 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.2 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
