Motif ID: Otx1

Z-value: 0.317


Transcription factors associated with Otx1:

Gene SymbolEntrez IDGene Name
Otx1 ENSMUSG00000005917.9 Otx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Otx1mm10_v2_chr11_-_22001605_22001631-0.371.8e-02Click!


Activity profile for motif Otx1.

activity profile for motif Otx1


Sorted Z-values histogram for motif Otx1

Sorted Z-values for motif Otx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Otx1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_94936224 2.204 ENSMUST00000001547.7
 Col1a1
collagen, type I, alpha 1
chr10_+_123264076 2.124 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr13_-_60897439 1.177 ENSMUST00000171347.1
ENSMUST00000021884.8
 Ctla2b

cytotoxic T lymphocyte-associated protein 2 beta

chr12_+_103434211 1.023 ENSMUST00000079294.5
ENSMUST00000076788.5
ENSMUST00000076702.5
ENSMUST00000066701.6
ENSMUST00000085065.5
ENSMUST00000140838.1
 Ifi27





interferon, alpha-inducible protein 27





chr2_-_60963192 0.845 ENSMUST00000028347.6
 Rbms1
RNA binding motif, single stranded interacting protein 1
chr14_-_87141206 0.773 ENSMUST00000022599.7
 Diap3
diaphanous homolog 3 (Drosophila)
chr13_-_92030897 0.755 ENSMUST00000149630.1
 Rasgrf2
RAS protein-specific guanine nucleotide-releasing factor 2
chr1_-_165708088 0.588 ENSMUST00000040357.8
ENSMUST00000097474.3
 Rcsd1

RCSD domain containing 1

chr14_-_87141114 0.568 ENSMUST00000168889.1
 Diap3
diaphanous homolog 3 (Drosophila)
chr3_+_18054258 0.527 ENSMUST00000026120.6
 Bhlhe22
basic helix-loop-helix family, member e22
chr2_-_153225396 0.434 ENSMUST00000099194.2
 Tspyl3
TSPY-like 3
chr13_+_104178797 0.429 ENSMUST00000022225.5
ENSMUST00000069187.5
 Trim23

tripartite motif-containing 23

chr8_-_54718664 0.429 ENSMUST00000144711.2
ENSMUST00000093510.2
 Wdr17

WD repeat domain 17

chr15_-_79285502 0.423 ENSMUST00000165408.1
 Baiap2l2
BAI1-associated protein 2-like 2
chr10_+_127642975 0.409 ENSMUST00000092074.5
ENSMUST00000120279.1
 Stat6

signal transducer and activator of transcription 6

chr5_-_104456467 0.382 ENSMUST00000069263.4
 Gm10047
predicted gene 10047
chr7_-_79848191 0.379 ENSMUST00000107392.1
 Anpep
alanyl (membrane) aminopeptidase
chr6_-_29507946 0.351 ENSMUST00000101614.3
ENSMUST00000078112.6
 Kcp

kielin/chordin-like protein

chr8_-_46151705 0.345 ENSMUST00000041582.8
 Snx25
sorting nexin 25
chr12_-_27160311 0.315 ENSMUST00000182473.1
ENSMUST00000177636.1
ENSMUST00000183238.1
 Gm9866


predicted gene 9866


chr3_+_101377074 0.313 ENSMUST00000043983.5
 Igsf3
immunoglobulin superfamily, member 3
chr5_+_109923400 0.290 ENSMUST00000112544.1
 Gm15446
predicted gene 15446
chr2_-_144011202 0.287 ENSMUST00000016072.5
ENSMUST00000037875.5
 Rrbp1

ribosome binding protein 1

chr9_-_20521375 0.268 ENSMUST00000068296.7
ENSMUST00000174462.1
 Zfp266

zinc finger protein 266

chr13_-_23368969 0.264 ENSMUST00000152557.1
 Zfp322a
zinc finger protein 322A
chr1_+_131910458 0.254 ENSMUST00000062264.6
 Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr4_+_32657107 0.250 ENSMUST00000071642.4
ENSMUST00000178134.1
 Mdn1

midasin homolog (yeast)

chr10_-_7473361 0.227 ENSMUST00000169796.2
ENSMUST00000177585.1
 Ulbp1

UL16 binding protein 1

chr4_+_58943575 0.209 ENSMUST00000107554.1
 Zkscan16
zinc finger with KRAB and SCAN domains 16
chr6_+_145953429 0.201 ENSMUST00000111701.1
 Sspn
sarcospan
chr8_-_47675556 0.190 ENSMUST00000125536.1
 Ing2
inhibitor of growth family, member 2
chr3_+_66985947 0.189 ENSMUST00000161726.1
ENSMUST00000160504.1
 Rsrc1

arginine/serine-rich coiled-coil 1

chr18_+_86711520 0.189 ENSMUST00000122464.1
 Cbln2
cerebellin 2 precursor protein
chr5_-_62765618 0.183 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chrX_+_37126777 0.177 ENSMUST00000016553.4
 Nkap
NFKB activating protein
chr10_+_29313164 0.160 ENSMUST00000160399.1
 Echdc1
enoyl Coenzyme A hydratase domain containing 1
chr18_-_46597299 0.147 ENSMUST00000036030.7
 Tmed7
transmembrane emp24 protein transport domain containing 7
chr15_-_74734313 0.143 ENSMUST00000023260.3
 Lypd2
Ly6/Plaur domain containing 2
chr1_+_118321834 0.135 ENSMUST00000027626.6
ENSMUST00000112688.3
 Mki67ip

Mki67 (FHA domain) interacting nucleolar phosphoprotein

chr7_-_83550258 0.126 ENSMUST00000177929.1
 Gm10610
predicted gene 10610
chr14_-_74947865 0.118 ENSMUST00000088970.5
 Lrch1
leucine-rich repeats and calponin homology (CH) domain containing 1
chr16_+_23107754 0.117 ENSMUST00000077605.5
ENSMUST00000115341.3
 Eif4a2

eukaryotic translation initiation factor 4A2

chr3_+_66985647 0.116 ENSMUST00000162362.1
ENSMUST00000065074.7
 Rsrc1

arginine/serine-rich coiled-coil 1

chr9_+_108479849 0.109 ENSMUST00000065014.4
 Lamb2
laminin, beta 2
chr18_+_23954668 0.099 ENSMUST00000060762.4
 Zfp397
zinc finger protein 397
chr4_-_126201117 0.092 ENSMUST00000136157.1
 Thrap3
thyroid hormone receptor associated protein 3
chr2_+_175275125 0.091 ENSMUST00000109051.1
 Gm14440
predicted gene 14440
chr19_+_5024006 0.085 ENSMUST00000025826.5
 Slc29a2
solute carrier family 29 (nucleoside transporters), member 2
chr10_+_3973086 0.085 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
 Mthfd1l


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chr13_+_18717289 0.080 ENSMUST00000072961.4
 Vps41
vacuolar protein sorting 41 (yeast)
chr2_+_154656959 0.079 ENSMUST00000044277.9
 Chmp4b
charged multivesicular body protein 4B
chr4_+_74242468 0.071 ENSMUST00000077851.3
 Kdm4c
lysine (K)-specific demethylase 4C
chr17_+_8165501 0.068 ENSMUST00000097419.3
ENSMUST00000024636.8
 Fgfr1op

Fgfr1 oncogene partner

chr6_-_148831395 0.064 ENSMUST00000145960.1
 Ipo8
importin 8
chrM_+_10167 0.059 ENSMUST00000082414.1
 mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr16_+_91647859 0.057 ENSMUST00000119368.1
ENSMUST00000114037.2
ENSMUST00000114036.2
ENSMUST00000122302.1
 Son



Son DNA binding protein



chrX_-_167209149 0.056 ENSMUST00000112176.1
 Tmsb4x
thymosin, beta 4, X chromosome
chr11_+_103116228 0.054 ENSMUST00000053063.5
 Hexim1
hexamethylene bis-acetamide inducible 1
chr7_-_118129567 0.051 ENSMUST00000032888.7
 Arl6ip1
ADP-ribosylation factor-like 6 interacting protein 1
chr2_-_156180135 0.047 ENSMUST00000126992.1
ENSMUST00000146288.1
ENSMUST00000029149.6
ENSMUST00000109587.2
ENSMUST00000109584.1
 Rbm39




RNA binding motif protein 39




chr17_-_47611449 0.047 ENSMUST00000024783.8
 Bysl
bystin-like
chr2_+_129065934 0.042 ENSMUST00000035812.7
 Ttl
tubulin tyrosine ligase
chr1_+_133131143 0.039 ENSMUST00000052529.3
 Ppp1r15b
protein phosphatase 1, regulatory (inhibitor) subunit 15b
chr17_+_47611570 0.038 ENSMUST00000024778.2
 Med20
mediator complex subunit 20
chr7_-_30072801 0.031 ENSMUST00000183115.1
ENSMUST00000182919.1
ENSMUST00000183190.1
ENSMUST00000080834.8
 Zfp82



zinc finger protein 82



chr2_+_178023284 0.028 ENSMUST00000108925.3
ENSMUST00000108926.2
 Etohi1

ethanol induced 1

chr1_-_118311132 0.023 ENSMUST00000027623.7
 Tsn
translin
chr10_-_93889758 0.019 ENSMUST00000181091.1
ENSMUST00000181217.1
ENSMUST00000047910.8
ENSMUST00000180688.1
 Metap2



methionine aminopeptidase 2



chr7_-_4063195 0.019 ENSMUST00000068865.5
ENSMUST00000086400.6
 Lair1

leukocyte-associated Ig-like receptor 1

chr9_+_68653761 0.018 ENSMUST00000034766.7
 Rora
RAR-related orphan receptor alpha
chr12_-_3426700 0.013 ENSMUST00000180149.1
 1110002L01Rik
RIKEN cDNA 1110002L01 gene
chr11_+_3963970 0.009 ENSMUST00000020705.4
ENSMUST00000109985.1
 Pes1

pescadillo homolog 1, containing BRCT domain (zebrafish)

chr12_-_98259416 0.005 ENSMUST00000021390.7
 Galc
galactosylceramidase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.2 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1 0.4 GO:0048289 interleukin-4-mediated signaling pathway(GO:0035771) isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.1 0.5 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.1 0.3 GO:0019046 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
0.1 0.2 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1 0.6 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.0 0.2 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0 0.1 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.0 0.4 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.0 0.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.7 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0 0.3 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 1.0 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.0 0.3 GO:0032808 lacrimal gland development(GO:0032808)
0.0 0.1 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.0 0.1 GO:1902774 late endosome to lysosome transport(GO:1902774)
0.0 0.1 GO:0036438 maintenance of lens transparency(GO:0036438) ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.0 0.3 GO:0006471 protein ADP-ribosylation(GO:0006471)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0005584 collagen type I trimer(GO:0005584)
0.1 0.4 GO:0031983 vesicle lumen(GO:0031983)
0.1 0.5 GO:0071439 clathrin complex(GO:0071439)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.1 GO:0043256 laminin complex(GO:0043256)
0.0 0.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.5 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.1 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 0.2 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.0 1.0 GO:0005521 lamin binding(GO:0005521)
0.0 0.2 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 1.2 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.3 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.1 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.0 0.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.8 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.4 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.1 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.0 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.2 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.8 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 1.0 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.2 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell