Motif ID: Pax3

Z-value: 0.484


Transcription factors associated with Pax3:

Gene SymbolEntrez IDGene Name
Pax3 ENSMUSG00000004872.9 Pax3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pax3mm10_v2_chr1_-_78197112_78197134-0.105.3e-01Click!


Activity profile for motif Pax3.

activity profile for motif Pax3


Sorted Z-values histogram for motif Pax3

Sorted Z-values for motif Pax3



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_114474312 1.809 ENSMUST00000113371.1
ENSMUST00000040504.5
 Klhl4

kelch-like 4

chr12_+_109540979 1.528 ENSMUST00000129245.1
ENSMUST00000143836.1
ENSMUST00000124106.1
 Meg3


maternally expressed 3


chr12_+_109747903 1.407 ENSMUST00000183084.1
ENSMUST00000182300.1
 Mirg

miRNA containing gene

chr4_+_127077374 1.175 ENSMUST00000046751.6
ENSMUST00000094713.3
 Zmym6

zinc finger, MYM-type 6

chr12_+_38780284 1.042 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr8_-_71043040 1.013 ENSMUST00000170101.1
 Gm17576
predicted gene, 17576
chrX_-_103623648 0.998 ENSMUST00000156211.1
 Ftx
Ftx transcript, Xist regulator (non-protein coding)
chr12_+_38780817 0.933 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr18_+_35562158 0.930 ENSMUST00000166793.1
 Matr3
matrin 3
chr14_+_51893610 0.912 ENSMUST00000047726.5
ENSMUST00000161888.1
 Slc39a2

solute carrier family 39 (zinc transporter), member 2

chr10_+_82138253 0.893 ENSMUST00000105314.2
 AU041133
expressed sequence AU041133
chr2_-_136387929 0.854 ENSMUST00000035264.2
ENSMUST00000077200.3
 Pak7

p21 protein (Cdc42/Rac)-activated kinase 7

chr12_+_38781093 0.845 ENSMUST00000161513.1
 Etv1
ets variant gene 1
chr3_-_59262825 0.751 ENSMUST00000050360.7
 P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr7_+_30121915 0.725 ENSMUST00000098596.3
ENSMUST00000153792.1
 Zfp382

zinc finger protein 382

chr8_+_33428709 0.704 ENSMUST00000059351.7
 5930422O12Rik
RIKEN cDNA 5930422O12 gene
chr3_+_36159522 0.675 ENSMUST00000165956.2
 D3Ertd254e
DNA segment, Chr 3, ERATO Doi 254, expressed
chr10_-_70592782 0.667 ENSMUST00000162251.1
 Phyhipl
phytanoyl-CoA hydroxylase interacting protein-like
chr1_+_176814660 0.639 ENSMUST00000056773.8
ENSMUST00000027785.8
 Sdccag8

serologically defined colon cancer antigen 8

chr8_+_71887264 0.590 ENSMUST00000034259.7
 Zfp709
zinc finger protein 709
chrX_-_103623704 0.547 ENSMUST00000130063.1
ENSMUST00000125419.1
 Ftx

Ftx transcript, Xist regulator (non-protein coding)

chr16_+_32877775 0.536 ENSMUST00000023489.4
ENSMUST00000171325.1
 Fyttd1

forty-two-three domain containing 1

chr13_+_24327415 0.522 ENSMUST00000167746.1
 Cmah
cytidine monophospho-N-acetylneuraminic acid hydroxylase
chr4_-_25281801 0.507 ENSMUST00000102994.3
 Ufl1
UFM1 specific ligase 1
chr11_-_88851462 0.439 ENSMUST00000107903.1
 Akap1
A kinase (PRKA) anchor protein 1
chr17_+_87107621 0.350 ENSMUST00000041369.6
 Socs5
suppressor of cytokine signaling 5
chr4_-_25281752 0.346 ENSMUST00000038705.7
 Ufl1
UFM1 specific ligase 1
chrX_+_159840463 0.338 ENSMUST00000112451.1
ENSMUST00000112453.2
 Sh3kbp1

SH3-domain kinase binding protein 1

chr17_+_21691860 0.316 ENSMUST00000072133.4
 Gm10226
predicted gene 10226
chr1_+_87404916 0.296 ENSMUST00000173152.1
ENSMUST00000173663.1
 Gigyf2

GRB10 interacting GYF protein 2

chr9_+_64235201 0.273 ENSMUST00000039011.3
 Uchl4
ubiquitin carboxyl-terminal esterase L4
chr16_-_88056176 0.231 ENSMUST00000072256.5
ENSMUST00000023652.8
ENSMUST00000114137.1
 Grik1


glutamate receptor, ionotropic, kainate 1


chr12_+_52699297 0.214 ENSMUST00000095737.3
 Akap6
A kinase (PRKA) anchor protein 6
chr7_+_120843551 0.198 ENSMUST00000106489.1
ENSMUST00000143279.1
 Eef2k

eukaryotic elongation factor-2 kinase

chr19_+_8757139 0.083 ENSMUST00000183939.1
 Nxf1
nuclear RNA export factor 1
chr11_+_3649494 0.083 ENSMUST00000093389.2
 Morc2a
microrchidia 2A
chr16_-_32877723 0.077 ENSMUST00000119810.1
 1700021K19Rik
RIKEN cDNA 1700021K19 gene
chr9_-_40346290 0.071 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr2_+_168230597 0.032 ENSMUST00000099071.3
 Mocs3
molybdenum cofactor synthesis 3
chr4_+_11486002 0.023 ENSMUST00000108307.2
 1110037F02Rik
RIKEN cDNA 1110037F02 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:1900095 regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.3 2.8 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.3 0.8 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.2 0.5 GO:0046381 CMP-N-acetylneuraminate metabolic process(GO:0046381)
0.1 0.9 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 0.4 GO:0071638 negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.1 1.5 GO:0008340 determination of adult lifespan(GO:0008340)
0.1 0.4 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.1 0.2 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0 0.2 GO:0032229 positive regulation of gamma-aminobutyric acid secretion(GO:0014054) negative regulation of synaptic transmission, GABAergic(GO:0032229)
0.0 0.9 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.3 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.0 0.7 GO:0003170 heart valve development(GO:0003170)
0.0 0.6 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.6 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.4 GO:0030061 mitochondrial crista(GO:0030061)
0.0 1.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.6 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.3 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.2 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.8 GO:0009925 basal plasma membrane(GO:0009925)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0071568 UFM1 transferase activity(GO:0071568)
0.2 0.5 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.1 0.8 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.2 GO:0004686 elongation factor-2 kinase activity(GO:0004686)
0.0 0.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.7 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.3 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.9 GO:0048365 Rac GTPase binding(GO:0048365)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.9 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.2 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 0.9 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 0.9 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.2 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.2 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.3 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers