Motif ID: Pou5f1
Z-value: 0.943
Transcription factors associated with Pou5f1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Pou5f1 | ENSMUSG00000024406.10 | Pou5f1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 12.9 | GO:0055095 | lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) |
| 2.5 | 7.4 | GO:0017055 | negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055) |
| 2.3 | 6.9 | GO:0060708 | spongiotrophoblast differentiation(GO:0060708) |
| 2.1 | 6.2 | GO:1902938 | regulation of intracellular calcium activated chloride channel activity(GO:1902938) |
| 1.7 | 5.1 | GO:0060596 | mammary placode formation(GO:0060596) |
| 0.9 | 2.7 | GO:0009826 | unidimensional cell growth(GO:0009826) susceptibility to natural killer cell mediated cytotoxicity(GO:0042271) |
| 0.8 | 3.3 | GO:0090126 | protein complex assembly involved in synapse maturation(GO:0090126) |
| 0.8 | 3.2 | GO:0099566 | regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566) negative regulation of dendritic spine maintenance(GO:1902951) |
| 0.8 | 5.4 | GO:0019532 | oxalate transport(GO:0019532) |
| 0.7 | 2.1 | GO:0001830 | trophectodermal cell fate commitment(GO:0001830) |
| 0.7 | 9.5 | GO:0045161 | neuronal ion channel clustering(GO:0045161) |
| 0.7 | 3.9 | GO:0032308 | positive regulation of prostaglandin secretion(GO:0032308) |
| 0.6 | 4.5 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.6 | 1.9 | GO:0048687 | positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) |
| 0.6 | 3.8 | GO:0060012 | synaptic transmission, glycinergic(GO:0060012) |
| 0.6 | 3.1 | GO:0090273 | regulation of somatostatin secretion(GO:0090273) |
| 0.6 | 3.1 | GO:0042045 | epithelial fluid transport(GO:0042045) |
| 0.6 | 1.8 | GO:0030070 | insulin processing(GO:0030070) |
| 0.6 | 5.3 | GO:0042756 | drinking behavior(GO:0042756) |
| 0.6 | 2.3 | GO:1903288 | positive regulation of potassium ion import(GO:1903288) |
| 0.6 | 3.4 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
| 0.6 | 3.3 | GO:0097491 | trigeminal nerve morphogenesis(GO:0021636) trigeminal nerve structural organization(GO:0021637) trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287) |
| 0.5 | 1.6 | GO:0010871 | negative regulation of receptor biosynthetic process(GO:0010871) |
| 0.5 | 1.0 | GO:0007196 | adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196) |
| 0.5 | 2.0 | GO:1904457 | positive regulation of neuronal action potential(GO:1904457) |
| 0.5 | 2.4 | GO:1904936 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
| 0.5 | 2.3 | GO:0042636 | negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279) |
| 0.4 | 6.5 | GO:1902004 | positive regulation of beta-amyloid formation(GO:1902004) |
| 0.4 | 6.0 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
| 0.4 | 13.5 | GO:0030325 | adrenal gland development(GO:0030325) |
| 0.4 | 2.0 | GO:2001015 | skeletal muscle satellite cell activation(GO:0014719) negative regulation of skeletal muscle cell differentiation(GO:2001015) |
| 0.4 | 1.5 | GO:0010986 | positive regulation of lipoprotein particle clearance(GO:0010986) |
| 0.4 | 1.9 | GO:0035405 | histone-threonine phosphorylation(GO:0035405) |
| 0.4 | 1.9 | GO:1901843 | positive regulation of high voltage-gated calcium channel activity(GO:1901843) |
| 0.4 | 4.1 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.4 | 1.5 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.4 | 3.6 | GO:0061470 | interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619) |
| 0.4 | 2.5 | GO:1990573 | potassium ion import across plasma membrane(GO:1990573) |
| 0.4 | 0.7 | GO:0003357 | noradrenergic neuron differentiation(GO:0003357) |
| 0.3 | 1.7 | GO:0048133 | germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728) |
| 0.3 | 0.9 | GO:0061744 | motor behavior(GO:0061744) |
| 0.3 | 1.2 | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process(GO:0010499) |
| 0.3 | 0.9 | GO:0000448 | cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448) |
| 0.3 | 0.9 | GO:0002182 | cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) |
| 0.3 | 0.9 | GO:0010958 | regulation of amino acid import(GO:0010958) regulation of DNA-templated transcription, termination(GO:0031554) |
| 0.3 | 3.7 | GO:0043653 | mitochondrial fragmentation involved in apoptotic process(GO:0043653) |
| 0.3 | 3.3 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
| 0.3 | 0.5 | GO:0002322 | B cell proliferation involved in immune response(GO:0002322) |
| 0.2 | 2.1 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
| 0.2 | 3.6 | GO:0021542 | dentate gyrus development(GO:0021542) |
| 0.2 | 1.4 | GO:0006072 | glycerol-3-phosphate metabolic process(GO:0006072) |
| 0.2 | 0.9 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 0.2 | 1.9 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.2 | 0.6 | GO:0016056 | rhodopsin mediated signaling pathway(GO:0016056) |
| 0.2 | 2.7 | GO:1901898 | regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.2 | 0.6 | GO:1905167 | positive regulation of lysosomal protein catabolic process(GO:1905167) |
| 0.2 | 0.6 | GO:0050975 | sensory perception of touch(GO:0050975) |
| 0.2 | 1.0 | GO:0070494 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 0.2 | 7.0 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 0.2 | 0.8 | GO:2001012 | mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012) |
| 0.2 | 8.8 | GO:0001919 | regulation of receptor recycling(GO:0001919) |
| 0.2 | 1.1 | GO:0071630 | nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630) |
| 0.2 | 0.7 | GO:0014012 | peripheral nervous system axon regeneration(GO:0014012) |
| 0.2 | 1.2 | GO:1900042 | positive regulation of interleukin-2 secretion(GO:1900042) |
| 0.2 | 2.0 | GO:0072189 | ureter development(GO:0072189) |
| 0.2 | 1.1 | GO:0030422 | production of siRNA involved in RNA interference(GO:0030422) |
| 0.2 | 9.9 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 0.2 | 0.8 | GO:0021993 | initiation of neural tube closure(GO:0021993) |
| 0.2 | 1.2 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.2 | 0.9 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368) |
| 0.2 | 2.1 | GO:0048642 | negative regulation of skeletal muscle tissue development(GO:0048642) |
| 0.1 | 0.6 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.1 | 2.0 | GO:0045898 | regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) |
| 0.1 | 0.6 | GO:0046909 | intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445) |
| 0.1 | 1.2 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.1 | 2.3 | GO:0002230 | positive regulation of defense response to virus by host(GO:0002230) |
| 0.1 | 8.3 | GO:0060395 | SMAD protein signal transduction(GO:0060395) |
| 0.1 | 0.8 | GO:0036438 | maintenance of lens transparency(GO:0036438) |
| 0.1 | 0.9 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 0.1 | 7.0 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
| 0.1 | 0.7 | GO:0036072 | intramembranous ossification(GO:0001957) direct ossification(GO:0036072) |
| 0.1 | 0.6 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
| 0.1 | 0.6 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.1 | 1.0 | GO:0046085 | adenosine metabolic process(GO:0046085) |
| 0.1 | 0.7 | GO:0043922 | negative regulation by host of viral transcription(GO:0043922) |
| 0.1 | 0.4 | GO:2000774 | positive regulation of cellular senescence(GO:2000774) |
| 0.1 | 0.5 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378) |
| 0.1 | 17.1 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.1 | 0.6 | GO:0035093 | spermatogenesis, exchange of chromosomal proteins(GO:0035093) |
| 0.1 | 2.1 | GO:0070207 | protein homotrimerization(GO:0070207) |
| 0.1 | 0.3 | GO:0048539 | bone marrow development(GO:0048539) |
| 0.1 | 3.3 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.1 | 0.6 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.1 | 0.6 | GO:0006003 | fructose 2,6-bisphosphate metabolic process(GO:0006003) |
| 0.1 | 0.5 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.1 | 1.0 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
| 0.1 | 0.5 | GO:0032261 | purine nucleotide salvage(GO:0032261) IMP salvage(GO:0032264) |
| 0.1 | 0.5 | GO:0006477 | protein sulfation(GO:0006477) |
| 0.1 | 0.9 | GO:0048520 | positive regulation of behavior(GO:0048520) |
| 0.1 | 0.2 | GO:1903215 | negative regulation of protein targeting to mitochondrion(GO:1903215) |
| 0.1 | 0.5 | GO:0051152 | positive regulation of smooth muscle cell differentiation(GO:0051152) |
| 0.1 | 0.6 | GO:2001214 | positive regulation of vasculogenesis(GO:2001214) |
| 0.1 | 1.2 | GO:0006622 | protein targeting to lysosome(GO:0006622) |
| 0.1 | 0.7 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.1 | 0.3 | GO:0045346 | regulation of MHC class II biosynthetic process(GO:0045346) negative regulation of MHC class II biosynthetic process(GO:0045347) |
| 0.1 | 0.4 | GO:0040016 | embryonic cleavage(GO:0040016) |
| 0.1 | 0.6 | GO:0006883 | cellular sodium ion homeostasis(GO:0006883) |
| 0.1 | 1.4 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.1 | 4.3 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 0.6 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.0 | 0.2 | GO:0008299 | isoprenoid biosynthetic process(GO:0008299) |
| 0.0 | 0.6 | GO:0014049 | positive regulation of glutamate secretion(GO:0014049) |
| 0.0 | 1.3 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.0 | 0.2 | GO:1902340 | telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340) |
| 0.0 | 1.7 | GO:0046847 | filopodium assembly(GO:0046847) |
| 0.0 | 1.0 | GO:0045956 | positive regulation of calcium ion-dependent exocytosis(GO:0045956) |
| 0.0 | 0.1 | GO:0072488 | ammonium transmembrane transport(GO:0072488) |
| 0.0 | 0.3 | GO:0060159 | regulation of dopamine receptor signaling pathway(GO:0060159) |
| 0.0 | 0.1 | GO:0097154 | GABAergic neuron differentiation(GO:0097154) |
| 0.0 | 0.8 | GO:0007274 | neuromuscular synaptic transmission(GO:0007274) |
| 0.0 | 2.0 | GO:0021766 | hippocampus development(GO:0021766) |
| 0.0 | 0.2 | GO:0070966 | nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) |
| 0.0 | 1.6 | GO:0001541 | ovarian follicle development(GO:0001541) |
| 0.0 | 1.2 | GO:0071300 | cellular response to retinoic acid(GO:0071300) |
| 0.0 | 1.4 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.0 | 0.4 | GO:0070995 | NADPH oxidation(GO:0070995) |
| 0.0 | 0.4 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033) |
| 0.0 | 0.2 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) |
| 0.0 | 1.1 | GO:0000038 | very long-chain fatty acid metabolic process(GO:0000038) |
| 0.0 | 0.5 | GO:0070306 | lens fiber cell differentiation(GO:0070306) |
| 0.0 | 0.6 | GO:0001763 | morphogenesis of a branching structure(GO:0001763) |
| 0.0 | 0.2 | GO:0021527 | spinal cord association neuron differentiation(GO:0021527) |
| 0.0 | 0.1 | GO:0008343 | adult feeding behavior(GO:0008343) |
| 0.0 | 2.3 | GO:0071805 | potassium ion transmembrane transport(GO:0071805) |
| 0.0 | 0.8 | GO:0007268 | chemical synaptic transmission(GO:0007268) anterograde trans-synaptic signaling(GO:0098916) trans-synaptic signaling(GO:0099537) |
| 0.0 | 1.9 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.0 | 2.1 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 0.0 | 1.8 | GO:0098656 | anion transmembrane transport(GO:0098656) |
| 0.0 | 0.2 | GO:0030953 | astral microtubule organization(GO:0030953) |
| 0.0 | 0.1 | GO:0097475 | motor neuron migration(GO:0097475) |
| 0.0 | 0.3 | GO:0031111 | negative regulation of microtubule polymerization or depolymerization(GO:0031111) |
| 0.0 | 0.8 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 3.1 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
| 0.9 | 6.2 | GO:0042627 | chylomicron(GO:0042627) |
| 0.8 | 9.9 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.8 | 4.9 | GO:0044308 | axonal spine(GO:0044308) |
| 0.8 | 2.3 | GO:0043512 | inhibin A complex(GO:0043512) |
| 0.7 | 6.9 | GO:0000805 | X chromosome(GO:0000805) |
| 0.5 | 13.3 | GO:0098839 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
| 0.5 | 7.2 | GO:0043196 | varicosity(GO:0043196) |
| 0.4 | 2.0 | GO:0044316 | cone cell pedicle(GO:0044316) |
| 0.4 | 3.3 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.4 | 1.1 | GO:1903095 | microprocessor complex(GO:0070877) ribonuclease III complex(GO:1903095) |
| 0.3 | 2.3 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.3 | 1.4 | GO:0009331 | glycerol-3-phosphate dehydrogenase complex(GO:0009331) |
| 0.2 | 1.2 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.2 | 0.6 | GO:0043540 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540) |
| 0.2 | 3.7 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.2 | 0.6 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.2 | 1.2 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
| 0.1 | 5.1 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.1 | 1.5 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.1 | 0.5 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.1 | 2.1 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.1 | 5.7 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 2.0 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.1 | 1.0 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.1 | 0.4 | GO:0001651 | dense fibrillar component(GO:0001651) |
| 0.1 | 11.9 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 2.1 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 3.8 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.1 | 1.2 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 5.8 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.1 | 10.0 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 0.6 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.1 | 1.0 | GO:0031045 | dense core granule(GO:0031045) |
| 0.1 | 0.5 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.1 | 2.9 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.1 | 0.9 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 0.4 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.0 | 0.7 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 9.3 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 2.7 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.0 | 2.3 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 1.9 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 0.8 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.0 | 1.2 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 1.3 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 1.7 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 3.3 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 4.6 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 0.4 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.0 | 1.2 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 0.1 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.0 | 1.0 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 2.3 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 0.8 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 2.3 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 0.4 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.0 | 0.6 | GO:0043195 | terminal bouton(GO:0043195) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 7.4 | GO:0002153 | steroid receptor RNA activator RNA binding(GO:0002153) |
| 1.8 | 14.3 | GO:0099583 | neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) |
| 1.3 | 6.7 | GO:0055100 | adiponectin binding(GO:0055100) |
| 1.3 | 3.8 | GO:0016934 | extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934) |
| 1.0 | 3.1 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
| 1.0 | 4.1 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.8 | 3.3 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.8 | 3.9 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.6 | 7.7 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.5 | 8.4 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.5 | 2.5 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.5 | 5.4 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
| 0.5 | 1.9 | GO:0047275 | glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275) |
| 0.5 | 1.4 | GO:0016901 | glycerol-3-phosphate dehydrogenase activity(GO:0004368) oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901) |
| 0.4 | 4.5 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.4 | 9.5 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.4 | 2.3 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.4 | 1.9 | GO:0005030 | neurotrophin receptor activity(GO:0005030) |
| 0.3 | 1.0 | GO:0052658 | inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) |
| 0.3 | 1.0 | GO:0070905 | serine binding(GO:0070905) |
| 0.3 | 2.0 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.3 | 1.9 | GO:0035184 | histone threonine kinase activity(GO:0035184) |
| 0.3 | 1.6 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.3 | 1.2 | GO:0000099 | sulfur amino acid transmembrane transporter activity(GO:0000099) |
| 0.3 | 0.9 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
| 0.3 | 10.3 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.3 | 0.8 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
| 0.2 | 1.0 | GO:0005008 | hepatocyte growth factor-activated receptor activity(GO:0005008) |
| 0.2 | 3.0 | GO:0050897 | cobalt ion binding(GO:0050897) |
| 0.2 | 2.3 | GO:0008556 | sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556) |
| 0.2 | 3.1 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.2 | 1.1 | GO:0004525 | ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296) |
| 0.2 | 0.6 | GO:0016964 | alpha-2 macroglobulin receptor activity(GO:0016964) |
| 0.2 | 3.2 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.2 | 3.9 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.1 | 0.6 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
| 0.1 | 1.8 | GO:0005225 | volume-sensitive anion channel activity(GO:0005225) |
| 0.1 | 0.9 | GO:0051731 | polynucleotide 5'-hydroxyl-kinase activity(GO:0051731) |
| 0.1 | 1.1 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.1 | 0.6 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.1 | 0.7 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.1 | 4.6 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.1 | 4.1 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.1 | 1.9 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.1 | 2.5 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.1 | 0.4 | GO:0097100 | supercoiled DNA binding(GO:0097100) |
| 0.1 | 0.4 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.1 | 2.9 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.1 | 8.7 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 0.5 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.1 | 1.1 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.1 | 0.7 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.1 | 0.6 | GO:0070095 | fructose-6-phosphate binding(GO:0070095) |
| 0.1 | 0.5 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 0.1 | 1.4 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 5.2 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.1 | 7.0 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.1 | 1.2 | GO:0031402 | sodium ion binding(GO:0031402) |
| 0.1 | 0.5 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.1 | 0.9 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.1 | 0.5 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 0.1 | 1.0 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 0.1 | 0.9 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.1 | 3.3 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.1 | 1.5 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.1 | 3.7 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.1 | 1.2 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.0 | 0.3 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.0 | 3.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 2.5 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 1.3 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.0 | 0.8 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.0 | 6.0 | GO:0043021 | ribonucleoprotein complex binding(GO:0043021) |
| 0.0 | 0.1 | GO:0019002 | GMP binding(GO:0019002) |
| 0.0 | 0.8 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.0 | 3.8 | GO:0005057 | receptor signaling protein activity(GO:0005057) |
| 0.0 | 3.7 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.2 | GO:0004311 | farnesyltranstransferase activity(GO:0004311) |
| 0.0 | 0.5 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 0.6 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 11.4 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 0.4 | GO:0004033 | aldo-keto reductase (NADP) activity(GO:0004033) |
| 0.0 | 0.6 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.0 | 2.7 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 0.4 | GO:0016208 | AMP binding(GO:0016208) |
| 0.0 | 1.2 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.0 | 1.8 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 0.1 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.0 | 2.1 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.0 | 0.4 | GO:0017022 | myosin binding(GO:0017022) |
| 0.0 | 0.2 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.0 | 0.1 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.1 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.2 | 3.9 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
| 0.2 | 2.8 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.2 | 6.8 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 5.6 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 11.9 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 2.5 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.1 | 7.0 | PID_EPHB_FWD_PATHWAY | EPHB forward signaling |
| 0.1 | 4.3 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 14.2 | PID_PDGFRB_PATHWAY | PDGFR-beta signaling pathway |
| 0.1 | 3.2 | PID_REELIN_PATHWAY | Reelin signaling pathway |
| 0.1 | 2.9 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
| 0.1 | 3.5 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.1 | 2.6 | ST_T_CELL_SIGNAL_TRANSDUCTION | T Cell Signal Transduction |
| 0.1 | 2.1 | PID_SHP2_PATHWAY | SHP2 signaling |
| 0.1 | 0.7 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 3.1 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 2.3 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.1 | 8.7 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 0.6 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 1.0 | PID_TCPTP_PATHWAY | Signaling events mediated by TCPTP |
| 0.0 | 0.6 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.0 | 1.2 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.4 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 2.7 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.2 | PID_TGFBR_PATHWAY | TGF-beta receptor signaling |
| 0.0 | 2.6 | NABA_MATRISOME_ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.0 | 0.5 | PID_LKB1_PATHWAY | LKB1 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 2.3 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
| 0.4 | 12.1 | REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.4 | 6.2 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.4 | 5.7 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.3 | 9.2 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.2 | 3.8 | REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT | Genes involved in Ligand-gated ion channel transport |
| 0.2 | 4.5 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.2 | 3.9 | REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.1 | 4.1 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.1 | 3.5 | REACTOME_BASIGIN_INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 2.4 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 1.0 | REACTOME_PYRIMIDINE_CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.1 | 1.9 | REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.1 | 0.6 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.1 | 1.0 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.1 | 2.7 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 1.8 | REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.1 | 2.5 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.1 | 4.7 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 4.1 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.1 | 1.6 | REACTOME_SYNTHESIS_OF_PC | Genes involved in Synthesis of PC |
| 0.1 | 1.8 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 1.1 | REACTOME_MICRORNA_MIRNA_BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.1 | 5.4 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 1.5 | REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.0 | 3.7 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 1.2 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 0.6 | REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.0 | 0.6 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 1.0 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 0.6 | REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.0 | 0.5 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
| 0.0 | 0.9 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 0.9 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 0.5 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.8 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
