Motif ID: Relb

Z-value: 0.524


Transcription factors associated with Relb:

Gene SymbolEntrez IDGene Name
Relb ENSMUSG00000002983.10 Relb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Relbmm10_v2_chr7_-_19629355_196294510.324.7e-02Click!


Activity profile for motif Relb.

activity profile for motif Relb


Sorted Z-values histogram for motif Relb

Sorted Z-values for motif Relb



Network of associatons between targets according to the STRING database.



First level regulatory network of Relb

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_80000292 2.794 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr2_-_5714490 2.599 ENSMUST00000044009.7
 Camk1d
calcium/calmodulin-dependent protein kinase ID
chr5_+_90891234 2.448 ENSMUST00000031327.8
 Cxcl1
chemokine (C-X-C motif) ligand 1
chr8_+_72319033 2.079 ENSMUST00000067912.7
 Klf2
Kruppel-like factor 2 (lung)
chr3_-_107760221 2.015 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
 Csf1


colony stimulating factor 1 (macrophage)


chr4_+_130915949 1.946 ENSMUST00000030316.6
 Laptm5
lysosomal-associated protein transmembrane 5
chr2_-_5063996 1.860 ENSMUST00000114996.1
 Optn
optineurin
chr2_+_10153563 1.781 ENSMUST00000026886.7
 Itih5
inter-alpha (globulin) inhibitor H5
chr15_-_98677451 1.621 ENSMUST00000120997.1
ENSMUST00000109149.2
ENSMUST00000003451.4
 Rnd1


Rho family GTPase 1


chr4_+_129985098 1.615 ENSMUST00000106017.1
ENSMUST00000121049.1
 Bai2

brain-specific angiogenesis inhibitor 2

chr3_-_9610074 1.528 ENSMUST00000041124.7
 Zfp704
zinc finger protein 704
chr2_-_5063932 1.525 ENSMUST00000027986.4
 Optn
optineurin
chr9_+_64385626 1.463 ENSMUST00000093829.2
ENSMUST00000118485.1
ENSMUST00000164113.1
 Megf11


multiple EGF-like-domains 11


chr4_+_129984833 1.384 ENSMUST00000120204.1
 Bai2
brain-specific angiogenesis inhibitor 2
chrX_+_36112110 1.297 ENSMUST00000033418.7
 Il13ra1
interleukin 13 receptor, alpha 1
chr18_+_37484955 1.256 ENSMUST00000053856.4
 Pcdhb17
protocadherin beta 17
chr2_-_125506385 1.171 ENSMUST00000028633.6
 Fbn1
fibrillin 1
chr16_-_55838827 1.132 ENSMUST00000096026.2
ENSMUST00000036273.6
ENSMUST00000114457.1
 Nfkbiz


nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta


chr9_+_64385675 1.119 ENSMUST00000068967.4
 Megf11
multiple EGF-like-domains 11
chr17_+_35424842 0.896 ENSMUST00000174699.1
 H2-Q6
histocompatibility 2, Q region locus 6
chr12_-_55492587 0.849 ENSMUST00000021413.7
 Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
chr7_+_99535652 0.827 ENSMUST00000032995.8
ENSMUST00000162404.1
 Arrb1

arrestin, beta 1

chr17_+_35424870 0.813 ENSMUST00000113879.3
 H2-Q6
histocompatibility 2, Q region locus 6
chr4_-_101265236 0.776 ENSMUST00000149297.1
ENSMUST00000102781.3
 Jak1

Janus kinase 1

chr7_+_99535439 0.703 ENSMUST00000098266.2
ENSMUST00000179755.1
 Arrb1

arrestin, beta 1

chr11_+_90030295 0.663 ENSMUST00000092788.3
 Tmem100
transmembrane protein 100
chr7_+_43463145 0.646 ENSMUST00000107977.1
 Vsig10l
ZV-set and immunoglobulin domain containing 10 like
chrX_+_141475385 0.622 ENSMUST00000112931.1
ENSMUST00000112930.1
 Col4a5

collagen, type IV, alpha 5

chr19_+_46304709 0.621 ENSMUST00000073116.5
 Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chr7_-_19629355 0.612 ENSMUST00000049912.8
ENSMUST00000094762.3
ENSMUST00000098754.4
 Relb


avian reticuloendotheliosis viral (v-rel) oncogene related B


chr1_-_170589791 0.577 ENSMUST00000161966.1
ENSMUST00000160456.1
 Nos1ap

nitric oxide synthase 1 (neuronal) adaptor protein

chr4_-_40239779 0.574 ENSMUST00000037907.6
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr7_+_16309577 0.535 ENSMUST00000002152.6
 Bbc3
BCL2 binding component 3
chr6_-_124741374 0.528 ENSMUST00000004389.5
 Grcc10
gene rich cluster, C10 gene
chr13_+_83732438 0.511 ENSMUST00000182701.1
 C130071C03Rik
RIKEN cDNA C130071C03 gene
chr7_+_28766747 0.498 ENSMUST00000170068.1
ENSMUST00000072965.4
 Sirt2

sirtuin 2

chr8_+_46739745 0.479 ENSMUST00000034041.7
 Irf2
interferon regulatory factor 2
chr15_-_79164477 0.474 ENSMUST00000040019.4
 Sox10
SRY-box containing gene 10
chr4_+_99715640 0.437 ENSMUST00000097961.2
ENSMUST00000107004.2
ENSMUST00000139799.1
 Alg6


asparagine-linked glycosylation 6 (alpha-1,3,-glucosyltransferase)


chr2_+_119972699 0.437 ENSMUST00000066058.7
 Mapkbp1
mitogen-activated protein kinase binding protein 1
chr10_-_93310963 0.435 ENSMUST00000151153.1
 Elk3
ELK3, member of ETS oncogene family
chr7_-_45920830 0.434 ENSMUST00000164119.1
 Emp3
epithelial membrane protein 3
chr2_+_59612034 0.391 ENSMUST00000112568.1
ENSMUST00000037526.4
 Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr16_+_97997313 0.385 ENSMUST00000122450.1
 B230307C23Rik
RIKEN cDNA B230307C23 gene
chrX_+_163908982 0.378 ENSMUST00000069041.8
 Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr2_+_18672384 0.373 ENSMUST00000171845.1
ENSMUST00000061158.4
 Commd3

COMM domain containing 3

chr7_-_28766469 0.365 ENSMUST00000085851.5
ENSMUST00000032815.4
 Nfkbib

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta

chr4_-_40239700 0.361 ENSMUST00000142055.1
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr17_+_37193889 0.345 ENSMUST00000038844.6
 Ubd
ubiquitin D
chr12_-_76369385 0.335 ENSMUST00000176187.1
ENSMUST00000167011.1
ENSMUST00000176967.1
 Zbtb25


zinc finger and BTB domain containing 25


chr12_-_76369586 0.316 ENSMUST00000176278.1
 Zbtb25
zinc finger and BTB domain containing 25
chr10_-_93311073 0.313 ENSMUST00000008542.5
 Elk3
ELK3, member of ETS oncogene family
chr4_+_114680769 0.311 ENSMUST00000146346.1
 Gm12829
predicted gene 12829
chr10_-_19015347 0.264 ENSMUST00000019997.4
 Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr5_-_122989086 0.262 ENSMUST00000046073.9
 Kdm2b
lysine (K)-specific demethylase 2B
chr14_+_55560480 0.257 ENSMUST00000121622.1
ENSMUST00000143431.1
ENSMUST00000150481.1
 Dcaf11


DDB1 and CUL4 associated factor 11


chr10_-_77902467 0.246 ENSMUST00000057608.4
 Lrrc3
leucine rich repeat containing 3
chrX_+_163909132 0.240 ENSMUST00000033734.7
ENSMUST00000112294.2
 Ap1s2

adaptor-related protein complex 1, sigma 2 subunit

chr5_-_122989260 0.203 ENSMUST00000118027.1
 Kdm2b
lysine (K)-specific demethylase 2B
chr17_+_74717743 0.177 ENSMUST00000024882.6
 Ttc27
tetratricopeptide repeat domain 27
chr5_+_90759299 0.177 ENSMUST00000031318.4
 Cxcl5
chemokine (C-X-C motif) ligand 5
chr7_-_99626936 0.164 ENSMUST00000178124.1
 Gm4980
predicted gene 4980
chr12_+_111538101 0.129 ENSMUST00000166123.1
 Eif5
eukaryotic translation initiation factor 5
chr2_-_27027909 0.118 ENSMUST00000102890.4
ENSMUST00000153388.1
ENSMUST00000045702.5
 Slc2a6


solute carrier family 2 (facilitated glucose transporter), member 6


chr1_+_135132693 0.106 ENSMUST00000049449.4
 Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr15_-_89429093 0.095 ENSMUST00000170460.1
 Chkb
choline kinase beta
chr18_+_36560581 0.094 ENSMUST00000155329.2
 Ankhd1
ankyrin repeat and KH domain containing 1
chr7_-_102250086 0.077 ENSMUST00000106923.1
ENSMUST00000098230.4
 Rhog

ras homolog gene family, member G

chr1_+_15287259 0.067 ENSMUST00000175681.1
 Kcnb2
potassium voltage gated channel, Shab-related subfamily, member 2
chr18_+_36559972 0.066 ENSMUST00000134146.1
 Ankhd1
ankyrin repeat and KH domain containing 1
chr4_+_126262325 0.056 ENSMUST00000030660.8
 Trappc3
trafficking protein particle complex 3
chr12_+_102948843 0.040 ENSMUST00000101099.5
 Unc79
unc-79 homolog (C. elegans)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.4 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.7 2.0 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.7 2.6 GO:0070942 neutrophil mediated cytotoxicity(GO:0070942) neutrophil mediated killing of symbiont cell(GO:0070943)
0.4 1.3 GO:0035963 response to interleukin-13(GO:0035962) cellular response to interleukin-13(GO:0035963)
0.4 1.2 GO:1903011 negative regulation of bone development(GO:1903011)
0.4 2.6 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.3 2.1 GO:0071499 response to laminar fluid shear stress(GO:0034616) cellular response to laminar fluid shear stress(GO:0071499)
0.3 1.5 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.2 0.9 GO:0009597 detection of virus(GO:0009597)
0.2 1.1 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.2 0.8 GO:0036015 response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016)
0.2 0.6 GO:2000170 positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170)
0.2 0.5 GO:0061744 motor behavior(GO:0061744)
0.2 0.5 GO:1900226 negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.1 0.5 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.1 1.6 GO:0016322 neuron remodeling(GO:0016322)
0.1 0.5 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.1 0.5 GO:0021993 initiation of neural tube closure(GO:0021993)
0.1 0.4 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 2.6 GO:0010842 retina layer formation(GO:0010842)
0.1 0.7 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.1 0.4 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.1 1.0 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.1 1.8 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.1 2.8 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 1.7 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 0.6 GO:0002467 germinal center formation(GO:0002467)
0.0 0.6 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0 0.4 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 0.4 GO:0032060 bleb assembly(GO:0032060)
0.0 0.1 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.4 GO:0097062 dendritic spine maintenance(GO:0097062)
0.0 0.1 GO:0035428 hexose transmembrane transport(GO:0035428)
0.0 0.6 GO:0060612 adipose tissue development(GO:0060612)
0.0 0.1 GO:0001731 formation of translation preinitiation complex(GO:0001731)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.2 2.8 GO:0042581 specific granule(GO:0042581)
0.2 1.2 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 0.6 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.1 1.7 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 0.6 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.1 1.5 GO:0031143 pseudopodium(GO:0031143)
0.1 1.2 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 0.5 GO:0033010 paranodal junction(GO:0033010)
0.1 0.5 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 0.4 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 3.4 GO:0005802 trans-Golgi network(GO:0005802)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.4 3.4 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.2 2.6 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.2 0.7 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 1.7 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.1 0.5 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739) tubulin deacetylase activity(GO:0042903)
0.1 0.8 GO:0005131 growth hormone receptor binding(GO:0005131)
0.1 2.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 1.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.3 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 1.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.8 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.4 GO:0046527 glucosyltransferase activity(GO:0046527)
0.0 1.3 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 0.5 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.1 GO:0004103 choline kinase activity(GO:0004103)
0.0 0.1 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 2.0 GO:0005125 cytokine activity(GO:0005125)
0.0 0.6 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.3 GO:0070628 proteasome binding(GO:0070628)
0.0 0.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.9 GO:0003725 double-stranded RNA binding(GO:0003725)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.1 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway
0.2 2.0 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 3.3 PID_IL23_PATHWAY IL23-mediated signaling events
0.1 1.2 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.5 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 1.2 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.6 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 0.5 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.6 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 1.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.1 2.6 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 1.6 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 0.8 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.1 2.1 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.5 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 1.8 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.5 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.4 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.1 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters