Motif ID: Runx3

Z-value: 0.479


Transcription factors associated with Runx3:

Gene SymbolEntrez IDGene Name
Runx3 ENSMUSG00000070691.4 Runx3



Activity profile for motif Runx3.

activity profile for motif Runx3


Sorted Z-values histogram for motif Runx3

Sorted Z-values for motif Runx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Runx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_22041352 2.166 ENSMUST00000102977.2
Hist1h4i
histone cluster 1, H4i
chr13_+_51645232 1.692 ENSMUST00000075853.5
Cks2
CDC28 protein kinase regulatory subunit 2
chrX_+_99136119 1.665 ENSMUST00000052839.6
Efnb1
ephrin B1
chr18_-_47368446 1.634 ENSMUST00000076043.6
ENSMUST00000135790.1
Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr15_+_40655020 1.561 ENSMUST00000053467.4
Zfpm2
zinc finger protein, multitype 2
chr5_-_36830647 1.528 ENSMUST00000031002.3
Man2b2
mannosidase 2, alpha B2
chr14_-_20181773 1.434 ENSMUST00000024011.8
Kcnk5
potassium channel, subfamily K, member 5
chr13_-_23698454 1.402 ENSMUST00000102967.1
Hist1h4c
histone cluster 1, H4c
chr13_-_21832194 1.222 ENSMUST00000102979.1
Hist1h4n
histone cluster 1, H4n
chr14_-_72709534 1.218 ENSMUST00000162478.1
Fndc3a
fibronectin type III domain containing 3A
chr14_-_72709986 1.212 ENSMUST00000089017.5
Fndc3a
fibronectin type III domain containing 3A
chr13_-_23551648 1.133 ENSMUST00000102971.1
Hist1h4f
histone cluster 1, H4f
chr2_+_145785980 1.105 ENSMUST00000110005.1
ENSMUST00000094480.4
Rin2

Ras and Rab interactor 2

chr13_+_21735055 1.101 ENSMUST00000087714.4
Hist1h4j
histone cluster 1, H4j
chr18_-_77713978 1.059 ENSMUST00000074653.4
8030462N17Rik
RIKEN cDNA 8030462N17 gene
chr7_+_141216626 0.961 ENSMUST00000141804.1
ENSMUST00000148975.1
Rassf7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr17_+_27556613 0.947 ENSMUST00000117600.1
ENSMUST00000114888.3
Hmga1

high mobility group AT-hook 1

chr17_+_30005029 0.933 ENSMUST00000057897.7
Zfand3
zinc finger, AN1-type domain 3
chr18_-_3337539 0.929 ENSMUST00000142690.1
ENSMUST00000025069.4
ENSMUST00000082141.5
ENSMUST00000165086.1
ENSMUST00000149803.1
Crem




cAMP responsive element modulator




chr17_+_27556668 0.916 ENSMUST00000117254.1
ENSMUST00000118570.1
Hmga1

high mobility group AT-hook 1

chr9_-_108094459 0.899 ENSMUST00000081309.7
Apeh
acylpeptide hydrolase
chr17_+_27556641 0.871 ENSMUST00000119486.1
ENSMUST00000118599.1
Hmga1

high mobility group AT-hook 1

chr3_-_154330543 0.842 ENSMUST00000184966.1
ENSMUST00000177846.2
Lhx8

LIM homeobox protein 8

chr2_+_155517948 0.822 ENSMUST00000029135.8
ENSMUST00000065973.2
ENSMUST00000103142.5
Acss2


acyl-CoA synthetase short-chain family member 2


chr9_+_121719172 0.790 ENSMUST00000035112.6
ENSMUST00000182311.1
Nktr

natural killer tumor recognition sequence

chr2_+_72476225 0.691 ENSMUST00000157019.1
Cdca7
cell division cycle associated 7
chr2_+_72476159 0.681 ENSMUST00000102691.4
Cdca7
cell division cycle associated 7
chr9_+_121719403 0.674 ENSMUST00000182225.1
Nktr
natural killer tumor recognition sequence
chr1_+_58713241 0.654 ENSMUST00000114309.1
ENSMUST00000069333.7
Cflar

CASP8 and FADD-like apoptosis regulator

chr10_+_128083273 0.621 ENSMUST00000026459.5
Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr1_-_24100306 0.621 ENSMUST00000027337.8
Fam135a
family with sequence similarity 135, member A
chr7_-_78783026 0.576 ENSMUST00000032841.5
Mrpl46
mitochondrial ribosomal protein L46
chr6_-_100671126 0.552 ENSMUST00000089245.6
ENSMUST00000113312.2
ENSMUST00000170667.1
Shq1


SHQ1 homolog (S. cerevisiae)


chr19_-_36736653 0.544 ENSMUST00000087321.2
Ppp1r3c
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr7_+_35802593 0.538 ENSMUST00000052454.2
E130304I02Rik
RIKEN cDNA E130304I02 gene
chr7_+_28808795 0.531 ENSMUST00000172529.1
Hnrnpl
heterogeneous nuclear ribonucleoprotein L
chr9_-_78481724 0.522 ENSMUST00000042235.8
Eef1a1
eukaryotic translation elongation factor 1 alpha 1
chrX_-_147554050 0.469 ENSMUST00000112819.2
ENSMUST00000136789.1
Lrch2

leucine-rich repeats and calponin homology (CH) domain containing 2

chr2_-_50296680 0.461 ENSMUST00000144143.1
ENSMUST00000102769.4
ENSMUST00000133768.1
Mmadhc


methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria


chr13_-_25020289 0.447 ENSMUST00000021772.2
Mrs2
MRS2 magnesium homeostasis factor homolog (S. cerevisiae)
chr9_-_20898592 0.442 ENSMUST00000004206.8
Eif3g
eukaryotic translation initiation factor 3, subunit G
chr7_-_35802968 0.431 ENSMUST00000061586.4
Zfp507
zinc finger protein 507
chr4_-_116627478 0.411 ENSMUST00000081182.4
ENSMUST00000030457.5
Nasp

nuclear autoantigenic sperm protein (histone-binding)

chr3_+_122245625 0.406 ENSMUST00000178826.1
Gclm
glutamate-cysteine ligase, modifier subunit
chr6_-_99632376 0.376 ENSMUST00000176255.1
Gm20696
predicted gene 20696
chrX_-_98890781 0.356 ENSMUST00000113826.1
ENSMUST00000033560.2
ENSMUST00000142267.1
Ophn1


oligophrenin 1


chr8_+_4243264 0.333 ENSMUST00000110996.1
Map2k7
mitogen-activated protein kinase kinase 7
chr15_+_8169067 0.325 ENSMUST00000110617.1
2410089E03Rik
RIKEN cDNA 2410089E03 gene
chr8_+_71908595 0.311 ENSMUST00000131544.1
ENSMUST00000110002.1
ENSMUST00000125802.1
Zfp617
Zfp882

zinc finger protein 617
zinc finger protein 882

chr16_+_92301266 0.311 ENSMUST00000063641.4
ENSMUST00000118064.1
Smim11

small integral membrane protein 11

chr11_-_23665862 0.310 ENSMUST00000020523.3
Pex13
peroxisomal biogenesis factor 13
chrX_-_73458990 0.310 ENSMUST00000033737.8
ENSMUST00000077243.4
Haus7

HAUS augmin-like complex, subunit 7

chr10_-_62602261 0.308 ENSMUST00000045866.7
Ddx21
DEAD (Asp-Glu-Ala-Asp) box polypeptide 21
chr11_-_70220969 0.307 ENSMUST00000060010.2
Slc16a13
solute carrier family 16 (monocarboxylic acid transporters), member 13
chr7_-_16816731 0.300 ENSMUST00000061390.7
Fkrp
fukutin related protein
chr13_+_14063776 0.297 ENSMUST00000129488.1
ENSMUST00000110536.1
ENSMUST00000110534.1
ENSMUST00000039538.8
ENSMUST00000110533.1
Arid4b




AT rich interactive domain 4B (RBP1-like)




chr11_-_70220794 0.291 ENSMUST00000159867.1
Slc16a13
solute carrier family 16 (monocarboxylic acid transporters), member 13
chr11_-_70220776 0.291 ENSMUST00000141290.1
Slc16a13
solute carrier family 16 (monocarboxylic acid transporters), member 13
chr11_+_75679259 0.290 ENSMUST00000017920.7
ENSMUST00000108426.1
ENSMUST00000108425.1
ENSMUST00000093115.3
Crk



v-crk sarcoma virus CT10 oncogene homolog (avian)



chr17_+_35879770 0.254 ENSMUST00000025292.8
Dhx16
DEAH (Asp-Glu-Ala-His) box polypeptide 16
chr9_+_70012540 0.252 ENSMUST00000118198.1
ENSMUST00000119905.1
ENSMUST00000119413.1
ENSMUST00000140305.1
ENSMUST00000122087.1
Gtf2a2




general transcription factor II A, 2




chr3_+_95658714 0.223 ENSMUST00000037947.8
Mcl1
myeloid cell leukemia sequence 1
chr3_+_95658771 0.209 ENSMUST00000178686.1
Mcl1
myeloid cell leukemia sequence 1
chr9_+_110532501 0.206 ENSMUST00000153838.2
Setd2
SET domain containing 2
chr1_+_40465976 0.194 ENSMUST00000108044.2
ENSMUST00000087983.2
Il18r1

interleukin 18 receptor 1

chr3_+_122245557 0.190 ENSMUST00000029769.7
Gclm
glutamate-cysteine ligase, modifier subunit
chr6_+_21949571 0.186 ENSMUST00000031680.3
ENSMUST00000115389.1
ENSMUST00000151473.1
Ing3


inhibitor of growth family, member 3


chr11_+_75532099 0.177 ENSMUST00000169547.2
Slc43a2
solute carrier family 43, member 2
chr15_-_95655960 0.164 ENSMUST00000054244.6
Dbx2
developing brain homeobox 2
chr9_+_106429537 0.161 ENSMUST00000059802.6
Rpl29
ribosomal protein L29
chr4_-_120570252 0.131 ENSMUST00000030381.7
Ctps
cytidine 5'-triphosphate synthase
chr9_+_106429399 0.129 ENSMUST00000150576.1
Rpl29
ribosomal protein L29
chr7_+_78783119 0.123 ENSMUST00000032840.4
Mrps11
mitochondrial ribosomal protein S11
chr12_-_98259416 0.114 ENSMUST00000021390.7
Galc
galactosylceramidase
chr11_+_75532127 0.103 ENSMUST00000127226.1
Slc43a2
solute carrier family 43, member 2
chr11_-_84916338 0.095 ENSMUST00000103195.4
Znhit3
zinc finger, HIT type 3
chr7_+_3617357 0.084 ENSMUST00000076657.4
ENSMUST00000108644.1
Ndufa3

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3

chr13_-_14063395 0.034 ENSMUST00000170957.1
Ggps1
geranylgeranyl diphosphate synthase 1
chr11_-_5878207 0.028 ENSMUST00000102922.3
Pold2
polymerase (DNA directed), delta 2, regulatory subunit
chr11_-_70410010 0.014 ENSMUST00000019065.3
ENSMUST00000135148.1
Pelp1

proline, glutamic acid and leucine rich protein 1

chr7_-_141437587 0.008 ENSMUST00000172654.1
ENSMUST00000106006.1
Slc25a22

solute carrier family 25 (mitochondrial carrier, glutamate), member 22

chr11_-_32267547 0.007 ENSMUST00000109389.2
ENSMUST00000129010.1
ENSMUST00000020530.5
Nprl3


nitrogen permease regulator-like 3


chr11_-_5762358 0.003 ENSMUST00000120306.1
ENSMUST00000170116.1
ENSMUST00000053427.4
ENSMUST00000118076.1
Urgcp



upregulator of cell proliferation




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0003195 tricuspid valve formation(GO:0003195) right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.4 7.0 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.3 0.8 GO:0006083 acetate metabolic process(GO:0006083)
0.2 0.7 GO:0014891 striated muscle atrophy(GO:0014891)
0.2 0.6 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.2 1.5 GO:0006013 mannose metabolic process(GO:0006013)
0.2 0.6 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.1 2.7 GO:0060009 Sertoli cell development(GO:0060009)
0.1 0.2 GO:0071351 interleukin-18-mediated signaling pathway(GO:0035655) cellular response to interleukin-18(GO:0071351)
0.1 0.3 GO:1990859 cellular response to endothelin(GO:1990859)
0.1 0.4 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.1 0.4 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.1 1.7 GO:0031295 T cell costimulation(GO:0031295)
0.1 0.5 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 0.2 GO:0035441 cell migration involved in vasculogenesis(GO:0035441)
0.1 0.6 GO:0051409 response to nitrosative stress(GO:0051409)
0.1 1.6 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 0.3 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.1 0.5 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.1 2.7 GO:0006284 base-excision repair(GO:0006284)
0.1 0.3 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.1 1.5 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.3 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 1.7 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.0 0.3 GO:2000671 regulation of motor neuron apoptotic process(GO:2000671)
0.0 0.4 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.0 0.4 GO:0015693 magnesium ion transport(GO:0015693)
0.0 1.0 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.0 0.9 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.0 0.5 GO:1903427 negative regulation of reactive oxygen species biosynthetic process(GO:1903427)
0.0 0.8 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.3 GO:0043330 response to exogenous dsRNA(GO:0043330)
0.0 0.1 GO:0046036 CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.7 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.2 0.6 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.2 5.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.8 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 0.7 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.1 0.6 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 0.5 GO:0042587 glycogen granule(GO:0042587)
0.1 0.3 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.3 GO:0070652 HAUS complex(GO:0070652)
0.0 0.2 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 1.2 GO:0000786 nucleosome(GO:0000786)
0.0 1.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.5 GO:0045120 pronucleus(GO:0045120)
0.0 0.4 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 1.9 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.3 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.3 0.8 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.3 2.7 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.2 0.6 GO:0004357 glutamate-cysteine ligase activity(GO:0004357)
0.1 0.9 GO:0008242 omega peptidase activity(GO:0008242)
0.1 0.6 GO:0043532 angiostatin binding(GO:0043532)
0.1 1.5 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.1 0.7 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 0.3 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.1 0.5 GO:1990715 mRNA CDS binding(GO:1990715)
0.1 1.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.4 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.3 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 2.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.5 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.3 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.2 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.1 GO:0003883 CTP synthase activity(GO:0003883)
0.0 7.6 GO:0042393 histone binding(GO:0042393)
0.0 0.3 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.4 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.9 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.1 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 1.8 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.7 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 4.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.3 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.8 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.9 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.1 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.3 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 0.2 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.7 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.2 0.8 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.2 5.7 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 0.7 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 1.1 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.6 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.6 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.3 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.3 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 1.6 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.8 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation