Motif ID: Scrt2

Z-value: 1.095


Transcription factors associated with Scrt2:

Gene SymbolEntrez IDGene Name
Scrt2 ENSMUSG00000060257.2 Scrt2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Scrt2mm10_v2_chr2_+_152081529_152081624-0.697.3e-07Click!


Activity profile for motif Scrt2.

activity profile for motif Scrt2


Sorted Z-values histogram for motif Scrt2

Sorted Z-values for motif Scrt2



Network of associatons between targets according to the STRING database.



First level regulatory network of Scrt2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_111066154 10.810 ENSMUST00000042970.2
 Kcnj2
potassium inwardly-rectifying channel, subfamily J, member 2
chr3_-_53657339 8.448 ENSMUST00000091137.4
 Frem2
Fras1 related extracellular matrix protein 2
chr11_-_55419898 6.678 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr18_-_58209926 6.633 ENSMUST00000025497.6
 Fbn2
fibrillin 2
chr8_-_71537402 5.630 ENSMUST00000051672.7
 Bst2
bone marrow stromal cell antigen 2
chr8_+_76902277 5.587 ENSMUST00000109912.1
ENSMUST00000128862.1
ENSMUST00000109911.1
 Nr3c2


nuclear receptor subfamily 3, group C, member 2


chr12_-_40037387 5.378 ENSMUST00000146905.1
 Arl4a
ADP-ribosylation factor-like 4A
chr15_-_71727815 5.019 ENSMUST00000022953.8
 Fam135b
family with sequence similarity 135, member B
chr9_+_45370185 4.930 ENSMUST00000085939.6
 Fxyd6
FXYD domain-containing ion transport regulator 6
chr7_+_126847908 4.849 ENSMUST00000147257.1
ENSMUST00000139174.1
 Doc2a

double C2, alpha

chr11_+_103649498 4.785 ENSMUST00000057870.2
 Rprml
reprimo-like
chr5_+_118169712 4.719 ENSMUST00000054836.6
 Hrk
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr17_-_25570678 4.316 ENSMUST00000025003.3
ENSMUST00000173447.1
 Sox8

SRY-box containing gene 8

chrX_+_150547375 3.591 ENSMUST00000066337.6
ENSMUST00000112715.1
 Alas2

aminolevulinic acid synthase 2, erythroid

chr19_-_57008187 3.589 ENSMUST00000118800.1
ENSMUST00000111584.2
ENSMUST00000122359.1
ENSMUST00000148049.1
 Afap1l2



actin filament associated protein 1-like 2



chr10_+_116177351 3.310 ENSMUST00000155606.1
ENSMUST00000128399.1
 Ptprr

protein tyrosine phosphatase, receptor type, R

chr15_+_6422240 3.239 ENSMUST00000163082.1
 Dab2
disabled 2, mitogen-responsive phosphoprotein
chrX_-_152769461 2.889 ENSMUST00000101141.2
ENSMUST00000062317.4
 Shroom2

shroom family member 2

chr4_-_119538769 2.852 ENSMUST00000079611.6
 AA415398
expressed sequence AA415398
chr10_-_79614012 2.766 ENSMUST00000059699.7
ENSMUST00000178228.1
 C2cd4c

C2 calcium-dependent domain containing 4C

chr2_-_164443177 2.509 ENSMUST00000017153.3
 Sdc4
syndecan 4
chr11_+_53770458 2.487 ENSMUST00000138913.1
ENSMUST00000123376.1
ENSMUST00000019043.6
ENSMUST00000133291.1
 Irf1



interferon regulatory factor 1



chr15_+_34306666 2.368 ENSMUST00000163455.2
ENSMUST00000022947.5
 Matn2

matrilin 2

chr6_-_23839137 2.368 ENSMUST00000166458.2
ENSMUST00000142913.2
ENSMUST00000115357.1
ENSMUST00000069074.7
ENSMUST00000115361.2
ENSMUST00000018122.7
ENSMUST00000115355.1
ENSMUST00000115356.2
 Cadps2







Ca2+-dependent activator protein for secretion 2







chr8_-_84147858 2.216 ENSMUST00000117424.2
ENSMUST00000040383.8
 Cc2d1a

coiled-coil and C2 domain containing 1A

chr2_-_60881360 2.153 ENSMUST00000164147.1
ENSMUST00000112509.1
 Rbms1

RNA binding motif, single stranded interacting protein 1

chr3_-_89101907 2.076 ENSMUST00000081848.8
 Fdps
farnesyl diphosphate synthetase
chr10_+_56377300 2.062 ENSMUST00000068581.7
 Gja1
gap junction protein, alpha 1
chr7_+_107370728 2.060 ENSMUST00000137663.1
ENSMUST00000073459.5
 Syt9

synaptotagmin IX

chr9_+_94669876 2.040 ENSMUST00000033463.9
 Slc9a9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr2_+_107290590 2.032 ENSMUST00000037012.2
 Kcna4
potassium voltage-gated channel, shaker-related subfamily, member 4
chr7_+_81523555 2.017 ENSMUST00000180385.1
ENSMUST00000180879.1
ENSMUST00000181164.1
ENSMUST00000181264.1
 2900076A07Rik



RIKEN cDNA 2900076A07 gene



chr12_-_4592927 1.988 ENSMUST00000170816.1
 Gm3625
predicted gene 3625
chr12_+_4592992 1.968 ENSMUST00000062580.7
 Itsn2
intersectin 2
chr1_-_79440039 1.881 ENSMUST00000049972.4
 Scg2
secretogranin II
chr7_-_25250720 1.877 ENSMUST00000116343.2
ENSMUST00000045847.8
 Erf

Ets2 repressor factor

chrX_+_153139941 1.867 ENSMUST00000039720.4
ENSMUST00000144175.2
 Rragb

Ras-related GTP binding B

chr9_-_78108587 1.860 ENSMUST00000162625.1
ENSMUST00000159099.1
 Fbxo9

f-box protein 9

chr7_+_81523531 1.848 ENSMUST00000181903.1
 2900076A07Rik
RIKEN cDNA 2900076A07 gene
chr19_+_26753588 1.689 ENSMUST00000177116.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr16_+_42907563 1.664 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr6_-_135168162 1.549 ENSMUST00000045855.7
 Hebp1
heme binding protein 1
chr5_+_37245792 1.548 ENSMUST00000031004.7
 Crmp1
collapsin response mediator protein 1
chr19_-_61228396 1.526 ENSMUST00000076046.6
 Csf2ra
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
chr13_+_97241096 1.402 ENSMUST00000041623.7
 Enc1
ectodermal-neural cortex 1
chr13_-_98206151 1.373 ENSMUST00000109426.1
 Arhgef28
Rho guanine nucleotide exchange factor (GEF) 28
chr7_+_123377982 1.366 ENSMUST00000033025.5
 Lcmt1
leucine carboxyl methyltransferase 1
chr2_+_31950257 1.273 ENSMUST00000001920.7
 Aif1l
allograft inflammatory factor 1-like
chr10_-_116473418 1.170 ENSMUST00000087965.4
ENSMUST00000164271.1
 Kcnmb4

potassium large conductance calcium-activated channel, subfamily M, beta member 4

chr3_-_122984404 1.159 ENSMUST00000090379.2
 Usp53
ubiquitin specific peptidase 53
chr2_-_148732457 1.154 ENSMUST00000028926.6
 Napb
N-ethylmaleimide sensitive fusion protein attachment protein beta
chr3_-_57301919 1.107 ENSMUST00000029376.8
 Tm4sf1
transmembrane 4 superfamily member 1
chr5_+_66676098 1.107 ENSMUST00000031131.9
 Uchl1
ubiquitin carboxy-terminal hydrolase L1
chr5_-_137611372 1.102 ENSMUST00000054564.6
 Pcolce
procollagen C-endopeptidase enhancer protein
chrX_+_85048309 1.091 ENSMUST00000113991.1
ENSMUST00000113992.2
 Dmd

dystrophin, muscular dystrophy

chr6_-_53820764 1.091 ENSMUST00000127748.2
 Tril
TLR4 interactor with leucine-rich repeats
chr4_-_129189512 1.041 ENSMUST00000117965.1
ENSMUST00000106061.2
ENSMUST00000072431.6
 S100pbp


S100P binding protein


chr7_-_127946725 1.023 ENSMUST00000118755.1
ENSMUST00000094026.3
 Prss36

protease, serine, 36

chr12_-_86884808 1.004 ENSMUST00000038422.6
 Irf2bpl
interferon regulatory factor 2 binding protein-like
chr3_-_95315086 1.000 ENSMUST00000098867.3
 Gm10691
predicted gene 10691
chrX_-_101085352 0.953 ENSMUST00000101362.1
ENSMUST00000073927.4
 Slc7a3

solute carrier family 7 (cationic amino acid transporter, y+ system), member 3

chr16_-_92466081 0.866 ENSMUST00000060005.8
 Rcan1
regulator of calcineurin 1
chr4_+_15265798 0.860 ENSMUST00000062684.8
 Tmem64
transmembrane protein 64
chr5_-_31241215 0.851 ENSMUST00000068997.3
 Gm9970
predicted gene 9970
chr5_-_137611429 0.834 ENSMUST00000031731.7
 Pcolce
procollagen C-endopeptidase enhancer protein
chr4_-_129189646 0.812 ENSMUST00000106059.1
 S100pbp
S100P binding protein
chr11_+_101070012 0.792 ENSMUST00000001802.9
 Naglu
alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)
chr15_+_31276491 0.774 ENSMUST00000068987.5
 Fam136b-ps
family with sequence similarity 136, member B, pseudogene
chr3_+_130180882 0.752 ENSMUST00000106353.1
ENSMUST00000080335.4
 Col25a1

collagen, type XXV, alpha 1

chr10_-_63244135 0.747 ENSMUST00000054837.3
 1700120B22Rik
RIKEN cDNA 1700120B22 gene
chr5_-_123684289 0.713 ENSMUST00000111564.1
ENSMUST00000063905.5
 Clip1

CAP-GLY domain containing linker protein 1

chr18_-_82406777 0.694 ENSMUST00000065224.6
 Galr1
galanin receptor 1
chr4_-_129189600 0.687 ENSMUST00000117497.1
ENSMUST00000117350.1
 S100pbp

S100P binding protein

chr4_+_129189760 0.684 ENSMUST00000106054.2
ENSMUST00000001365.2
 Yars

tyrosyl-tRNA synthetase

chr17_+_44188564 0.666 ENSMUST00000024755.5
 Clic5
chloride intracellular channel 5
chr16_+_3884629 0.660 ENSMUST00000176233.1
 Gm20695
predicted gene 20695
chr3_+_81036360 0.657 ENSMUST00000029652.3
 Pdgfc
platelet-derived growth factor, C polypeptide
chr13_+_109260481 0.637 ENSMUST00000153234.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chr1_+_120602405 0.613 ENSMUST00000079721.7
 En1
engrailed 1
chr7_-_45830776 0.604 ENSMUST00000107723.2
ENSMUST00000131384.1
 Grwd1

glutamate-rich WD repeat containing 1

chr17_-_24533709 0.582 ENSMUST00000061764.7
 Rab26
RAB26, member RAS oncogene family
chr16_+_17070127 0.561 ENSMUST00000115729.1
 Ypel1
yippee-like 1 (Drosophila)
chr4_+_98923908 0.546 ENSMUST00000169053.1
 Usp1
ubiquitin specific peptidase 1
chr3_-_108840477 0.541 ENSMUST00000106596.3
ENSMUST00000102621.4
 Stxbp3a

syntaxin binding protein 3A

chr2_-_32260138 0.474 ENSMUST00000002625.8
 Uck1
uridine-cytidine kinase 1
chrX_-_36645359 0.469 ENSMUST00000051906.6
 Akap17b
A kinase (PRKA) anchor protein 17B
chr11_-_106612928 0.453 ENSMUST00000042780.7
 Tex2
testis expressed gene 2
chr18_-_3281036 0.442 ENSMUST00000049942.6
ENSMUST00000139537.1
ENSMUST00000124747.1
 Crem


cAMP responsive element modulator


chr2_-_66634952 0.441 ENSMUST00000100064.2
ENSMUST00000100063.2
 Scn9a

sodium channel, voltage-gated, type IX, alpha

chr5_-_38561658 0.385 ENSMUST00000005234.9
 Wdr1
WD repeat domain 1
chr4_-_45084538 0.368 ENSMUST00000052236.6
 Fbxo10
F-box protein 10
chr5_+_138171997 0.328 ENSMUST00000019662.4
ENSMUST00000151318.1
 Ap4m1

adaptor-related protein complex AP-4, mu 1

chr13_+_21945084 0.318 ENSMUST00000176511.1
ENSMUST00000102978.1
ENSMUST00000152258.2
 Zfp184


zinc finger protein 184 (Kruppel-like)


chr17_-_56183887 0.292 ENSMUST00000019723.7
 D17Wsu104e
DNA segment, Chr 17, Wayne State University 104, expressed
chr8_-_9976294 0.216 ENSMUST00000095476.4
 Lig4
ligase IV, DNA, ATP-dependent
chr13_-_81633119 0.197 ENSMUST00000126444.1
ENSMUST00000128585.1
ENSMUST00000146749.1
ENSMUST00000095585.4
 Gpr98



G protein-coupled receptor 98



chrX_+_6047453 0.151 ENSMUST00000103007.3
 Nudt11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr18_-_3281712 0.149 ENSMUST00000182204.1
ENSMUST00000154705.1
ENSMUST00000182833.1
ENSMUST00000151084.1
 Crem



cAMP responsive element modulator



chr2_+_91257323 0.147 ENSMUST00000111349.2
ENSMUST00000131711.1
 Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chrX_+_74429671 0.123 ENSMUST00000114127.1
ENSMUST00000064407.3
ENSMUST00000156707.1
 Ikbkg


inhibitor of kappaB kinase gamma


chr5_-_138171813 0.120 ENSMUST00000155902.1
ENSMUST00000148879.1
 Mcm7

minichromosome maintenance deficient 7 (S. cerevisiae)

chr5_-_138171216 0.120 ENSMUST00000147920.1
 Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr2_+_91256813 0.057 ENSMUST00000144394.1
ENSMUST00000028694.5
ENSMUST00000168916.1
ENSMUST00000156919.1
 Pacsin3



protein kinase C and casein kinase substrate in neurons 3



chr10_-_61979073 0.052 ENSMUST00000105453.1
ENSMUST00000105452.2
ENSMUST00000105454.2
 Col13a1


collagen, type XIII, alpha 1


chr18_+_36559972 0.047 ENSMUST00000134146.1
 Ankhd1
ankyrin repeat and KH domain containing 1
chr9_+_6168638 0.034 ENSMUST00000058692.7
 Pdgfd
platelet-derived growth factor, D polypeptide

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 11.9 GO:0014819 regulation of skeletal muscle contraction(GO:0014819)
1.4 4.3 GO:0072034 renal vesicle induction(GO:0072034)
1.4 5.6 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
1.3 6.6 GO:0071692 protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694)
0.9 4.7 GO:0051365 cellular response to potassium ion starvation(GO:0051365)
0.8 2.5 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) negative regulation of regulatory T cell differentiation(GO:0045590) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.8 3.3 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.8 3.2 GO:0035026 leading edge cell differentiation(GO:0035026)
0.7 2.1 GO:0003104 positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643)
0.6 1.1 GO:0007412 axon target recognition(GO:0007412)
0.5 2.5 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.4 1.5 GO:1904529 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
0.4 1.9 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.4 1.9 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.4 1.4 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.3 1.4 GO:0006481 C-terminal protein methylation(GO:0006481)
0.3 2.4 GO:1990504 dense core granule exocytosis(GO:1990504)
0.3 5.6 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.3 0.9 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.3 2.1 GO:0016114 terpenoid biosynthetic process(GO:0016114)
0.2 2.9 GO:0045217 cell-cell junction maintenance(GO:0045217)
0.2 0.7 GO:0051464 positive regulation of cortisol secretion(GO:0051464)
0.2 2.0 GO:0097369 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.2 3.6 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.2 1.2 GO:0005513 detection of calcium ion(GO:0005513)
0.2 1.0 GO:0015819 lysine transport(GO:0015819) ornithine transport(GO:0015822)
0.2 1.7 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.2 1.9 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.2 6.7 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.2 0.7 GO:0002024 diet induced thermogenesis(GO:0002024)
0.2 1.2 GO:0010807 regulation of synaptic vesicle priming(GO:0010807)
0.2 5.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.2 0.7 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.2 2.0 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.2 0.6 GO:0061743 motor learning(GO:0061743)
0.1 5.4 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 0.6 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.1 3.6 GO:0032757 positive regulation of interleukin-8 production(GO:0032757)
0.1 1.5 GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011)
0.1 0.8 GO:0060385 axonogenesis involved in innervation(GO:0060385)
0.1 1.0 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.1 1.4 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.1 0.4 GO:0030043 actin filament fragmentation(GO:0030043)
0.1 0.5 GO:0008655 pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.1 4.9 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.1 0.6 GO:0010649 regulation of cell communication by electrical coupling(GO:0010649) regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.1 1.1 GO:0034142 toll-like receptor 4 signaling pathway(GO:0034142)
0.1 0.8 GO:0046548 retinal rod cell development(GO:0046548)
0.1 1.7 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 0.9 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.1 1.9 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 2.4 GO:0048678 response to axon injury(GO:0048678)
0.0 0.6 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 1.5 GO:0042168 heme metabolic process(GO:0042168)
0.0 1.2 GO:0010996 response to auditory stimulus(GO:0010996)
0.0 0.2 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0 6.6 GO:0048839 inner ear development(GO:0048839)
0.0 0.2 GO:1901911 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.4 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.0 0.3 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.6 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.0 GO:0035696 monocyte extravasation(GO:0035696) regulation of monocyte extravasation(GO:2000437)
0.0 2.3 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 0.7 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.2 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 1.9 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 0.6 GO:0006687 glycosphingolipid metabolic process(GO:0006687) response to cAMP(GO:0051591)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 6.7 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.8 3.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.5 6.6 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.4 1.9 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.2 3.9 GO:0031045 dense core granule(GO:0031045)
0.2 1.2 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.2 10.8 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.2 2.1 GO:0005916 fascia adherens(GO:0005916)
0.2 1.1 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.6 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 2.0 GO:0032279 asymmetric synapse(GO:0032279)
0.1 9.8 GO:0005604 basement membrane(GO:0005604)
0.1 1.7 GO:0071564 npBAF complex(GO:0071564)
0.1 4.4 GO:0031941 filamentous actin(GO:0031941)
0.1 3.6 GO:0043034 costamere(GO:0043034)
0.0 5.6 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.7 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.2 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.0 2.2 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.4 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 1.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.7 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 1.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 5.7 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.7 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.7 GO:0005884 actin filament(GO:0005884)
0.0 2.0 GO:0055037 recycling endosome(GO:0055037)
0.0 3.2 GO:0070382 exocytic vesicle(GO:0070382)
0.0 3.7 GO:0043235 receptor complex(GO:0043235)
0.0 0.8 GO:0005581 collagen trimer(GO:0005581)
0.0 2.2 GO:0001650 fibrillar center(GO:0001650)
0.0 0.1 GO:0008385 IkappaB kinase complex(GO:0008385)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 10.8 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
1.2 3.6 GO:0016748 succinyltransferase activity(GO:0016748)
0.5 2.1 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.5 2.5 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.5 5.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.3 2.1 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.3 1.4 GO:0003880 protein C-terminal carboxyl O-methyltransferase activity(GO:0003880)
0.3 1.2 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.3 1.1 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.3 3.6 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.3 2.0 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.2 3.1 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.2 1.0 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.2 0.6 GO:0019002 GMP binding(GO:0019002)
0.2 8.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 0.7 GO:0004966 galanin receptor activity(GO:0004966)
0.2 5.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.9 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 6.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 4.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 1.5 GO:0031005 filamin binding(GO:0031005)
0.1 1.9 GO:0042056 chemoattractant activity(GO:0042056)
0.1 0.5 GO:0004849 uridine kinase activity(GO:0004849)
0.1 1.1 GO:0002162 dystroglycan binding(GO:0002162)
0.1 5.6 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 1.2 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 0.8 GO:0015929 hexosaminidase activity(GO:0015929)
0.1 1.1 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 4.3 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.7 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 1.9 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.1 GO:1990450 linear polyubiquitin binding(GO:1990450)
0.0 0.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.2 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 4.1 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 1.7 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 1.5 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 3.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 2.9 GO:0008013 beta-catenin binding(GO:0008013)
0.0 1.9 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.2 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.0 1.5 GO:0020037 heme binding(GO:0020037)
0.0 0.2 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.4 GO:0031402 voltage-gated sodium channel activity(GO:0005248) sodium ion binding(GO:0031402)
0.0 0.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.7 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 5.1 GO:0003924 GTPase activity(GO:0003924)
0.0 0.6 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 1.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.8 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 1.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.7 GO:0005249 voltage-gated potassium channel activity(GO:0005249)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 17.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 11.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 4.7 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 1.5 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 0.6 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 2.1 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 3.2 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 1.1 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 2.4 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.7 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.9 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.3 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.3 10.8 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2 3.6 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 2.5 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 2.5 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 0.7 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 2.1 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 5.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.5 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 7.1 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.5 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 1.2 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 1.1 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 2.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.0 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.7 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.5 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.6 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.2 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.0 0.1 REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10