Motif ID: Six3_Six1_Six2

Z-value: 0.911

Transcription factors associated with Six3_Six1_Six2:

Gene SymbolEntrez IDGene Name
Six1 ENSMUSG00000051367.8 Six1
Six2 ENSMUSG00000024134.10 Six2
Six3 ENSMUSG00000038805.9 Six3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six2mm10_v2_chr17_-_85688252_856882750.143.8e-01Click!
Six1mm10_v2_chr12_-_73047179_730471790.124.6e-01Click!
Six3mm10_v2_chr17_+_85620816_85620843-0.105.5e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Six3_Six1_Six2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_85722474 9.303 ENSMUST00000119077.1
Fam160a1
family with sequence similarity 160, member A1
chr13_+_94083490 6.068 ENSMUST00000156071.1
Lhfpl2
lipoma HMGIC fusion partner-like 2
chr15_-_75894474 4.266 ENSMUST00000023237.6
Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr1_+_139454747 3.964 ENSMUST00000053364.8
ENSMUST00000097554.3
Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr7_-_80115294 3.778 ENSMUST00000107384.3
Idh2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr10_-_128180265 3.308 ENSMUST00000099139.1
Rbms2
RNA binding motif, single stranded interacting protein 2
chr9_+_65141154 3.234 ENSMUST00000034961.4
Igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chr15_-_82244716 3.059 ENSMUST00000089155.4
ENSMUST00000089157.3
Cenpm

centromere protein M

chr5_+_139423151 2.289 ENSMUST00000066211.4
Gper1
G protein-coupled estrogen receptor 1
chr4_-_32950813 2.219 ENSMUST00000084750.1
ENSMUST00000084748.2
Ankrd6

ankyrin repeat domain 6

chr18_+_56432116 2.109 ENSMUST00000070166.5
Gramd3
GRAM domain containing 3
chrX_-_142966709 2.004 ENSMUST00000041317.2
Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr3_-_37724321 1.720 ENSMUST00000108105.1
ENSMUST00000079755.4
ENSMUST00000099128.1
Gm5148


predicted gene 5148


chr15_+_98571004 1.589 ENSMUST00000023728.6
4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr2_+_131491764 1.475 ENSMUST00000028806.5
ENSMUST00000110179.2
ENSMUST00000110189.2
ENSMUST00000110182.2
ENSMUST00000110183.2
ENSMUST00000110186.2
ENSMUST00000110188.1
Smox






spermine oxidase






chr9_+_72958785 1.420 ENSMUST00000098567.2
ENSMUST00000034734.8
Dyx1c1

dyslexia susceptibility 1 candidate 1 homolog (human)

chr2_+_106693185 1.340 ENSMUST00000111063.1
Mpped2
metallophosphoesterase domain containing 2
chr3_+_130068390 1.337 ENSMUST00000076703.6
Gm9396
predicted gene 9396
chr1_+_136467958 1.329 ENSMUST00000047817.6
Kif14
kinesin family member 14
chr7_-_126676357 1.319 ENSMUST00000106371.1
ENSMUST00000106372.3
ENSMUST00000155419.1
Sult1a1


sulfotransferase family 1A, phenol-preferring, member 1


chr7_-_126676428 1.308 ENSMUST00000106373.1
Sult1a1
sulfotransferase family 1A, phenol-preferring, member 1
chr17_-_56716788 1.173 ENSMUST00000067931.5
Vmac
vimentin-type intermediate filament associated coiled-coil protein
chr3_+_94398517 1.135 ENSMUST00000050975.3
Lingo4
leucine rich repeat and Ig domain containing 4
chr1_-_118982551 1.054 ENSMUST00000159678.1
Gli2
GLI-Kruppel family member GLI2
chr7_-_141168671 1.035 ENSMUST00000106033.3
Rnh1
ribonuclease/angiogenin inhibitor 1
chrX_+_169685191 0.939 ENSMUST00000112104.1
ENSMUST00000112107.1
Mid1

midline 1

chr17_-_56717681 0.930 ENSMUST00000164907.1
Vmac
vimentin-type intermediate filament associated coiled-coil protein
chr2_-_13271268 0.924 ENSMUST00000137670.1
ENSMUST00000114791.2
Rsu1

Ras suppressor protein 1

chr4_+_133176336 0.915 ENSMUST00000105912.1
Wasf2
WAS protein family, member 2
chr3_+_88207308 0.912 ENSMUST00000180582.1
Gm3764
predicted gene 3764
chr2_-_13271419 0.893 ENSMUST00000028059.2
Rsu1
Ras suppressor protein 1
chr8_+_57455898 0.825 ENSMUST00000034023.3
Scrg1
scrapie responsive gene 1
chr8_-_4275886 0.820 ENSMUST00000003029.7
Timm44
translocase of inner mitochondrial membrane 44
chr6_+_115675983 0.815 ENSMUST00000068960.9
D830050J10Rik
RIKEN cDNA D830050J10 gene
chr6_+_38534823 0.769 ENSMUST00000019833.4
1110001J03Rik
RIKEN cDNA 1110001J03 gene
chr6_-_115675871 0.696 ENSMUST00000112949.1
Raf1
v-raf-leukemia viral oncogene 1
chr16_-_45724600 0.576 ENSMUST00000096057.4
Tagln3
transgelin 3
chr7_+_30232310 0.544 ENSMUST00000108193.1
ENSMUST00000108192.1
Polr2i

polymerase (RNA) II (DNA directed) polypeptide I

chr4_-_43030440 0.534 ENSMUST00000135660.1
Stoml2
stomatin (Epb7.2)-like 2
chr8_+_84831522 0.514 ENSMUST00000036734.5
Gadd45gip1
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr14_+_57798182 0.507 ENSMUST00000111269.1
Sap18
Sin3-associated polypeptide 18
chr15_-_76206309 0.413 ENSMUST00000073418.6
ENSMUST00000171634.1
ENSMUST00000076442.5
Plec


plectin


chr11_-_69695521 0.404 ENSMUST00000181261.1
Tnfsf12
tumor necrosis factor (ligand) superfamily, member 12
chrX_-_74373218 0.401 ENSMUST00000178691.1
ENSMUST00000114146.1
Ubl4
Slc10a3
ubiquitin-like 4
solute carrier family 10 (sodium/bile acid cotransporter family), member 3
chr13_+_104229366 0.375 ENSMUST00000022227.6
Cenpk
centromere protein K
chr11_-_99230998 0.339 ENSMUST00000103133.3
Smarce1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr14_+_58893465 0.314 ENSMUST00000079960.1
Rpl13-ps3
ribosomal protein L13, pseudogene 3
chrY_-_6237995 0.312 ENSMUST00000177612.1
Gm21746
predicted gene, 21746
chr17_+_25133385 0.260 ENSMUST00000040729.2
Clcn7
chloride channel 7
chr9_-_70503718 0.248 ENSMUST00000034739.5
Rnf111
ring finger 111
chr4_+_11758147 0.239 ENSMUST00000029871.5
ENSMUST00000108303.1
Cdh17

cadherin 17

chr7_-_101903783 0.225 ENSMUST00000106969.1
Tomt
transmembrane O-methyltransferase
chr12_+_30584429 0.209 ENSMUST00000057151.8
Tmem18
transmembrane protein 18
chr10_+_24595623 0.209 ENSMUST00000176228.1
ENSMUST00000129142.1
Ctgf

connective tissue growth factor

chr12_+_84773262 0.199 ENSMUST00000021667.5
Isca2
iron-sulfur cluster assembly 2 homolog (S. cerevisiae)
chr9_+_98422961 0.199 ENSMUST00000052068.9
Rbp1
retinol binding protein 1, cellular
chr16_-_18235074 0.185 ENSMUST00000076957.5
Zdhhc8
zinc finger, DHHC domain containing 8
chr2_+_158028481 0.179 ENSMUST00000103123.3
Rprd1b
regulation of nuclear pre-mRNA domain containing 1B
chr19_-_55315980 0.175 ENSMUST00000076891.5
Zdhhc6
zinc finger, DHHC domain containing 6
chr5_+_23787691 0.165 ENSMUST00000030852.6
ENSMUST00000120869.1
ENSMUST00000117783.1
ENSMUST00000115113.2
Rint1



RAD50 interactor 1



chr8_-_106573461 0.161 ENSMUST00000073722.5
Gm10073
predicted pseudogene 10073
chr1_-_119504736 0.156 ENSMUST00000004565.8
Ralb
v-ral simian leukemia viral oncogene homolog B (ras related)
chr8_+_69832633 0.140 ENSMUST00000131637.2
ENSMUST00000081503.6
Pbx4

pre B cell leukemia homeobox 4

chr4_-_116651644 0.139 ENSMUST00000030455.8
Akr1a1
aldo-keto reductase family 1, member A1 (aldehyde reductase)
chr5_+_21543525 0.115 ENSMUST00000035651.4
Lrrc17
leucine rich repeat containing 17
chr11_-_87826023 0.111 ENSMUST00000103177.3
Lpo
lactoperoxidase
chr9_+_119341487 0.104 ENSMUST00000175743.1
ENSMUST00000176397.1
Acaa1a

acetyl-Coenzyme A acyltransferase 1A

chr17_+_56717759 0.099 ENSMUST00000002452.6
Ndufa11
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 11
chr8_-_22653406 0.071 ENSMUST00000033938.5
Polb
polymerase (DNA directed), beta
chr6_+_48537560 0.062 ENSMUST00000040361.5
Atp6v0e2
ATPase, H+ transporting, lysosomal V0 subunit E2
chr10_-_78487842 0.057 ENSMUST00000069431.4
Gm9978
predicted gene 9978
chr7_+_43690418 0.029 ENSMUST00000056329.6
Klk14
kallikrein related-peptidase 14
chrX_-_74373260 0.023 ENSMUST00000073067.4
ENSMUST00000037967.5
Slc10a3

solute carrier family 10 (sodium/bile acid cotransporter family), member 3

chr19_+_8764934 0.018 ENSMUST00000184663.1
Nxf1
nuclear RNA export factor 1
chr8_+_71951038 0.015 ENSMUST00000131237.1
ENSMUST00000136516.1
ENSMUST00000109997.2
ENSMUST00000132848.1
Zfp961



zinc finger protein 961



chr17_-_36951636 0.008 ENSMUST00000040402.7
ENSMUST00000174711.1
Ppp1r11

protein phosphatase 1, regulatory (inhibitor) subunit 11

chr14_+_57798156 0.006 ENSMUST00000128764.1
Sap18
Sin3-associated polypeptide 18

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:0006097 glyoxylate cycle(GO:0006097) negative regulation of glial cell migration(GO:1903976)
0.8 4.0 GO:0051661 maintenance of centrosome location(GO:0051661)
0.6 2.3 GO:1904706 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579) negative regulation of vascular smooth muscle cell proliferation(GO:1904706) positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.3 1.3 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.3 1.5 GO:0046208 spermine catabolic process(GO:0046208)
0.3 1.1 GO:0060032 notochord regression(GO:0060032)
0.2 2.6 GO:0051923 sulfation(GO:0051923)
0.2 0.7 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.2 0.5 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
0.1 2.2 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 1.4 GO:0036159 outer dynein arm assembly(GO:0036158) inner dynein arm assembly(GO:0036159)
0.1 0.9 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 0.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.3 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.1 0.2 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.2 GO:0072425 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434)
0.1 0.2 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.1 0.2 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.1 0.5 GO:1903862 positive regulation of oxidative phosphorylation(GO:1903862)
0.1 0.8 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.2 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.2 GO:0019614 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.0 0.9 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.1 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.2 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 3.1 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.0 0.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.1 GO:0042364 L-ascorbic acid metabolic process(GO:0019852) water-soluble vitamin biosynthetic process(GO:0042364)
0.0 1.8 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
0.0 0.1 GO:0071707 immunoglobulin heavy chain V-D-J recombination(GO:0071707)
0.0 0.1 GO:0048539 bone marrow development(GO:0048539)
0.0 0.3 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.2 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.0 0.4 GO:0018345 protein palmitoylation(GO:0018345)
0.0 1.1 GO:0051965 positive regulation of synapse assembly(GO:0051965)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.0 GO:0036449 microtubule minus-end(GO:0036449)
0.5 2.1 GO:0045098 type III intermediate filament(GO:0045098)
0.3 1.0 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.2 2.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 1.1 GO:0097542 ciliary tip(GO:0097542)
0.1 0.9 GO:0031209 SCAR complex(GO:0031209)
0.1 0.5 GO:0061574 ASAP complex(GO:0061574)
0.1 0.2 GO:0070939 Dsl1p complex(GO:0070939)
0.0 3.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.7 GO:0031143 pseudopodium(GO:0031143)
0.0 1.3 GO:0051233 spindle midzone(GO:0051233)
0.0 0.4 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.5 GO:0042101 T cell receptor complex(GO:0042101)
0.0 3.4 GO:0000776 kinetochore(GO:0000776)
0.0 3.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)
0.0 0.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.9 2.6 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.5 1.5 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.4 2.3 GO:0030284 estrogen receptor activity(GO:0030284)
0.1 2.1 GO:0019215 intermediate filament binding(GO:0019215)
0.1 1.0 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.1 0.4 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 0.2 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.5 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.1 0.2 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 1.3 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.2 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.2 GO:0019841 retinol binding(GO:0019841)
0.0 1.4 GO:0030331 estrogen receptor binding(GO:0030331)
0.0 1.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.7 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.1 GO:0008410 CoA-transferase activity(GO:0008410)
0.0 0.3 GO:0030506 ankyrin binding(GO:0030506)
0.0 4.0 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.4 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.3 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.2 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.7 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.1 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.3 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.9 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.6 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.2 3.8 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 1.5 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 1.8 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.7 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.0 3.4 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.4 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.3 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.2 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events