Motif ID: Six3_Six1_Six2
Z-value: 0.911
Transcription factors associated with Six3_Six1_Six2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Six1 | ENSMUSG00000051367.8 | Six1 |
Six2 | ENSMUSG00000024134.10 | Six2 |
Six3 | ENSMUSG00000038805.9 | Six3 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Six2 | mm10_v2_chr17_-_85688252_85688275 | 0.14 | 3.8e-01 | Click! |
Six1 | mm10_v2_chr12_-_73047179_73047179 | 0.12 | 4.6e-01 | Click! |
Six3 | mm10_v2_chr17_+_85620816_85620843 | -0.10 | 5.5e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.3 | 3.8 | GO:0006097 | glyoxylate cycle(GO:0006097) negative regulation of glial cell migration(GO:1903976) |
0.8 | 4.0 | GO:0051661 | maintenance of centrosome location(GO:0051661) |
0.6 | 2.3 | GO:1904706 | regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579) negative regulation of vascular smooth muscle cell proliferation(GO:1904706) positive regulation of vascular smooth muscle cell differentiation(GO:1905065) |
0.3 | 1.3 | GO:0021698 | cerebellar cortex structural organization(GO:0021698) |
0.3 | 1.5 | GO:0046208 | spermine catabolic process(GO:0046208) |
0.3 | 1.1 | GO:0060032 | notochord regression(GO:0060032) |
0.2 | 2.6 | GO:0051923 | sulfation(GO:0051923) |
0.2 | 0.7 | GO:0071550 | death-inducing signaling complex assembly(GO:0071550) |
0.2 | 0.5 | GO:1990046 | positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046) |
0.1 | 2.2 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
0.1 | 1.4 | GO:0036159 | outer dynein arm assembly(GO:0036158) inner dynein arm assembly(GO:0036159) |
0.1 | 0.9 | GO:0035372 | protein localization to microtubule(GO:0035372) |
0.1 | 0.4 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
0.1 | 0.3 | GO:0001193 | maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193) |
0.1 | 0.2 | GO:0002314 | germinal center B cell differentiation(GO:0002314) |
0.1 | 0.2 | GO:0072425 | signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) |
0.1 | 0.2 | GO:0070318 | positive regulation of G0 to G1 transition(GO:0070318) |
0.1 | 0.2 | GO:0001928 | regulation of exocyst assembly(GO:0001928) |
0.1 | 0.5 | GO:1903862 | positive regulation of oxidative phosphorylation(GO:1903862) |
0.1 | 0.8 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
0.0 | 0.2 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
0.0 | 0.2 | GO:0019614 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
0.0 | 0.9 | GO:0035855 | megakaryocyte development(GO:0035855) |
0.0 | 0.1 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
0.0 | 0.2 | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process(GO:0030579) |
0.0 | 3.1 | GO:0050885 | neuromuscular process controlling balance(GO:0050885) |
0.0 | 0.2 | GO:0097428 | protein maturation by iron-sulfur cluster transfer(GO:0097428) |
0.0 | 0.1 | GO:0042364 | L-ascorbic acid metabolic process(GO:0019852) water-soluble vitamin biosynthetic process(GO:0042364) |
0.0 | 1.8 | GO:2000179 | positive regulation of neural precursor cell proliferation(GO:2000179) |
0.0 | 0.1 | GO:0071707 | immunoglobulin heavy chain V-D-J recombination(GO:0071707) |
0.0 | 0.1 | GO:0048539 | bone marrow development(GO:0048539) |
0.0 | 0.3 | GO:0006337 | nucleosome disassembly(GO:0006337) |
0.0 | 0.2 | GO:0070940 | dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940) |
0.0 | 0.4 | GO:0018345 | protein palmitoylation(GO:0018345) |
0.0 | 1.1 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 4.0 | GO:0036449 | microtubule minus-end(GO:0036449) |
0.5 | 2.1 | GO:0045098 | type III intermediate filament(GO:0045098) |
0.3 | 1.0 | GO:0032311 | angiogenin-PRI complex(GO:0032311) |
0.2 | 2.3 | GO:0032591 | dendritic spine membrane(GO:0032591) |
0.1 | 1.1 | GO:0097542 | ciliary tip(GO:0097542) |
0.1 | 0.9 | GO:0031209 | SCAR complex(GO:0031209) |
0.1 | 0.5 | GO:0061574 | ASAP complex(GO:0061574) |
0.1 | 0.2 | GO:0070939 | Dsl1p complex(GO:0070939) |
0.0 | 3.0 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
0.0 | 0.7 | GO:0031143 | pseudopodium(GO:0031143) |
0.0 | 1.3 | GO:0051233 | spindle midzone(GO:0051233) |
0.0 | 0.4 | GO:0030056 | hemidesmosome(GO:0030056) |
0.0 | 0.5 | GO:0042101 | T cell receptor complex(GO:0042101) |
0.0 | 3.4 | GO:0000776 | kinetochore(GO:0000776) |
0.0 | 3.9 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
0.0 | 0.3 | GO:0071564 | npBAF complex(GO:0071564) |
0.0 | 0.3 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.3 | 3.8 | GO:0004450 | isocitrate dehydrogenase (NADP+) activity(GO:0004450) |
0.9 | 2.6 | GO:0050656 | 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656) |
0.5 | 1.5 | GO:0046592 | polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901) |
0.4 | 2.3 | GO:0030284 | estrogen receptor activity(GO:0030284) |
0.1 | 2.1 | GO:0019215 | intermediate filament binding(GO:0019215) |
0.1 | 1.0 | GO:0008428 | ribonuclease inhibitor activity(GO:0008428) |
0.1 | 0.4 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
0.1 | 0.2 | GO:0035673 | oligopeptide transmembrane transporter activity(GO:0035673) |
0.1 | 0.5 | GO:1901612 | phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612) |
0.1 | 0.2 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
0.0 | 1.3 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
0.0 | 0.2 | GO:0032184 | SUMO polymer binding(GO:0032184) |
0.0 | 0.2 | GO:0019841 | retinol binding(GO:0019841) |
0.0 | 1.4 | GO:0030331 | estrogen receptor binding(GO:0030331) |
0.0 | 1.1 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
0.0 | 0.7 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
0.0 | 0.1 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
0.0 | 0.1 | GO:0008410 | CoA-transferase activity(GO:0008410) |
0.0 | 0.3 | GO:0030506 | ankyrin binding(GO:0030506) |
0.0 | 4.0 | GO:0005516 | calmodulin binding(GO:0005516) |
0.0 | 0.3 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
0.0 | 0.4 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
0.0 | 0.4 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
0.0 | 0.3 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 2.2 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
0.0 | 0.7 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
0.0 | 1.1 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
0.0 | 0.3 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
0.0 | 0.9 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 2.6 | REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
0.2 | 3.8 | REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
0.1 | 1.5 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
0.1 | 1.8 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
0.0 | 0.7 | REACTOME_RAF_MAP_KINASE_CASCADE | Genes involved in RAF/MAP kinase cascade |
0.0 | 3.4 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
0.0 | 0.4 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
0.0 | 0.3 | REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
0.0 | 0.8 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
0.0 | 0.2 | REACTOME_P38MAPK_EVENTS | Genes involved in p38MAPK events |