Motif ID: Smad3
Z-value: 0.595
Transcription factors associated with Smad3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Smad3 | ENSMUSG00000032402.6 | Smad3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Smad3 | mm10_v2_chr9_-_63711969_63711994 | -0.54 | 3.3e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 4.4 | GO:0090274 | positive regulation of somatostatin secretion(GO:0090274) |
| 0.5 | 1.4 | GO:1902460 | transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462) |
| 0.4 | 8.3 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
| 0.2 | 0.6 | GO:1904347 | intestine smooth muscle contraction(GO:0014827) regulation of gastro-intestinal system smooth muscle contraction(GO:1904304) regulation of small intestine smooth muscle contraction(GO:1904347) small intestine smooth muscle contraction(GO:1990770) |
| 0.2 | 2.3 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
| 0.2 | 2.1 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.2 | 0.7 | GO:0046655 | glycine biosynthetic process(GO:0006545) folic acid metabolic process(GO:0046655) |
| 0.2 | 0.5 | GO:2000659 | regulation of interleukin-1-mediated signaling pathway(GO:2000659) |
| 0.1 | 1.0 | GO:0072697 | protein localization to cell cortex(GO:0072697) |
| 0.1 | 0.4 | GO:0021691 | cerebellar Purkinje cell layer maturation(GO:0021691) |
| 0.1 | 0.4 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.1 | 0.3 | GO:1904139 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
| 0.1 | 0.4 | GO:0071287 | peptidyl-aspartic acid modification(GO:0018197) cellular response to manganese ion(GO:0071287) |
| 0.1 | 0.5 | GO:0010908 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) |
| 0.1 | 1.2 | GO:0045603 | positive regulation of endothelial cell differentiation(GO:0045603) |
| 0.1 | 2.7 | GO:0006182 | cGMP biosynthetic process(GO:0006182) |
| 0.1 | 0.5 | GO:0097428 | protein maturation by iron-sulfur cluster transfer(GO:0097428) |
| 0.1 | 6.6 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.1 | 0.2 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 1.4 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.0 | 0.1 | GO:0001180 | transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180) |
| 0.0 | 0.2 | GO:0052428 | modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428) |
| 0.0 | 1.7 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 0.0 | 1.4 | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042) |
| 0.0 | 2.7 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.0 | 0.2 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
| 0.0 | 0.1 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
| 0.0 | 0.2 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.0 | 0.2 | GO:0019321 | pentose metabolic process(GO:0019321) neuron cellular homeostasis(GO:0070050) |
| 0.0 | 0.1 | GO:2001168 | regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168) |
| 0.0 | 0.4 | GO:0051894 | positive regulation of focal adhesion assembly(GO:0051894) |
| 0.0 | 2.6 | GO:0007050 | cell cycle arrest(GO:0007050) |
| 0.0 | 1.6 | GO:0031110 | regulation of microtubule polymerization or depolymerization(GO:0031110) |
| 0.0 | 0.3 | GO:1900037 | regulation of cellular response to hypoxia(GO:1900037) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.6 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.2 | 7.1 | GO:0000786 | nucleosome(GO:0000786) |
| 0.1 | 2.7 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.1 | 1.6 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.1 | 0.3 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.1 | 0.4 | GO:0031310 | integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310) |
| 0.1 | 1.4 | GO:0070938 | contractile ring(GO:0070938) |
| 0.1 | 0.6 | GO:0001520 | outer dense fiber(GO:0001520) |
| 0.1 | 0.2 | GO:1990667 | PCSK9-AnxA2 complex(GO:1990667) |
| 0.1 | 0.5 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.0 | 3.2 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 0.2 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 2.4 | GO:0044306 | neuron projection terminus(GO:0044306) |
| 0.0 | 1.1 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.3 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.2 | 0.7 | GO:0051870 | methotrexate binding(GO:0051870) |
| 0.1 | 2.7 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.1 | 0.9 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.1 | 1.7 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.1 | 4.4 | GO:0008528 | G-protein coupled peptide receptor activity(GO:0008528) |
| 0.1 | 0.6 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
| 0.1 | 1.4 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
| 0.1 | 0.2 | GO:0004859 | phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834) |
| 0.0 | 0.9 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 1.0 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.0 | 9.7 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 0.3 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
| 0.0 | 0.5 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 0.4 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 1.2 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 0.1 | GO:0001179 | RNA polymerase I transcription factor binding(GO:0001179) |
| 0.0 | 0.5 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
| 0.0 | 1.8 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.0 | 4.3 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 0.4 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.7 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 0.3 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.2 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 11.3 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 2.9 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 4.4 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 0.5 | REACTOME_TRYPTOPHAN_CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 0.7 | REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.0 | 0.2 | REACTOME_COMMON_PATHWAY | Genes involved in Common Pathway |
| 0.0 | 0.6 | REACTOME_REGULATION_OF_KIT_SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.0 | 2.3 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 1.6 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 0.2 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
