Motif ID: Sox11

Z-value: 0.532


Transcription factors associated with Sox11:

Gene SymbolEntrez IDGene Name
Sox11 ENSMUSG00000063632.5 Sox11

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox11mm10_v2_chr12_-_27342696_273427260.731.2e-07Click!


Activity profile for motif Sox11.

activity profile for motif Sox11


Sorted Z-values histogram for motif Sox11

Sorted Z-values for motif Sox11



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox11

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_47418407 4.242 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr9_+_65890237 3.626 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr2_-_79456750 3.174 ENSMUST00000041099.4
 Neurod1
neurogenic differentiation 1
chr6_-_23248264 2.606 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr1_+_82233112 2.566 ENSMUST00000023262.5
 Gm9747
predicted gene 9747
chr5_+_64812336 2.322 ENSMUST00000166409.1
 Klf3
Kruppel-like factor 3 (basic)
chr2_+_154548888 2.053 ENSMUST00000045116.4
ENSMUST00000109709.3
 1700003F12Rik

RIKEN cDNA 1700003F12 gene

chr16_-_50330987 2.045 ENSMUST00000114488.1
 Bbx
bobby sox homolog (Drosophila)
chr4_-_97584605 1.950 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_97584612 1.938 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr7_+_70388305 1.868 ENSMUST00000080024.5
 B130024G19Rik
RIKEN cDNA B130024G19 gene
chr9_+_52047150 1.666 ENSMUST00000163153.1
 Rdx
radixin
chr7_-_73541738 1.227 ENSMUST00000169922.2
 Chd2
chromodomain helicase DNA binding protein 2
chr16_-_38341812 1.159 ENSMUST00000114740.2
ENSMUST00000023501.8
 Maats1

MYCBP-associated, testis expressed 1

chr11_-_64436653 1.097 ENSMUST00000177999.1
 F930015N05Rik
RIKEN cDNA F930015N05 gene
chr2_+_15055274 1.089 ENSMUST00000069870.3
 Arl5b
ADP-ribosylation factor-like 5B
chr15_+_76797628 1.071 ENSMUST00000165535.2
 Gm17271
predicted gene, 17271
chr11_-_50292302 1.033 ENSMUST00000059458.4
 Maml1
mastermind like 1 (Drosophila)
chr13_-_41487306 0.911 ENSMUST00000021794.6
 Nedd9
neural precursor cell expressed, developmentally down-regulated gene 9
chr17_-_29007925 0.883 ENSMUST00000009138.5
ENSMUST00000119274.1
 Stk38

serine/threonine kinase 38

chr5_-_131616599 0.826 ENSMUST00000161804.1
 Auts2
autism susceptibility candidate 2
chr10_-_76110956 0.781 ENSMUST00000120757.1
 Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr7_+_83631959 0.746 ENSMUST00000075418.7
ENSMUST00000117410.1
 Stard5

StAR-related lipid transfer (START) domain containing 5

chr10_+_17796256 0.691 ENSMUST00000037964.6
 Txlnb
taxilin beta
chr14_-_52213379 0.677 ENSMUST00000140603.1
 Chd8
chromodomain helicase DNA binding protein 8
chrM_+_7005 0.631 ENSMUST00000082405.1
 mt-Co2
mitochondrially encoded cytochrome c oxidase II
chr1_-_45503282 0.628 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr5_-_148552783 0.605 ENSMUST00000079324.7
ENSMUST00000164904.1
 Ubl3

ubiquitin-like 3

chrX_+_166344692 0.580 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
 Gpm6b





glycoprotein m6b





chr4_+_21848039 0.568 ENSMUST00000098238.2
ENSMUST00000108229.1
 Sfrs18

serine/arginine-rich splicing factor 18

chr10_-_14718191 0.542 ENSMUST00000020016.4
 Gje1
gap junction protein, epsilon 1
chr12_-_54862783 0.524 ENSMUST00000078124.7
 Cfl2
cofilin 2, muscle
chrX_-_37104523 0.510 ENSMUST00000130324.1
 Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr6_-_42693030 0.502 ENSMUST00000045140.4
 Fam115a
family with sequence similarity 115, member A
chr2_-_36136602 0.438 ENSMUST00000122456.1
 Rbm18
RNA binding motif protein 18
chr6_-_12109583 0.428 ENSMUST00000080891.5
 Gm6578
predicted gene 6578
chr6_-_42693087 0.424 ENSMUST00000121083.1
 Fam115a
family with sequence similarity 115, member A
chr10_+_115569986 0.404 ENSMUST00000173620.1
 A930009A15Rik
RIKEN cDNA A930009A15 gene
chrM_+_7759 0.376 ENSMUST00000082407.1
ENSMUST00000082408.1
 mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr16_-_44558864 0.351 ENSMUST00000023370.4
 Boc
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
chr13_+_24327415 0.328 ENSMUST00000167746.1
 Cmah
cytidine monophospho-N-acetylneuraminic acid hydroxylase
chr4_-_43030440 0.327 ENSMUST00000135660.1
 Stoml2
stomatin (Epb7.2)-like 2
chr2_-_156111954 0.321 ENSMUST00000142960.2
ENSMUST00000136296.2
ENSMUST00000059647.5
ENSMUST00000109604.2
ENSMUST00000138068.1
ENSMUST00000128499.1
 Cpne1

Rbm12



copine I

RNA binding motif protein 12



chr1_+_44119952 0.294 ENSMUST00000114709.2
 Bivm
basic, immunoglobulin-like variable motif containing
chr16_-_44558879 0.293 ENSMUST00000114634.1
 Boc
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
chr2_-_36136773 0.273 ENSMUST00000028251.3
 Rbm18
RNA binding motif protein 18
chr7_-_55962466 0.271 ENSMUST00000032635.7
ENSMUST00000152649.1
 Nipa2

non imprinted in Prader-Willi/Angelman syndrome 2 homolog (human)

chr3_+_67430096 0.256 ENSMUST00000077271.6
ENSMUST00000161009.1
 Gfm1

G elongation factor, mitochondrial 1

chr3_+_28805436 0.238 ENSMUST00000043867.5
 Rpl22l1
ribosomal protein L22 like 1
chr7_-_105737376 0.228 ENSMUST00000098148.4
 Rrp8
ribosomal RNA processing 8, methyltransferase, homolog (yeast)
chr9_+_101074727 0.222 ENSMUST00000085177.3
 Msl2
male-specific lethal 2 homolog (Drosophila)
chr5_+_121795034 0.211 ENSMUST00000162327.1
 Atxn2
ataxin 2
chr4_-_123139929 0.207 ENSMUST00000030404.4
 Ppie
peptidylprolyl isomerase E (cyclophilin E)
chr3_+_60877002 0.198 ENSMUST00000099086.2
 Gm8325
predicted pseudogene 8325
chr16_+_8830093 0.182 ENSMUST00000023150.5
 1810013L24Rik
RIKEN cDNA 1810013L24 gene
chr16_-_44016387 0.157 ENSMUST00000036174.3
 Gramd1c
GRAM domain containing 1C
chr2_-_86347764 0.155 ENSMUST00000099894.2
 Olfr1055
olfactory receptor 1055
chr16_+_65520503 0.131 ENSMUST00000176330.1
ENSMUST00000004964.8
ENSMUST00000176038.1
 Pou1f1


POU domain, class 1, transcription factor 1


chr9_+_107888129 0.104 ENSMUST00000035202.2
 Mon1a
MON1 homolog A (yeast)
chr19_-_46969474 0.101 ENSMUST00000086961.7
 Nt5c2
5'-nucleotidase, cytosolic II
chr3_+_95499273 0.097 ENSMUST00000015664.3
 Ctsk
cathepsin K
chr13_+_40859768 0.096 ENSMUST00000110191.2
 Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr10_+_119992916 0.070 ENSMUST00000105261.2
 Grip1
glutamate receptor interacting protein 1
chr11_-_106193511 0.039 ENSMUST00000007444.7
ENSMUST00000152008.1
ENSMUST00000103072.3
ENSMUST00000106867.1
 Strada



STE20-related kinase adaptor alpha



chr10_+_24869982 0.022 ENSMUST00000092646.6
 Med23
mediator complex subunit 23
chr9_-_16378231 0.015 ENSMUST00000082170.5
 Fat3
FAT tumor suppressor homolog 3 (Drosophila)
chr2_-_109278274 0.012 ENSMUST00000081631.3
 Mettl15
methyltransferase like 15

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.2 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.4 2.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 1.0 GO:0003162 atrioventricular node development(GO:0003162)
0.3 0.8 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.2 1.7 GO:1902965 regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966)
0.2 0.6 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.2 0.8 GO:1904659 glucose transmembrane transport(GO:1904659)
0.1 0.5 GO:0030043 actin filament fragmentation(GO:0030043)
0.1 0.3 GO:0046381 CMP-N-acetylneuraminate metabolic process(GO:0046381)
0.1 0.3 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
0.1 0.3 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.1 1.2 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.1 0.3 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 0.7 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.0 0.7 GO:0070508 sterol import(GO:0035376) cholesterol import(GO:0070508)
0.0 0.1 GO:0060126 somatotropin secreting cell differentiation(GO:0060126)
0.0 0.6 GO:2000009 negative regulation of protein localization to cell surface(GO:2000009)
0.0 0.2 GO:0046015 regulation of transcription by glucose(GO:0046015)
0.0 0.6 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.0 0.1 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.3 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.4 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.5 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.2 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0 0.9 GO:0043407 negative regulation of MAP kinase activity(GO:0043407)
0.0 0.2 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.1 GO:0046085 adenosine metabolic process(GO:0046085)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.2 0.6 GO:0005588 collagen type V trimer(GO:0005588)
0.2 1.0 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 1.7 GO:0051286 cell tip(GO:0051286)
0.0 0.2 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.2 GO:0072487 MSL complex(GO:0072487)
0.0 0.5 GO:0005922 connexon complex(GO:0005922)
0.0 0.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.3 GO:0042101 T cell receptor complex(GO:0042101)
0.0 3.2 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.7 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.5 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.6 GO:0044295 axonal growth cone(GO:0044295)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0032052 bile acid binding(GO:0032052)
0.1 0.3 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.1 3.2 GO:0070888 E-box binding(GO:0070888)
0.1 0.8 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 0.3 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.0 1.0 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.7 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.6 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.9 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 4.2 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 0.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 1.7 GO:0051117 ATPase binding(GO:0051117)
0.0 0.2 GO:0050692 DBD domain binding(GO:0050692)
0.0 2.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.3 GO:0003746 translation elongation factor activity(GO:0003746)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.2 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.7 ST_GA13_PATHWAY G alpha 13 Pathway
0.0 0.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.0 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 0.5 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.6 NABA_COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.2 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.0 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 0.7 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 1.7 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 0.6 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.1 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.5 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.1 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism