Motif ID: Sox8

Z-value: 0.441


Transcription factors associated with Sox8:

Gene SymbolEntrez IDGene Name
Sox8 ENSMUSG00000024176.4 Sox8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox8mm10_v2_chr17_-_25570678_25570694-0.381.6e-02Click!


Activity profile for motif Sox8.

activity profile for motif Sox8


Sorted Z-values histogram for motif Sox8

Sorted Z-values for motif Sox8



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_110095937 2.445 ENSMUST00000106664.3
ENSMUST00000046223.7
ENSMUST00000106662.1
 Abca8a


ATP-binding cassette, sub-family A (ABC1), member 8a


chr13_+_65512678 1.689 ENSMUST00000081471.2
 Gm10139
predicted gene 10139
chr11_-_110095974 1.503 ENSMUST00000100287.2
 Abca8a
ATP-binding cassette, sub-family A (ABC1), member 8a
chr11_+_97415527 1.374 ENSMUST00000121799.1
 Arhgap23
Rho GTPase activating protein 23
chr13_-_66227573 1.278 ENSMUST00000167981.2
 Gm10772
predicted gene 10772
chr3_+_65109343 1.258 ENSMUST00000159525.1
ENSMUST00000049230.8
 Kcnab1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr18_-_62741387 1.091 ENSMUST00000097557.3
 Spink13
serine peptidase inhibitor, Kazal type 13
chr18_+_36952621 1.075 ENSMUST00000115661.2
 Pcdha2
protocadherin alpha 2
chr13_-_19395728 1.051 ENSMUST00000039694.7
 Stard3nl
STARD3 N-terminal like
chrX_-_162643575 0.994 ENSMUST00000101102.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chrX_-_162643629 0.980 ENSMUST00000112334.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chrX_+_134404780 0.976 ENSMUST00000113224.2
ENSMUST00000113226.1
 Drp2

dystrophin related protein 2

chr17_+_70561739 0.880 ENSMUST00000097288.2
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr4_+_43401232 0.804 ENSMUST00000125399.1
 Rusc2
RUN and SH3 domain containing 2
chr13_+_93304799 0.790 ENSMUST00000080127.5
 Homer1
homer homolog 1 (Drosophila)
chr15_-_97020322 0.626 ENSMUST00000166223.1
 Slc38a4
solute carrier family 38, member 4
chr11_+_32286946 0.608 ENSMUST00000101387.3
 Hbq1b
hemoglobin, theta 1B
chr14_-_49783327 0.588 ENSMUST00000118129.1
ENSMUST00000036972.6
 3632451O06Rik

RIKEN cDNA 3632451O06 gene

chr13_-_66852017 0.522 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr13_+_93304066 0.491 ENSMUST00000109493.1
 Homer1
homer homolog 1 (Drosophila)
chr4_-_134245579 0.422 ENSMUST00000030644.7
 Zfp593
zinc finger protein 593
chr7_-_126800354 0.394 ENSMUST00000106348.1
 Aldoa
aldolase A, fructose-bisphosphate
chr19_+_24875679 0.378 ENSMUST00000073080.5
 Gm10053
predicted gene 10053
chr11_+_69991061 0.329 ENSMUST00000018711.8
 Gabarap
gamma-aminobutyric acid receptor associated protein
chr7_-_126800036 0.311 ENSMUST00000133514.1
ENSMUST00000151137.1
 Aldoa

aldolase A, fructose-bisphosphate

chr10_+_82378593 0.304 ENSMUST00000165906.1
 Gm4924
predicted gene 4924
chr11_+_69991633 0.296 ENSMUST00000108592.1
 Gabarap
gamma-aminobutyric acid receptor associated protein
chr1_+_109983737 0.293 ENSMUST00000172005.1
 Cdh7
cadherin 7, type 2
chr16_-_29541483 0.276 ENSMUST00000057018.8
ENSMUST00000182627.1
 Atp13a4

ATPase type 13A4

chr11_-_26591729 0.239 ENSMUST00000109504.1
 Vrk2
vaccinia related kinase 2
chr4_+_154142363 0.238 ENSMUST00000030895.5
 Wrap73
WD repeat containing, antisense to Trp73
chr1_+_109993982 0.234 ENSMUST00000027542.6
 Cdh7
cadherin 7, type 2
chr8_-_33747724 0.217 ENSMUST00000179364.1
 Smim18
small integral membrane protein 18
chr2_-_84715160 0.203 ENSMUST00000035840.5
 Zdhhc5
zinc finger, DHHC domain containing 5
chr13_-_66851513 0.172 ENSMUST00000169322.1
 Gm17404
predicted gene, 17404
chr9_-_95815389 0.161 ENSMUST00000119760.1
 Pls1
plastin 1 (I-isoform)
chr15_-_89149557 0.144 ENSMUST00000088823.3
 Mapk11
mitogen-activated protein kinase 11
chr9_-_4309432 0.128 ENSMUST00000051589.7
 Aasdhppt
aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
chr4_-_129578535 0.123 ENSMUST00000052835.8
 Fam167b
family with sequence similarity 167, member B
chr13_-_30950298 0.111 ENSMUST00000102946.1
 Exoc2
exocyst complex component 2
chr15_-_103215285 0.109 ENSMUST00000122182.1
ENSMUST00000108813.3
ENSMUST00000127191.1
 Cbx5


chromobox 5


chr18_+_65698253 0.093 ENSMUST00000115097.1
ENSMUST00000117694.1
 Oacyl

O-acyltransferase like

chrX_-_72918284 0.076 ENSMUST00000152200.1
 Cetn2
centrin 2
chr2_+_176236860 0.074 ENSMUST00000166464.1
 2210418O10Rik
RIKEN cDNA 2210418O10 gene
chr6_-_119467210 0.062 ENSMUST00000118120.1
 Wnt5b
wingless-related MMTV integration site 5B
chr4_-_58553553 0.033 ENSMUST00000107575.2
ENSMUST00000107574.1
ENSMUST00000147354.1
 Lpar1


lysophosphatidic acid receptor 1


chr7_-_42578588 0.026 ENSMUST00000179470.1
 Gm21028
predicted gene, 21028
chr4_-_116405986 0.019 ENSMUST00000123072.1
ENSMUST00000144281.1
 Mast2

microtubule associated serine/threonine kinase 2

chr2_-_37647199 0.017 ENSMUST00000028279.3
 Strbp
spermatid perinuclear RNA binding protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0060467 negative regulation of fertilization(GO:0060467)
0.1 1.3 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 1.3 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.1 0.2 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.1 0.7 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 0.9 GO:0070842 aggresome assembly(GO:0070842)
0.1 0.4 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.1 0.2 GO:0001951 intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896)
0.1 0.6 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.1 GO:0006553 lysine metabolic process(GO:0006553)
0.0 0.1 GO:2001184 regulation of interleukin-12 secretion(GO:2001182) positive regulation of interleukin-12 secretion(GO:2001184)
0.0 0.1 GO:0001927 exocyst assembly(GO:0001927)
0.0 0.6 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 3.9 GO:0006869 lipid transport(GO:0006869)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 GO:1990635 proximal dendrite(GO:1990635)
0.1 1.1 GO:0044232 organelle membrane contact site(GO:0044232)
0.1 0.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.6 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.2 GO:1990357 terminal web(GO:1990357)
0.0 1.3 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 0.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 1.1 GO:0001669 acrosomal vesicle(GO:0001669)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 1.3 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 1.3 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.0 0.4 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.6 GO:0050811 GABA receptor binding(GO:0050811)
0.0 3.1 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 1.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.1 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.1 GO:0032795 heterotrimeric G-protein binding(GO:0032795)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.6 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions