Motif ID: Tbx1_Eomes

Z-value: 1.049

Transcription factors associated with Tbx1_Eomes:

Gene SymbolEntrez IDGene Name
Eomes ENSMUSG00000032446.8 Eomes
Tbx1 ENSMUSG00000009097.9 Tbx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Eomesmm10_v2_chr9_+_118478344_1184784510.305.9e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx1_Eomes

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_6730051 14.555 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
St18



suppression of tumorigenicity 18



chr10_+_26229707 14.430 ENSMUST00000060716.5
ENSMUST00000164660.1
Samd3

sterile alpha motif domain containing 3

chr2_-_13011747 11.669 ENSMUST00000061545.5
C1ql3
C1q-like 3
chr4_+_125490688 10.193 ENSMUST00000030676.7
Grik3
glutamate receptor, ionotropic, kainate 3
chr1_+_6730135 9.818 ENSMUST00000155921.1
St18
suppression of tumorigenicity 18
chr6_+_15196949 8.753 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
Foxp2



forkhead box P2



chr1_-_138847579 8.740 ENSMUST00000093486.3
ENSMUST00000046870.6
Lhx9

LIM homeobox protein 9

chr7_-_28302238 6.170 ENSMUST00000108315.3
Dll3
delta-like 3 (Drosophila)
chr1_+_153665274 5.768 ENSMUST00000152114.1
ENSMUST00000111812.1
Rgs8

regulator of G-protein signaling 8

chr1_+_132316112 5.252 ENSMUST00000082125.5
ENSMUST00000072177.7
Nuak2

NUAK family, SNF1-like kinase, 2

chr1_+_153665666 4.735 ENSMUST00000111814.1
ENSMUST00000111810.1
Rgs8

regulator of G-protein signaling 8

chr1_+_153665587 4.440 ENSMUST00000147700.1
Rgs8
regulator of G-protein signaling 8
chr1_+_153665627 4.204 ENSMUST00000147482.1
Rgs8
regulator of G-protein signaling 8
chr17_+_29093763 3.725 ENSMUST00000023829.6
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr2_-_57114970 3.508 ENSMUST00000028166.2
Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr13_-_89742490 3.489 ENSMUST00000109546.2
Vcan
versican
chr2_+_164562579 3.415 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
Wfdc2


WAP four-disulfide core domain 2


chr18_-_46212595 2.792 ENSMUST00000037011.4
Trim36
tripartite motif-containing 36
chrX_-_162829379 2.707 ENSMUST00000041370.4
ENSMUST00000112316.2
ENSMUST00000112315.1
Txlng


taxilin gamma


chrX_+_41401476 2.313 ENSMUST00000165288.1
Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr3_+_75557530 2.312 ENSMUST00000161776.1
ENSMUST00000029423.8
Serpini1

serine (or cysteine) peptidase inhibitor, clade I, member 1

chr7_-_141443989 2.194 ENSMUST00000026580.5
Lrdd
leucine-rich and death domain containing
chr4_-_35845204 2.147 ENSMUST00000164772.1
ENSMUST00000065173.2
Lingo2

leucine rich repeat and Ig domain containing 2

chr11_-_84068766 1.948 ENSMUST00000018792.5
Dusp14
dual specificity phosphatase 14
chr11_+_98348404 1.875 ENSMUST00000078694.6
Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr16_-_50330987 1.833 ENSMUST00000114488.1
Bbx
bobby sox homolog (Drosophila)
chr17_+_47630690 1.788 ENSMUST00000024779.8
Usp49
ubiquitin specific peptidase 49
chr6_-_94700137 1.775 ENSMUST00000101126.2
ENSMUST00000032105.4
Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr11_-_84068357 1.736 ENSMUST00000100705.4
Dusp14
dual specificity phosphatase 14
chr6_+_42286709 1.690 ENSMUST00000163936.1
Clcn1
chloride channel 1
chrX_+_41401304 1.624 ENSMUST00000076349.5
Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chrX_+_41401128 1.622 ENSMUST00000115103.2
Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr18_+_60963517 1.621 ENSMUST00000115295.2
ENSMUST00000039904.6
Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr9_-_43239816 1.604 ENSMUST00000034512.5
Oaf
OAF homolog (Drosophila)
chr4_+_84884418 1.568 ENSMUST00000169371.2
Cntln
centlein, centrosomal protein
chr8_-_8639363 1.526 ENSMUST00000152698.1
Efnb2
ephrin B2
chr4_+_84884276 1.524 ENSMUST00000047023.6
Cntln
centlein, centrosomal protein
chr11_-_94507337 1.479 ENSMUST00000040692.8
Mycbpap
MYCBP associated protein
chr16_-_16527364 1.462 ENSMUST00000069284.7
Fgd4
FYVE, RhoGEF and PH domain containing 4
chr10_-_92162753 1.442 ENSMUST00000182197.1
Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr10_-_120899067 1.366 ENSMUST00000092143.5
Msrb3
methionine sulfoxide reductase B3
chr2_+_54436317 1.353 ENSMUST00000112636.1
ENSMUST00000112635.1
ENSMUST00000112634.1
Galnt13


UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13


chr6_+_7555053 1.350 ENSMUST00000090679.2
ENSMUST00000184986.1
Tac1

tachykinin 1

chr6_+_61180313 1.294 ENSMUST00000126214.1
Ccser1
coiled-coil serine rich 1
chr12_+_3891728 1.292 ENSMUST00000172689.1
ENSMUST00000111186.1
Dnmt3a

DNA methyltransferase 3A

chr3_+_51415986 1.287 ENSMUST00000029303.7
Naa15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr9_+_27299205 1.270 ENSMUST00000115247.1
ENSMUST00000133213.1
Igsf9b

immunoglobulin superfamily, member 9B

chr1_+_131970589 1.242 ENSMUST00000027695.6
Slc45a3
solute carrier family 45, member 3
chr7_-_115824699 1.229 ENSMUST00000169129.1
Sox6
SRY-box containing gene 6
chr9_+_35421541 1.199 ENSMUST00000119129.2
Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr14_+_56887795 1.199 ENSMUST00000022511.8
Zmym2
zinc finger, MYM-type 2
chr2_+_20519776 1.188 ENSMUST00000114604.2
ENSMUST00000066509.3
Etl4

enhancer trap locus 4

chr4_-_132510493 1.181 ENSMUST00000030724.8
Sesn2
sestrin 2
chr4_-_123750236 1.156 ENSMUST00000102636.3
Akirin1
akirin 1
chr6_+_42286676 1.144 ENSMUST00000031894.6
Clcn1
chloride channel 1
chr19_+_20601958 1.137 ENSMUST00000087638.3
Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chrX_+_56454871 1.115 ENSMUST00000039374.2
ENSMUST00000101553.2
Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chr10_-_85916902 1.091 ENSMUST00000037646.7
Prdm4
PR domain containing 4
chr1_-_105356658 1.086 ENSMUST00000058688.5
ENSMUST00000172299.1
Rnf152

ring finger protein 152

chr17_-_70849644 1.080 ENSMUST00000134654.1
ENSMUST00000172229.1
ENSMUST00000127719.1
Tgif1


TGFB-induced factor homeobox 1


chrM_+_9870 1.071 ENSMUST00000084013.1
mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr9_-_95845215 1.067 ENSMUST00000093800.2
Pls1
plastin 1 (I-isoform)
chrX_+_42151002 1.041 ENSMUST00000123245.1
Stag2
stromal antigen 2
chr9_+_108296853 0.994 ENSMUST00000035230.5
Amt
aminomethyltransferase
chrX_-_53269020 0.988 ENSMUST00000114838.1
Fam122b
family with sequence similarity 122, member B
chr1_-_161876656 0.987 ENSMUST00000048377.5
Suco
SUN domain containing ossification factor
chrM_+_7759 0.984 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr3_+_102734496 0.980 ENSMUST00000029451.5
Tspan2
tetraspanin 2
chr8_+_106870827 0.937 ENSMUST00000176144.1
ENSMUST00000175987.1
Has3

hyaluronan synthase 3

chr1_-_69108039 0.931 ENSMUST00000121473.1
Erbb4
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
chr2_+_68861433 0.926 ENSMUST00000028426.2
Cers6
ceramide synthase 6
chr13_-_43304153 0.920 ENSMUST00000055341.5
Gfod1
glucose-fructose oxidoreductase domain containing 1
chrX_+_42150672 0.897 ENSMUST00000069619.7
Stag2
stromal antigen 2
chr4_+_43641262 0.894 ENSMUST00000123351.1
ENSMUST00000128549.1
Npr2

natriuretic peptide receptor 2

chr1_-_24612700 0.880 ENSMUST00000088336.1
Gm10222
predicted gene 10222
chrM_+_10167 0.880 ENSMUST00000082414.1
mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr5_-_24329556 0.861 ENSMUST00000115098.2
Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr6_-_21851914 0.839 ENSMUST00000134635.1
ENSMUST00000123116.1
ENSMUST00000120965.1
Tspan12


tetraspanin 12


chr6_+_50110837 0.816 ENSMUST00000167628.1
Mpp6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr2_+_68861564 0.815 ENSMUST00000176018.1
Cers6
ceramide synthase 6
chr2_+_27079371 0.815 ENSMUST00000091233.6
Adamtsl2
ADAMTS-like 2
chr11_-_22286795 0.802 ENSMUST00000109563.2
ENSMUST00000180360.1
Ehbp1

EH domain binding protein 1

chr4_-_82505749 0.794 ENSMUST00000107245.2
ENSMUST00000107246.1
Nfib

nuclear factor I/B

chr9_-_13818665 0.789 ENSMUST00000150893.1
ENSMUST00000124883.1
Cep57

centrosomal protein 57

chr4_-_134018829 0.785 ENSMUST00000051674.2
Lin28a
lin-28 homolog A (C. elegans)
chr5_+_115908644 0.754 ENSMUST00000141101.1
Cit
citron
chrX_+_163909132 0.725 ENSMUST00000033734.7
ENSMUST00000112294.2
Ap1s2

adaptor-related protein complex 1, sigma 2 subunit

chr10_+_56377300 0.725 ENSMUST00000068581.7
Gja1
gap junction protein, alpha 1
chrX_+_20425688 0.721 ENSMUST00000115384.2
Phf16
PHD finger protein 16
chr12_-_31634592 0.717 ENSMUST00000020979.7
ENSMUST00000177962.1
Bcap29

B cell receptor associated protein 29

chrX_-_152016269 0.715 ENSMUST00000026288.4
Ribc1
RIB43A domain with coiled-coils 1
chr12_-_56345862 0.663 ENSMUST00000021416.7
Mbip
MAP3K12 binding inhibitory protein 1
chr4_-_34882919 0.661 ENSMUST00000098163.2
ENSMUST00000047950.5
Zfp292

zinc finger protein 292

chr18_-_42899470 0.611 ENSMUST00000120632.1
Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr7_-_98656530 0.601 ENSMUST00000038359.4
2210018M11Rik
RIKEN cDNA 2210018M11 gene
chr19_-_19001099 0.583 ENSMUST00000040153.8
ENSMUST00000112828.1
Rorb

RAR-related orphan receptor beta

chr14_-_51988829 0.575 ENSMUST00000181008.1
Gm16617
predicted gene, 16617
chr13_+_93304066 0.574 ENSMUST00000109493.1
Homer1
homer homolog 1 (Drosophila)
chr1_-_126830632 0.566 ENSMUST00000112583.1
ENSMUST00000094609.3
Nckap5

NCK-associated protein 5

chr1_-_126830786 0.548 ENSMUST00000162646.1
Nckap5
NCK-associated protein 5
chr4_+_11191354 0.527 ENSMUST00000170901.1
Ccne2
cyclin E2
chr2_-_60125651 0.510 ENSMUST00000112550.1
Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr4_+_148000722 0.488 ENSMUST00000103230.4
Nppa
natriuretic peptide type A
chr17_-_56982120 0.488 ENSMUST00000056113.4
Acer1
alkaline ceramidase 1
chr18_-_42899294 0.458 ENSMUST00000117687.1
Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr1_+_180726019 0.452 ENSMUST00000027780.4
Acbd3
acyl-Coenzyme A binding domain containing 3
chr10_-_86705485 0.451 ENSMUST00000020238.7
Hsp90b1
heat shock protein 90, beta (Grp94), member 1
chr11_-_86544754 0.431 ENSMUST00000138810.1
ENSMUST00000058286.2
ENSMUST00000154617.1
Rps6kb1


ribosomal protein S6 kinase, polypeptide 1


chr3_-_75556759 0.405 ENSMUST00000162138.1
ENSMUST00000029424.5
ENSMUST00000161137.1
Pdcd10


programmed cell death 10


chr7_+_46796088 0.392 ENSMUST00000006774.4
ENSMUST00000165031.1
Gtf2h1

general transcription factor II H, polypeptide 1

chr17_+_48932368 0.389 ENSMUST00000046254.2
Lrfn2
leucine rich repeat and fibronectin type III domain containing 2
chr16_-_56024628 0.375 ENSMUST00000119981.1
ENSMUST00000096021.3
Pcnp

PEST proteolytic signal containing nuclear protein

chr10_+_86705811 0.357 ENSMUST00000061458.7
ENSMUST00000075632.6
BC030307

cDNA sequence BC030307

chrX_+_142681398 0.351 ENSMUST00000112889.1
ENSMUST00000101198.2
ENSMUST00000112891.1
ENSMUST00000087333.2
Tmem164



transmembrane protein 164



chr9_-_69760924 0.341 ENSMUST00000071281.4
Foxb1
forkhead box B1
chr13_-_96542479 0.327 ENSMUST00000022172.4
Polk
polymerase (DNA directed), kappa
chr5_-_24601961 0.322 ENSMUST00000030791.7
Smarcd3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chrX_+_152016428 0.297 ENSMUST00000045312.5
Smc1a
structural maintenance of chromosomes 1A
chr16_+_19028232 0.293 ENSMUST00000074116.4
Gm10088
predicted gene 10088
chr11_+_95414078 0.290 ENSMUST00000107724.2
ENSMUST00000150884.1
ENSMUST00000107722.1
ENSMUST00000127713.1
Spop



speckle-type POZ protein



chrX_+_163908982 0.279 ENSMUST00000069041.8
Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr3_-_19311269 0.269 ENSMUST00000099195.3
Pde7a
phosphodiesterase 7A
chr12_+_78861693 0.256 ENSMUST00000071230.7
Eif2s1
eukaryotic translation initiation factor 2, subunit 1 alpha
chr3_-_103791075 0.255 ENSMUST00000106845.2
ENSMUST00000029438.8
ENSMUST00000121324.1
Hipk1


homeodomain interacting protein kinase 1


chr19_+_21272276 0.239 ENSMUST00000025659.4
Zfand5
zinc finger, AN1-type domain 5
chr6_-_28261907 0.227 ENSMUST00000115320.1
ENSMUST00000123098.1
ENSMUST00000115321.2
ENSMUST00000155494.1
Zfp800



zinc finger protein 800



chr7_-_132813715 0.188 ENSMUST00000134946.1
Fam53b
family with sequence similarity 53, member B
chr7_-_46795881 0.186 ENSMUST00000107653.1
ENSMUST00000107654.1
ENSMUST00000014562.7
ENSMUST00000152759.1
Hps5



Hermansky-Pudlak syndrome 5 homolog (human)



chr16_+_62814676 0.175 ENSMUST00000055557.5
Stx19
syntaxin 19
chr15_+_99670574 0.170 ENSMUST00000023758.7
Asic1
acid-sensing (proton-gated) ion channel 1
chr18_-_36766198 0.135 ENSMUST00000061522.7
Dnd1
dead end homolog 1 (zebrafish)
chr12_+_55598917 0.129 ENSMUST00000051857.3
Insm2
insulinoma-associated 2
chr8_-_31918203 0.128 ENSMUST00000073884.4
Nrg1
neuregulin 1
chr7_+_130577334 0.126 ENSMUST00000059145.7
ENSMUST00000084513.4
Tacc2

transforming, acidic coiled-coil containing protein 2

chrX_+_153006461 0.118 ENSMUST00000095755.3
Usp51
ubiquitin specific protease 51
chr15_+_74516196 0.097 ENSMUST00000042035.9
Bai1
brain-specific angiogenesis inhibitor 1
chr3_-_154328634 0.093 ENSMUST00000167744.1
Lhx8
LIM homeobox protein 8
chrX_+_140956892 0.088 ENSMUST00000112971.1
Atg4a
autophagy related 4A, cysteine peptidase
chr9_+_87015537 0.084 ENSMUST00000058846.4
Ripply2
ripply2 homolog (zebrafish)
chr14_+_45351473 0.067 ENSMUST00000111835.2
Styx
serine/threonine/tyrosine interaction protein
chr13_+_96542727 0.063 ENSMUST00000077672.4
ENSMUST00000109444.2
Col4a3bp

collagen, type IV, alpha 3 (Goodpasture antigen) binding protein

chr7_+_127746775 0.059 ENSMUST00000033081.7
Fbxl19
F-box and leucine-rich repeat protein 19
chr13_+_80886095 0.059 ENSMUST00000161441.1
Arrdc3
arrestin domain containing 3
chr2_+_138278481 0.051 ENSMUST00000075410.4
Btbd3
BTB (POZ) domain containing 3
chr1_+_74236479 0.045 ENSMUST00000113820.2
ENSMUST00000006467.7
ENSMUST00000113819.1
Arpc2


actin related protein 2/3 complex, subunit 2


chr17_+_35135695 0.042 ENSMUST00000174478.1
ENSMUST00000174281.2
ENSMUST00000173550.1
Bag6


BCL2-associated athanogene 6


chr3_+_55461758 0.041 ENSMUST00000070418.4
Dclk1
doublecortin-like kinase 1
chr7_-_46795661 0.035 ENSMUST00000123725.1
Hps5
Hermansky-Pudlak syndrome 5 homolog (human)
chr3_-_103791537 0.020 ENSMUST00000118317.1
Hipk1
homeodomain interacting protein kinase 1
chr18_+_76241580 0.018 ENSMUST00000168423.1
ENSMUST00000091831.6
Smad2

SMAD family member 2

chr14_+_62292475 0.014 ENSMUST00000166879.1
Rnaseh2b
ribonuclease H2, subunit B
chr10_+_4710119 0.007 ENSMUST00000105588.1
ENSMUST00000105589.1
Esr1

estrogen receptor 1 (alpha)


Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 24.4 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
1.7 8.7 GO:0035262 gonad morphogenesis(GO:0035262)
1.4 19.1 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
1.2 6.2 GO:0007386 compartment pattern specification(GO:0007386)
0.9 10.2 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.9 3.5 GO:0051866 general adaptation syndrome(GO:0051866)
0.7 8.8 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.7 1.4 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.6 1.9 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.6 1.8 GO:0032474 otolith morphogenesis(GO:0032474)
0.5 0.9 GO:0036118 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.4 3.7 GO:0071493 cellular response to UV-B(GO:0071493)
0.4 1.2 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.4 1.2 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.4 1.8 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.4 1.1 GO:0001951 intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896)
0.3 1.4 GO:0030091 protein repair(GO:0030091)
0.3 1.0 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.3 0.3 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.3 1.1 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.3 2.8 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.3 1.5 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.2 1.0 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.2 0.7 GO:0003104 positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643)
0.2 0.7 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.2 0.9 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.2 2.2 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.2 0.8 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.2 1.3 GO:1902302 regulation of potassium ion export(GO:1902302)
0.2 1.3 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.2 2.7 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.2 1.5 GO:0030035 microspike assembly(GO:0030035)
0.2 1.3 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.2 1.1 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.1 1.2 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.1 0.4 GO:0048633 positive regulation of skeletal muscle tissue growth(GO:0048633)
0.1 0.4 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.1 0.7 GO:0051189 molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.1 5.3 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 1.6 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.1 1.3 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.1 5.6 GO:0001919 regulation of receptor recycling(GO:0001919)
0.1 1.2 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 2.8 GO:0007340 acrosome reaction(GO:0007340)
0.1 0.9 GO:1900194 receptor guanylyl cyclase signaling pathway(GO:0007168) negative regulation of oocyte maturation(GO:1900194)
0.1 0.8 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 3.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 1.1 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.1 0.5 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.1 0.3 GO:0007412 axon target recognition(GO:0007412)
0.1 0.2 GO:0050915 sensory perception of sour taste(GO:0050915)
0.1 0.6 GO:0046549 retinal cone cell development(GO:0046549)
0.1 3.3 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.1 12.6 GO:0050807 regulation of synapse organization(GO:0050807)
0.1 1.1 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 0.8 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.1 0.9 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 0.8 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 1.0 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.0 0.3 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.0 0.5 GO:0046512 sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520)
0.0 2.7 GO:0030500 regulation of bone mineralization(GO:0030500)
0.0 0.6 GO:0048875 chemical homeostasis within a tissue(GO:0048875)
0.0 0.8 GO:0034453 microtubule anchoring(GO:0034453)
0.0 1.1 GO:0010842 retina layer formation(GO:0010842)
0.0 0.1 GO:0003161 cardiac conduction system development(GO:0003161)
0.0 5.0 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 0.1 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.0 1.4 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 1.1 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.0 GO:0071362 cellular response to ether(GO:0071362)
0.0 0.1 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.4 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 1.0 GO:0060612 adipose tissue development(GO:0060612)
0.0 0.1 GO:0051697 protein delipidation(GO:0051697)
0.0 0.5 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.5 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.2 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.0 1.1 GO:2000177 regulation of neural precursor cell proliferation(GO:2000177)
0.0 0.1 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
0.0 0.2 GO:0048745 smooth muscle tissue development(GO:0048745)
0.0 1.9 GO:0060348 bone development(GO:0060348)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.7 GO:0070557 PCNA-p21 complex(GO:0070557)
0.6 2.3 GO:0031983 vesicle lumen(GO:0031983)
0.5 1.6 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.5 19.1 GO:0032809 neuronal cell body membrane(GO:0032809)
0.4 5.6 GO:0043083 synaptic cleft(GO:0043083)
0.3 10.2 GO:0032839 dendrite cytoplasm(GO:0032839)
0.2 0.9 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.2 1.1 GO:1990357 terminal web(GO:1990357)
0.2 0.5 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.2 1.3 GO:0031415 NatA complex(GO:0031415)
0.2 11.1 GO:0005581 collagen trimer(GO:0005581)
0.1 1.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 21.0 GO:0032993 protein-DNA complex(GO:0032993)
0.1 0.7 GO:0005916 fascia adherens(GO:0005916)
0.1 0.8 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 2.8 GO:0034707 chloride channel complex(GO:0034707)
0.1 0.3 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 0.5 GO:0042629 mast cell granule(GO:0042629)
0.1 0.3 GO:0030893 meiotic cohesin complex(GO:0030893)
0.1 0.2 GO:0031084 BLOC-2 complex(GO:0031084)
0.1 1.3 GO:0001741 XY body(GO:0001741)
0.0 0.4 GO:0000439 core TFIIH complex(GO:0000439)
0.0 1.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.7 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 1.3 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.5 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 2.8 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 3.1 GO:0005814 centriole(GO:0005814)
0.0 1.7 GO:0070469 respiratory chain(GO:0070469)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)
0.0 1.7 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 3.8 GO:0031965 nuclear membrane(GO:0031965)
0.0 1.5 GO:0016605 PML body(GO:0016605)
0.0 0.1 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.8 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.6 GO:0043034 costamere(GO:0043034)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 10.2 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
1.2 3.7 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.8 5.6 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.7 3.4 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.6 1.9 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
0.5 19.1 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.4 1.2 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.3 0.9 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.2 3.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 1.4 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.2 1.1 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.2 0.8 GO:0050436 microfibril binding(GO:0050436)
0.2 1.2 GO:0070728 leucine binding(GO:0070728)
0.2 0.6 GO:0008502 melatonin receptor activity(GO:0008502)
0.2 3.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 1.7 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.2 0.9 GO:0038132 neuregulin binding(GO:0038132)
0.2 0.7 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.2 2.8 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.2 0.9 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.2 6.2 GO:0005112 Notch binding(GO:0005112)
0.2 0.5 GO:0071633 dihydroceramidase activity(GO:0071633)
0.2 1.3 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 0.4 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.1 1.6 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 1.8 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 0.3 GO:0036033 mediator complex binding(GO:0036033)
0.1 1.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 1.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 1.1 GO:1990226 histone methyltransferase binding(GO:1990226)
0.1 0.7 GO:0016783 sulfurtransferase activity(GO:0016783)
0.1 0.8 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.1 18.1 GO:0001047 core promoter binding(GO:0001047)
0.1 1.9 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 1.0 GO:0070410 co-SMAD binding(GO:0070410)
0.1 0.5 GO:0046790 virion binding(GO:0046790)
0.1 0.6 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 1.0 GO:0008483 transaminase activity(GO:0008483)
0.0 0.9 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.8 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 1.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 1.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.8 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 1.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 5.2 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.5 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 3.1 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.4 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 1.1 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 2.6 GO:0051015 actin filament binding(GO:0051015)
0.0 0.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 1.1 GO:0019905 syntaxin binding(GO:0019905)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.7 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 3.5 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 11.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.1 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 1.6 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 5.9 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 2.0 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 0.5 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 1.2 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.5 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.5 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.8 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 0.2 PID_FOXO_PATHWAY FoxO family signaling
0.0 1.9 PID_PLK1_PATHWAY PLK1 signaling events
0.0 3.0 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.1 PID_ATR_PATHWAY ATR signaling pathway
0.0 1.2 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.1 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.4 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.8 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.3 PID_ATM_PATHWAY ATM pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 10.2 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.3 1.1 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.2 3.5 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.2 6.2 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 3.7 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 18.0 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 1.8 REACTOME_SIGNALING_BY_EGFR_IN_CANCER Genes involved in Signaling by EGFR in Cancer
0.1 0.9 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 1.0 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 2.2 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 0.5 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 1.9 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.1 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 1.2 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.5 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 1.4 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.4 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 2.2 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.8 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 1.0 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.5 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 0.8 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.5 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 0.4 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.8 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.3 REACTOME_PERK_REGULATED_GENE_EXPRESSION Genes involved in PERK regulated gene expression
0.0 0.2 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling