Motif ID: Tbx21

Z-value: 1.021


Transcription factors associated with Tbx21:

Gene SymbolEntrez IDGene Name
Tbx21 ENSMUSG00000001444.2 Tbx21



Activity profile for motif Tbx21.

activity profile for motif Tbx21


Sorted Z-values histogram for motif Tbx21

Sorted Z-values for motif Tbx21



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx21

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_56969864 8.888 ENSMUST00000177424.1
Satb2
special AT-rich sequence binding protein 2
chr1_-_56969827 8.725 ENSMUST00000176759.1
Satb2
special AT-rich sequence binding protein 2
chr9_-_112185726 8.669 ENSMUST00000160240.1
ENSMUST00000162065.1
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr18_+_67088287 7.539 ENSMUST00000025402.7
Gnal
guanine nucleotide binding protein, alpha stimulating, olfactory type
chr9_-_112185939 7.199 ENSMUST00000070218.5
Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr19_+_12460749 4.566 ENSMUST00000081035.7
Mpeg1
macrophage expressed gene 1
chr7_+_45785331 4.196 ENSMUST00000120005.1
ENSMUST00000123585.1
Lmtk3

lemur tyrosine kinase 3

chr10_-_13868932 4.153 ENSMUST00000019942.5
ENSMUST00000162610.1
Aig1

androgen-induced 1

chr10_-_13868779 3.918 ENSMUST00000105534.3
Aig1
androgen-induced 1
chr18_+_37020097 3.701 ENSMUST00000047614.1
Pcdha2
protocadherin alpha 2
chr8_-_68735058 3.272 ENSMUST00000136060.1
ENSMUST00000130214.1
ENSMUST00000078350.6
Csgalnact1


chondroitin sulfate N-acetylgalactosaminyltransferase 1


chr11_-_74590186 3.239 ENSMUST00000102521.1
Rap1gap2
RAP1 GTPase activating protein 2
chr7_-_4789541 3.208 ENSMUST00000168578.1
Tmem238
transmembrane protein 238
chr11_-_74590065 3.192 ENSMUST00000145524.1
ENSMUST00000047488.7
Rap1gap2

RAP1 GTPase activating protein 2

chrX_-_152769461 3.173 ENSMUST00000101141.2
ENSMUST00000062317.4
Shroom2

shroom family member 2

chr6_-_50261743 2.999 ENSMUST00000101405.3
ENSMUST00000165099.1
ENSMUST00000170142.1
Dfna5


deafness, autosomal dominant 5 (human)


chr9_-_106656081 2.897 ENSMUST00000023959.7
Grm2
glutamate receptor, metabotropic 2
chr16_+_8470763 2.802 ENSMUST00000046470.9
ENSMUST00000150790.1
ENSMUST00000142899.1
Mettl22


methyltransferase like 22


chr12_-_70227622 2.712 ENSMUST00000071250.6
Pygl
liver glycogen phosphorylase
chrX_+_170009659 2.694 ENSMUST00000179760.1
Gm21887
predicted gene, 21887
chr1_+_34801704 2.686 ENSMUST00000047664.9
Arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
chr19_+_34192229 2.527 ENSMUST00000054956.8
Stambpl1
STAM binding protein like 1
chr3_-_127499095 2.447 ENSMUST00000182594.1
Ank2
ankyrin 2, brain
chr10_-_75560330 2.382 ENSMUST00000051129.9
Fam211b
family with sequence similarity 211, member B
chr8_+_40423786 2.360 ENSMUST00000049389.4
ENSMUST00000128166.1
ENSMUST00000167766.1
Zdhhc2


zinc finger, DHHC domain containing 2


chr6_+_36388055 2.155 ENSMUST00000172278.1
Chrm2
cholinergic receptor, muscarinic 2, cardiac
chr11_-_65162904 2.141 ENSMUST00000093002.5
ENSMUST00000047463.8
Arhgap44

Rho GTPase activating protein 44

chr8_+_25849618 2.064 ENSMUST00000098858.3
Kcnu1
potassium channel, subfamily U, member 1
chr6_+_83101565 1.945 ENSMUST00000101254.3
Ccdc142
coiled-coil domain containing 142
chr3_-_89322883 1.904 ENSMUST00000029673.5
Efna3
ephrin A3
chr2_-_51934644 1.887 ENSMUST00000165313.1
Rbm43
RNA binding motif protein 43
chr16_+_75592844 1.848 ENSMUST00000114249.1
ENSMUST00000046378.7
ENSMUST00000114253.1
Rbm11


RNA binding motif protein 11


chr11_+_70451905 1.839 ENSMUST00000151013.1
ENSMUST00000019067.7
Med11

mediator of RNA polymerase II transcription, subunit 11 homolog (S. cerevisiae)

chr17_-_27029009 1.753 ENSMUST00000078691.5
Bak1
BCL2-antagonist/killer 1
chr11_-_120643643 1.744 ENSMUST00000141254.1
ENSMUST00000170556.1
ENSMUST00000151876.1
ENSMUST00000026133.8
ENSMUST00000139706.1
Pycr1




pyrroline-5-carboxylate reductase 1




chr12_-_70231414 1.732 ENSMUST00000161083.1
Pygl
liver glycogen phosphorylase
chrX_-_136868537 1.728 ENSMUST00000058814.6
Rab9b
RAB9B, member RAS oncogene family
chr19_+_44989073 1.700 ENSMUST00000026225.8
Sema4g
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr7_-_126704816 1.682 ENSMUST00000032949.7
Coro1a
coronin, actin binding protein 1A
chr11_+_103171081 1.662 ENSMUST00000042286.5
Fmnl1
formin-like 1
chr13_-_100108337 1.618 ENSMUST00000180822.1
BC001981
cDNA sequence BC001981
chr15_-_84105662 1.611 ENSMUST00000082365.5
Sult4a1
sulfotransferase family 4A, member 1
chr2_+_28641227 1.603 ENSMUST00000028155.5
ENSMUST00000113869.1
ENSMUST00000113867.2
Tsc1


tuberous sclerosis 1


chr16_-_4003750 1.598 ENSMUST00000171658.1
ENSMUST00000171762.1
Slx4

SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)

chr13_+_56609516 1.588 ENSMUST00000045173.8
Tgfbi
transforming growth factor, beta induced
chr1_+_60409612 1.566 ENSMUST00000052332.8
Abi2
abl-interactor 2
chr2_+_84678396 1.553 ENSMUST00000102645.3
Med19
mediator of RNA polymerase II transcription, subunit 19 homolog (yeast)
chr11_+_22971991 1.434 ENSMUST00000049506.5
Zrsr1
zinc finger (CCCH type), RNA binding motif and serine/arginine rich 1
chr1_-_97661668 1.431 ENSMUST00000153115.1
ENSMUST00000142234.1
D1Ertd622e

DNA segment, Chr 1, ERATO Doi 622, expressed

chr6_-_38124568 1.425 ENSMUST00000040259.4
Atp6v0a4
ATPase, H+ transporting, lysosomal V0 subunit A4
chr6_-_50261943 1.425 ENSMUST00000167893.1
Dfna5
deafness, autosomal dominant 5 (human)
chrX_+_74297097 1.399 ENSMUST00000019231.5
ENSMUST00000147900.1
ENSMUST00000147275.1
ENSMUST00000114171.3
Atp6ap1



ATPase, H+ transporting, lysosomal accessory protein 1



chr5_-_36582381 1.341 ENSMUST00000141043.1
ENSMUST00000031094.8
Tbc1d14

TBC1 domain family, member 14

chr11_+_24080664 1.324 ENSMUST00000118955.1
Bcl11a
B cell CLL/lymphoma 11A (zinc finger protein)
chr13_+_104178797 1.275 ENSMUST00000022225.5
ENSMUST00000069187.5
Trim23

tripartite motif-containing 23

chr17_-_24527830 1.243 ENSMUST00000176353.1
ENSMUST00000176237.1
Traf7

TNF receptor-associated factor 7

chr1_+_153652943 1.224 ENSMUST00000041776.5
Rgs8
regulator of G-protein signaling 8
chr1_+_183388981 1.210 ENSMUST00000097043.5
Taf1a
TATA box binding protein (Tbp)-associated factor, RNA polymerase I, A
chr14_-_54517353 1.209 ENSMUST00000023873.5
Prmt5
protein arginine N-methyltransferase 5
chr1_+_59912972 1.163 ENSMUST00000036540.5
Fam117b
family with sequence similarity 117, member B
chr7_-_29954049 1.143 ENSMUST00000108211.1
ENSMUST00000108205.1
Zfp74

zinc finger protein 74

chr5_-_24730635 1.128 ENSMUST00000068693.5
Wdr86
WD repeat domain 86
chr17_-_24527925 1.075 ENSMUST00000176652.1
Traf7
TNF receptor-associated factor 7
chr7_+_18884679 1.056 ENSMUST00000032573.6
Pglyrp1
peptidoglycan recognition protein 1
chr4_-_155669171 1.031 ENSMUST00000103176.3
Mib2
mindbomb homolog 2 (Drosophila)
chr6_-_60829826 1.011 ENSMUST00000163779.1
Snca
synuclein, alpha
chr1_-_179546261 1.000 ENSMUST00000027769.5
Tfb2m
transcription factor B2, mitochondrial
chr4_+_155086577 0.994 ENSMUST00000030915.4
ENSMUST00000155775.1
ENSMUST00000127457.1
Morn1


MORN repeat containing 1


chr10_-_39899238 0.981 ENSMUST00000178563.1
AA474331
expressed sequence AA474331
chr9_-_35558522 0.973 ENSMUST00000034612.5
Ddx25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr10_+_7792891 0.913 ENSMUST00000015901.4
Ppil4
peptidylprolyl isomerase (cyclophilin)-like 4
chr17_+_6270475 0.888 ENSMUST00000088940.4
Tmem181a
transmembrane protein 181A
chr14_+_54426902 0.875 ENSMUST00000010550.7
Mrpl52
mitochondrial ribosomal protein L52
chr19_-_5610038 0.860 ENSMUST00000113641.2
Kat5
K(lysine) acetyltransferase 5
chr7_-_126861648 0.811 ENSMUST00000129812.1
ENSMUST00000106342.1
Ino80e

INO80 complex subunit E

chr2_+_164823001 0.798 ENSMUST00000132282.1
Zswim1
zinc finger SWIM-type containing 1
chr9_-_86546795 0.730 ENSMUST00000167814.1
Gm17530
predicted gene, 17530
chrX_-_95444789 0.684 ENSMUST00000084535.5
Amer1
APC membrane recruitment 1
chr4_+_115563649 0.668 ENSMUST00000141033.1
ENSMUST00000030486.8
ENSMUST00000126645.1
ENSMUST00000030480.3
Cyp4a31



cytochrome P450, family 4, subfamily a, polypeptide 31



chr11_+_88047302 0.635 ENSMUST00000139129.2
Srsf1
serine/arginine-rich splicing factor 1
chr2_+_55411790 0.628 ENSMUST00000155997.1
ENSMUST00000128307.1
Gm14033

predicted gene 14033

chr6_+_94500313 0.616 ENSMUST00000061118.8
Slc25a26
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26
chr7_-_126861828 0.582 ENSMUST00000106343.1
Ino80e
INO80 complex subunit E
chr18_+_37742088 0.563 ENSMUST00000003599.6
Pcdhga9
protocadherin gamma subfamily A, 9
chr2_-_3419066 0.562 ENSMUST00000115082.3
Meig1
meiosis expressed gene 1
chr6_-_113377866 0.546 ENSMUST00000032410.7
Tada3
transcriptional adaptor 3
chr2_-_84678828 0.541 ENSMUST00000111665.1
Tmx2
thioredoxin-related transmembrane protein 2
chr1_+_85100164 0.524 ENSMUST00000097669.1
Gm10553
predicted gene 10553
chr10_+_77978524 0.514 ENSMUST00000105397.3
ENSMUST00000105398.1
1810043G02Rik

RIKEN cDNA 1810043G02 gene

chr7_-_27178835 0.483 ENSMUST00000093040.6
Rab4b
RAB4B, member RAS oncogene family
chrY_-_6681243 0.435 ENSMUST00000115940.1
Gm21719
predicted gene, 21719
chr18_+_9958147 0.432 ENSMUST00000025137.7
Thoc1
THO complex 1
chr8_-_105701077 0.415 ENSMUST00000042608.6
Acd
adrenocortical dysplasia
chrX_-_160138375 0.395 ENSMUST00000033662.8
Pdha1
pyruvate dehydrogenase E1 alpha 1
chr6_-_113377510 0.388 ENSMUST00000099118.2
Tada3
transcriptional adaptor 3
chr8_+_12984246 0.380 ENSMUST00000110873.3
ENSMUST00000173006.1
ENSMUST00000145067.1
Mcf2l


mcf.2 transforming sequence-like


chr1_+_179546303 0.379 ENSMUST00000040706.8
Cnst
consortin, connexin sorting protein
chr7_+_19149722 0.356 ENSMUST00000049294.2
Snrpd2
small nuclear ribonucleoprotein D2
chr1_-_80758536 0.350 ENSMUST00000077946.5
Dock10
dedicator of cytokinesis 10
chr9_+_14860210 0.346 ENSMUST00000034408.5
ENSMUST00000115624.2
Gpr83

G protein-coupled receptor 83

chr13_+_21945084 0.333 ENSMUST00000176511.1
ENSMUST00000102978.1
ENSMUST00000152258.2
Zfp184


zinc finger protein 184 (Kruppel-like)


chr19_-_6128208 0.320 ENSMUST00000025702.7
Snx15
sorting nexin 15
chr4_+_109000770 0.312 ENSMUST00000106644.2
Nrd1
nardilysin, N-arginine dibasic convertase, NRD convertase 1
chr8_+_105701142 0.296 ENSMUST00000098444.2
Pard6a
par-6 (partitioning defective 6,) homolog alpha (C. elegans)
chr5_-_138619653 0.293 ENSMUST00000129832.1
Zfp68
zinc finger protein 68
chr5_-_86676346 0.292 ENSMUST00000038448.6
Tmprss11bnl
transmembrane protease, serine 11b N terminal like
chr7_-_13034722 0.284 ENSMUST00000005711.4
Chmp2a
charged multivesicular body protein 2A
chr5_-_138619751 0.274 ENSMUST00000085852.4
ENSMUST00000110905.2
Zfp68

zinc finger protein 68

chr16_-_20426322 0.274 ENSMUST00000115547.2
ENSMUST00000096199.4
Abcc5

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

chr1_+_74153981 0.268 ENSMUST00000027372.7
ENSMUST00000106899.2
Cxcr2

chemokine (C-X-C motif) receptor 2

chr11_-_118248590 0.256 ENSMUST00000106305.2
Cyth1
cytohesin 1
chr3_-_94436574 0.231 ENSMUST00000029787.4
Oaz3
ornithine decarboxylase antizyme 3
chr10_-_62578387 0.231 ENSMUST00000162525.1
ENSMUST00000159704.1
ENSMUST00000162759.1
ENSMUST00000065887.7
2510003E04Rik



RIKEN cDNA 2510003E04 gene



chr3_+_137918526 0.220 ENSMUST00000168345.1
Lamtor3
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
chr6_+_113378113 0.218 ENSMUST00000171058.1
ENSMUST00000156898.1
Arpc4

actin related protein 2/3 complex, subunit 4

chr6_-_113377712 0.186 ENSMUST00000113107.1
ENSMUST00000113106.1
Tada3

transcriptional adaptor 3

chr3_-_89402650 0.173 ENSMUST00000168325.1
ENSMUST00000057431.5
Lenep

lens epithelial protein

chrX_+_99821021 0.150 ENSMUST00000096363.2
Tmem28
transmembrane protein 28
chr2_+_30364227 0.149 ENSMUST00000077977.7
ENSMUST00000140075.2
Fam73b

family with sequence similarity 73, member B

chr6_-_142964404 0.148 ENSMUST00000032421.3
St8sia1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr17_+_30485511 0.144 ENSMUST00000064223.1
Gm9874
predicted gene 9874
chr13_+_54789500 0.134 ENSMUST00000163915.1
ENSMUST00000099503.3
ENSMUST00000171859.1
Tspan17


tetraspanin 17


chr19_-_44555398 0.128 ENSMUST00000167027.1
ENSMUST00000171415.1
ENSMUST00000026222.4
Ndufb8


NADH dehydrogenase (ubiquinone) 1 beta subcomplex 8


chr2_-_121442574 0.124 ENSMUST00000116432.1
Ell3
elongation factor RNA polymerase II-like 3
chr3_+_106684943 0.122 ENSMUST00000098751.3
Lrif1
ligand dependent nuclear receptor interacting factor 1
chr10_+_80292453 0.122 ENSMUST00000068408.7
ENSMUST00000062674.6
Rps15

ribosomal protein S15

chr8_-_92356103 0.119 ENSMUST00000034183.3
4933436C20Rik
RIKEN cDNA 4933436C20 gene
chr8_-_13974715 0.117 ENSMUST00000119182.1
ENSMUST00000062613.4
Tdrp

testis development related protein

chr5_-_120777628 0.112 ENSMUST00000044833.8
Oas3
2'-5' oligoadenylate synthetase 3
chrY_-_17937330 0.107 ENSMUST00000179900.1
Srsy
serine-rich, secreted, Y-linked
chr11_-_45955465 0.098 ENSMUST00000011398.6
Thg1l
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr16_+_32099781 0.087 ENSMUST00000115168.2
Cep19
centrosomal protein 19
chr13_-_74807913 0.085 ENSMUST00000065629.4
Cast
calpastatin
chr2_-_37703845 0.079 ENSMUST00000155237.1
Strbp
spermatid perinuclear RNA binding protein
chr17_-_33713372 0.074 ENSMUST00000173392.1
March2
membrane-associated ring finger (C3HC4) 2
chr17_-_56074542 0.063 ENSMUST00000139371.1
Ubxn6
UBX domain protein 6
chr2_-_66440753 0.062 ENSMUST00000112371.2
ENSMUST00000138910.1
Scn1a

sodium channel, voltage-gated, type I, alpha

chr16_-_20425881 0.052 ENSMUST00000077867.3
Abcc5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr5_-_138619702 0.042 ENSMUST00000063262.4
Zfp68
zinc finger protein 68
chr12_+_73286779 0.040 ENSMUST00000140523.1
Slc38a6
solute carrier family 38, member 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 8.4 GO:0009405 pathogenesis(GO:0009405)
1.1 4.4 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
1.1 17.6 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.8 3.3 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.7 2.1 GO:0098886 modification of dendritic spine(GO:0098886)
0.6 1.8 GO:0010248 B cell negative selection(GO:0002352) establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.5 1.6 GO:0043379 rRNA export from nucleus(GO:0006407) memory T cell differentiation(GO:0043379) response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.5 1.6 GO:1904431 positive regulation of t-circle formation(GO:1904431)
0.5 1.4 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.4 2.2 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.4 1.9 GO:1905247 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.4 1.1 GO:0051715 cytolysis in other organism(GO:0051715)
0.3 1.3 GO:1903860 negative regulation of dendrite extension(GO:1903860) regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800)
0.3 16.0 GO:0034605 cellular response to heat(GO:0034605)
0.3 3.5 GO:0045217 cell-cell junction maintenance(GO:0045217)
0.3 1.7 GO:0032796 uropod organization(GO:0032796)
0.3 2.4 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.3 1.0 GO:0010040 response to iron(II) ion(GO:0010040) positive regulation of hydrogen peroxide metabolic process(GO:0010726) negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) regulation of peroxidase activity(GO:2000468)
0.2 1.2 GO:0060161 histone H4-R3 methylation(GO:0043985) positive regulation of dopamine receptor signaling pathway(GO:0060161)
0.2 1.3 GO:0071955 recycling endosome to Golgi transport(GO:0071955)
0.2 1.7 GO:0051014 actin filament severing(GO:0051014)
0.2 2.3 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.2 1.6 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.2 1.1 GO:0006561 proline biosynthetic process(GO:0006561)
0.2 1.4 GO:0010764 negative regulation of fibroblast migration(GO:0010764) negative regulation of cytokine production involved in inflammatory response(GO:1900016)
0.2 1.4 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.4 GO:0045829 negative regulation of isotype switching(GO:0045829)
0.1 0.4 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.1 1.2 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.1 0.4 GO:0090004 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.1 1.0 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 1.1 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.1 0.6 GO:0051182 coenzyme transport(GO:0051182)
0.1 0.7 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.1 0.3 GO:1903722 regulation of centriole elongation(GO:1903722)
0.1 2.4 GO:0018345 protein palmitoylation(GO:0018345)
0.1 0.6 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 2.9 GO:0014047 glutamate secretion(GO:0014047)
0.1 0.3 GO:0033030 negative regulation of neutrophil apoptotic process(GO:0033030)
0.1 0.2 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.1 4.4 GO:0060113 inner ear receptor cell differentiation(GO:0060113)
0.1 0.4 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.1 4.2 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.9 GO:0032703 negative regulation of interleukin-2 production(GO:0032703)
0.0 1.3 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.3 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 2.7 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.9 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 1.8 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 6.4 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.0 0.1 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 0.1 GO:0042795 snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 1.7 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 1.2 GO:0006360 transcription from RNA polymerase I promoter(GO:0006360)
0.0 0.3 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.1 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.4 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 1.0 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 0.1 GO:0060700 regulation of ribonuclease activity(GO:0060700)
0.0 0.1 GO:0007343 egg activation(GO:0007343)
0.0 2.1 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.0 0.4 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.3 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.3 1.6 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.3 1.0 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.2 1.2 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.2 3.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.2 1.4 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.2 0.9 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.2 17.6 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 1.8 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.2 1.4 GO:0089701 U2AF(GO:0089701)
0.2 7.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 1.6 GO:0034709 methylosome(GO:0034709)
0.2 1.4 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.2 1.7 GO:0032426 stereocilium tip(GO:0032426)
0.1 1.0 GO:0033391 chromatoid body(GO:0033391)
0.1 1.6 GO:0031209 SCAR complex(GO:0031209)
0.1 2.4 GO:0031430 M band(GO:0031430)
0.1 3.4 GO:0016592 mediator complex(GO:0016592)
0.1 1.1 GO:0000124 SAGA complex(GO:0000124)
0.1 3.4 GO:0045335 phagocytic vesicle(GO:0045335)
0.1 2.4 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 3.2 GO:0031941 filamentous actin(GO:0031941)
0.1 0.4 GO:0070187 telosome(GO:0070187)
0.1 0.4 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 2.1 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.4 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 2.9 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.2 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.3 GO:0042629 mast cell granule(GO:0042629)
0.0 1.4 GO:0035869 ciliary transition zone(GO:0035869)
0.0 1.2 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.0 2.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.6 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 1.0 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.5 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 1.6 GO:0005604 basement membrane(GO:0005604)
0.0 1.8 GO:0055037 recycling endosome(GO:0055037)
0.0 1.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.9 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.3 GO:0034451 centriolar satellite(GO:0034451)
0.0 3.3 GO:0000151 ubiquitin ligase complex(GO:0000151)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.4 GO:0032052 bile acid binding(GO:0032052)
0.8 3.3 GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237) glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.7 2.1 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.6 2.9 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.4 2.2 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.3 1.6 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.3 1.2 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.3 7.5 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.3 1.1 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.3 1.1 GO:0042834 peptidoglycan binding(GO:0042834)
0.3 1.0 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.2 0.7 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.2 1.0 GO:0050544 arachidonic acid binding(GO:0050544)
0.2 3.3 GO:0032794 GTPase activating protein binding(GO:0032794)
0.2 1.7 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 2.8 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 1.6 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 0.6 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.1 1.4 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.1 0.5 GO:0051185 coenzyme transporter activity(GO:0051185)
0.1 0.3 GO:0016494 C-X-C chemokine receptor activity(GO:0016494) C-X-C chemokine binding(GO:0019958)
0.1 2.7 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 2.4 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 0.4 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.1 1.8 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 15.9 GO:0005516 calmodulin binding(GO:0005516)
0.1 0.9 GO:0015643 toxic substance binding(GO:0015643)
0.1 2.4 GO:0030507 spectrin binding(GO:0030507)
0.1 0.2 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.1 0.3 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.1 0.4 GO:0071253 connexin binding(GO:0071253)
0.0 0.1 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 3.0 GO:0019003 GDP binding(GO:0019003)
0.0 0.9 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.4 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 2.1 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 1.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 3.9 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.1 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.0 1.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 1.1 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 3.4 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 4.5 GO:0031072 heat shock protein binding(GO:0031072)
0.0 0.9 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 1.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 6.9 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.3 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.4 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 11.9 GO:0003682 chromatin binding(GO:0003682)
0.0 0.6 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 1.9 GO:0008237 metallopeptidase activity(GO:0008237)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.5 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 1.5 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 1.8 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 1.9 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.0 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.9 PID_MYC_PATHWAY C-MYC pathway
0.0 1.8 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 1.6 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.7 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.2 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 1.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.3 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 7.5 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.2 1.6 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.2 2.9 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 4.4 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.2 6.4 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.2 2.2 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.2 3.3 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 1.6 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 0.4 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 1.7 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.4 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 2.6 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 1.2 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 1.8 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 3.4 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 2.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 0.4 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 1.6 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.0 1.0 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.3 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 1.0 REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
0.0 0.6 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.3 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.5 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 0.3 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)