Motif ID: Tbx5
Z-value: 0.795
Transcription factors associated with Tbx5:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Tbx5 | ENSMUSG00000018263.8 | Tbx5 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tbx5 | mm10_v2_chr5_+_119834663_119834663 | 0.11 | 5.0e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 6.9 | GO:0035022 | positive regulation of Rac protein signal transduction(GO:0035022) |
| 1.1 | 5.5 | GO:0035262 | gonad morphogenesis(GO:0035262) |
| 0.9 | 2.6 | GO:0003349 | epicardium-derived cardiac endothelial cell differentiation(GO:0003349) |
| 0.8 | 3.4 | GO:0007228 | positive regulation of hh target transcription factor activity(GO:0007228) |
| 0.8 | 3.1 | GO:1900224 | positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224) |
| 0.6 | 3.2 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 0.6 | 1.9 | GO:0034184 | positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184) |
| 0.6 | 2.2 | GO:0061386 | closure of optic fissure(GO:0061386) |
| 0.5 | 2.7 | GO:0035426 | extracellular matrix-cell signaling(GO:0035426) |
| 0.5 | 2.1 | GO:1903764 | regulation of potassium ion export across plasma membrane(GO:1903764) |
| 0.5 | 1.5 | GO:0030200 | heparan sulfate proteoglycan catabolic process(GO:0030200) |
| 0.5 | 1.5 | GO:0001951 | intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896) |
| 0.5 | 3.2 | GO:0031508 | pericentric heterochromatin assembly(GO:0031508) |
| 0.4 | 1.5 | GO:0030091 | protein repair(GO:0030091) |
| 0.4 | 1.1 | GO:0006428 | isoleucyl-tRNA aminoacylation(GO:0006428) |
| 0.3 | 1.0 | GO:0070634 | transepithelial ammonium transport(GO:0070634) |
| 0.3 | 2.9 | GO:0010587 | miRNA catabolic process(GO:0010587) |
| 0.3 | 0.9 | GO:0070093 | negative regulation of glucagon secretion(GO:0070093) |
| 0.3 | 0.9 | GO:1902302 | regulation of potassium ion export(GO:1902302) |
| 0.3 | 3.2 | GO:0060272 | embryonic skeletal joint morphogenesis(GO:0060272) |
| 0.2 | 1.0 | GO:0035624 | receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625) |
| 0.2 | 1.9 | GO:0043951 | negative regulation of cAMP-mediated signaling(GO:0043951) |
| 0.2 | 1.1 | GO:0010025 | wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166) |
| 0.2 | 1.5 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.2 | 0.6 | GO:2000373 | regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373) |
| 0.2 | 1.1 | GO:0060024 | rhythmic synaptic transmission(GO:0060024) |
| 0.2 | 0.7 | GO:0009957 | epidermal cell fate specification(GO:0009957) |
| 0.2 | 1.6 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.2 | 1.6 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.1 | 0.4 | GO:0033364 | mast cell secretory granule organization(GO:0033364) |
| 0.1 | 1.2 | GO:0008635 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635) |
| 0.1 | 0.6 | GO:1902608 | regulation of large conductance calcium-activated potassium channel activity(GO:1902606) positive regulation of large conductance calcium-activated potassium channel activity(GO:1902608) |
| 0.1 | 0.6 | GO:0003192 | mitral valve formation(GO:0003192) cell migration involved in endocardial cushion formation(GO:0003273) condensed mesenchymal cell proliferation(GO:0072137) |
| 0.1 | 0.4 | GO:0021852 | pyramidal neuron migration(GO:0021852) |
| 0.1 | 1.1 | GO:0045900 | negative regulation of translational elongation(GO:0045900) |
| 0.1 | 1.6 | GO:0045602 | negative regulation of endothelial cell differentiation(GO:0045602) |
| 0.1 | 0.8 | GO:1904491 | protein localization to ciliary transition zone(GO:1904491) |
| 0.1 | 1.4 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
| 0.1 | 0.2 | GO:0097360 | chorionic trophoblast cell proliferation(GO:0097360) regulation of chorionic trophoblast cell proliferation(GO:1901382) |
| 0.1 | 0.4 | GO:1904154 | positive regulation of retrograde protein transport, ER to cytosol(GO:1904154) |
| 0.1 | 1.2 | GO:1904152 | negative regulation of protein exit from endoplasmic reticulum(GO:0070862) regulation of retrograde protein transport, ER to cytosol(GO:1904152) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153) |
| 0.1 | 0.2 | GO:0090327 | negative regulation of locomotion involved in locomotory behavior(GO:0090327) |
| 0.1 | 0.3 | GO:0006106 | fumarate metabolic process(GO:0006106) aspartate biosynthetic process(GO:0006532) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401) |
| 0.1 | 1.1 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 0.1 | 2.2 | GO:0007340 | acrosome reaction(GO:0007340) |
| 0.1 | 0.6 | GO:1903012 | positive regulation of bone development(GO:1903012) |
| 0.1 | 2.0 | GO:0048240 | sperm capacitation(GO:0048240) |
| 0.1 | 2.1 | GO:0035036 | binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) |
| 0.1 | 1.4 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 0.1 | 0.3 | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
| 0.1 | 0.6 | GO:0010747 | positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) |
| 0.1 | 2.2 | GO:0046596 | regulation of viral entry into host cell(GO:0046596) |
| 0.1 | 0.2 | GO:0002339 | B cell selection(GO:0002339) |
| 0.1 | 1.1 | GO:0006857 | oligopeptide transport(GO:0006857) |
| 0.1 | 0.3 | GO:0035526 | retrograde transport, plasma membrane to Golgi(GO:0035526) |
| 0.1 | 0.2 | GO:0023016 | signal transduction by trans-phosphorylation(GO:0023016) |
| 0.1 | 0.7 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.1 | 0.9 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
| 0.1 | 0.8 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) |
| 0.1 | 1.2 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.1 | 2.4 | GO:0060236 | regulation of mitotic spindle organization(GO:0060236) |
| 0.1 | 0.5 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.1 | 0.6 | GO:0031424 | keratinization(GO:0031424) |
| 0.1 | 0.2 | GO:0097278 | complement-dependent cytotoxicity(GO:0097278) |
| 0.1 | 0.4 | GO:1901029 | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029) |
| 0.1 | 1.0 | GO:0010457 | centriole-centriole cohesion(GO:0010457) |
| 0.1 | 0.2 | GO:0009174 | UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049) |
| 0.1 | 1.3 | GO:0042711 | maternal behavior(GO:0042711) |
| 0.1 | 0.9 | GO:0007288 | sperm axoneme assembly(GO:0007288) |
| 0.1 | 0.1 | GO:0044333 | Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) |
| 0.1 | 0.3 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
| 0.1 | 0.7 | GO:0071318 | cellular response to ATP(GO:0071318) |
| 0.1 | 0.7 | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148) |
| 0.1 | 1.2 | GO:0045672 | positive regulation of osteoclast differentiation(GO:0045672) |
| 0.1 | 0.3 | GO:0048133 | germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728) |
| 0.1 | 2.1 | GO:0042149 | cellular response to glucose starvation(GO:0042149) |
| 0.1 | 0.4 | GO:0032286 | central nervous system myelin maintenance(GO:0032286) |
| 0.1 | 1.2 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
| 0.0 | 1.4 | GO:0006471 | protein ADP-ribosylation(GO:0006471) |
| 0.0 | 0.2 | GO:0097343 | ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026) |
| 0.0 | 0.2 | GO:0097167 | circadian regulation of translation(GO:0097167) |
| 0.0 | 0.1 | GO:0060385 | axonogenesis involved in innervation(GO:0060385) |
| 0.0 | 1.5 | GO:0032292 | myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292) |
| 0.0 | 0.8 | GO:0016973 | poly(A)+ mRNA export from nucleus(GO:0016973) |
| 0.0 | 1.0 | GO:0060009 | Sertoli cell development(GO:0060009) |
| 0.0 | 0.3 | GO:0051152 | positive regulation of smooth muscle cell differentiation(GO:0051152) |
| 0.0 | 0.2 | GO:0030214 | hyaluronan catabolic process(GO:0030214) |
| 0.0 | 1.6 | GO:0009409 | response to cold(GO:0009409) |
| 0.0 | 0.8 | GO:0042119 | neutrophil activation(GO:0042119) |
| 0.0 | 0.6 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
| 0.0 | 0.5 | GO:0097067 | cellular response to thyroid hormone stimulus(GO:0097067) |
| 0.0 | 0.5 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
| 0.0 | 0.6 | GO:0007130 | synaptonemal complex assembly(GO:0007130) |
| 0.0 | 0.1 | GO:0042138 | meiotic DNA double-strand break formation(GO:0042138) |
| 0.0 | 0.5 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
| 0.0 | 0.3 | GO:0035095 | behavioral response to nicotine(GO:0035095) |
| 0.0 | 0.2 | GO:0006551 | leucine metabolic process(GO:0006551) |
| 0.0 | 1.7 | GO:0032465 | regulation of cytokinesis(GO:0032465) |
| 0.0 | 0.8 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.0 | 0.1 | GO:0034473 | U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) nuclear polyadenylation-dependent mRNA catabolic process(GO:0071042) polyadenylation-dependent mRNA catabolic process(GO:0071047) |
| 0.0 | 0.7 | GO:0051457 | maintenance of protein location in nucleus(GO:0051457) |
| 0.0 | 1.1 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.0 | 1.2 | GO:0030517 | negative regulation of axon extension(GO:0030517) |
| 0.0 | 0.2 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
| 0.0 | 0.2 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.0 | 0.3 | GO:0019368 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.0 | 0.1 | GO:0051890 | regulation of cardioblast differentiation(GO:0051890) |
| 0.0 | 1.3 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.0 | 0.2 | GO:0002517 | T cell tolerance induction(GO:0002517) regulation of T cell tolerance induction(GO:0002664) |
| 0.0 | 1.0 | GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774) |
| 0.0 | 0.1 | GO:0031507 | heterochromatin assembly(GO:0031507) |
| 0.0 | 0.4 | GO:2000637 | positive regulation of gene silencing by miRNA(GO:2000637) |
| 0.0 | 0.1 | GO:0046600 | negative regulation of centriole replication(GO:0046600) |
| 0.0 | 0.7 | GO:0007638 | mechanosensory behavior(GO:0007638) |
| 0.0 | 0.1 | GO:1902951 | negative regulation of dendritic spine maintenance(GO:1902951) |
| 0.0 | 0.1 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.0 | 0.7 | GO:0045670 | regulation of osteoclast differentiation(GO:0045670) |
| 0.0 | 1.5 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.0 | 0.3 | GO:0001916 | positive regulation of T cell mediated cytotoxicity(GO:0001916) |
| 0.0 | 0.2 | GO:0006691 | leukotriene metabolic process(GO:0006691) |
| 0.0 | 0.1 | GO:0001575 | globoside metabolic process(GO:0001575) |
| 0.0 | 0.7 | GO:0015909 | long-chain fatty acid transport(GO:0015909) |
| 0.0 | 0.5 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.0 | 0.4 | GO:0095500 | acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145) |
| 0.0 | 0.4 | GO:0051897 | positive regulation of protein kinase B signaling(GO:0051897) |
| 0.0 | 0.5 | GO:0033119 | negative regulation of RNA splicing(GO:0033119) |
| 0.0 | 0.1 | GO:0098974 | postsynaptic actin cytoskeleton organization(GO:0098974) |
| 0.0 | 0.2 | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process(GO:0010667) |
| 0.0 | 1.6 | GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway(GO:2001243) |
| 0.0 | 0.6 | GO:0051567 | histone H3-K9 methylation(GO:0051567) |
| 0.0 | 1.8 | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) |
| 0.0 | 1.3 | GO:0051028 | mRNA transport(GO:0051028) |
| 0.0 | 0.2 | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552) |
| 0.0 | 0.3 | GO:0032958 | inositol phosphate biosynthetic process(GO:0032958) |
| 0.0 | 0.4 | GO:0010259 | multicellular organism aging(GO:0010259) |
| 0.0 | 0.4 | GO:0070534 | protein K63-linked ubiquitination(GO:0070534) |
| 0.0 | 0.4 | GO:0051647 | nucleus localization(GO:0051647) |
| 0.0 | 0.5 | GO:0046513 | ceramide biosynthetic process(GO:0046513) |
| 0.0 | 0.3 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 1.9 | GO:0035061 | interchromatin granule(GO:0035061) |
| 0.4 | 1.4 | GO:0031983 | vesicle lumen(GO:0031983) |
| 0.3 | 1.0 | GO:0098592 | cytoplasmic side of apical plasma membrane(GO:0098592) |
| 0.3 | 1.5 | GO:1990357 | terminal web(GO:1990357) |
| 0.3 | 1.2 | GO:0043293 | apoptosome(GO:0043293) |
| 0.3 | 2.3 | GO:0002177 | manchette(GO:0002177) |
| 0.2 | 1.7 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.2 | 0.9 | GO:1902937 | inward rectifier potassium channel complex(GO:1902937) |
| 0.2 | 2.3 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.2 | 5.7 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.1 | 1.6 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.1 | 0.6 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.1 | 3.0 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.1 | 1.7 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 0.1 | 0.5 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.1 | 0.2 | GO:0048179 | activin receptor complex(GO:0048179) |
| 0.1 | 0.9 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.1 | 2.6 | GO:0090544 | BAF-type complex(GO:0090544) |
| 0.1 | 0.4 | GO:0030915 | Smc5-Smc6 complex(GO:0030915) |
| 0.1 | 4.7 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.1 | 0.4 | GO:0071817 | MMXD complex(GO:0071817) |
| 0.1 | 0.6 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.1 | 1.1 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.1 | 0.6 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.1 | 0.4 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.1 | 0.8 | GO:0042405 | nuclear inclusion body(GO:0042405) |
| 0.1 | 1.1 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.1 | 0.7 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 0.3 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.0 | 0.2 | GO:0019815 | B cell receptor complex(GO:0019815) |
| 0.0 | 0.5 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.0 | 0.2 | GO:0033093 | multivesicular body membrane(GO:0032585) Weibel-Palade body(GO:0033093) |
| 0.0 | 0.8 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.0 | 2.5 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 1.2 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 1.1 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) |
| 0.0 | 1.8 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.0 | 3.3 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 0.4 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 1.0 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.0 | 1.3 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 1.1 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 2.4 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 0.3 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.0 | 0.3 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.0 | 0.9 | GO:0035869 | ciliary transition zone(GO:0035869) |
| 0.0 | 0.2 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.0 | 1.0 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 1.2 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 0.7 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
| 0.0 | 0.5 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 0.5 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 1.1 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 2.4 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 0.7 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 0.1 | GO:0034451 | centriolar satellite(GO:0034451) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 6.9 | GO:0031432 | titin binding(GO:0031432) |
| 0.6 | 3.2 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.5 | 1.4 | GO:0003953 | NAD+ nucleosidase activity(GO:0003953) |
| 0.4 | 1.1 | GO:0004822 | isoleucine-tRNA ligase activity(GO:0004822) |
| 0.3 | 1.0 | GO:0004936 | alpha-adrenergic receptor activity(GO:0004936) epinephrine binding(GO:0051379) |
| 0.3 | 2.7 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.3 | 1.7 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.3 | 1.4 | GO:0050265 | RNA uridylyltransferase activity(GO:0050265) |
| 0.3 | 1.5 | GO:0033743 | peptide-methionine (R)-S-oxide reductase activity(GO:0033743) |
| 0.3 | 1.5 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.2 | 1.2 | GO:0004095 | carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416) |
| 0.2 | 1.1 | GO:0072542 | protein phosphatase activator activity(GO:0072542) |
| 0.2 | 0.7 | GO:0005119 | smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158) |
| 0.2 | 1.1 | GO:0080019 | fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019) |
| 0.2 | 0.5 | GO:0005105 | type 1 fibroblast growth factor receptor binding(GO:0005105) |
| 0.2 | 1.9 | GO:0002151 | G-quadruplex RNA binding(GO:0002151) |
| 0.2 | 0.9 | GO:1902282 | voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282) |
| 0.2 | 0.9 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.2 | 1.1 | GO:0015198 | oligopeptide transporter activity(GO:0015198) |
| 0.1 | 0.6 | GO:0034046 | poly(G) binding(GO:0034046) |
| 0.1 | 0.6 | GO:0004966 | galanin receptor activity(GO:0004966) |
| 0.1 | 0.5 | GO:0051378 | serotonin binding(GO:0051378) |
| 0.1 | 1.0 | GO:0043559 | insulin binding(GO:0043559) |
| 0.1 | 0.9 | GO:0046974 | histone methyltransferase activity (H3-K9 specific)(GO:0046974) |
| 0.1 | 0.3 | GO:0004069 | L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069) |
| 0.1 | 0.3 | GO:0051765 | inositol tetrakisphosphate kinase activity(GO:0051765) |
| 0.1 | 2.4 | GO:0016504 | peptidase activator activity(GO:0016504) |
| 0.1 | 3.2 | GO:0005112 | Notch binding(GO:0005112) |
| 0.1 | 1.1 | GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656) |
| 0.1 | 0.8 | GO:0050291 | sphingosine N-acyltransferase activity(GO:0050291) |
| 0.1 | 0.7 | GO:0046790 | virion binding(GO:0046790) |
| 0.1 | 1.3 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.1 | 2.0 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.1 | 0.6 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 0.1 | 0.6 | GO:0097642 | calcitonin family receptor activity(GO:0097642) |
| 0.1 | 2.1 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.1 | 1.1 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.1 | 3.5 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.1 | 1.2 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.1 | 1.1 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.1 | 1.3 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.1 | 1.9 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 2.0 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.1 | 0.6 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.1 | 1.0 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.1 | 0.2 | GO:0016361 | activin receptor activity, type I(GO:0016361) |
| 0.1 | 0.3 | GO:0023029 | MHC class Ib protein binding(GO:0023029) |
| 0.1 | 0.4 | GO:0034711 | inhibin binding(GO:0034711) |
| 0.0 | 0.3 | GO:0061665 | SUMO ligase activity(GO:0061665) |
| 0.0 | 0.7 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.0 | 1.4 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.0 | 1.6 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.0 | 0.4 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
| 0.0 | 0.2 | GO:0004415 | hyalurononglucosaminidase activity(GO:0004415) |
| 0.0 | 0.4 | GO:0015217 | ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217) |
| 0.0 | 0.2 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.0 | 1.4 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.0 | 0.4 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.0 | 0.8 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.0 | 1.8 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 1.4 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 0.5 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.0 | 0.5 | GO:0015464 | acetylcholine receptor activity(GO:0015464) |
| 0.0 | 0.6 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.0 | 0.3 | GO:0009922 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.0 | 3.1 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 0.0 | 1.1 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.0 | 0.1 | GO:0042610 | CD8 receptor binding(GO:0042610) |
| 0.0 | 1.7 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.0 | 2.0 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.0 | 1.1 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 0.2 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 0.5 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.0 | 0.4 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
| 0.0 | 0.4 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.0 | 0.1 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.0 | 0.7 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 0.2 | GO:0031690 | adrenergic receptor binding(GO:0031690) |
| 0.0 | 0.4 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 2.9 | GO:0004386 | helicase activity(GO:0004386) |
| 0.0 | 0.2 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.0 | 8.3 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 0.1 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.0 | 0.1 | GO:0003993 | acid phosphatase activity(GO:0003993) |
| 0.0 | 0.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.7 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 0.2 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 0.3 | GO:0016423 | tRNA (guanine) methyltransferase activity(GO:0016423) |
| 0.0 | 2.4 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 0.2 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
| 0.0 | 0.4 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.0 | 1.2 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
| 0.0 | 0.5 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.0 | 3.3 | GO:0008134 | transcription factor binding(GO:0008134) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.5 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 5.1 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 3.3 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 3.5 | PID_SYNDECAN_1_PATHWAY | Syndecan-1-mediated signaling events |
| 0.1 | 1.2 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 2.9 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.7 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 2.8 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 1.1 | ST_INTERLEUKIN_4_PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 0.9 | ST_G_ALPHA_I_PATHWAY | G alpha i Pathway |
| 0.0 | 1.6 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.9 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
| 0.0 | 2.5 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.0 | 0.4 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 2.8 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.2 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.8 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.2 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 1.1 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.0 | 0.1 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.9 | PID_RHOA_PATHWAY | RhoA signaling pathway |
| 0.0 | 0.1 | PID_ECADHERIN_KERATINOCYTE_PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 0.4 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.0 | 1.7 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 0.2 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
| 0.0 | 0.2 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.3 | PID_AURORA_A_PATHWAY | Aurora A signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.1 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.2 | 4.5 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.1 | 1.5 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.1 | 0.7 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.1 | 1.0 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.1 | 1.5 | REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.1 | 0.5 | REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.1 | 1.5 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 0.4 | REACTOME_COMMON_PATHWAY | Genes involved in Common Pathway |
| 0.1 | 1.0 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.1 | 2.1 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.9 | REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT | Genes involved in Ligand-gated ion channel transport |
| 0.0 | 2.9 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 0.4 | REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS | Genes involved in Interactions of Vpr with host cellular proteins |
| 0.0 | 2.0 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 1.1 | REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 0.4 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 0.9 | REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 0.3 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.0 | 0.3 | REACTOME_REGULATION_OF_IFNG_SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.0 | 1.2 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 1.1 | REACTOME_PEROXISOMAL_LIPID_METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.0 | 0.4 | REACTOME_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 0.4 | REACTOME_AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 7.4 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 1.1 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 0.2 | REACTOME_SIGNALING_BY_NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 1.5 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 1.2 | REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.0 | 0.9 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 0.9 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.3 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 0.8 | REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT | Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript |
| 0.0 | 0.7 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.3 | REACTOME_ERKS_ARE_INACTIVATED | Genes involved in ERKs are inactivated |
| 0.0 | 0.6 | REACTOME_MEIOSIS | Genes involved in Meiosis |
| 0.0 | 1.9 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.2 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.2 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 0.2 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 0.1 | REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
