Motif ID: Tfap2e
Z-value: 0.704
Transcription factors associated with Tfap2e:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Tfap2e | ENSMUSG00000042477.7 | Tfap2e |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Tfap2e | mm10_v2_chr4_-_126736236_126736245 | -0.15 | 3.6e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.0 | 7.2 | GO:0010624 | regulation of Schwann cell proliferation(GO:0010624) |
0.5 | 1.4 | GO:0015910 | peroxisomal long-chain fatty acid import(GO:0015910) |
0.4 | 1.1 | GO:0071579 | phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092) regulation of zinc ion transport(GO:0071579) |
0.4 | 1.4 | GO:0072531 | pyrimidine-containing compound transmembrane transport(GO:0072531) |
0.3 | 3.2 | GO:0010459 | negative regulation of heart rate(GO:0010459) |
0.3 | 1.9 | GO:0042045 | epithelial fluid transport(GO:0042045) |
0.3 | 2.4 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
0.3 | 0.8 | GO:0097212 | lysosomal membrane organization(GO:0097212) |
0.2 | 1.7 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
0.2 | 1.7 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
0.2 | 0.6 | GO:0014877 | response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
0.2 | 0.8 | GO:0048686 | regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690) |
0.2 | 0.8 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
0.2 | 0.6 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
0.2 | 0.8 | GO:2000189 | positive regulation of cholesterol homeostasis(GO:2000189) |
0.1 | 0.7 | GO:1900095 | regulation of dosage compensation by inactivation of X chromosome(GO:1900095) |
0.1 | 0.9 | GO:0089700 | protein kinase D signaling(GO:0089700) |
0.1 | 0.8 | GO:0032483 | regulation of Rab protein signal transduction(GO:0032483) |
0.1 | 2.0 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
0.1 | 0.5 | GO:2000786 | positive regulation of autophagosome assembly(GO:2000786) |
0.0 | 0.5 | GO:0033601 | positive regulation of mammary gland epithelial cell proliferation(GO:0033601) regulation of wound healing, spreading of epidermal cells(GO:1903689) |
0.0 | 0.6 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
0.0 | 1.0 | GO:0051457 | maintenance of protein location in nucleus(GO:0051457) |
0.0 | 0.2 | GO:2000676 | positive regulation of type B pancreatic cell apoptotic process(GO:2000676) |
0.0 | 0.5 | GO:0031268 | pseudopodium organization(GO:0031268) |
0.0 | 0.1 | GO:0044208 | 'de novo' AMP biosynthetic process(GO:0044208) |
0.0 | 0.4 | GO:1990403 | embryonic brain development(GO:1990403) |
0.0 | 0.1 | GO:1990573 | potassium ion import across plasma membrane(GO:1990573) |
0.0 | 0.8 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
0.0 | 0.3 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
0.0 | 0.1 | GO:0097168 | condensed mesenchymal cell proliferation(GO:0072137) mesenchymal stem cell proliferation(GO:0097168) |
0.0 | 0.0 | GO:0070829 | heterochromatin maintenance(GO:0070829) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.8 | 7.2 | GO:0097450 | astrocyte end-foot(GO:0097450) |
0.6 | 1.9 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
0.3 | 0.8 | GO:0072534 | perineuronal net(GO:0072534) |
0.2 | 0.5 | GO:0005940 | septin ring(GO:0005940) |
0.1 | 0.8 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
0.1 | 2.7 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
0.1 | 1.7 | GO:0000242 | pericentriolar material(GO:0000242) |
0.1 | 0.8 | GO:0030127 | COPII vesicle coat(GO:0030127) |
0.0 | 1.4 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) |
0.0 | 1.7 | GO:0030673 | axolemma(GO:0030673) |
0.0 | 1.2 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
0.0 | 0.6 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
0.0 | 0.3 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
0.0 | 0.6 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
0.0 | 0.7 | GO:0035145 | exon-exon junction complex(GO:0035145) |
0.0 | 0.8 | GO:0030665 | clathrin-coated vesicle membrane(GO:0030665) |
0.0 | 1.7 | GO:0016605 | PML body(GO:0016605) |
0.0 | 0.8 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
0.0 | 1.5 | GO:0043204 | perikaryon(GO:0043204) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 1.9 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
0.4 | 1.6 | GO:0043125 | ErbB-3 class receptor binding(GO:0043125) |
0.3 | 1.7 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
0.3 | 1.4 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
0.2 | 0.5 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
0.1 | 0.8 | GO:0097016 | L27 domain binding(GO:0097016) |
0.1 | 1.2 | GO:0097157 | pre-mRNA intronic binding(GO:0097157) |
0.1 | 1.1 | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005) |
0.1 | 2.4 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
0.1 | 7.2 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
0.1 | 1.6 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
0.1 | 1.4 | GO:0015215 | nucleotide transmembrane transporter activity(GO:0015215) |
0.0 | 0.8 | GO:0046625 | sphingolipid binding(GO:0046625) |
0.0 | 0.2 | GO:0050347 | trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347) |
0.0 | 0.9 | GO:0004697 | protein kinase C activity(GO:0004697) |
0.0 | 1.3 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
0.0 | 0.1 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
0.0 | 0.0 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
0.0 | 0.7 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 3.9 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
0.1 | 2.4 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
0.1 | 1.6 | PID_IL5_PATHWAY | IL5-mediated signaling events |
0.0 | 1.1 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
0.0 | 1.1 | PID_AVB3_INTEGRIN_PATHWAY | Integrins in angiogenesis |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 7.2 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
0.2 | 1.6 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
0.1 | 2.4 | REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING | Genes involved in Spry regulation of FGF signaling |
0.1 | 1.1 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
0.1 | 1.4 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
0.0 | 1.1 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
0.0 | 1.7 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
0.0 | 0.7 | REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
0.0 | 1.7 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
0.0 | 1.6 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
0.0 | 1.2 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |