Motif ID: Tfap4
Z-value: 0.565
Transcription factors associated with Tfap4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Tfap4 | ENSMUSG00000005718.7 | Tfap4 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tfap4 | mm10_v2_chr16_-_4559720_4559747 | 0.53 | 4.1e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.6 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
| 0.3 | 1.3 | GO:1904451 | regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453) |
| 0.3 | 1.6 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.3 | 0.8 | GO:0003104 | positive regulation of glomerular filtration(GO:0003104) negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) phenotypic switching(GO:0036166) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262) |
| 0.3 | 1.6 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
| 0.2 | 0.7 | GO:0070543 | response to linoleic acid(GO:0070543) |
| 0.2 | 1.0 | GO:0045347 | negative regulation of MHC class II biosynthetic process(GO:0045347) negative regulation of cytolysis(GO:0045918) |
| 0.2 | 0.8 | GO:0015889 | cobalamin transport(GO:0015889) |
| 0.2 | 0.6 | GO:0038095 | positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095) |
| 0.2 | 0.6 | GO:1904020 | regulation of G-protein coupled receptor internalization(GO:1904020) |
| 0.2 | 1.1 | GO:0048597 | post-embryonic camera-type eye morphogenesis(GO:0048597) |
| 0.2 | 0.5 | GO:0018214 | peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214) |
| 0.2 | 0.5 | GO:0046544 | regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544) |
| 0.1 | 0.7 | GO:1902732 | positive regulation of chondrocyte proliferation(GO:1902732) |
| 0.1 | 0.8 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) |
| 0.1 | 0.5 | GO:0021603 | cranial nerve formation(GO:0021603) |
| 0.1 | 0.3 | GO:0046133 | pyrimidine ribonucleoside catabolic process(GO:0046133) |
| 0.1 | 1.0 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.1 | 1.2 | GO:0009404 | toxin metabolic process(GO:0009404) |
| 0.1 | 0.7 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 0.1 | 0.4 | GO:0030647 | polyketide metabolic process(GO:0030638) aminoglycoside antibiotic metabolic process(GO:0030647) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598) |
| 0.1 | 0.3 | GO:0071873 | response to norepinephrine(GO:0071873) |
| 0.1 | 0.5 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.1 | 0.3 | GO:2000318 | positive regulation of T-helper 17 type immune response(GO:2000318) |
| 0.1 | 0.3 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378) |
| 0.1 | 0.3 | GO:0034145 | positive regulation of toll-like receptor 4 signaling pathway(GO:0034145) |
| 0.1 | 2.7 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.1 | 1.1 | GO:0002495 | antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) |
| 0.1 | 0.6 | GO:0033601 | positive regulation of mammary gland epithelial cell proliferation(GO:0033601) |
| 0.1 | 0.4 | GO:0060923 | cardiac muscle cell fate commitment(GO:0060923) |
| 0.0 | 0.0 | GO:0003266 | regulation of secondary heart field cardioblast proliferation(GO:0003266) |
| 0.0 | 0.7 | GO:0051386 | regulation of neurotrophin TRK receptor signaling pathway(GO:0051386) |
| 0.0 | 1.4 | GO:0010866 | regulation of triglyceride biosynthetic process(GO:0010866) |
| 0.0 | 0.7 | GO:0072112 | renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311) |
| 0.0 | 0.8 | GO:0060219 | camera-type eye photoreceptor cell differentiation(GO:0060219) |
| 0.0 | 0.3 | GO:0006561 | proline biosynthetic process(GO:0006561) |
| 0.0 | 0.2 | GO:0033580 | protein glycosylation at cell surface(GO:0033575) protein galactosylation at cell surface(GO:0033580) protein galactosylation(GO:0042125) |
| 0.0 | 0.1 | GO:0019074 | viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074) |
| 0.0 | 0.2 | GO:1902995 | apolipoprotein A-I-mediated signaling pathway(GO:0038027) regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995) positive regulation of apoptotic cell clearance(GO:2000427) |
| 0.0 | 0.3 | GO:0032074 | negative regulation of nuclease activity(GO:0032074) |
| 0.0 | 0.6 | GO:0036297 | interstrand cross-link repair(GO:0036297) |
| 0.0 | 0.2 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 0.0 | 0.3 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
| 0.0 | 0.1 | GO:0006546 | glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464) |
| 0.0 | 0.2 | GO:0071442 | positive regulation of histone H3-K14 acetylation(GO:0071442) |
| 0.0 | 0.3 | GO:0043922 | negative regulation by host of viral transcription(GO:0043922) |
| 0.0 | 0.1 | GO:2000974 | comma-shaped body morphogenesis(GO:0072049) negative regulation of pro-B cell differentiation(GO:2000974) |
| 0.0 | 0.3 | GO:0032897 | negative regulation of viral transcription(GO:0032897) |
| 0.0 | 0.2 | GO:0019262 | N-acetylneuraminate catabolic process(GO:0019262) |
| 0.0 | 0.4 | GO:0060742 | epithelial cell differentiation involved in prostate gland development(GO:0060742) |
| 0.0 | 0.1 | GO:0070650 | actin filament bundle distribution(GO:0070650) |
| 0.0 | 0.1 | GO:0003032 | detection of oxygen(GO:0003032) |
| 0.0 | 0.1 | GO:0048630 | skeletal muscle tissue growth(GO:0048630) |
| 0.0 | 2.3 | GO:0048663 | neuron fate commitment(GO:0048663) |
| 0.0 | 0.2 | GO:0033184 | positive regulation of histone ubiquitination(GO:0033184) |
| 0.0 | 0.5 | GO:0042832 | defense response to protozoan(GO:0042832) |
| 0.0 | 0.5 | GO:0006516 | glycoprotein catabolic process(GO:0006516) |
| 0.0 | 0.1 | GO:1901420 | cell migration involved in endocardial cushion formation(GO:0003273) negative regulation of response to alcohol(GO:1901420) |
| 0.0 | 0.8 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.0 | 0.2 | GO:0006013 | mannose metabolic process(GO:0006013) |
| 0.0 | 2.2 | GO:0051592 | response to calcium ion(GO:0051592) |
| 0.0 | 0.0 | GO:0097309 | cap1 mRNA methylation(GO:0097309) |
| 0.0 | 0.6 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.0 | 0.4 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
| 0.0 | 0.0 | GO:0046168 | glycerol-3-phosphate catabolic process(GO:0046168) |
| 0.0 | 0.2 | GO:0030431 | sleep(GO:0030431) |
| 0.0 | 0.6 | GO:0032330 | regulation of chondrocyte differentiation(GO:0032330) |
| 0.0 | 0.8 | GO:0008542 | visual learning(GO:0008542) |
| 0.0 | 0.1 | GO:0090527 | actin filament reorganization(GO:0090527) |
| 0.0 | 0.1 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.3 | GO:0097574 | lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795) |
| 0.1 | 1.6 | GO:0020005 | symbiont-containing vacuole membrane(GO:0020005) |
| 0.1 | 0.3 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.1 | 0.5 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.1 | 0.8 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.1 | 0.6 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.1 | 0.3 | GO:1990761 | growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812) |
| 0.0 | 0.2 | GO:0030314 | junctional membrane complex(GO:0030314) |
| 0.0 | 1.1 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 0.1 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.0 | 0.2 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.0 | 0.1 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 0.0 | 0.3 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 1.2 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.0 | 0.1 | GO:0000127 | transcription factor TFIIIC complex(GO:0000127) |
| 0.0 | 0.1 | GO:0097513 | myosin II filament(GO:0097513) |
| 0.0 | 0.1 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.0 | 0.3 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.2 | GO:0016715 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715) |
| 0.2 | 0.7 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.2 | 1.0 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.2 | 1.6 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.2 | 1.6 | GO:0001025 | RNA polymerase III transcription factor binding(GO:0001025) |
| 0.2 | 1.3 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.2 | 1.2 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.2 | 1.1 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
| 0.1 | 0.8 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.1 | 0.8 | GO:0031419 | cobalamin binding(GO:0031419) |
| 0.1 | 0.6 | GO:0032027 | myosin light chain binding(GO:0032027) |
| 0.1 | 1.4 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.1 | 0.4 | GO:0004565 | beta-galactosidase activity(GO:0004565) |
| 0.1 | 0.4 | GO:0004301 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) epoxide hydrolase activity(GO:0004301) |
| 0.1 | 0.8 | GO:0016151 | nickel cation binding(GO:0016151) |
| 0.1 | 0.3 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.1 | 0.2 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556) |
| 0.1 | 0.8 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 0.3 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
| 0.1 | 0.2 | GO:0008332 | low voltage-gated calcium channel activity(GO:0008332) |
| 0.1 | 0.5 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 0.3 | GO:0051425 | PTB domain binding(GO:0051425) |
| 0.0 | 1.1 | GO:0042287 | MHC protein binding(GO:0042287) |
| 0.0 | 0.6 | GO:0015923 | mannosidase activity(GO:0015923) |
| 0.0 | 0.8 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 0.5 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.0 | 0.5 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
| 0.0 | 0.2 | GO:0045322 | unmethylated CpG binding(GO:0045322) |
| 0.0 | 0.1 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
| 0.0 | 0.2 | GO:0047276 | N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276) |
| 0.0 | 0.1 | GO:0000026 | alpha-1,2-mannosyltransferase activity(GO:0000026) |
| 0.0 | 0.3 | GO:0016004 | phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229) |
| 0.0 | 0.9 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.0 | 0.4 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.0 | 0.3 | GO:0048038 | quinone binding(GO:0048038) |
| 0.0 | 0.3 | GO:0019104 | DNA N-glycosylase activity(GO:0019104) |
| 0.0 | 0.1 | GO:0009374 | biotin binding(GO:0009374) |
| 0.0 | 0.1 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.0 | 0.7 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.0 | 0.3 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.0 | 0.7 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 0.7 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 3.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 0.3 | GO:0046965 | retinoid X receptor binding(GO:0046965) |
| 0.0 | 0.2 | GO:0015464 | acetylcholine receptor activity(GO:0015464) |
| 0.0 | 1.7 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.0 | 0.2 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 0.2 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
| 0.0 | 0.2 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 0.6 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 0.2 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
| 0.0 | 0.0 | GO:0004483 | mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483) |
| 0.0 | 0.0 | GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 1.3 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.0 | 0.8 | PID_S1P_S1P1_PATHWAY | S1P1 pathway |
| 0.0 | 0.5 | PID_IL5_PATHWAY | IL5-mediated signaling events |
| 0.0 | 0.6 | ST_GA12_PATHWAY | G alpha 12 Pathway |
| 0.0 | 1.0 | PID_CXCR3_PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 0.7 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 0.8 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 2.9 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.3 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.0 | 0.6 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.4 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.0 | REACTOME_COMMON_PATHWAY | Genes involved in Common Pathway |
| 0.1 | 1.1 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 0.5 | REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.1 | 0.5 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.0 | 0.5 | REACTOME_PROLACTIN_RECEPTOR_SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 1.3 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 0.3 | REACTOME_THE_NLRP3_INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 0.3 | REACTOME_PYRIMIDINE_CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.0 | 0.2 | REACTOME_ENDOGENOUS_STEROLS | Genes involved in Endogenous sterols |
| 0.0 | 2.4 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 2.3 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 0.1 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.0 | 0.2 | REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.0 | 0.2 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
