Motif ID: Thrb

Z-value: 0.396


Transcription factors associated with Thrb:

Gene SymbolEntrez IDGene Name
Thrb ENSMUSG00000021779.10 Thrb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Thrbmm10_v2_chr14_+_17660956_176609630.163.2e-01Click!


Activity profile for motif Thrb.

activity profile for motif Thrb


Sorted Z-values histogram for motif Thrb

Sorted Z-values for motif Thrb



Network of associatons between targets according to the STRING database.



First level regulatory network of Thrb

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_111761697 1.892 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
 E130006D01Rik


RIKEN cDNA E130006D01 gene


chr12_+_112620030 1.812 ENSMUST00000180015.1
ENSMUST00000021726.6
 Adssl1

adenylosuccinate synthetase like 1

chr3_+_14863495 1.365 ENSMUST00000029076.4
 Car3
carbonic anhydrase 3
chr2_-_25469742 1.363 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr2_-_25470031 1.292 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr16_+_37916440 0.953 ENSMUST00000061274.7
 Gpr156
G protein-coupled receptor 156
chr14_+_54476100 0.893 ENSMUST00000164766.1
ENSMUST00000164697.1
 Rem2

rad and gem related GTP binding protein 2

chr9_-_107668967 0.850 ENSMUST00000177567.1
 Slc38a3
solute carrier family 38, member 3
chr16_+_36934976 0.797 ENSMUST00000023531.8
 Hcls1
hematopoietic cell specific Lyn substrate 1
chr2_-_105399286 0.704 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr4_-_148444744 0.604 ENSMUST00000051633.2
 Ubiad1
UbiA prenyltransferase domain containing 1
chr11_-_103344651 0.504 ENSMUST00000041385.7
 Arhgap27
Rho GTPase activating protein 27
chr14_-_61360395 0.413 ENSMUST00000022494.8
 Ebpl
emopamil binding protein-like
chr1_-_137969213 0.402 ENSMUST00000182680.1
ENSMUST00000182424.1
 Gm26936

predicted gene, 26936

chrX_+_112311334 0.400 ENSMUST00000026599.3
ENSMUST00000113415.1
 Apool

apolipoprotein O-like

chr11_-_115612491 0.389 ENSMUST00000106507.2
 Mif4gd
MIF4G domain containing
chr2_+_92382911 0.347 ENSMUST00000054316.2
ENSMUST00000111280.2
 1700029I15Rik

RIKEN cDNA 1700029I15 gene

chr2_+_119167758 0.341 ENSMUST00000057454.3
 Gchfr
GTP cyclohydrolase I feedback regulator
chr11_+_109485606 0.341 ENSMUST00000106697.1
 Arsg
arylsulfatase G
chr4_+_20042046 0.339 ENSMUST00000098242.3
 Ggh
gamma-glutamyl hydrolase
chr11_-_58938851 0.310 ENSMUST00000094151.5
 Rnf187
ring finger protein 187
chr9_+_102626278 0.307 ENSMUST00000038673.7
 Anapc13
anaphase promoting complex subunit 13
chr3_-_36475688 0.303 ENSMUST00000029266.8
 Anxa5
annexin A5
chr3_+_67374116 0.273 ENSMUST00000061322.8
 Mlf1
myeloid leukemia factor 1
chr3_-_116712198 0.267 ENSMUST00000120120.1
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr16_+_23290464 0.236 ENSMUST00000115335.1
 St6gal1
beta galactoside alpha 2,6 sialyltransferase 1
chr3_+_67374091 0.230 ENSMUST00000077916.5
 Mlf1
myeloid leukemia factor 1
chr1_+_87213924 0.168 ENSMUST00000113230.1
ENSMUST00000123735.1
 Eif4e2

eukaryotic translation initiation factor 4E member 2

chr1_+_87214286 0.137 ENSMUST00000113231.3
 Eif4e2
eukaryotic translation initiation factor 4E member 2
chr15_-_103251465 0.117 ENSMUST00000133600.1
ENSMUST00000134554.1
ENSMUST00000156927.1
ENSMUST00000149111.1
ENSMUST00000132836.1
 Nfe2




nuclear factor, erythroid derived 2




chr16_+_32419696 0.092 ENSMUST00000014220.8
ENSMUST00000080316.7
 Tctex1d2

Tctex1 domain containing 2

chr5_+_130219706 0.079 ENSMUST00000065329.6
 Tmem248
transmembrane protein 248
chrX_-_71492799 0.073 ENSMUST00000037391.5
ENSMUST00000114586.2
ENSMUST00000114587.2
 Cd99l2


CD99 antigen-like 2


chr2_-_24049389 0.066 ENSMUST00000051416.5
 Hnmt
histamine N-methyltransferase
chr5_-_92278155 0.055 ENSMUST00000159345.1
ENSMUST00000113102.3
 Naaa

N-acylethanolamine acid amidase

chr10_+_81176631 0.050 ENSMUST00000047864.9
 Eef2
eukaryotic translation elongation factor 2
chr9_-_102626509 0.026 ENSMUST00000161645.1
ENSMUST00000162297.1
ENSMUST00000162655.1
 Cep63


centrosomal protein 63



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.5 2.7 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.2 0.9 GO:0015817 glutamine transport(GO:0006868) histidine transport(GO:0015817) cellular response to potassium ion starvation(GO:0051365)
0.2 0.6 GO:0042373 vitamin K metabolic process(GO:0042373)
0.1 0.8 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 0.3 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.1 0.9 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.1 0.3 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.1 0.2 GO:2000110 protein sialylation(GO:1990743) negative regulation of macrophage apoptotic process(GO:2000110)
0.1 0.5 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.1 0.3 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.0 1.4 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.4 GO:0042407 cristae formation(GO:0042407)
0.0 0.1 GO:0001692 histamine metabolic process(GO:0001692) imidazole-containing compound catabolic process(GO:0052805)
0.0 0.1 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0061617 MICOS complex(GO:0061617)
0.0 2.7 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.2 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.3 GO:0034518 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 0.1 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.0 0.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.5 GO:0097546 ciliary base(GO:0097546)
0.0 0.3 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.3 GO:0005680 anaphase-promoting complex(GO:0005680)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.7 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.3 0.9 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)
0.2 1.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 1.4 GO:0016151 nickel cation binding(GO:0016151)
0.0 0.3 GO:0008242 omega peptidase activity(GO:0008242)
0.0 0.2 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.6 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 0.4 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 1.8 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.0 0.3 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.3 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.3 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 0.3 GO:0030742 GTP-dependent protein binding(GO:0030742)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.3 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.9 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.2 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.3 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation