Motif ID: Trp73

Z-value: 0.529


Transcription factors associated with Trp73:

Gene SymbolEntrez IDGene Name
Trp73 ENSMUSG00000029026.10 Trp73

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Trp73mm10_v2_chr4_-_154097105_1540971730.604.9e-05Click!


Activity profile for motif Trp73.

activity profile for motif Trp73


Sorted Z-values histogram for motif Trp73

Sorted Z-values for motif Trp73



Network of associatons between targets according to the STRING database.



First level regulatory network of Trp73

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_116038734 3.294 ENSMUST00000166877.1
 Sox6
SRY-box containing gene 6
chr17_+_29090969 2.648 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr7_-_141443314 2.613 ENSMUST00000106005.2
 Lrdd
leucine-rich and death domain containing
chr1_+_135729147 2.588 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr1_+_153665274 2.318 ENSMUST00000152114.1
ENSMUST00000111812.1
 Rgs8

regulator of G-protein signaling 8

chr12_-_45074112 1.903 ENSMUST00000120531.1
ENSMUST00000143376.1
 Stxbp6

syntaxin binding protein 6 (amisyn)

chr1_+_72824482 1.892 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chrX_+_10717390 1.834 ENSMUST00000115524.1
ENSMUST00000008179.6
 Mid1ip1

Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))

chr12_-_45074457 1.832 ENSMUST00000053768.6
 Stxbp6
syntaxin binding protein 6 (amisyn)
chrX_+_10717451 1.790 ENSMUST00000156321.1
 Mid1ip1
Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))
chr9_-_67760208 1.609 ENSMUST00000068526.5
 M5C1000I18Rik
RIKEN cDNA M5C1000I18 gene
chr16_-_17125106 1.604 ENSMUST00000093336.6
 2610318N02Rik
RIKEN cDNA 2610318N02 gene
chr13_+_48261427 1.543 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4
chr4_+_62583568 1.438 ENSMUST00000098031.3
 Rgs3
regulator of G-protein signaling 3
chr4_-_45489794 1.407 ENSMUST00000146236.1
 Shb
src homology 2 domain-containing transforming protein B
chr11_-_69948145 1.325 ENSMUST00000179298.1
ENSMUST00000018710.6
ENSMUST00000135437.1
ENSMUST00000141837.2
ENSMUST00000142500.1
 Slc2a4




solute carrier family 2 (facilitated glucose transporter), member 4




chr11_-_102230127 1.312 ENSMUST00000107150.1
ENSMUST00000156337.1
ENSMUST00000107151.2
ENSMUST00000107152.2
 Hdac5



histone deacetylase 5



chr11_-_102230091 1.312 ENSMUST00000008999.5
 Hdac5
histone deacetylase 5
chr3_-_107931579 1.129 ENSMUST00000133947.2
ENSMUST00000124215.1
ENSMUST00000106688.1
ENSMUST00000106687.2
 Gstm7



glutathione S-transferase, mu 7



chr10_+_41810528 0.971 ENSMUST00000099931.3
 Sesn1
sestrin 1
chr15_+_84232030 0.923 ENSMUST00000023072.6
 Parvb
parvin, beta
chr3_+_159839729 0.880 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr8_-_70659645 0.852 ENSMUST00000070173.7
 Pgpep1
pyroglutamyl-peptidase I
chr1_-_12991109 0.707 ENSMUST00000115403.2
ENSMUST00000115402.1
 Slco5a1

solute carrier organic anion transporter family, member 5A1

chr14_-_73325773 0.643 ENSMUST00000022701.6
 Rb1
retinoblastoma 1
chr5_+_43233928 0.546 ENSMUST00000114066.1
ENSMUST00000114065.1
 Cpeb2

cytoplasmic polyadenylation element binding protein 2

chr9_-_58313189 0.538 ENSMUST00000061799.8
 Loxl1
lysyl oxidase-like 1
chr2_-_180920925 0.518 ENSMUST00000037299.8
ENSMUST00000108876.2
 Ythdf1

YTH domain family 1

chr6_+_29398920 0.515 ENSMUST00000181464.1
ENSMUST00000180829.1
 Ccdc136

coiled-coil domain containing 136

chrX_-_109013389 0.507 ENSMUST00000033597.8
 Hmgn5
high-mobility group nucleosome binding domain 5
chr19_-_50030735 0.505 ENSMUST00000071866.1
 Rpl13a-ps1
ribosomal protein 13A, pseudogene 1
chr2_+_34772089 0.488 ENSMUST00000028222.6
ENSMUST00000100171.2
 Hspa5

heat shock protein 5

chr2_-_164857671 0.482 ENSMUST00000059954.7
 Pltp
phospholipid transfer protein
chr7_-_5014645 0.461 ENSMUST00000165320.1
 Fiz1
Flt3 interacting zinc finger protein 1
chr9_-_109082372 0.459 ENSMUST00000167504.1
 Tma7
translational machinery associated 7 homolog (S. cerevisiae)
chr1_-_5070281 0.457 ENSMUST00000147158.1
ENSMUST00000118000.1
 Rgs20

regulator of G-protein signaling 20

chr2_-_164857542 0.457 ENSMUST00000109316.1
ENSMUST00000156255.1
ENSMUST00000128110.1
ENSMUST00000109317.3
 Pltp



phospholipid transfer protein



chr4_+_129820198 0.438 ENSMUST00000030578.7
 Ptp4a2
protein tyrosine phosphatase 4a2
chr14_-_52104015 0.411 ENSMUST00000111610.4
ENSMUST00000164655.1
 Hnrnpc

heterogeneous nuclear ribonucleoprotein C

chr18_+_56432116 0.382 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr4_-_11386757 0.375 ENSMUST00000108313.1
ENSMUST00000108311.2
 Esrp1

epithelial splicing regulatory protein 1

chr11_-_120348513 0.367 ENSMUST00000071555.6
 Actg1
actin, gamma, cytoplasmic 1
chr9_+_108662098 0.365 ENSMUST00000035222.5
 Slc25a20
solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20
chrX_-_10216918 0.348 ENSMUST00000072393.2
ENSMUST00000044598.6
ENSMUST00000073392.4
ENSMUST00000115533.1
ENSMUST00000115532.1
 Rpgr




retinitis pigmentosa GTPase regulator




chr19_-_7105729 0.334 ENSMUST00000113383.2
 Flrt1
fibronectin leucine rich transmembrane protein 1
chr15_+_76696725 0.334 ENSMUST00000023203.4
 Gpt
glutamic pyruvic transaminase, soluble
chr11_+_69913888 0.297 ENSMUST00000072581.2
ENSMUST00000116358.1
 Gps2

G protein pathway suppressor 2

chr19_-_47138280 0.285 ENSMUST00000140512.1
ENSMUST00000035822.1
 Calhm2

calcium homeostasis modulator 2

chr17_+_28232723 0.269 ENSMUST00000002320.8
 Ppard
peroxisome proliferator activator receptor delta
chr19_+_41911851 0.258 ENSMUST00000011896.6
 Pgam1
phosphoglycerate mutase 1
chr5_-_30960236 0.258 ENSMUST00000088063.2
 Preb
prolactin regulatory element binding
chr5_-_30960326 0.248 ENSMUST00000074840.5
 Preb
prolactin regulatory element binding
chr10_+_110745433 0.221 ENSMUST00000174857.1
ENSMUST00000073781.5
ENSMUST00000173471.1
ENSMUST00000173634.1
 E2f7



E2F transcription factor 7



chr10_-_105841323 0.217 ENSMUST00000046638.9
 Mettl25
methyltransferase like 25
chr9_-_65885024 0.216 ENSMUST00000122410.1
ENSMUST00000117083.1
 Trip4

thyroid hormone receptor interactor 4

chr9_-_44713196 0.209 ENSMUST00000144251.1
ENSMUST00000156918.1
 Phldb1

pleckstrin homology-like domain, family B, member 1

chr19_+_46304709 0.200 ENSMUST00000073116.5
 Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chr4_+_101068983 0.193 ENSMUST00000038463.8
ENSMUST00000106955.1
 Raver2

ribonucleoprotein, PTB-binding 2

chr1_+_170214826 0.180 ENSMUST00000159201.1
ENSMUST00000055830.1
 4930500M09Rik

RIKEN cDNA 4930500M09 gene

chr10_+_39369750 0.180 ENSMUST00000063091.6
ENSMUST00000099967.3
ENSMUST00000126486.1
 Fyn


Fyn proto-oncogene


chr3_+_89245952 0.158 ENSMUST00000040888.5
 Krtcap2
keratinocyte associated protein 2
chr7_+_140882430 0.155 ENSMUST00000164681.1
ENSMUST00000163610.1
 Psmd13

proteasome (prosome, macropain) 26S subunit, non-ATPase, 13

chr3_+_14641722 0.147 ENSMUST00000029071.8
 Car13
carbonic anhydrase 13
chr14_+_53665912 0.131 ENSMUST00000181768.1
 Trav3-3
T cell receptor alpha variable 3-3
chr11_+_114851507 0.112 ENSMUST00000177952.1
 Gprc5c
G protein-coupled receptor, family C, group 5, member C
chr2_+_150909565 0.111 ENSMUST00000028948.4
 Gins1
GINS complex subunit 1 (Psf1 homolog)
chr3_-_89402650 0.102 ENSMUST00000168325.1
ENSMUST00000057431.5
 Lenep

lens epithelial protein

chr1_-_170215380 0.087 ENSMUST00000027979.7
ENSMUST00000123399.1
 Uhmk1

U2AF homology motif (UHM) kinase 1

chr11_+_114851142 0.064 ENSMUST00000133245.1
ENSMUST00000122967.2
 Gprc5c

G protein-coupled receptor, family C, group 5, member C

chr2_-_90904827 0.059 ENSMUST00000005647.3
 Ndufs3
NADH dehydrogenase (ubiquinone) Fe-S protein 3
chr7_+_140881898 0.040 ENSMUST00000026560.7
 Psmd13
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr4_+_74251928 0.038 ENSMUST00000030102.5
 Kdm4c
lysine (K)-specific demethylase 4C
chr12_+_109747903 0.023 ENSMUST00000183084.1
ENSMUST00000182300.1
 Mirg

miRNA containing gene

chr11_+_57801575 0.014 ENSMUST00000020826.5
 Sap30l
SAP30-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.7 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.4 1.5 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.3 0.9 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.3 3.3 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.3 2.6 GO:0071493 cellular response to UV-B(GO:0071493)
0.3 0.9 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
0.3 1.1 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.3 2.6 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.2 0.9 GO:0042360 vitamin E metabolic process(GO:0042360)
0.2 0.9 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.2 3.6 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.2 0.5 GO:0048209 regulation of vesicle targeting, to, from or within Golgi(GO:0048209)
0.2 2.3 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) regulation of dopamine receptor signaling pathway(GO:0060159)
0.2 0.5 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.2 1.4 GO:1900194 negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194)
0.1 1.9 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1 0.4 GO:0090365 regulation of mRNA modification(GO:0090365)
0.1 0.3 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.1 0.5 GO:0045900 negative regulation of translational elongation(GO:0045900)
0.1 0.3 GO:0006776 vitamin A metabolic process(GO:0006776)
0.1 1.0 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.1 1.3 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)
0.1 0.7 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 0.4 GO:0015879 carnitine transport(GO:0015879)
0.0 0.5 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.2 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.0 2.4 GO:0070527 platelet aggregation(GO:0070527)
0.0 0.6 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 0.2 GO:2001197 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0 0.2 GO:0002467 germinal center formation(GO:0002467)
0.0 0.2 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.4 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.0 0.2 GO:0018195 peptidyl-arginine modification(GO:0018195)
0.0 0.1 GO:1902969 mitotic DNA replication(GO:1902969)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0070557 PCNA-p21 complex(GO:0070557)
0.3 2.6 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.2 3.7 GO:0000145 exocyst(GO:0000145)
0.1 0.6 GO:0035189 Rb-E2F complex(GO:0035189)
0.1 1.0 GO:0061700 GATOR2 complex(GO:0061700)
0.1 1.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 2.7 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.5 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.1 GO:0000811 GINS complex(GO:0000811)
0.0 0.9 GO:0032590 dendrite membrane(GO:0032590)
0.0 0.2 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.5 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.5 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.4 GO:0045120 pronucleus(GO:0045120)
0.0 0.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.2 GO:0045180 basal cortex(GO:0045180)
0.0 1.1 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 1.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.4 GO:0043034 costamere(GO:0043034)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.4 2.6 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.3 1.3 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.2 1.9 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 3.7 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.2 1.0 GO:0070728 leucine binding(GO:0070728)
0.1 0.9 GO:0008242 omega peptidase activity(GO:0008242)
0.1 0.9 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 0.4 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.1 0.3 GO:0016501 prostacyclin receptor activity(GO:0016501)
0.1 0.9 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 0.3 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.1 0.6 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.1 0.7 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1 2.3 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 0.2 GO:0005118 sevenless binding(GO:0005118)
0.0 1.1 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.5 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.5 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 1.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.2 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 3.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.3 GO:0008483 transaminase activity(GO:0008483)
0.0 0.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.1 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.2 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 1.5 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.6 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.6 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.4 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 1.3 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 2.6 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 0.9 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.4 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 0.6 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.5 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 0.4 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 1.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 1.9 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 2.6 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 0.9 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 0.5 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 0.6 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.9 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 2.6 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 2.8 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 0.4 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.3 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.2 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.5 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification