Motif ID: Zbtb12

Z-value: 0.569


Transcription factors associated with Zbtb12:

Gene SymbolEntrez IDGene Name
Zbtb12 ENSMUSG00000049823.8 Zbtb12

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb12mm10_v2_chr17_+_34894515_34894573-0.721.2e-07Click!


Activity profile for motif Zbtb12.

activity profile for motif Zbtb12


Sorted Z-values histogram for motif Zbtb12

Sorted Z-values for motif Zbtb12



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb12

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_12027958 5.290 ENSMUST00000109654.1
 Grb10
growth factor receptor bound protein 10
chr17_-_15375969 3.869 ENSMUST00000014917.7
 Dll1
delta-like 1 (Drosophila)
chr4_-_45489794 3.447 ENSMUST00000146236.1
 Shb
src homology 2 domain-containing transforming protein B
chr3_+_88081997 3.309 ENSMUST00000071812.5
 Iqgap3
IQ motif containing GTPase activating protein 3
chr3_+_5218546 2.592 ENSMUST00000026284.6
 Zfhx4
zinc finger homeodomain 4
chr3_+_5218516 2.420 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr13_+_104229366 2.106 ENSMUST00000022227.6
 Cenpk
centromere protein K
chr3_+_5218589 2.010 ENSMUST00000177488.1
 Zfhx4
zinc finger homeodomain 4
chr4_-_149909719 1.935 ENSMUST00000105685.1
 Spsb1
splA/ryanodine receptor domain and SOCS box containing 1
chr11_-_88718078 1.879 ENSMUST00000092794.5
 Msi2
musashi RNA-binding protein 2
chr4_-_151057933 1.546 ENSMUST00000030797.3
 Vamp3
vesicle-associated membrane protein 3
chr9_+_57827284 1.474 ENSMUST00000163186.1
 Gm17231
predicted gene 17231
chr6_-_124814288 1.470 ENSMUST00000172132.2
 Tpi1
triosephosphate isomerase 1
chr8_-_45382198 1.421 ENSMUST00000093526.6
 Fam149a
family with sequence similarity 149, member A
chr4_-_119173849 1.406 ENSMUST00000052715.4
ENSMUST00000179290.1
ENSMUST00000154226.1
 Zfp691


zinc finger protein 691


chr6_+_29398920 1.250 ENSMUST00000181464.1
ENSMUST00000180829.1
 Ccdc136

coiled-coil domain containing 136

chr7_-_25477607 1.243 ENSMUST00000098669.1
ENSMUST00000098668.1
ENSMUST00000098666.2
 Ceacam1


carcinoembryonic antigen-related cell adhesion molecule 1


chr18_-_70472429 1.190 ENSMUST00000067556.3
 4930503L19Rik
RIKEN cDNA 4930503L19 gene
chr14_+_79481164 1.165 ENSMUST00000040131.5
 Elf1
E74-like factor 1
chr2_-_28916668 1.102 ENSMUST00000113847.1
 Barhl1
BarH-like 1 (Drosophila)
chr17_+_17831004 0.890 ENSMUST00000172097.2
 4930546H06Rik
RIKEN cDNA 4930546H06 gene
chr17_+_27909337 0.881 ENSMUST00000114842.1
ENSMUST00000025058.7
ENSMUST00000088027.5
 Anks1


ankyrin repeat and SAM domain containing 1


chr2_+_31759932 0.859 ENSMUST00000028190.6
 Abl1
c-abl oncogene 1, non-receptor tyrosine kinase
chr17_-_27909206 0.859 ENSMUST00000114848.1
 Taf11
TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr14_-_79481268 0.845 ENSMUST00000022601.5
 Wbp4
WW domain binding protein 4
chr2_+_31759993 0.797 ENSMUST00000124089.1
 Abl1
c-abl oncogene 1, non-receptor tyrosine kinase
chr15_+_82341179 0.763 ENSMUST00000050349.2
 Fam109b
family with sequence similarity 109, member B
chrX_-_140956675 0.683 ENSMUST00000033805.8
ENSMUST00000112978.1
 Psmd10

proteasome (prosome, macropain) 26S subunit, non-ATPase, 10

chr7_-_141918481 0.629 ENSMUST00000151890.1
 Tollip
toll interacting protein
chr9_-_78481724 0.522 ENSMUST00000042235.8
 Eef1a1
eukaryotic translation elongation factor 1 alpha 1
chr7_+_92875253 0.492 ENSMUST00000076052.6
 Prcp
prolylcarboxypeptidase (angiotensinase C)
chr6_+_37900477 0.487 ENSMUST00000120238.1
 Trim24
tripartite motif-containing 24
chr8_-_69774884 0.486 ENSMUST00000137573.1
ENSMUST00000149782.1
 Zfp866
Gm20422
zinc finger protein 866
predicted gene 20422
chr12_+_105784694 0.476 ENSMUST00000109901.2
ENSMUST00000168186.1
ENSMUST00000163473.1
ENSMUST00000170540.1
ENSMUST00000166735.1
ENSMUST00000170002.1
 Papola





poly (A) polymerase alpha





chr7_+_126976338 0.469 ENSMUST00000032920.3
 Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr19_-_10240689 0.468 ENSMUST00000088013.5
 Myrf
myelin regulatory factor
chr10_-_86011833 0.436 ENSMUST00000105304.1
ENSMUST00000061699.5
 Bpifc

BPI fold containing family C

chr11_+_54902917 0.418 ENSMUST00000149324.1
 Gpx3
glutathione peroxidase 3
chr1_+_69826986 0.411 ENSMUST00000065425.5
ENSMUST00000113940.2
 Spag16

sperm associated antigen 16

chr13_+_76098734 0.387 ENSMUST00000091466.3
 Ttc37
tetratricopeptide repeat domain 37
chr11_+_54902743 0.357 ENSMUST00000082430.3
 Gpx3
glutathione peroxidase 3
chr4_+_43669266 0.327 ENSMUST00000107864.1
 Tmem8b
transmembrane protein 8B
chr11_+_69991061 0.317 ENSMUST00000018711.8
 Gabarap
gamma-aminobutyric acid receptor associated protein
chr17_+_27029259 0.311 ENSMUST00000053683.6
 Ggnbp1
gametogenetin binding protein 1
chr19_-_6080311 0.264 ENSMUST00000159832.1
 Vps51
vacuolar protein sorting 51 homolog (S. cerevisiae)
chr15_-_79546741 0.224 ENSMUST00000054014.7
 Ddx17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr14_+_34220028 0.211 ENSMUST00000119693.1
ENSMUST00000035351.5
 Syt15

synaptotagmin XV

chr5_+_67260696 0.197 ENSMUST00000161233.1
ENSMUST00000160352.1
 Tmem33

transmembrane protein 33

chr17_-_32189457 0.188 ENSMUST00000087721.3
ENSMUST00000162117.1
 Ephx3

epoxide hydrolase 3

chr6_+_108065035 0.174 ENSMUST00000049246.6
 Setmar
SET domain without mariner transposase fusion
chr12_-_101958148 0.172 ENSMUST00000159883.1
ENSMUST00000160251.1
ENSMUST00000161011.1
ENSMUST00000021606.5
 Atxn3



ataxin 3



chr3_-_84155762 0.171 ENSMUST00000047368.6
 Mnd1
meiotic nuclear divisions 1 homolog (S. cerevisiae)
chr5_+_122850186 0.155 ENSMUST00000031434.6
 Rnf34
ring finger protein 34
chr5_+_95956916 0.123 ENSMUST00000023840.5
 Cxcl13
chemokine (C-X-C motif) ligand 13
chr16_+_55966275 0.087 ENSMUST00000023269.4
 RPL24
60S ribosomal protein L24
chr6_-_33060172 0.084 ENSMUST00000115091.1
ENSMUST00000127666.1
 Chchd3

coiled-coil-helix-coiled-coil-helix domain containing 3

chr17_-_56874421 0.062 ENSMUST00000043062.4
 Acsbg2
acyl-CoA synthetase bubblegum family member 2
chr11_-_59228162 0.062 ENSMUST00000163300.1
ENSMUST00000061242.7
 Arf1

ADP-ribosylation factor 1

chr19_+_46573362 0.043 ENSMUST00000026011.6
 Sfxn2
sideroflexin 2
chr1_+_37997975 0.037 ENSMUST00000027252.7
 Eif5b
eukaryotic translation initiation factor 5B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.9 GO:0001757 somite specification(GO:0001757) arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel endothelial cell fate specification(GO:0097101)
0.6 5.3 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.6 1.7 GO:1900275 negative regulation of phospholipase C activity(GO:1900275)
0.5 1.5 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.4 1.2 GO:2001187 natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.4 3.4 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.3 3.3 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.3 0.9 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.2 0.7 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.2 0.5 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.5 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 1.3 GO:0001675 acrosome assembly(GO:0001675)
0.1 0.4 GO:0051012 microtubule sliding(GO:0051012)
0.1 1.5 GO:0035493 SNARE complex assembly(GO:0035493)
0.1 1.2 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 0.2 GO:1903896 positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
0.1 0.1 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)
0.1 0.5 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154) regulation of thyroid hormone mediated signaling pathway(GO:0002155)
0.1 0.5 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.8 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.9 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.0 0.2 GO:0072592 oxygen metabolic process(GO:0072592) negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.8 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 0.1 GO:0097212 lysosomal membrane organization(GO:0097212)
0.0 0.6 GO:0036010 protein localization to endosome(GO:0036010)
0.0 0.3 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.3 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 0.2 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0 1.1 GO:0030901 midbrain development(GO:0030901)
0.0 0.2 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.8 GO:0007032 endosome organization(GO:0007032)
0.0 0.5 GO:0031440 regulation of mRNA 3'-end processing(GO:0031440)
0.0 0.5 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364) negative regulation of reactive oxygen species biosynthetic process(GO:1903427)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0055087 Ski complex(GO:0055087)
0.1 1.2 GO:0042101 T cell receptor complex(GO:0042101)
0.1 0.5 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 1.3 GO:0002080 acrosomal membrane(GO:0002080)
0.1 0.3 GO:1990745 EARP complex(GO:1990745)
0.1 0.7 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 3.3 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 1.5 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 3.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.9 GO:0005844 polysome(GO:0005844)
0.0 0.4 GO:0044447 axoneme part(GO:0044447)
0.0 0.9 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.3 GO:0097225 sperm midpiece(GO:0097225)
0.0 3.9 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.5 GO:0045178 basal part of cell(GO:0045178)
0.0 0.8 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 1.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.2 GO:0042405 nuclear inclusion body(GO:0042405)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.3 GO:0032027 myosin light chain binding(GO:0032027)
0.2 3.9 GO:0030957 Tat protein binding(GO:0030957)
0.2 7.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.2 1.2 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 1.7 GO:0070097 delta-catenin binding(GO:0070097)
0.1 1.5 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 1.9 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 0.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 0.8 GO:0008430 selenium binding(GO:0008430)
0.1 0.5 GO:0034056 estrogen response element binding(GO:0034056)
0.1 0.5 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 0.5 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.1 1.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 0.9 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.6 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.8 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.1 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
0.0 0.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.3 GO:0050811 GABA receptor binding(GO:0050811)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.4 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.1 5.3 PID_IGF1_PATHWAY IGF1 pathway
0.1 3.9 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 3.3 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 1.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.2 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.6 PID_IL1_PATHWAY IL1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.9 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.3 5.3 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 0.5 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 1.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 2.1 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 1.5 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.5 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.9 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.6 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.5 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.7 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 2.1 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation