Motif ID: Zic2
Z-value: 0.754
Transcription factors associated with Zic2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Zic2 | ENSMUSG00000061524.8 | Zic2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Zic2 | mm10_v2_chr14_+_122475397_122475435 | 0.20 | 2.1e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 9.2 | GO:1903002 | regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002) |
| 0.6 | 5.4 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.5 | 2.5 | GO:0007197 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207) |
| 0.5 | 1.5 | GO:0006601 | creatine biosynthetic process(GO:0006601) |
| 0.4 | 1.8 | GO:0090238 | positive regulation of arachidonic acid secretion(GO:0090238) |
| 0.4 | 1.2 | GO:0032430 | positive regulation of phospholipase A2 activity(GO:0032430) |
| 0.4 | 2.2 | GO:0019695 | choline metabolic process(GO:0019695) |
| 0.4 | 1.4 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
| 0.3 | 3.8 | GO:0090232 | positive regulation of spindle checkpoint(GO:0090232) |
| 0.3 | 1.0 | GO:1904139 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
| 0.3 | 1.6 | GO:0002339 | B cell selection(GO:0002339) |
| 0.3 | 0.9 | GO:0002423 | natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) susceptibility to natural killer cell mediated cytotoxicity(GO:0042271) |
| 0.3 | 2.1 | GO:0061092 | regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092) |
| 0.3 | 1.5 | GO:1901731 | positive regulation of platelet aggregation(GO:1901731) |
| 0.3 | 1.4 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 0.3 | 0.6 | GO:0090237 | regulation of arachidonic acid secretion(GO:0090237) |
| 0.3 | 2.2 | GO:0005513 | detection of calcium ion(GO:0005513) |
| 0.3 | 0.6 | GO:0070560 | protein secretion by platelet(GO:0070560) |
| 0.3 | 1.3 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 0.2 | 0.7 | GO:1905072 | detection of oxygen(GO:0003032) cardiac jelly development(GO:1905072) |
| 0.2 | 0.9 | GO:0014012 | peripheral nervous system axon regeneration(GO:0014012) |
| 0.2 | 0.9 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 0.2 | 0.4 | GO:0010920 | negative regulation of inositol phosphate biosynthetic process(GO:0010920) |
| 0.2 | 0.6 | GO:0043181 | vacuolar sequestering(GO:0043181) |
| 0.2 | 1.0 | GO:0070305 | response to cGMP(GO:0070305) cellular response to cGMP(GO:0071321) |
| 0.2 | 1.5 | GO:0007195 | adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195) |
| 0.2 | 4.5 | GO:0095500 | acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145) |
| 0.2 | 0.5 | GO:0021759 | globus pallidus development(GO:0021759) |
| 0.2 | 0.8 | GO:2000551 | regulation of T-helper 2 cell cytokine production(GO:2000551) positive regulation of T-helper 2 cell cytokine production(GO:2000553) |
| 0.2 | 0.5 | GO:0051771 | negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771) |
| 0.2 | 2.0 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.2 | 1.0 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 0.2 | 0.8 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.2 | 0.6 | GO:0090126 | protein complex assembly involved in synapse maturation(GO:0090126) |
| 0.2 | 0.5 | GO:0046462 | monoacylglycerol metabolic process(GO:0046462) |
| 0.1 | 0.4 | GO:0006116 | NADH oxidation(GO:0006116) |
| 0.1 | 0.5 | GO:0042414 | epinephrine metabolic process(GO:0042414) |
| 0.1 | 0.3 | GO:0045590 | negative regulation of regulatory T cell differentiation(GO:0045590) |
| 0.1 | 0.4 | GO:0010814 | substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959) |
| 0.1 | 0.9 | GO:1902302 | regulation of potassium ion export(GO:1902302) |
| 0.1 | 0.9 | GO:0033031 | positive regulation of neutrophil apoptotic process(GO:0033031) |
| 0.1 | 0.5 | GO:0035470 | positive regulation of vascular wound healing(GO:0035470) |
| 0.1 | 0.6 | GO:0010273 | detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169) |
| 0.1 | 0.5 | GO:0046604 | positive regulation of mitotic centrosome separation(GO:0046604) |
| 0.1 | 0.4 | GO:0060743 | epithelial cell maturation involved in prostate gland development(GO:0060743) alveolar secondary septum development(GO:0061144) |
| 0.1 | 0.5 | GO:0030576 | Cajal body organization(GO:0030576) |
| 0.1 | 0.7 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 0.1 | 0.5 | GO:0002322 | B cell proliferation involved in immune response(GO:0002322) |
| 0.1 | 0.2 | GO:2000344 | positive regulation of acrosome reaction(GO:2000344) |
| 0.1 | 0.3 | GO:0098928 | presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526) |
| 0.1 | 0.8 | GO:0032534 | regulation of microvillus assembly(GO:0032534) |
| 0.1 | 0.3 | GO:1901608 | regulation of vesicle transport along microtubule(GO:1901608) |
| 0.1 | 0.7 | GO:0031547 | brain-derived neurotrophic factor receptor signaling pathway(GO:0031547) |
| 0.1 | 0.7 | GO:0060024 | rhythmic synaptic transmission(GO:0060024) |
| 0.1 | 2.0 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.1 | 1.6 | GO:0051386 | regulation of neurotrophin TRK receptor signaling pathway(GO:0051386) |
| 0.1 | 0.9 | GO:1902474 | positive regulation of protein localization to synapse(GO:1902474) |
| 0.1 | 1.3 | GO:0007190 | activation of adenylate cyclase activity(GO:0007190) |
| 0.1 | 0.5 | GO:0032346 | positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) leading edge cell differentiation(GO:0035026) regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298) |
| 0.1 | 1.2 | GO:0046473 | phosphatidic acid metabolic process(GO:0046473) |
| 0.1 | 0.7 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 0.1 | 0.6 | GO:0032488 | Cdc42 protein signal transduction(GO:0032488) |
| 0.1 | 0.7 | GO:0030388 | fructose 6-phosphate metabolic process(GO:0006002) fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.1 | 0.3 | GO:1901228 | positive regulation of skeletal muscle tissue growth(GO:0048633) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228) |
| 0.1 | 0.3 | GO:1902938 | regulation of intracellular calcium activated chloride channel activity(GO:1902938) |
| 0.1 | 0.8 | GO:1902416 | positive regulation of mRNA binding(GO:1902416) |
| 0.1 | 0.3 | GO:0006049 | UDP-N-acetylglucosamine catabolic process(GO:0006049) |
| 0.1 | 0.7 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 0.1 | 0.2 | GO:0035928 | rRNA import into mitochondrion(GO:0035928) |
| 0.1 | 0.7 | GO:0006013 | mannose metabolic process(GO:0006013) |
| 0.1 | 1.1 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.1 | 0.8 | GO:0046959 | habituation(GO:0046959) |
| 0.1 | 0.3 | GO:0010756 | positive regulation of plasminogen activation(GO:0010756) |
| 0.1 | 1.3 | GO:0005980 | polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247) |
| 0.1 | 0.5 | GO:0010747 | positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) |
| 0.1 | 0.2 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
| 0.1 | 0.6 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
| 0.1 | 0.3 | GO:0061743 | motor learning(GO:0061743) |
| 0.1 | 0.7 | GO:0061470 | interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619) |
| 0.1 | 0.7 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.1 | 0.4 | GO:0050861 | positive regulation of B cell receptor signaling pathway(GO:0050861) |
| 0.1 | 0.2 | GO:0030200 | heparan sulfate proteoglycan catabolic process(GO:0030200) |
| 0.1 | 0.4 | GO:1903300 | negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300) |
| 0.1 | 0.2 | GO:0006931 | substrate-dependent cell migration, cell attachment to substrate(GO:0006931) transforming growth factor-beta secretion(GO:0038044) blood coagulation, fibrin clot formation(GO:0072378) |
| 0.1 | 0.7 | GO:0006047 | UDP-N-acetylglucosamine metabolic process(GO:0006047) |
| 0.1 | 0.3 | GO:0006244 | pyrimidine nucleotide catabolic process(GO:0006244) pyrimidine deoxyribonucleotide catabolic process(GO:0009223) |
| 0.1 | 0.3 | GO:0002606 | positive regulation of dendritic cell antigen processing and presentation(GO:0002606) |
| 0.1 | 0.9 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
| 0.1 | 0.7 | GO:0072643 | interferon-gamma secretion(GO:0072643) |
| 0.1 | 2.3 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
| 0.1 | 0.5 | GO:0000050 | urea cycle(GO:0000050) urea metabolic process(GO:0019627) |
| 0.1 | 0.1 | GO:0048630 | skeletal muscle tissue growth(GO:0048630) |
| 0.1 | 0.2 | GO:0035523 | protein K29-linked deubiquitination(GO:0035523) protein K6-linked deubiquitination(GO:0044313) |
| 0.1 | 0.8 | GO:0015809 | arginine transport(GO:0015809) |
| 0.1 | 1.0 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.1 | 0.6 | GO:0051103 | DNA ligation involved in DNA repair(GO:0051103) |
| 0.1 | 0.5 | GO:0099640 | axo-dendritic protein transport(GO:0099640) |
| 0.1 | 0.4 | GO:0044375 | regulation of peroxisome size(GO:0044375) |
| 0.1 | 0.9 | GO:0001516 | prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457) |
| 0.1 | 0.7 | GO:0042711 | maternal behavior(GO:0042711) |
| 0.1 | 0.7 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
| 0.1 | 0.6 | GO:0033211 | adiponectin-activated signaling pathway(GO:0033211) long-chain fatty acid import(GO:0044539) |
| 0.1 | 0.3 | GO:0098909 | regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909) |
| 0.1 | 0.2 | GO:0019355 | nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628) |
| 0.1 | 0.3 | GO:0002934 | desmosome organization(GO:0002934) |
| 0.1 | 0.3 | GO:0097491 | trigeminal nerve morphogenesis(GO:0021636) trigeminal nerve structural organization(GO:0021637) trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491) neural crest cell migration involved in autonomic nervous system development(GO:1901166) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287) |
| 0.1 | 0.2 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378) |
| 0.0 | 0.7 | GO:0048681 | negative regulation of axon regeneration(GO:0048681) |
| 0.0 | 0.1 | GO:0033087 | negative regulation of immature T cell proliferation(GO:0033087) |
| 0.0 | 0.2 | GO:0042699 | follicle-stimulating hormone signaling pathway(GO:0042699) |
| 0.0 | 0.4 | GO:0014816 | skeletal muscle satellite cell differentiation(GO:0014816) |
| 0.0 | 0.3 | GO:0030382 | sperm mitochondrion organization(GO:0030382) |
| 0.0 | 0.1 | GO:0019482 | beta-alanine metabolic process(GO:0019482) |
| 0.0 | 1.6 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
| 0.0 | 0.4 | GO:0035845 | photoreceptor cell outer segment organization(GO:0035845) |
| 0.0 | 0.3 | GO:0035434 | copper ion transmembrane transport(GO:0035434) |
| 0.0 | 0.3 | GO:0032026 | response to magnesium ion(GO:0032026) |
| 0.0 | 1.1 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.0 | 0.3 | GO:0006729 | tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146) |
| 0.0 | 1.3 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.0 | 0.2 | GO:1901552 | positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142) |
| 0.0 | 0.1 | GO:0003199 | endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) |
| 0.0 | 0.1 | GO:0055091 | phospholipid homeostasis(GO:0055091) |
| 0.0 | 1.1 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.0 | 0.3 | GO:0070257 | positive regulation of mucus secretion(GO:0070257) |
| 0.0 | 0.2 | GO:0015862 | uridine transport(GO:0015862) |
| 0.0 | 0.6 | GO:0014046 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
| 0.0 | 0.7 | GO:0019835 | cytolysis(GO:0019835) |
| 0.0 | 0.5 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
| 0.0 | 0.7 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.0 | 0.3 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.0 | 0.1 | GO:1900864 | tRNA wobble position uridine thiolation(GO:0002143) mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864) |
| 0.0 | 0.1 | GO:0042891 | antibiotic transport(GO:0042891) |
| 0.0 | 0.7 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.0 | 0.3 | GO:0007602 | phototransduction(GO:0007602) |
| 0.0 | 0.1 | GO:2000987 | positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987) |
| 0.0 | 0.2 | GO:0007202 | activation of phospholipase C activity(GO:0007202) |
| 0.0 | 0.7 | GO:0043949 | regulation of cAMP-mediated signaling(GO:0043949) |
| 0.0 | 0.7 | GO:0007520 | myoblast fusion(GO:0007520) |
| 0.0 | 0.2 | GO:0051152 | positive regulation of smooth muscle cell differentiation(GO:0051152) |
| 0.0 | 0.1 | GO:0046501 | protoporphyrinogen IX metabolic process(GO:0046501) |
| 0.0 | 0.1 | GO:0045578 | negative regulation of B cell differentiation(GO:0045578) |
| 0.0 | 0.2 | GO:0060136 | embryonic process involved in female pregnancy(GO:0060136) |
| 0.0 | 0.7 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 0.0 | 0.1 | GO:0002710 | negative regulation of T cell mediated immunity(GO:0002710) |
| 0.0 | 0.6 | GO:0045687 | positive regulation of glial cell differentiation(GO:0045687) |
| 0.0 | 0.1 | GO:1900226 | negative regulation of NLRP3 inflammasome complex assembly(GO:1900226) |
| 0.0 | 0.2 | GO:0040031 | snRNA modification(GO:0040031) |
| 0.0 | 0.1 | GO:0006478 | peptidyl-tyrosine sulfation(GO:0006478) |
| 0.0 | 0.1 | GO:0071394 | cellular response to testosterone stimulus(GO:0071394) |
| 0.0 | 0.1 | GO:0042048 | olfactory behavior(GO:0042048) |
| 0.0 | 0.3 | GO:0048148 | behavioral response to cocaine(GO:0048148) |
| 0.0 | 0.1 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) |
| 0.0 | 0.6 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
| 0.0 | 0.9 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 0.0 | 0.0 | GO:0043113 | receptor clustering(GO:0043113) |
| 0.0 | 0.1 | GO:0051902 | negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180) regulation of caveolin-mediated endocytosis(GO:2001286) |
| 0.0 | 0.3 | GO:0008206 | bile acid metabolic process(GO:0008206) |
| 0.0 | 1.1 | GO:0046785 | microtubule polymerization(GO:0046785) |
| 0.0 | 0.1 | GO:0035509 | negative regulation of myosin-light-chain-phosphatase activity(GO:0035509) |
| 0.0 | 0.2 | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
| 0.0 | 0.2 | GO:0070234 | positive regulation of T cell apoptotic process(GO:0070234) |
| 0.0 | 0.1 | GO:0018344 | protein geranylgeranylation(GO:0018344) |
| 0.0 | 0.1 | GO:0090315 | negative regulation of protein targeting to membrane(GO:0090315) |
| 0.0 | 0.2 | GO:0030252 | growth hormone secretion(GO:0030252) |
| 0.0 | 0.0 | GO:0032271 | regulation of protein polymerization(GO:0032271) |
| 0.0 | 0.3 | GO:0097320 | membrane tubulation(GO:0097320) |
| 0.0 | 2.1 | GO:0030041 | actin filament polymerization(GO:0030041) |
| 0.0 | 0.1 | GO:0006516 | glycoprotein catabolic process(GO:0006516) |
| 0.0 | 0.0 | GO:0006667 | sphinganine metabolic process(GO:0006667) |
| 0.0 | 0.2 | GO:0043982 | histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982) |
| 0.0 | 0.4 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.0 | 0.1 | GO:0048096 | chromatin-mediated maintenance of transcription(GO:0048096) |
| 0.0 | 0.1 | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 9.2 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.7 | 2.0 | GO:0005940 | septin ring(GO:0005940) |
| 0.5 | 1.9 | GO:0032280 | symmetric synapse(GO:0032280) |
| 0.5 | 1.9 | GO:0019815 | B cell receptor complex(GO:0019815) |
| 0.4 | 1.2 | GO:0032311 | angiogenin-PRI complex(GO:0032311) |
| 0.3 | 1.0 | GO:0098855 | HCN channel complex(GO:0098855) |
| 0.3 | 1.1 | GO:1902937 | inward rectifier potassium channel complex(GO:1902937) |
| 0.2 | 0.5 | GO:0045009 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.2 | 0.7 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.2 | 0.5 | GO:0044194 | cytolytic granule(GO:0044194) |
| 0.2 | 0.5 | GO:0036488 | CHOP-C/EBP complex(GO:0036488) |
| 0.2 | 0.5 | GO:0005965 | protein farnesyltransferase complex(GO:0005965) |
| 0.2 | 1.5 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.2 | 3.3 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.2 | 2.1 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.2 | 0.8 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 0.2 | 0.5 | GO:0097233 | lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233) |
| 0.2 | 1.4 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.1 | 0.8 | GO:0045179 | apical cortex(GO:0045179) |
| 0.1 | 0.5 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.1 | 4.9 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.1 | 1.1 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.1 | 2.2 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.1 | 0.3 | GO:1990257 | piccolo-bassoon transport vesicle(GO:1990257) |
| 0.1 | 0.9 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
| 0.1 | 0.4 | GO:1902636 | kinociliary basal body(GO:1902636) |
| 0.1 | 0.6 | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807) |
| 0.1 | 1.0 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.1 | 0.4 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.1 | 0.4 | GO:0043527 | tRNA methyltransferase complex(GO:0043527) |
| 0.1 | 0.2 | GO:0071953 | fibrinogen complex(GO:0005577) elastic fiber(GO:0071953) |
| 0.1 | 0.3 | GO:0001652 | granular component(GO:0001652) |
| 0.1 | 0.3 | GO:0044301 | climbing fiber(GO:0044301) |
| 0.1 | 1.3 | GO:0043218 | compact myelin(GO:0043218) |
| 0.1 | 0.3 | GO:0097227 | sperm annulus(GO:0097227) |
| 0.1 | 3.7 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 0.7 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.0 | 5.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 1.5 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 0.6 | GO:0031256 | leading edge membrane(GO:0031256) ruffle membrane(GO:0032587) |
| 0.0 | 0.8 | GO:0045120 | pronucleus(GO:0045120) |
| 0.0 | 0.4 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.0 | 1.5 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 0.9 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 2.8 | GO:0030315 | T-tubule(GO:0030315) |
| 0.0 | 0.6 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.0 | 1.2 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 0.7 | GO:0044291 | cell-cell contact zone(GO:0044291) |
| 0.0 | 2.0 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 0.5 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 0.3 | GO:0044754 | autolysosome(GO:0044754) |
| 0.0 | 0.7 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.0 | 0.3 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.0 | 0.2 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.0 | 1.2 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 0.3 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 0.2 | GO:0016272 | prefoldin complex(GO:0016272) |
| 0.0 | 0.4 | GO:0070822 | Sin3-type complex(GO:0070822) |
| 0.0 | 0.3 | GO:0031045 | dense core granule(GO:0031045) |
| 0.0 | 1.3 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 0.4 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 0.2 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 0.1 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.0 | 0.2 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.0 | 0.1 | GO:0005968 | Rab-protein geranylgeranyltransferase complex(GO:0005968) |
| 0.0 | 0.1 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.0 | 0.3 | GO:0030137 | COPI-coated vesicle(GO:0030137) |
| 0.0 | 0.1 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.0 | 0.5 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 0.4 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 0.9 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 1.5 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 0.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 0.1 | GO:0042825 | TAP complex(GO:0042825) |
| 0.0 | 0.3 | GO:0031526 | brush border membrane(GO:0031526) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 9.2 | GO:0046911 | hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.5 | 2.2 | GO:0004104 | cholinesterase activity(GO:0004104) choline binding(GO:0033265) |
| 0.5 | 2.5 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
| 0.5 | 2.8 | GO:0008294 | calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294) |
| 0.5 | 1.4 | GO:0070905 | serine binding(GO:0070905) |
| 0.4 | 1.3 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
| 0.3 | 2.6 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
| 0.3 | 1.4 | GO:2001070 | starch binding(GO:2001070) |
| 0.3 | 0.8 | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity(GO:0008113) |
| 0.3 | 1.0 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) |
| 0.2 | 0.7 | GO:0030158 | protein xylosyltransferase activity(GO:0030158) |
| 0.2 | 0.6 | GO:0043758 | acetate-CoA ligase (ADP-forming) activity(GO:0043758) |
| 0.2 | 0.6 | GO:0004574 | oligo-1,6-glucosidase activity(GO:0004574) |
| 0.2 | 0.9 | GO:1902282 | voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282) |
| 0.2 | 2.0 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
| 0.2 | 0.5 | GO:0047179 | platelet-activating factor acetyltransferase activity(GO:0047179) |
| 0.2 | 0.7 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
| 0.2 | 0.5 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
| 0.2 | 0.7 | GO:0008184 | glycogen phosphorylase activity(GO:0008184) |
| 0.2 | 0.5 | GO:0004660 | protein farnesyltransferase activity(GO:0004660) |
| 0.2 | 0.5 | GO:0070140 | isopeptidase activity(GO:0070122) ubiquitin-like protein-specific isopeptidase activity(GO:0070138) SUMO-specific isopeptidase activity(GO:0070140) |
| 0.2 | 0.5 | GO:0004686 | elongation factor-2 kinase activity(GO:0004686) |
| 0.1 | 0.7 | GO:0005534 | galactose binding(GO:0005534) |
| 0.1 | 0.9 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.1 | 0.7 | GO:0008761 | UDP-N-acetylglucosamine 2-epimerase activity(GO:0008761) |
| 0.1 | 2.2 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.1 | 1.0 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.1 | 1.5 | GO:0015250 | water channel activity(GO:0015250) |
| 0.1 | 0.7 | GO:0005030 | neurotrophin receptor activity(GO:0005030) |
| 0.1 | 1.4 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.1 | 0.8 | GO:0016714 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714) |
| 0.1 | 0.7 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.1 | 0.6 | GO:0008427 | calcium-dependent protein kinase inhibitor activity(GO:0008427) |
| 0.1 | 0.9 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813) |
| 0.1 | 0.4 | GO:0004090 | carbonyl reductase (NADPH) activity(GO:0004090) |
| 0.1 | 0.4 | GO:0004692 | cGMP-dependent protein kinase activity(GO:0004692) |
| 0.1 | 0.2 | GO:0070051 | fibrinogen binding(GO:0070051) |
| 0.1 | 0.8 | GO:0015181 | arginine transmembrane transporter activity(GO:0015181) |
| 0.1 | 1.9 | GO:0008188 | neuropeptide receptor activity(GO:0008188) |
| 0.1 | 0.6 | GO:1990599 | 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599) |
| 0.1 | 3.8 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.1 | 2.1 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.1 | 0.8 | GO:1990715 | mRNA CDS binding(GO:1990715) |
| 0.1 | 0.3 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.1 | 1.3 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 0.3 | GO:0005375 | copper ion transmembrane transporter activity(GO:0005375) |
| 0.1 | 0.3 | GO:0004844 | uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506) |
| 0.1 | 1.1 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 0.2 | GO:0031826 | type 2A serotonin receptor binding(GO:0031826) |
| 0.1 | 0.3 | GO:0008410 | CoA-transferase activity(GO:0008410) |
| 0.1 | 0.2 | GO:0046538 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
| 0.1 | 0.7 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.1 | 0.6 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
| 0.1 | 0.3 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.1 | 0.9 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.1 | 0.3 | GO:1903135 | cupric ion binding(GO:1903135) |
| 0.1 | 1.0 | GO:0045503 | dynein light chain binding(GO:0045503) |
| 0.1 | 0.1 | GO:0043426 | MRF binding(GO:0043426) |
| 0.1 | 1.5 | GO:0016769 | transferase activity, transferring nitrogenous groups(GO:0016769) |
| 0.1 | 0.2 | GO:0008332 | low voltage-gated calcium channel activity(GO:0008332) |
| 0.1 | 0.8 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.1 | 1.0 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.1 | 0.6 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.1 | 0.9 | GO:0042809 | vitamin D receptor binding(GO:0042809) |
| 0.1 | 0.6 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.1 | 0.2 | GO:0004515 | nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515) |
| 0.1 | 0.2 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.0 | 0.2 | GO:0004792 | thiosulfate sulfurtransferase activity(GO:0004792) |
| 0.0 | 2.3 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.0 | 2.5 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 0.5 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
| 0.0 | 0.5 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.0 | 0.4 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.0 | 1.1 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.0 | 0.1 | GO:0008525 | phosphatidylcholine transporter activity(GO:0008525) |
| 0.0 | 1.4 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 0.2 | GO:0035184 | histone threonine kinase activity(GO:0035184) |
| 0.0 | 0.2 | GO:1904288 | BAT3 complex binding(GO:1904288) |
| 0.0 | 1.0 | GO:0030291 | protein serine/threonine kinase inhibitor activity(GO:0030291) |
| 0.0 | 0.8 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.0 | 0.5 | GO:0004622 | lysophospholipase activity(GO:0004622) acylglycerol lipase activity(GO:0047372) |
| 0.0 | 0.1 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
| 0.0 | 1.5 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.0 | 0.7 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.1 | GO:0016167 | glial cell-derived neurotrophic factor receptor activity(GO:0016167) |
| 0.0 | 0.7 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.0 | 0.5 | GO:0001013 | RNA polymerase I regulatory region DNA binding(GO:0001013) |
| 0.0 | 0.7 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.0 | 1.1 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.0 | 0.1 | GO:0004427 | inorganic diphosphatase activity(GO:0004427) |
| 0.0 | 0.1 | GO:0001032 | RNA polymerase III type 3 promoter DNA binding(GO:0001032) |
| 0.0 | 0.6 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 0.5 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.0 | 0.1 | GO:0033142 | progesterone receptor binding(GO:0033142) |
| 0.0 | 0.2 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.0 | 0.3 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.0 | 0.1 | GO:0042895 | antibiotic transporter activity(GO:0042895) |
| 0.0 | 0.5 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.0 | 1.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.1 | GO:0005093 | Rab GDP-dissociation inhibitor activity(GO:0005093) |
| 0.0 | 0.4 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.0 | 0.6 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.0 | 1.1 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 0.1 | GO:0004663 | Rab geranylgeranyltransferase activity(GO:0004663) |
| 0.0 | 0.1 | GO:0004458 | D-lactate dehydrogenase (cytochrome) activity(GO:0004458) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898) |
| 0.0 | 0.1 | GO:0004954 | icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955) |
| 0.0 | 0.5 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.0 | 0.1 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.0 | 0.8 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.0 | 0.1 | GO:0004043 | L-aminoadipate-semialdehyde dehydrogenase activity(GO:0004043) |
| 0.0 | 0.3 | GO:0003988 | acetyl-CoA C-acyltransferase activity(GO:0003988) |
| 0.0 | 0.1 | GO:0015923 | mannosidase activity(GO:0015923) |
| 0.0 | 0.1 | GO:0008476 | protein-tyrosine sulfotransferase activity(GO:0008476) |
| 0.0 | 0.5 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.0 | 0.2 | GO:0043995 | histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972) |
| 0.0 | 0.3 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 0.0 | 0.1 | GO:0004768 | stearoyl-CoA 9-desaturase activity(GO:0004768) |
| 0.0 | 0.1 | GO:0031628 | opioid peptide activity(GO:0001515) opioid receptor binding(GO:0031628) |
| 0.0 | 0.4 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.0 | 0.2 | GO:0005248 | voltage-gated sodium channel activity(GO:0005248) |
| 0.0 | 0.0 | GO:0009881 | photoreceptor activity(GO:0009881) |
| 0.0 | 0.2 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
| 0.0 | 0.3 | GO:0017110 | nucleoside-diphosphatase activity(GO:0017110) |
| 0.0 | 0.3 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.0 | 0.5 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 0.7 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 0.1 | GO:0016783 | sulfurtransferase activity(GO:0016783) |
| 0.0 | 1.2 | GO:0005525 | GTP binding(GO:0005525) |
| 0.0 | 0.1 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.0 | 0.4 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 0.1 | GO:0016634 | oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634) |
| 0.0 | 0.0 | GO:0042284 | sphingolipid delta-4 desaturase activity(GO:0042284) |
| 0.0 | 0.5 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.0 | 0.9 | GO:0016209 | antioxidant activity(GO:0016209) |
| 0.0 | 0.1 | GO:0015464 | acetylcholine receptor activity(GO:0015464) acetylcholine binding(GO:0042166) |
| 0.0 | 0.2 | GO:0004623 | phospholipase A2 activity(GO:0004623) |
| 0.0 | 0.4 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 0.0 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.0 | 0.1 | GO:0046978 | TAP1 binding(GO:0046978) TAP2 binding(GO:0046979) |
| 0.0 | 0.0 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
| 0.0 | 0.1 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
| 0.0 | 0.0 | GO:0052658 | inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) |
| 0.0 | 0.5 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.0 | 0.2 | GO:0042608 | T cell receptor binding(GO:0042608) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.2 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.2 | 2.8 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.1 | 3.7 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 2.7 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 1.3 | PID_A6B1_A6B4_INTEGRIN_PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 4.6 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 3.4 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
| 0.0 | 2.2 | PID_INTEGRIN_A4B1_PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 0.4 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 2.0 | PID_NEPHRIN_NEPH1_PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 0.9 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
| 0.0 | 0.2 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 0.6 | PID_NFKAPPAB_ATYPICAL_PATHWAY | Atypical NF-kappaB pathway |
| 0.0 | 0.8 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.0 | 3.6 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.6 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 0.3 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.0 | 0.2 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 0.5 | PID_WNT_CANONICAL_PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 0.8 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 1.6 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.1 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 0.4 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.4 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 0.4 | ST_P38_MAPK_PATHWAY | p38 MAPK Pathway |
| 0.0 | 0.4 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 0.6 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 9.2 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.2 | 2.8 | REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.2 | 2.5 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.2 | 2.1 | REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.1 | 1.4 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.1 | 1.0 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.1 | 2.7 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.1 | 2.1 | REACTOME_SYNTHESIS_OF_PC | Genes involved in Synthesis of PC |
| 0.1 | 0.7 | REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.1 | 0.1 | REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS | Genes involved in Eicosanoid ligand-binding receptors |
| 0.1 | 3.6 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.1 | 0.7 | REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.1 | 2.1 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 1.0 | REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 0.5 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 1.5 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.0 | 1.1 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 0.7 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 1.1 | REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 1.5 | REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 0.8 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 0.4 | REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS | Genes involved in G alpha (z) signalling events |
| 0.0 | 0.6 | REACTOME_INTEGRATION_OF_PROVIRUS | Genes involved in Integration of provirus |
| 0.0 | 0.1 | REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 0.0 | 1.7 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 0.3 | REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.0 | 0.5 | REACTOME_MTORC1_MEDIATED_SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 0.3 | REACTOME_PYRIMIDINE_CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.0 | 0.5 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 0.3 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 0.1 | REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.0 | 0.6 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 0.5 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 1.1 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 0.6 | REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 1.9 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 1.0 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.4 | REACTOME_PLATELET_SENSITIZATION_BY_LDL | Genes involved in Platelet sensitization by LDL |
| 0.0 | 0.7 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.6 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.3 | REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.0 | 0.7 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 0.2 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.3 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
| 0.0 | 0.7 | REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.0 | 0.6 | REACTOME_TRIGLYCERIDE_BIOSYNTHESIS | Genes involved in Triglyceride Biosynthesis |
| 0.0 | 0.4 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.0 | 0.1 | REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.0 | 0.1 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.0 | 1.1 | REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.0 | 0.7 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 0.9 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 0.6 | REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS | Genes involved in Post NMDA receptor activation events |
| 0.0 | 0.2 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
