Motif ID: Zscan4c
Z-value: 0.916
Transcription factors associated with Zscan4c:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Zscan4c | ENSMUSG00000054272.5 | Zscan4c |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 8.4 | GO:0001928 | regulation of exocyst assembly(GO:0001928) |
| 1.5 | 7.7 | GO:0055095 | lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) |
| 1.2 | 3.5 | GO:2000501 | natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501) |
| 1.1 | 3.4 | GO:0035585 | calcium-mediated signaling using extracellular calcium source(GO:0035585) |
| 1.1 | 8.8 | GO:0099550 | trans-synaptic signalling, modulating synaptic transmission(GO:0099550) |
| 0.8 | 2.5 | GO:0046098 | guanine metabolic process(GO:0046098) |
| 0.8 | 3.3 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.7 | 3.7 | GO:0007197 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207) |
| 0.7 | 2.2 | GO:0070343 | white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) |
| 0.7 | 2.1 | GO:0002842 | positive regulation of T cell mediated immune response to tumor cell(GO:0002842) positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) |
| 0.6 | 3.6 | GO:0060718 | chorionic trophoblast cell differentiation(GO:0060718) |
| 0.6 | 2.8 | GO:2001025 | positive regulation of response to drug(GO:2001025) |
| 0.6 | 4.4 | GO:0097264 | self proteolysis(GO:0097264) |
| 0.5 | 10.3 | GO:0050650 | chondroitin sulfate proteoglycan biosynthetic process(GO:0050650) |
| 0.5 | 2.9 | GO:0006072 | glycerol-3-phosphate metabolic process(GO:0006072) |
| 0.5 | 2.8 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 0.4 | 2.6 | GO:1904936 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
| 0.4 | 2.3 | GO:0033600 | negative regulation of mammary gland epithelial cell proliferation(GO:0033600) |
| 0.3 | 2.1 | GO:0061092 | involuntary skeletal muscle contraction(GO:0003011) regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092) |
| 0.3 | 2.0 | GO:1900116 | sequestering of extracellular ligand from receptor(GO:0035581) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116) |
| 0.3 | 1.3 | GO:0019659 | fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661) |
| 0.2 | 6.9 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.2 | 0.7 | GO:1902277 | negative regulation of pancreatic amylase secretion(GO:1902277) |
| 0.2 | 1.4 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
| 0.2 | 1.1 | GO:0060907 | positive regulation of macrophage cytokine production(GO:0060907) |
| 0.1 | 2.8 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
| 0.1 | 1.0 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 0.1 | 2.6 | GO:0035020 | regulation of Rac protein signal transduction(GO:0035020) |
| 0.1 | 0.8 | GO:0048170 | positive regulation of long-term neuronal synaptic plasticity(GO:0048170) |
| 0.1 | 2.1 | GO:0042178 | xenobiotic catabolic process(GO:0042178) |
| 0.1 | 1.0 | GO:0060120 | auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120) |
| 0.1 | 8.7 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.1 | 0.3 | GO:0060217 | hemangioblast cell differentiation(GO:0060217) |
| 0.1 | 2.1 | GO:0021542 | dentate gyrus development(GO:0021542) |
| 0.1 | 4.5 | GO:0007200 | phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200) |
| 0.1 | 5.0 | GO:0003073 | regulation of systemic arterial blood pressure(GO:0003073) |
| 0.1 | 1.5 | GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193) |
| 0.1 | 2.1 | GO:1901381 | positive regulation of potassium ion transmembrane transport(GO:1901381) |
| 0.0 | 0.9 | GO:0006044 | N-acetylglucosamine metabolic process(GO:0006044) |
| 0.0 | 0.6 | GO:1902902 | negative regulation of autophagosome assembly(GO:1902902) |
| 0.0 | 0.2 | GO:1900170 | negative regulation of glucocorticoid mediated signaling pathway(GO:1900170) |
| 0.0 | 0.4 | GO:1901020 | negative regulation of calcium ion transmembrane transporter activity(GO:1901020) |
| 0.0 | 0.6 | GO:2000785 | regulation of autophagosome assembly(GO:2000785) |
| 0.0 | 0.2 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.0 | 1.7 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
| 0.0 | 0.7 | GO:1902653 | cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653) |
| 0.0 | 0.0 | GO:0006438 | valyl-tRNA aminoacylation(GO:0006438) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 6.9 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.8 | 3.4 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.6 | 2.9 | GO:0009331 | glycerol-3-phosphate dehydrogenase complex(GO:0009331) |
| 0.3 | 2.8 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.2 | 2.1 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.2 | 8.8 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.2 | 3.7 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.2 | 2.8 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.1 | 17.1 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 1.9 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 2.6 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 0.3 | GO:0033193 | Lsd1/2 complex(GO:0033193) |
| 0.1 | 1.3 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.1 | 2.9 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.1 | 1.0 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 1.5 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 10.3 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 0.4 | GO:0016589 | NURF complex(GO:0016589) |
| 0.0 | 2.1 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 0.8 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.0 | 0.4 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 15.7 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 2.1 | GO:0043209 | myelin sheath(GO:0043209) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 8.8 | GO:0005030 | neurotrophin receptor activity(GO:0005030) |
| 1.7 | 10.3 | GO:0015018 | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018) |
| 1.5 | 7.7 | GO:0055100 | adiponectin binding(GO:0055100) |
| 1.2 | 6.9 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 1.0 | 2.9 | GO:0016901 | glycerol-3-phosphate dehydrogenase activity(GO:0004368) oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901) |
| 0.7 | 3.7 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
| 0.7 | 3.3 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.4 | 8.4 | GO:0030275 | LRR domain binding(GO:0030275) |
| 0.3 | 1.3 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 0.3 | 2.8 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.2 | 4.6 | GO:0008188 | neuropeptide receptor activity(GO:0008188) |
| 0.2 | 2.0 | GO:0036122 | BMP binding(GO:0036122) |
| 0.2 | 1.5 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.2 | 2.8 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.2 | 2.1 | GO:0016151 | nickel cation binding(GO:0016151) |
| 0.2 | 1.4 | GO:0016308 | 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308) |
| 0.2 | 2.1 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.2 | 3.1 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.2 | 3.6 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.2 | 7.2 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.1 | 5.0 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.1 | 3.5 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.1 | 2.4 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.1 | 1.1 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.1 | 1.0 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 0.1 | 1.3 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.1 | 4.0 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.1 | 2.1 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.1 | 2.5 | GO:0016814 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814) |
| 0.1 | 0.4 | GO:0031698 | beta-2 adrenergic receptor binding(GO:0031698) |
| 0.1 | 5.4 | GO:0035254 | glutamate receptor binding(GO:0035254) |
| 0.1 | 3.4 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 2.1 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.0 | 0.2 | GO:0038049 | glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051) |
| 0.0 | 0.7 | GO:0016628 | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628) |
| 0.0 | 1.0 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 0.4 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.0 | 0.4 | GO:0070566 | adenylyltransferase activity(GO:0070566) |
| 0.0 | 0.8 | GO:0045182 | translation regulator activity(GO:0045182) |
| 0.0 | 0.7 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.2 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 0.2 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.0 | 0.0 | GO:0004832 | valine-tRNA ligase activity(GO:0004832) |
| 0.0 | 2.9 | GO:0008022 | protein C-terminus binding(GO:0008022) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.4 | PID_FGF_PATHWAY | FGF signaling pathway |
| 0.1 | 8.8 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 1.5 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
| 0.1 | 5.2 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 2.6 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.0 | 6.7 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 5.1 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.3 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 1.0 | PID_REELIN_PATHWAY | Reelin signaling pathway |
| 0.0 | 0.9 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 3.2 | NABA_MATRISOME_ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.0 | 1.3 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 1.0 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.0 | 0.4 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.0 | 0.7 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 6.9 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.3 | 10.3 | REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.3 | 3.7 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.3 | 5.0 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.2 | 3.6 | REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.2 | 2.5 | REACTOME_PURINE_CATABOLISM | Genes involved in Purine catabolism |
| 0.2 | 7.7 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.2 | 8.4 | REACTOME_INTERFERON_GAMMA_SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 1.4 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 2.1 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 1.0 | REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.1 | 2.0 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
| 0.1 | 2.8 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 1.3 | REACTOME_PYRUVATE_METABOLISM | Genes involved in Pyruvate metabolism |
| 0.1 | 2.1 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 1.1 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 1.5 | REACTOME_G_PROTEIN_ACTIVATION | Genes involved in G-protein activation |
| 0.0 | 0.9 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |
| 0.0 | 0.4 | REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.0 | 0.7 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 3.3 | REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM | Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism |
| 0.0 | 0.2 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
