Motif ID: Aire

Z-value: 0.487


Transcription factors associated with Aire:

Gene SymbolEntrez IDGene Name
Aire ENSMUSG00000000731.9 Aire



Activity profile for motif Aire.

activity profile for motif Aire


Sorted Z-values histogram for motif Aire

Sorted Z-values for motif Aire



Network of associatons between targets according to the STRING database.



First level regulatory network of Aire

PNG image of the network

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Top targets:


Showing 1 to 20 of 97 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_61185558 10.239 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr9_-_124493793 1.551 ENSMUST00000178787.1
 Gm21836
predicted gene, 21836
chr5_-_135251209 0.944 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chr16_+_36875119 0.815 ENSMUST00000135406.1
ENSMUST00000114812.1
ENSMUST00000134616.1
ENSMUST00000023534.6
 Golgb1


Golgb1
golgi autoantigen, golgin subfamily b, macrogolgin 1


golgi autoantigen, golgin subfamily b, macrogolgin 1
chr5_+_43672289 0.814 ENSMUST00000156034.1
 Cc2d2a
coiled-coil and C2 domain containing 2A
chr3_-_116968969 0.805 ENSMUST00000143611.1
ENSMUST00000040097.7
 Palmd

palmdelphin

chr12_-_78983476 0.800 ENSMUST00000070174.7
 Tmem229b
transmembrane protein 229B
chr5_-_84417359 0.733 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr19_-_28963863 0.629 ENSMUST00000161813.1
 4430402I18Rik
RIKEN cDNA 4430402I18 gene
chrM_+_11734 0.609 ENSMUST00000082418.1
 mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr7_-_127895578 0.540 ENSMUST00000033074.6
 Vkorc1
vitamin K epoxide reductase complex, subunit 1
chr14_+_124005355 0.528 ENSMUST00000166105.1
 Gm17615
predicted gene, 17615
chr12_+_84052114 0.514 ENSMUST00000120927.1
 Acot3
acyl-CoA thioesterase 3
chr7_-_126922887 0.471 ENSMUST00000134134.1
ENSMUST00000119781.1
ENSMUST00000121612.2
 Tmem219


transmembrane protein 219


chr14_+_76476913 0.448 ENSMUST00000140251.2
 Tsc22d1
TSC22 domain family, member 1
chr9_-_108263706 0.448 ENSMUST00000171412.1
 Dag1
dystroglycan 1
chr16_-_91618986 0.437 ENSMUST00000143058.1
ENSMUST00000049244.8
ENSMUST00000169982.1
ENSMUST00000133731.1
 Dnajc28



DnaJ (Hsp40) homolog, subfamily C, member 28



chr18_+_37725706 0.409 ENSMUST00000066149.6
 Pcdhga9
protocadherin gamma subfamily A, 9
chr2_+_175283298 0.407 ENSMUST00000098998.3
 Gm14440
predicted gene 14440
chr13_-_110280103 0.397 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 0.9 GO:1990523 bone regeneration(GO:1990523)
0.1 0.8 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.1 0.7 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.2 0.5 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.1 0.5 GO:0032788 saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.1 0.4 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.1 0.4 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.1 0.4 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.4 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.1 0.3 GO:0006550 isoleucine catabolic process(GO:0006550) acetyl-CoA catabolic process(GO:0046356) ketone body catabolic process(GO:0046952)
0.1 0.3 GO:0034241 positive regulation of macrophage fusion(GO:0034241) regulation of osteoclast proliferation(GO:0090289)
0.0 0.3 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.3 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0 0.3 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.3 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 0.3 GO:1902414 protein localization to cell junction(GO:1902414)
0.0 0.3 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.3 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.3 GO:0032288 myelin assembly(GO:0032288)
0.1 0.2 GO:1900369 negative regulation of RNA interference(GO:1900369)

Gene overrepresentation in cellular_component category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 GO:0031527 filopodium membrane(GO:0031527)
0.1 0.8 GO:0036038 MKS complex(GO:0036038)
0.0 0.8 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.6 GO:0017119 Golgi transport complex(GO:0017119)
0.1 0.4 GO:0016011 dystroglycan complex(GO:0016011)
0.0 0.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.2 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.2 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.1 GO:1990037 Lewy body core(GO:1990037)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.7 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 0.5 GO:0048038 quinone binding(GO:0048038)
0.0 0.5 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.4 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.4 GO:0031489 myosin V binding(GO:0031489)
0.0 0.4 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.1 0.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.3 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.3 GO:0016453 acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.0 0.3 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 0.2 GO:0003692 left-handed Z-DNA binding(GO:0003692)
0.1 0.2 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 0.2 GO:0015234 thiamine transmembrane transporter activity(GO:0015234)
0.0 0.2 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 0.2 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.1 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.7 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 0.4 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 0.4 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 0.5 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.3 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.3 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.3 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.1 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol