Motif ID: Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Z-value: 0.561

Transcription factors associated with Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec:

Gene SymbolEntrez IDGene Name
Arntl ENSMUSG00000055116.7 Arntl
Mitf ENSMUSG00000035158.9 Mitf
Mlx ENSMUSG00000017801.9 Mlx
Mlxipl ENSMUSG00000005373.7 Mlxipl
Tfe3 ENSMUSG00000000134.11 Tfe3
Tfec ENSMUSG00000029553.7 Tfec

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Arntlmm10_v2_chr7_+_113207465_113207595-0.438.0e-03Click!
Mlxmm10_v2_chr11_+_101087277_1010873230.334.4e-02Click!
Mlxiplmm10_v2_chr5_+_135106881_135106918-0.241.5e-01Click!
Tfe3mm10_v2_chrX_+_7763943_77640870.212.1e-01Click!
Mitfmm10_v2_chr6_+_97807014_978070670.019.6e-01Click!


Activity profile for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec.

activity profile for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec


Sorted Z-values histogram for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Sorted Z-values for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec



Network of associatons between targets according to the STRING database.



First level regulatory network of Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_148039097 3.112 ENSMUST00000141283.1
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr10_+_127063527 2.776 ENSMUST00000006911.5
 Cdk4
cyclin-dependent kinase 4
chr4_+_148039035 2.737 ENSMUST00000097788.4
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr10_+_127063599 2.677 ENSMUST00000120226.1
ENSMUST00000133115.1
 Cdk4

cyclin-dependent kinase 4

chr6_+_128362919 2.185 ENSMUST00000073316.6
 Foxm1
forkhead box M1
chr7_+_35802593 2.050 ENSMUST00000052454.2
 E130304I02Rik
RIKEN cDNA E130304I02 gene
chr11_+_70000578 2.012 ENSMUST00000019362.8
 Dvl2
dishevelled 2, dsh homolog (Drosophila)
chr2_+_92915080 1.994 ENSMUST00000028648.2
 Syt13
synaptotagmin XIII
chr13_+_108316332 1.951 ENSMUST00000051594.5
 Depdc1b
DEP domain containing 1B
chr17_-_12769605 1.896 ENSMUST00000024599.7
 Igf2r
insulin-like growth factor 2 receptor
chr13_+_108316395 1.798 ENSMUST00000171178.1
 Depdc1b
DEP domain containing 1B
chr7_-_46795661 1.745 ENSMUST00000123725.1
 Hps5
Hermansky-Pudlak syndrome 5 homolog (human)
chr1_-_82291370 1.685 ENSMUST00000069799.2
 Irs1
insulin receptor substrate 1
chr10_+_41519493 1.639 ENSMUST00000019962.8
 Cd164
CD164 antigen
chr19_-_4201591 1.593 ENSMUST00000025740.6
 Rad9a
RAD9 homolog A
chr7_-_105752193 1.465 ENSMUST00000033184.4
 Tpp1
tripeptidyl peptidase I
chr9_-_22389113 1.414 ENSMUST00000040912.7
 Anln
anillin, actin binding protein
chr11_-_94653964 1.324 ENSMUST00000039949.4
 Eme1
essential meiotic endonuclease 1 homolog 1 (S. pombe)
chr10_-_18023229 1.302 ENSMUST00000020002.7
 Abracl
ABRA C-terminal like
chr4_-_41275091 1.256 ENSMUST00000030143.6
ENSMUST00000108068.1
 Ubap2

ubiquitin-associated protein 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 419 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 5.8 GO:0070829 heterochromatin maintenance(GO:0070829)
1.4 5.5 GO:0010288 response to lead ion(GO:0010288)
0.7 3.5 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.3 3.1 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 2.4 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
0.1 2.3 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
0.2 2.2 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.1 2.2 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.1 2.2 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.4 2.0 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.1 1.9 GO:0060009 Sertoli cell development(GO:0060009)
0.3 1.8 GO:1904715 negative regulation of chaperone-mediated autophagy(GO:1904715)
0.3 1.8 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.0 1.8 GO:0043473 pigmentation(GO:0043473)
0.3 1.7 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.2 1.7 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.1 1.7 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 1.7 GO:0032526 response to retinoic acid(GO:0032526)
0.4 1.5 GO:0015889 cobalamin transport(GO:0015889)
0.2 1.5 GO:0046502 uroporphyrinogen III metabolic process(GO:0046502)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 162 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 5.5 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.3 2.6 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.6 2.3 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 2.3 GO:0072686 mitotic spindle(GO:0072686)
0.0 2.2 GO:0016235 aggresome(GO:0016235)
0.4 2.1 GO:0044611 nuclear pore inner ring(GO:0044611)
0.3 2.0 GO:0001740 Barr body(GO:0001740)
0.1 1.9 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.6 1.7 GO:0005899 insulin receptor complex(GO:0005899)
0.3 1.6 GO:0030896 checkpoint clamp complex(GO:0030896)
0.5 1.5 GO:0033186 CAF-1 complex(GO:0033186)
0.1 1.5 GO:0031083 BLOC-1 complex(GO:0031083)
0.3 1.4 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 1.4 GO:0022626 cytosolic ribosome(GO:0022626)
0.3 1.3 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.1 1.3 GO:0097542 ciliary tip(GO:0097542)
0.1 1.3 GO:0000421 autophagosome membrane(GO:0000421)
0.0 1.3 GO:0031519 PcG protein complex(GO:0031519)
0.1 1.2 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.1 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 257 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 5.8 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 5.8 GO:0030332 cyclin binding(GO:0030332)
0.0 4.2 GO:0005096 GTPase activator activity(GO:0005096)
0.1 3.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.4 2.5 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.3 2.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 2.1 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 2.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 2.0 GO:0005109 frizzled binding(GO:0005109)
0.2 1.9 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 1.8 GO:0016831 carboxy-lyase activity(GO:0016831)
0.2 1.7 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 1.7 GO:0008186 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.0 1.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.4 1.6 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 1.6 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.2 1.5 GO:0031419 cobalamin binding(GO:0031419)
0.2 1.4 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 1.4 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2 1.3 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 3.4 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 2.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 2.7 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 2.2 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.1 2.1 PID_ATR_PATHWAY ATR signaling pathway
0.1 1.9 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 1.9 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 1.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.5 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 1.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.3 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 1.2 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.2 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.9 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.8 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 0.7 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.7 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 0.7 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 0.6 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.1 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 4.4 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 3.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 3.3 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 2.9 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 2.7 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 2.5 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 2.4 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 2.3 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.1 2.2 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.0 2.2 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 1.8 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 1.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.7 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 1.6 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.1 1.4 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 1.3 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 1.3 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.2 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 1.1 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint