Motif ID: Atf3

Z-value: 1.189


Transcription factors associated with Atf3:

Gene SymbolEntrez IDGene Name
Atf3 ENSMUSG00000026628.8 Atf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf3mm10_v2_chr1_-_191183244_191183340-0.624.3e-05Click!


Activity profile for motif Atf3.

activity profile for motif Atf3


Sorted Z-values histogram for motif Atf3

Sorted Z-values for motif Atf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_113619318 6.936 ENSMUST00000146390.2
ENSMUST00000106630.1
 Sstr2

somatostatin receptor 2

chr11_-_84068766 5.640 ENSMUST00000018792.5
 Dusp14
dual specificity phosphatase 14
chr9_+_118478182 5.417 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chrX_+_134308084 4.634 ENSMUST00000081064.5
ENSMUST00000101251.1
ENSMUST00000129782.1
 Cenpi


centromere protein I


chr3_+_159495408 4.390 ENSMUST00000120272.1
ENSMUST00000029825.7
ENSMUST00000106041.2
 Depdc1a


DEP domain containing 1a


chr14_-_47411666 4.220 ENSMUST00000111778.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr15_-_10713537 4.138 ENSMUST00000090339.3
 Rai14
retinoic acid induced 14
chr3_+_135212557 4.112 ENSMUST00000062893.7
 Cenpe
centromere protein E
chr5_-_124032214 4.109 ENSMUST00000040967.7
 Vps37b
vacuolar protein sorting 37B (yeast)
chr11_-_84069179 3.971 ENSMUST00000138208.1
 Dusp14
dual specificity phosphatase 14
chr6_+_113531675 3.899 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr14_+_122475397 3.679 ENSMUST00000075888.5
 Zic2
zinc finger protein of the cerebellum 2
chr9_+_118478344 3.630 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr6_-_23248264 3.569 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr15_+_99074968 3.563 ENSMUST00000039665.6
 Troap
trophinin associated protein
chr11_+_101468164 3.533 ENSMUST00000001347.6
 Rnd2
Rho family GTPase 2
chr2_+_172549581 3.443 ENSMUST00000030391.2
 Tfap2c
transcription factor AP-2, gamma
chr3_+_127553462 3.439 ENSMUST00000043108.4
 4930422G04Rik
RIKEN cDNA 4930422G04 gene
chr4_-_117182623 3.222 ENSMUST00000065896.2
 Kif2c
kinesin family member 2C
chr7_-_137314394 3.094 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 543 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.6 GO:0034508 centromere complex assembly(GO:0034508)
0.3 9.6 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
3.0 9.0 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
2.6 7.7 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.8 7.0 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
1.7 6.7 GO:1902724 positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
1.2 5.9 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.9 5.2 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.1 5.1 GO:0070527 platelet aggregation(GO:0070527)
0.2 4.9 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.6 4.5 GO:0036089 cleavage furrow formation(GO:0036089)
0.6 4.5 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.6 4.4 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.2 4.4 GO:0007140 male meiosis(GO:0007140)
1.4 4.2 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.4 4.1 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.2 4.0 GO:0015693 magnesium ion transport(GO:0015693)
1.3 3.9 GO:0072382 minus-end-directed vesicle transport along microtubule(GO:0072382)
0.4 3.8 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.2 3.8 GO:0006270 DNA replication initiation(GO:0006270)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 214 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.2 GO:0005871 kinesin complex(GO:0005871)
0.1 10.7 GO:0000776 kinetochore(GO:0000776)
0.1 10.7 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.5 9.9 GO:0031616 spindle pole centrosome(GO:0031616)
0.7 9.7 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 8.5 GO:0005657 replication fork(GO:0005657)
0.1 6.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.3 5.2 GO:0051233 spindle midzone(GO:0051233)
0.6 4.5 GO:0001940 male pronucleus(GO:0001940)
0.6 4.5 GO:0072687 meiotic spindle(GO:0072687)
0.5 4.4 GO:0000813 ESCRT I complex(GO:0000813)
0.1 4.4 GO:0005844 polysome(GO:0005844)
1.0 4.1 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.6 4.1 GO:0008278 cohesin complex(GO:0008278)
0.3 4.1 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 4.1 GO:0044815 DNA packaging complex(GO:0044815)
0.1 3.7 GO:0000922 spindle pole(GO:0000922)
0.0 3.7 GO:0000793 condensed chromosome(GO:0000793)
0.2 3.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.2 3.1 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 362 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
2.9 8.8 GO:0004994 somatostatin receptor activity(GO:0004994)
0.6 8.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 7.3 GO:0003682 chromatin binding(GO:0003682)
0.4 7.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 7.0 GO:1990939 ATP-dependent microtubule motor activity(GO:1990939)
0.7 6.7 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.4 6.7 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 6.1 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.4 5.9 GO:0003688 DNA replication origin binding(GO:0003688)
0.2 5.9 GO:0070182 DNA polymerase binding(GO:0070182)
1.1 5.4 GO:0043515 kinetochore binding(GO:0043515)
0.0 5.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 4.9 GO:0005109 frizzled binding(GO:0005109)
0.1 4.5 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 4.4 GO:0003777 microtubule motor activity(GO:0003777)
0.1 4.4 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 4.4 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.3 3.9 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.2 3.8 GO:0008266 poly(U) RNA binding(GO:0008266)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 15.3 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 11.7 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 7.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 7.4 PID_ATR_PATHWAY ATR signaling pathway
0.4 7.0 ST_STAT3_PATHWAY STAT3 Pathway
0.1 5.9 PID_E2F_PATHWAY E2F transcription factor network
0.4 5.6 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 5.4 PID_PLK1_PATHWAY PLK1 signaling events
0.5 4.2 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 3.7 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 3.6 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 3.2 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 3.1 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.8 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 2.6 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 2.5 PID_IGF1_PATHWAY IGF1 pathway
0.1 2.3 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 1.9 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 1.8 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 1.7 PID_BARD1_PATHWAY BARD1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 20.2 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.6 14.9 REACTOME_KINESINS Genes involved in Kinesins
0.3 7.3 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.6 6.7 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.4 5.7 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 5.7 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 4.4 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 4.3 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.4 4.2 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.1 4.2 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.6 3.9 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.2 3.7 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.2 3.3 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 3.2 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.1 3.2 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 3.1 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 2.6 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 2.3 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.0 2.3 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 2.2 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells