Motif ID: Atf4

Z-value: 1.028


Transcription factors associated with Atf4:

Gene SymbolEntrez IDGene Name
Atf4 ENSMUSG00000042406.7 Atf4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf4mm10_v2_chr15_+_80255184_80255263-0.192.5e-01Click!


Activity profile for motif Atf4.

activity profile for motif Atf4


Sorted Z-values histogram for motif Atf4

Sorted Z-values for motif Atf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_71653162 7.637 ENSMUST00000055226.6
Fn1
fibronectin 1
chr19_-_12501996 6.301 ENSMUST00000045521.7
Dtx4
deltex 4 homolog (Drosophila)
chr2_+_119351222 4.509 ENSMUST00000028780.3
Chac1
ChaC, cation transport regulator 1
chr9_+_109931774 3.837 ENSMUST00000169851.2
Map4
microtubule-associated protein 4
chr5_-_148399901 3.329 ENSMUST00000048116.8
Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr11_-_35798884 3.310 ENSMUST00000160726.2
Fbll1
fibrillarin-like 1
chr4_+_43957678 3.234 ENSMUST00000107855.1
Glipr2
GLI pathogenesis-related 2
chr1_-_22315792 3.043 ENSMUST00000164877.1
Rims1
regulating synaptic membrane exocytosis 1
chrX_-_162565514 2.854 ENSMUST00000154424.1
Reps2
RALBP1 associated Eps domain containing protein 2
chrX_+_103422010 2.719 ENSMUST00000182089.1
Gm26992
predicted gene, 26992
chr4_+_117835387 2.676 ENSMUST00000169885.1
Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr11_-_120643643 2.390 ENSMUST00000141254.1
ENSMUST00000170556.1
ENSMUST00000151876.1
ENSMUST00000026133.8
ENSMUST00000139706.1
Pycr1




pyrroline-5-carboxylate reductase 1




chr11_-_20332689 1.946 ENSMUST00000109594.1
Slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr11_-_20332654 1.833 ENSMUST00000004634.6
Slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr7_-_126566364 1.655 ENSMUST00000032992.5
Eif3c
eukaryotic translation initiation factor 3, subunit C
chr18_-_64516547 1.578 ENSMUST00000025483.9
Nars
asparaginyl-tRNA synthetase
chr11_-_115276973 1.471 ENSMUST00000021078.2
Fdxr
ferredoxin reductase
chr3_-_127409014 1.461 ENSMUST00000182008.1
ENSMUST00000182711.1
ENSMUST00000182547.1
Ank2


ankyrin 2, brain


chr15_-_98953541 1.431 ENSMUST00000097014.5
Tuba1a
tubulin, alpha 1A
chr4_+_129189760 1.405 ENSMUST00000106054.2
ENSMUST00000001365.2
Yars

tyrosyl-tRNA synthetase

chr3_-_127408937 1.375 ENSMUST00000183095.1
ENSMUST00000182610.1
Ank2

ankyrin 2, brain

chr8_+_75093591 1.347 ENSMUST00000005548.6
Hmox1
heme oxygenase (decycling) 1
chr3_-_127408986 1.347 ENSMUST00000182588.1
ENSMUST00000182959.1
ENSMUST00000182452.1
Ank2


ankyrin 2, brain


chr3_-_127409044 1.342 ENSMUST00000182704.1
Ank2
ankyrin 2, brain
chr10_-_83533383 1.328 ENSMUST00000146640.1
Aldh1l2
aldehyde dehydrogenase 1 family, member L2
chr7_-_143600049 1.320 ENSMUST00000105909.3
ENSMUST00000010899.7
Cars

cysteinyl-tRNA synthetase

chr12_+_85599047 1.317 ENSMUST00000177587.1
Jdp2
Jun dimerization protein 2
chr6_+_129533183 1.296 ENSMUST00000032264.6
Gabarapl1
gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1
chr4_-_129189600 1.283 ENSMUST00000117497.1
ENSMUST00000117350.1
S100pbp

S100P binding protein

chr1_-_191183244 1.239 ENSMUST00000027941.8
Atf3
activating transcription factor 3
chr9_+_109931458 1.160 ENSMUST00000072772.5
ENSMUST00000035055.8
Map4

microtubule-associated protein 4

chr2_+_163995503 1.159 ENSMUST00000131288.1
Ywhab
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr6_+_55037988 1.146 ENSMUST00000003572.8
Gars
glycyl-tRNA synthetase
chr2_-_3512746 1.112 ENSMUST00000027961.5
ENSMUST00000056700.7
Hspa14
Hspa14
heat shock protein 14
heat shock protein 14
chr14_-_66868572 1.098 ENSMUST00000022629.8
Dpysl2
dihydropyrimidinase-like 2
chr4_-_129189512 1.088 ENSMUST00000117965.1
ENSMUST00000106061.2
ENSMUST00000072431.6
S100pbp


S100P binding protein


chrX_+_94234594 1.088 ENSMUST00000153900.1
Klhl15
kelch-like 15
chr5_-_90223923 1.087 ENSMUST00000118816.1
ENSMUST00000048363.7
Cox18

cytochrome c oxidase assembly protein 18

chr4_+_127021311 1.059 ENSMUST00000030623.7
Sfpq
splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)
chr10_+_102158858 1.016 ENSMUST00000138522.1
ENSMUST00000163753.1
ENSMUST00000138016.1
Mgat4c


mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)


chr10_-_68278713 0.991 ENSMUST00000020106.7
Arid5b
AT rich interactive domain 5B (MRF1-like)
chr1_-_78488846 0.943 ENSMUST00000068333.7
ENSMUST00000170217.1
Farsb

phenylalanyl-tRNA synthetase, beta subunit

chr3_+_89715016 0.928 ENSMUST00000098924.2
Adar
adenosine deaminase, RNA-specific
chr7_+_138846579 0.924 ENSMUST00000155672.1
Ppp2r2d
protein phosphatase 2, regulatory subunit B, delta isoform
chr12_+_85599388 0.916 ENSMUST00000050687.6
Jdp2
Jun dimerization protein 2
chr9_+_109931863 0.910 ENSMUST00000165876.1
Map4
microtubule-associated protein 4
chr13_-_101692624 0.900 ENSMUST00000035532.6
Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr15_+_99393219 0.889 ENSMUST00000159209.1
Tmbim6
transmembrane BAX inhibitor motif containing 6
chr10_+_121739915 0.845 ENSMUST00000065600.7
ENSMUST00000136432.1
BC048403

cDNA sequence BC048403

chr4_-_129189646 0.810 ENSMUST00000106059.1
S100pbp
S100P binding protein
chr11_-_87826023 0.761 ENSMUST00000103177.3
Lpo
lactoperoxidase
chr4_+_41942037 0.743 ENSMUST00000181518.1
Gm20878
predicted gene, 20878
chr11_+_100320596 0.667 ENSMUST00000152521.1
Eif1
eukaryotic translation initiation factor 1
chr5_-_145140238 0.659 ENSMUST00000031627.8
Pdap1
PDGFA associated protein 1
chr17_+_34187545 0.655 ENSMUST00000170086.1
Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr6_-_129533267 0.648 ENSMUST00000181594.1
1700101I11Rik
RIKEN cDNA 1700101I11 gene
chr7_-_126625676 0.622 ENSMUST00000032961.3
Nupr1
nuclear protein transcription regulator 1
chr7_+_126565919 0.592 ENSMUST00000180459.1
G730046D07Rik
RIKEN cDNA G730046D07 gene
chr10_-_127311740 0.589 ENSMUST00000037290.5
ENSMUST00000171564.1
Mars

methionine-tRNA synthetase

chr11_-_53430417 0.575 ENSMUST00000109019.1
Uqcrq
ubiquinol-cytochrome c reductase, complex III subunit VII
chr4_-_41774097 0.563 ENSMUST00000108036.1
ENSMUST00000173865.1
ENSMUST00000108037.2
ENSMUST00000108032.2
Ccl27a



chemokine (C-C motif) ligand 27A



chr13_+_49682191 0.563 ENSMUST00000172254.1
Iars
isoleucine-tRNA synthetase
chr4_+_124741844 0.549 ENSMUST00000094782.3
ENSMUST00000153837.1
ENSMUST00000154229.1
Inpp5b


inositol polyphosphate-5-phosphatase B


chr17_+_34187789 0.548 ENSMUST00000041633.8
Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr16_-_34095983 0.540 ENSMUST00000114973.1
ENSMUST00000114964.1
Kalrn

kalirin, RhoGEF kinase

chr7_-_126502094 0.493 ENSMUST00000179818.1
Atxn2l
ataxin 2-like
chr7_+_110018301 0.493 ENSMUST00000084731.3
Ipo7
importin 7
chr15_-_83510861 0.473 ENSMUST00000109479.1
ENSMUST00000109480.1
ENSMUST00000016897.4
Ttll1


tubulin tyrosine ligase-like 1


chr13_-_30545254 0.471 ENSMUST00000042834.3
Uqcrfs1
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
chr8_+_105701624 0.465 ENSMUST00000093195.6
Pard6a
par-6 (partitioning defective 6,) homolog alpha (C. elegans)
chr12_-_104865076 0.447 ENSMUST00000109937.1
ENSMUST00000109936.1
Clmn

calmin

chr13_-_53473074 0.442 ENSMUST00000021922.8
Msx2
msh homeobox 2
chr11_-_118290188 0.429 ENSMUST00000106296.2
ENSMUST00000092382.3
Usp36

ubiquitin specific peptidase 36

chr8_+_111033890 0.428 ENSMUST00000034441.7
Aars
alanyl-tRNA synthetase
chr2_+_3513035 0.422 ENSMUST00000036350.2
Cdnf
cerebral dopamine neurotrophic factor
chr15_-_83510793 0.408 ENSMUST00000154401.1
Ttll1
tubulin tyrosine ligase-like 1
chr4_-_118179628 0.408 ENSMUST00000097911.2
Kdm4a
lysine (K)-specific demethylase 4A
chr11_+_58009064 0.407 ENSMUST00000071487.6
ENSMUST00000178636.1
Larp1

La ribonucleoprotein domain family, member 1

chr6_-_23248264 0.405 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr8_+_117157972 0.392 ENSMUST00000064488.4
ENSMUST00000162997.1
Gan

giant axonal neuropathy

chr11_-_53430779 0.389 ENSMUST00000061326.4
ENSMUST00000109021.3
Uqcrq

ubiquinol-cytochrome c reductase, complex III subunit VII

chr11_-_118290167 0.379 ENSMUST00000144153.1
Usp36
ubiquitin specific peptidase 36
chr7_-_126502312 0.374 ENSMUST00000166682.2
Atxn2l
ataxin 2-like
chr1_-_36709904 0.360 ENSMUST00000043951.3
Actr1b
ARP1 actin-related protein 1B, centractin beta
chr13_-_118387224 0.338 ENSMUST00000022245.8
Mrps30
mitochondrial ribosomal protein S30
chr19_-_43524462 0.321 ENSMUST00000026196.7
Got1
glutamate oxaloacetate transaminase 1, soluble
chr9_-_71771535 0.303 ENSMUST00000122065.1
ENSMUST00000121322.1
ENSMUST00000072899.2
Cgnl1


cingulin-like 1


chr3_-_89998656 0.280 ENSMUST00000079724.4
Hax1
HCLS1 associated X-1
chr11_-_98400393 0.278 ENSMUST00000128897.1
Pgap3
post-GPI attachment to proteins 3
chr17_-_34187219 0.274 ENSMUST00000173831.1
Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr7_-_126502380 0.274 ENSMUST00000167759.1
Atxn2l
ataxin 2-like
chr18_-_42262053 0.272 ENSMUST00000097590.3
Lars
leucyl-tRNA synthetase
chr1_+_185363076 0.271 ENSMUST00000046514.7
Eprs
glutamyl-prolyl-tRNA synthetase
chr11_-_75422524 0.267 ENSMUST00000125982.1
ENSMUST00000137103.1
Serpinf1

serine (or cysteine) peptidase inhibitor, clade F, member 1

chr4_+_42735545 0.266 ENSMUST00000068158.3
4930578G10Rik
RIKEN cDNA 4930578G10 gene
chr19_+_44203265 0.260 ENSMUST00000026220.5
Scd3
stearoyl-coenzyme A desaturase 3
chr5_-_36695969 0.231 ENSMUST00000031091.9
ENSMUST00000140063.1
D5Ertd579e

DNA segment, Chr 5, ERATO Doi 579, expressed

chr12_-_108893197 0.197 ENSMUST00000161154.1
ENSMUST00000161410.1
Wars

tryptophanyl-tRNA synthetase

chr4_-_139380374 0.191 ENSMUST00000181556.1
2700016F22Rik
RIKEN cDNA 2700016F22 gene
chr15_+_99393574 0.182 ENSMUST00000162624.1
Tmbim6
transmembrane BAX inhibitor motif containing 6
chr13_+_49682100 0.178 ENSMUST00000165316.1
ENSMUST00000047363.7
Iars

isoleucine-tRNA synthetase

chr10_+_80141457 0.165 ENSMUST00000105367.1
Atp5d
ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
chr3_-_138143352 0.163 ENSMUST00000098580.2
Mttp
microsomal triglyceride transfer protein
chr11_-_75422586 0.130 ENSMUST00000138661.1
ENSMUST00000000769.7
Serpinf1

serine (or cysteine) peptidase inhibitor, clade F, member 1

chr8_-_105701077 0.096 ENSMUST00000042608.6
Acd
adrenocortical dysplasia
chr11_-_98400453 0.086 ENSMUST00000090827.5
Pgap3
post-GPI attachment to proteins 3
chr1_+_133131143 0.077 ENSMUST00000052529.3
Ppp1r15b
protein phosphatase 1, regulatory (inhibitor) subunit 15b
chr8_+_105701142 0.075 ENSMUST00000098444.2
Pard6a
par-6 (partitioning defective 6,) homolog alpha (C. elegans)
chr10_-_121626316 0.044 ENSMUST00000039810.7
Xpot
exportin, tRNA (nuclear export receptor for tRNAs)
chr19_+_53140430 0.025 ENSMUST00000111741.2
Add3
adducin 3 (gamma)
chr7_+_44468051 0.019 ENSMUST00000118493.1
Josd2
Josephin domain containing 2
chr15_+_82147238 0.016 ENSMUST00000023100.6
Srebf2
sterol regulatory element binding factor 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.6 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161) transforming growth factor-beta secretion(GO:0038044)
1.2 5.9 GO:0051012 microtubule sliding(GO:0051012)
1.1 4.5 GO:0006751 glutathione catabolic process(GO:0006751)
0.9 3.8 GO:0015825 L-serine transport(GO:0015825)
0.9 2.7 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.8 3.0 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.7 3.3 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.6 5.5 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.4 1.3 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.4 1.6 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.3 1.3 GO:1904706 heme oxidation(GO:0006788) negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.3 1.2 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.3 0.9 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.3 1.2 GO:0046967 cytosol to ER transport(GO:0046967)
0.3 0.8 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2 0.7 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.2 0.9 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.2 1.1 GO:0015960 diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966)
0.2 3.3 GO:0015809 arginine transport(GO:0015809)
0.2 1.0 GO:1904721 regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.2 1.4 GO:0006561 proline biosynthetic process(GO:0006561)
0.2 0.6 GO:0071677 positive regulation of mononuclear cell migration(GO:0071677)
0.2 1.1 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.2 1.7 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.2 1.0 GO:0021539 subthalamus development(GO:0021539)
0.2 1.1 GO:0051204 protein insertion into mitochondrial membrane(GO:0051204)
0.2 1.1 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.1 0.4 GO:0035880 embryonic nail plate morphogenesis(GO:0035880) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.1 0.4 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.1 0.4 GO:1901355 response to rapamycin(GO:1901355)
0.1 4.1 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 1.5 GO:0070995 NADPH oxidation(GO:0070995)
0.1 1.0 GO:0060613 fat pad development(GO:0060613)
0.1 1.3 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 0.3 GO:0006106 fumarate metabolic process(GO:0006106) aspartate biosynthetic process(GO:0006532) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401)
0.1 0.9 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 0.9 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 2.2 GO:0031065 positive regulation of histone deacetylation(GO:0031065)
0.1 0.4 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.1 0.6 GO:2000194 regulation of female gonad development(GO:2000194)
0.1 0.5 GO:1904781 positive regulation of protein localization to centrosome(GO:1904781)
0.1 0.5 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.1 0.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 0.3 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.1 1.1 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.1 0.8 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.1 0.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 1.0 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.1 1.1 GO:0014049 positive regulation of glutamate secretion(GO:0014049)
0.1 3.2 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.0 0.7 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.4 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.0 0.2 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0 6.3 GO:0007219 Notch signaling pathway(GO:0007219)
0.0 0.1 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.0 1.2 GO:0051220 cytoplasmic sequestering of protein(GO:0051220)
0.0 0.8 GO:1903146 regulation of mitophagy(GO:1903146)
0.0 0.5 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.0 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 0.7 GO:0048008 platelet-derived growth factor receptor signaling pathway(GO:0048008)
0.0 0.4 GO:0071542 dopaminergic neuron differentiation(GO:0071542)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.6 GO:0005577 fibrinogen complex(GO:0005577)
0.6 3.0 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.5 3.3 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.3 0.9 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.2 3.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.2 5.5 GO:0031430 M band(GO:0031430)
0.2 1.7 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.2 1.2 GO:0042825 TAP complex(GO:0042825)
0.2 0.9 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 1.4 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.1 1.1 GO:0042382 paraspeckles(GO:0042382)
0.1 0.3 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 5.9 GO:0072686 mitotic spindle(GO:0072686)
0.1 3.8 GO:0005882 intermediate filament(GO:0005882)
0.1 1.3 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.9 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.9 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.4 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.4 GO:0043203 axon hillock(GO:0043203)
0.0 1.1 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.4 GO:0005869 dynactin complex(GO:0005869)
0.0 1.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.2 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.5 GO:0034451 centriolar satellite(GO:0034451)
0.0 1.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 4.5 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.1 GO:0070187 telosome(GO:0070187)
0.0 1.3 GO:0005901 caveola(GO:0005901)
0.0 0.4 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 3.2 GO:0000139 Golgi membrane(GO:0000139)
0.0 4.4 GO:0016607 nuclear speck(GO:0016607)
0.0 1.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.2 GO:0031528 microvillus membrane(GO:0031528)
0.0 3.8 GO:0098793 presynapse(GO:0098793)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 7.6 GO:0045340 mercury ion binding(GO:0045340)
0.9 4.5 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.6 2.4 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.5 1.6 GO:0004816 asparagine-tRNA ligase activity(GO:0004816)
0.5 3.8 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) L-proline transmembrane transporter activity(GO:0015193) alanine transmembrane transporter activity(GO:0022858)
0.4 1.3 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.4 3.3 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.3 1.3 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.3 2.7 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.3 0.9 GO:0003692 left-handed Z-DNA binding(GO:0003692)
0.3 1.2 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.2 0.7 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.2 0.9 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.2 0.9 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.2 3.3 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.2 1.0 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.2 0.9 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.2 0.5 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.2 1.4 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.2 1.0 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.1 5.6 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 0.3 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.1 1.2 GO:0050815 phosphoserine binding(GO:0050815)
0.1 5.5 GO:0030507 spectrin binding(GO:0030507)
0.1 0.3 GO:0019966 interleukin-1 binding(GO:0019966)
0.1 1.5 GO:0070402 NADPH binding(GO:0070402)
0.1 1.3 GO:0030957 Tat protein binding(GO:0030957)
0.1 0.4 GO:0008494 translation activator activity(GO:0008494)
0.1 0.3 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.0 0.7 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 1.7 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 3.2 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.4 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454) histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 1.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 3.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 5.6 GO:0008017 microtubule binding(GO:0008017)
0.0 0.5 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 3.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 1.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.8 GO:0004601 peroxidase activity(GO:0004601)
0.0 1.1 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 1.6 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.7 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) proteasome binding(GO:0070628)
0.0 0.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.2 GO:0034185 apolipoprotein binding(GO:0034185)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.6 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.9 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 2.6 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 1.3 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.7 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 1.4 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 1.5 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.5 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.5 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 1.2 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 7.6 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.3 3.0 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.3 2.7 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.3 7.3 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 7.1 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 6.3 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 1.4 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.2 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.1 0.9 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.2 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 1.6 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.1 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 1.0 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 1.3 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.0 1.7 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.5 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.9 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.4 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.2 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport