Motif ID: Atf6

Z-value: 0.886


Transcription factors associated with Atf6:

Gene SymbolEntrez IDGene Name
Atf6 ENSMUSG00000026663.6 Atf6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf6mm10_v2_chr1_-_170867761_170867784-0.241.5e-01Click!


Activity profile for motif Atf6.

activity profile for motif Atf6


Sorted Z-values histogram for motif Atf6

Sorted Z-values for motif Atf6



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_23988852 10.034 ENSMUST00000023151.5
 Bcl6
B cell leukemia/lymphoma 6
chr5_-_89883321 6.179 ENSMUST00000163159.1
ENSMUST00000061427.5
 Adamts3

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3

chr12_+_82616885 6.166 ENSMUST00000161801.1
 Rgs6
regulator of G-protein signaling 6
chr16_+_41532999 5.072 ENSMUST00000099761.3
 Lsamp
limbic system-associated membrane protein
chr6_-_136173492 5.013 ENSMUST00000111905.1
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr8_+_125995102 4.938 ENSMUST00000046765.8
 Kcnk1
potassium channel, subfamily K, member 1
chr4_+_125490688 4.745 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr3_+_123267445 4.319 ENSMUST00000047923.7
 Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chr6_-_126740151 4.053 ENSMUST00000112242.1
 Kcna6
potassium voltage-gated channel, shaker-related, subfamily, member 6
chr5_+_134986191 3.888 ENSMUST00000094245.2
 Cldn3
claudin 3
chr6_+_77242644 3.670 ENSMUST00000159616.1
 Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr6_+_77242715 3.611 ENSMUST00000161677.1
 Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr13_+_58807884 3.486 ENSMUST00000079828.5
 Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
chrY_-_1245685 3.437 ENSMUST00000143286.1
ENSMUST00000137048.1
ENSMUST00000069309.7
ENSMUST00000139365.1
 Uty



ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome



chrX_+_41401128 3.326 ENSMUST00000115103.2
 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr16_+_41532851 3.242 ENSMUST00000078873.4
 Lsamp
limbic system-associated membrane protein
chr11_-_108343917 2.963 ENSMUST00000059595.4
 Prkca
protein kinase C, alpha
chr5_+_137288273 2.810 ENSMUST00000024099.4
ENSMUST00000085934.3
 Ache

acetylcholinesterase

chr13_+_118714678 2.728 ENSMUST00000022246.8
 Fgf10
fibroblast growth factor 10
chr3_+_104638658 2.726 ENSMUST00000046212.1
 Slc16a1
solute carrier family 16 (monocarboxylic acid transporters), member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 158 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 16.1 GO:0035640 exploration behavior(GO:0035640)
3.3 10.0 GO:0043379 memory T cell differentiation(GO:0043379) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.0 8.3 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
0.5 8.0 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
1.2 6.2 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
1.3 5.0 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.8 5.0 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.1 4.7 GO:0001881 receptor recycling(GO:0001881)
0.1 4.4 GO:0007528 neuromuscular junction development(GO:0007528)
0.5 4.3 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.2 4.2 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
0.0 4.2 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.7 4.0 GO:0019695 choline metabolic process(GO:0019695)
0.5 3.9 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
1.2 3.6 GO:0070343 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350)
0.3 3.6 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.6 3.5 GO:0099550 trans-synaptic signalling, modulating synaptic transmission(GO:0099550)
0.3 3.1 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
1.0 3.0 GO:0002159 desmosome assembly(GO:0002159)
0.1 2.9 GO:0007094 mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.5 GO:0045211 postsynaptic membrane(GO:0045211)
0.7 11.1 GO:0043083 synaptic cleft(GO:0043083)
0.1 9.8 GO:0005657 replication fork(GO:0005657)
0.2 8.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 8.6 GO:0043034 costamere(GO:0043034)
0.1 5.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
1.2 4.9 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.1 4.9 GO:0031594 neuromuscular junction(GO:0031594)
0.2 3.9 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.3 3.8 GO:0030127 COPII vesicle coat(GO:0030127)
0.5 3.7 GO:0005827 polar microtubule(GO:0005827)
0.1 3.5 GO:0048786 presynaptic active zone(GO:0048786)
0.0 3.2 GO:0009986 cell surface(GO:0009986)
0.1 3.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 3.0 GO:0031201 SNARE complex(GO:0031201)
0.1 2.9 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 2.5 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 2.5 GO:0043209 myelin sheath(GO:0043209)
0.1 2.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 2.0 GO:0097449 astrocyte projection(GO:0097449)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 119 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 10.0 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.1 8.2 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 6.8 GO:0005096 GTPase activator activity(GO:0005096)
0.0 5.8 GO:0004175 endopeptidase activity(GO:0004175)
0.6 5.0 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.5 5.0 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.9 4.7 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.6 4.3 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.4 4.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 4.2 GO:0005158 insulin receptor binding(GO:0005158)
0.2 4.1 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
1.0 4.0 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.7 3.5 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.7 3.3 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.3 3.3 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 3.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 3.1 GO:0015459 potassium channel regulator activity(GO:0015459)
1.0 3.0 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.7 2.7 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.4 2.7 GO:0015129 lactate transmembrane transporter activity(GO:0015129)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.9 PID_FOXO_PATHWAY FoxO family signaling
0.0 6.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.5 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 4.0 PID_SHP2_PATHWAY SHP2 signaling
0.2 2.9 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 2.6 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 2.2 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 2.1 PID_MTOR_4PATHWAY mTOR signaling pathway
0.1 1.9 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 1.7 PID_LKB1_PATHWAY LKB1 signaling events
0.1 1.5 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 1.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.4 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.2 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 1.0 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.7 PID_EPO_PATHWAY EPO signaling pathway
0.0 0.7 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 0.6 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.5 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 0.4 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.3 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 6.7 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 5.9 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.7 5.0 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 4.6 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 4.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.2 4.1 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 4.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 3.9 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 3.3 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.4 3.0 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.3 2.7 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 2.7 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.3 2.6 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.2 2.4 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 2.3 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 2.1 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.6 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 1.6 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.3 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis