Motif ID: Atf7_E4f1

Z-value: 1.062

Transcription factors associated with Atf7_E4f1:

Gene SymbolEntrez IDGene Name
Atf7 ENSMUSG00000052414.9 Atf7
Atf7 ENSMUSG00000071584.1 Atf7
E4f1 ENSMUSG00000024137.8 E4f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E4f1mm10_v2_chr17_-_24455265_24455345-0.144.2e-01Click!
Atf7mm10_v2_chr15_-_102529025_102529025-0.134.3e-01Click!


Activity profile for motif Atf7_E4f1.

activity profile for motif Atf7_E4f1


Sorted Z-values histogram for motif Atf7_E4f1

Sorted Z-values for motif Atf7_E4f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf7_E4f1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_113619318 10.551 ENSMUST00000146390.2
ENSMUST00000106630.1
 Sstr2

somatostatin receptor 2

chr3_+_135212557 10.010 ENSMUST00000062893.7
 Cenpe
centromere protein E
chr5_-_106458440 8.922 ENSMUST00000086795.6
 Barhl2
BarH-like 2 (Drosophila)
chr3_-_36571952 8.610 ENSMUST00000029270.3
 Ccna2
cyclin A2
chr15_+_99074968 8.099 ENSMUST00000039665.6
 Troap
trophinin associated protein
chr17_-_71526819 7.963 ENSMUST00000024851.9
 Ndc80
NDC80 homolog, kinetochore complex component (S. cerevisiae)
chr6_-_23248264 7.475 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr2_+_105668888 7.102 ENSMUST00000111086.4
ENSMUST00000111087.3
 Pax6

paired box gene 6

chr11_+_101468164 7.072 ENSMUST00000001347.6
 Rnd2
Rho family GTPase 2
chr6_+_113531675 6.606 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr8_+_116921735 6.572 ENSMUST00000034205.4
 Cenpn
centromere protein N
chr5_-_124032214 6.531 ENSMUST00000040967.7
 Vps37b
vacuolar protein sorting 37B (yeast)
chr2_+_105668935 6.136 ENSMUST00000142772.1
 Pax6
paired box gene 6
chr2_+_109280738 6.071 ENSMUST00000028527.7
 Kif18a
kinesin family member 18A
chr11_-_88718223 5.474 ENSMUST00000107909.1
 Msi2
musashi RNA-binding protein 2
chr17_+_72918298 5.425 ENSMUST00000024857.6
 Lbh
limb-bud and heart
chr1_+_74791516 5.309 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr4_+_11704439 5.152 ENSMUST00000108304.2
 Gem
GTP binding protein (gene overexpressed in skeletal muscle)
chr3_+_40800054 4.956 ENSMUST00000168287.1
 Plk4
polo-like kinase 4
chr3_+_127553462 4.956 ENSMUST00000043108.4
 4930422G04Rik
RIKEN cDNA 4930422G04 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 187 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 21.7 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
2.6 13.2 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
1.0 10.6 GO:0030432 peristalsis(GO:0030432)
0.3 8.9 GO:0001709 cell fate determination(GO:0001709)
2.2 8.8 GO:1902724 positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.3 8.1 GO:0034508 centromere complex assembly(GO:0034508)
0.2 7.9 GO:0016572 histone phosphorylation(GO:0016572)
1.2 7.5 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.0 7.2 GO:0098535 positive regulation of centriole replication(GO:0046601) de novo centriole assembly(GO:0098535)
0.5 7.1 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.9 6.6 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
2.2 6.5 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.7 6.3 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.3 6.1 GO:0072520 seminiferous tubule development(GO:0072520)
1.0 5.9 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
1.1 5.4 GO:1904672 regulation of somatic stem cell population maintenance(GO:1904672)
0.6 5.3 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.6 5.2 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.5 5.0 GO:0014883 transition between fast and slow fiber(GO:0014883)
1.4 4.3 GO:0051316 attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation(GO:0051316)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.2 GO:0005667 transcription factor complex(GO:0005667)
1.4 13.7 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.1 11.6 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 8.7 GO:0005844 polysome(GO:0005844)
1.2 8.6 GO:0001940 male pronucleus(GO:0001940)
0.2 8.4 GO:0097546 ciliary base(GO:0097546)
2.0 8.0 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
1.2 7.2 GO:0098536 deuterosome(GO:0098536)
0.1 7.2 GO:0000776 kinetochore(GO:0000776)
0.1 7.0 GO:0005871 kinesin complex(GO:0005871)
0.7 6.5 GO:0000813 ESCRT I complex(GO:0000813)
0.9 6.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.4 5.9 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 5.8 GO:0005769 early endosome(GO:0005769)
0.1 5.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 5.2 GO:0051233 spindle midzone(GO:0051233)
1.2 4.9 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.0 4.6 GO:0000793 condensed chromosome(GO:0000793)
0.3 4.4 GO:0030008 TRAPP complex(GO:0030008)
1.2 3.5 GO:0000799 nuclear condensin complex(GO:0000799)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 132 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 18.1 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.8 13.2 GO:0003680 AT DNA binding(GO:0003680)
3.5 10.6 GO:0004994 somatostatin receptor activity(GO:0004994)
0.2 10.6 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
2.0 10.0 GO:0043515 kinetochore binding(GO:0043515)
0.6 9.8 GO:0051010 microtubule plus-end binding(GO:0051010)
0.4 8.7 GO:0008266 poly(U) RNA binding(GO:0008266)
0.9 8.4 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.2 7.3 GO:0070182 DNA polymerase binding(GO:0070182)
0.4 5.9 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 4.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 4.7 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.1 4.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 3.7 GO:0005109 frizzled binding(GO:0005109)
0.1 3.6 GO:0003684 damaged DNA binding(GO:0003684)
0.6 3.5 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.4 3.3 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.1 3.3 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 3.3 GO:0030507 spectrin binding(GO:0030507)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 15.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.3 12.9 PID_BARD1_PATHWAY BARD1 signaling events
0.8 11.6 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.6 10.0 ST_STAT3_PATHWAY STAT3 Pathway
0.2 8.5 PID_PLK1_PATHWAY PLK1 signaling events
0.1 7.1 PID_CDC42_PATHWAY CDC42 signaling events
0.1 5.9 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 3.8 PID_E2F_PATHWAY E2F transcription factor network
0.1 3.2 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 3.1 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 2.3 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 1.6 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 1.5 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.4 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.1 1.3 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.0 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 1.0 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.8 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.1 0.7 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.7 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 13.2 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.5 12.7 REACTOME_KINESINS Genes involved in Kinesins
0.2 12.7 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 9.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.7 8.8 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.5 8.6 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 8.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 6.9 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.7 6.6 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.8 6.5 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.1 5.8 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 4.9 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 4.5 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.3 4.0 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.0 3.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 3.3 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 3.2 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 3.1 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 2.5 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.1 2.2 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines