Motif ID: Atoh1_Bhlhe23

Z-value: 0.599

Transcription factors associated with Atoh1_Bhlhe23:

Gene SymbolEntrez IDGene Name
Atoh1 ENSMUSG00000073043.4 Atoh1
Bhlhe23 ENSMUSG00000045493.3 Bhlhe23

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bhlhe23mm10_v2_chr2_-_180776900_1807769000.429.7e-03Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Atoh1_Bhlhe23

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_91191733 6.731 ENSMUST00000069511.6
Abcd2
ATP-binding cassette, sub-family D (ALD), member 2
chr2_-_79456750 4.554 ENSMUST00000041099.4
Neurod1
neurogenic differentiation 1
chr10_-_92164666 4.446 ENSMUST00000183123.1
ENSMUST00000182033.1
Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr1_+_6730051 3.594 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
St18



suppression of tumorigenicity 18



chr4_-_110292719 2.990 ENSMUST00000106601.1
Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr16_+_43235856 2.791 ENSMUST00000146708.1
Zbtb20
zinc finger and BTB domain containing 20
chr13_-_97747373 2.553 ENSMUST00000123535.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr13_-_97747399 2.523 ENSMUST00000144993.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr1_+_6730135 2.276 ENSMUST00000155921.1
St18
suppression of tumorigenicity 18
chr1_-_155232710 2.160 ENSMUST00000035914.3
BC034090
cDNA sequence BC034090
chr14_+_28511344 2.070 ENSMUST00000112272.1
Wnt5a
wingless-related MMTV integration site 5A
chr1_+_15287259 1.890 ENSMUST00000175681.1
Kcnb2
potassium voltage gated channel, Shab-related subfamily, member 2
chr5_+_3343893 1.844 ENSMUST00000165117.1
Cdk6
cyclin-dependent kinase 6
chr4_-_82850721 1.703 ENSMUST00000139401.1
Zdhhc21
zinc finger, DHHC domain containing 21
chr19_+_7268296 1.654 ENSMUST00000066646.4
Rcor2
REST corepressor 2
chr1_+_42697146 1.565 ENSMUST00000054883.2
Pou3f3
POU domain, class 3, transcription factor 3
chr4_+_11579647 1.490 ENSMUST00000180239.1
Fsbp
fibrinogen silencer binding protein
chr15_+_25622525 1.475 ENSMUST00000110457.1
ENSMUST00000137601.1
Myo10

myosin X

chr5_+_124194894 1.449 ENSMUST00000159053.1
ENSMUST00000162577.1
Gm16338

predicted gene 16338

chr9_-_71896047 1.407 ENSMUST00000184448.1
Tcf12
transcription factor 12
chrX_+_56454871 1.386 ENSMUST00000039374.2
ENSMUST00000101553.2
Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chr11_+_117232254 1.358 ENSMUST00000106354.2
Sept9
septin 9
chr2_-_105399286 1.345 ENSMUST00000006128.6
Rcn1
reticulocalbin 1
chr6_+_112273758 1.292 ENSMUST00000032376.5
Lmcd1
LIM and cysteine-rich domains 1
chr5_+_129096740 1.188 ENSMUST00000056617.7
ENSMUST00000156437.1
Gpr133

G protein-coupled receptor 133

chrX_+_36328353 1.157 ENSMUST00000016383.3
Lonrf3
LON peptidase N-terminal domain and ring finger 3
chr17_+_88626549 1.146 ENSMUST00000163588.1
ENSMUST00000064035.6
Ston1

stonin 1

chr3_-_84259812 1.145 ENSMUST00000107691.1
Trim2
tripartite motif-containing 2
chr16_+_43510267 1.139 ENSMUST00000114695.2
Zbtb20
zinc finger and BTB domain containing 20
chr17_-_47016956 1.022 ENSMUST00000165525.1
Gm16494
predicted gene 16494
chr17_+_82539258 0.953 ENSMUST00000097278.3
Gm6594
predicted pseudogene 6594
chr4_+_80910646 0.819 ENSMUST00000055922.3
Lurap1l
leucine rich adaptor protein 1-like
chr8_+_94838321 0.808 ENSMUST00000034234.8
ENSMUST00000159871.1
Coq9

coenzyme Q9 homolog (yeast)

chr17_+_88626569 0.802 ENSMUST00000150023.1
Ston1
stonin 1
chr18_+_34759551 0.796 ENSMUST00000097622.3
Fam53c
family with sequence similarity 53, member C
chr2_+_59612034 0.777 ENSMUST00000112568.1
ENSMUST00000037526.4
Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr1_+_150392794 0.773 ENSMUST00000124973.2
Tpr
translocated promoter region
chr2_+_150323702 0.752 ENSMUST00000133235.2
Gm10130
predicted gene 10130
chr17_-_6449571 0.719 ENSMUST00000180035.1
Tmem181b-ps
transmembrane protein 181B, pseudogene
chr2_+_62046580 0.710 ENSMUST00000054484.8
Slc4a10
solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
chr2_+_62046623 0.704 ENSMUST00000112480.2
Slc4a10
solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
chr2_+_62046462 0.662 ENSMUST00000102735.3
Slc4a10
solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
chr2_+_69670100 0.660 ENSMUST00000100050.3
Klhl41
kelch-like 41
chr11_-_35980473 0.639 ENSMUST00000018993.6
Wwc1
WW, C2 and coiled-coil domain containing 1
chr5_-_66618772 0.560 ENSMUST00000162994.1
ENSMUST00000159512.1
ENSMUST00000159786.1
Apbb2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr14_-_62454793 0.555 ENSMUST00000128573.1
Gucy1b2
guanylate cyclase 1, soluble, beta 2
chr19_-_53371766 0.539 ENSMUST00000086887.1
Gm10197
predicted gene 10197
chr6_-_3494587 0.503 ENSMUST00000049985.8
Hepacam2
HEPACAM family member 2
chr5_-_66618636 0.492 ENSMUST00000162382.1
ENSMUST00000160870.1
ENSMUST00000087256.5
ENSMUST00000160103.1
ENSMUST00000162349.1
Apbb2




amyloid beta (A4) precursor protein-binding, family B, member 2




chr5_-_28210168 0.480 ENSMUST00000117098.1
Cnpy1
canopy 1 homolog (zebrafish)
chr9_+_66946057 0.446 ENSMUST00000040917.7
ENSMUST00000127896.1
Rps27l

ribosomal protein S27-like

chr5_-_66618752 0.405 ENSMUST00000162366.1
Apbb2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr2_-_39065438 0.374 ENSMUST00000112850.2
Golga1
golgi autoantigen, golgin subfamily a, 1
chr9_-_88719798 0.374 ENSMUST00000113110.3
Gm2382
predicted gene 2382
chr16_+_11008898 0.367 ENSMUST00000180624.1
Gm4262
predicted gene 4262
chr10_-_22149270 0.357 ENSMUST00000179054.1
ENSMUST00000069372.6
E030030I06Rik

RIKEN cDNA E030030I06 gene

chr7_+_101394361 0.352 ENSMUST00000154239.1
ENSMUST00000098243.2
Arap1

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

chr2_-_39065505 0.341 ENSMUST00000039165.8
Golga1
golgi autoantigen, golgin subfamily a, 1
chr9_+_72985568 0.324 ENSMUST00000150826.2
ENSMUST00000085350.4
ENSMUST00000140675.1
Ccpg1


cell cycle progression 1


chr9_+_72985504 0.317 ENSMUST00000156879.1
Ccpg1
cell cycle progression 1
chr6_-_83033422 0.312 ENSMUST00000089651.5
Dok1
docking protein 1
chr11_-_87404380 0.304 ENSMUST00000067692.6
Rad51c
RAD51 homolog C
chr10_+_61175206 0.304 ENSMUST00000079235.5
Tbata
thymus, brain and testes associated
chr2_-_121807024 0.287 ENSMUST00000138157.1
Frmd5
FERM domain containing 5
chr2_-_54085542 0.262 ENSMUST00000100089.2
Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr9_-_21918089 0.262 ENSMUST00000128442.1
ENSMUST00000119055.1
ENSMUST00000122211.1
ENSMUST00000115351.3
Rab3d



RAB3D, member RAS oncogene family



chr2_-_156180135 0.258 ENSMUST00000126992.1
ENSMUST00000146288.1
ENSMUST00000029149.6
ENSMUST00000109587.2
ENSMUST00000109584.1
Rbm39




RNA binding motif protein 39




chr11_+_108920342 0.250 ENSMUST00000052915.7
Axin2
axin2
chr17_-_25792284 0.231 ENSMUST00000072735.7
Fam173a
family with sequence similarity 173, member A
chr17_-_6827990 0.226 ENSMUST00000181895.1
Gm2885
predicted gene 2885
chr2_-_29253001 0.212 ENSMUST00000071201.4
Ntng2
netrin G2
chr11_-_69602741 0.206 ENSMUST00000138694.1
Atp1b2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr4_-_25281801 0.205 ENSMUST00000102994.3
Ufl1
UFM1 specific ligase 1
chr7_+_127904079 0.205 ENSMUST00000071056.7
Bckdk
branched chain ketoacid dehydrogenase kinase
chr2_+_21367532 0.188 ENSMUST00000055946.7
Gpr158
G protein-coupled receptor 158
chr19_-_53589067 0.183 ENSMUST00000095978.3
Nutf2-ps1
nuclear transport factor 2, pseudogene 1
chr6_-_148831395 0.178 ENSMUST00000145960.1
Ipo8
importin 8
chr1_-_111864869 0.164 ENSMUST00000035462.5
Dsel
dermatan sulfate epimerase-like
chr16_-_57292845 0.160 ENSMUST00000023434.8
ENSMUST00000120112.1
ENSMUST00000119407.1
Tmem30c


transmembrane protein 30C


chr8_+_4243264 0.153 ENSMUST00000110996.1
Map2k7
mitogen-activated protein kinase kinase 7
chr8_+_25601591 0.130 ENSMUST00000155861.1
Whsc1l1
Wolf-Hirschhorn syndrome candidate 1-like 1 (human)
chr18_+_77185979 0.127 ENSMUST00000075290.6
St8sia5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr2_+_155382186 0.118 ENSMUST00000134218.1
Trp53inp2
transformation related protein 53 inducible nuclear protein 2
chr10_+_59879617 0.110 ENSMUST00000142819.1
ENSMUST00000020309.6
Dnajb12

DnaJ (Hsp40) homolog, subfamily B, member 12

chr17_-_35074485 0.109 ENSMUST00000007259.3
Ly6g6d
lymphocyte antigen 6 complex, locus G6D
chr9_-_26999491 0.106 ENSMUST00000060513.7
ENSMUST00000120367.1
Acad8

acyl-Coenzyme A dehydrogenase family, member 8

chr2_+_164833781 0.103 ENSMUST00000143780.1
Ctsa
cathepsin A
chr10_+_59879556 0.095 ENSMUST00000147914.1
ENSMUST00000146590.1
Dnajb12

DnaJ (Hsp40) homolog, subfamily B, member 12

chr10_+_53596936 0.095 ENSMUST00000020004.6
Asf1a
ASF1 anti-silencing function 1 homolog A (S. cerevisiae)
chr2_+_127587214 0.078 ENSMUST00000028852.6
Mrps5
mitochondrial ribosomal protein S5
chr17_+_35126316 0.069 ENSMUST00000061859.6
D17H6S53E
DNA segment, Chr 17, human D6S53E
chr2_+_164833841 0.045 ENSMUST00000152721.1
Ctsa
cathepsin A
chr6_+_17743582 0.020 ENSMUST00000000674.6
ENSMUST00000077080.2
St7

suppression of tumorigenicity 7

chr11_-_101417615 0.019 ENSMUST00000070395.8
Aarsd1
alanyl-tRNA synthetase domain containing 1

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.6 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.7 6.7 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.7 2.1 GO:0061349 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) hypophysis morphogenesis(GO:0048850) cervix development(GO:0060067) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354)
0.5 5.9 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.4 1.6 GO:0072236 DCT cell differentiation(GO:0072069) metanephric loop of Henle development(GO:0072236) metanephric DCT cell differentiation(GO:0072240)
0.3 1.8 GO:0044838 cell quiescence(GO:0044838)
0.3 0.8 GO:0032240 RNA import into nucleus(GO:0006404) mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832)
0.2 0.6 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.2 1.7 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 1.3 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 3.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 0.6 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 0.3 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.1 2.1 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 0.3 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
0.1 0.3 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.1 1.4 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.1 0.2 GO:1903288 positive regulation of potassium ion import(GO:1903288)
0.1 0.7 GO:0031272 regulation of pseudopodium assembly(GO:0031272)
0.0 0.8 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.2 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.2 GO:0030205 dermatan sulfate metabolic process(GO:0030205)
0.0 0.8 GO:0097062 dendritic spine maintenance(GO:0097062)
0.0 1.8 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.1 GO:1904715 negative regulation of chaperone-mediated autophagy(GO:1904715)
0.0 0.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.3 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.0 0.2 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.6 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.0 0.2 GO:2000671 regulation of motor neuron apoptotic process(GO:2000671)
0.0 1.3 GO:0043488 regulation of mRNA stability(GO:0043488)
0.0 1.2 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.1 GO:0097441 basilar dendrite(GO:0097441)
0.2 3.0 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.8 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.1 1.4 GO:0031105 septin complex(GO:0031105)
0.1 6.7 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 0.3 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) Holliday junction resolvase complex(GO:0048476)
0.1 0.2 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 1.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.7 GO:0031143 pseudopodium(GO:0031143)
0.0 6.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 5.5 GO:0032993 protein-DNA complex(GO:0032993)
0.0 1.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.2 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 1.5 GO:0016459 myosin complex(GO:0016459)
0.0 1.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.3 GO:0042588 zymogen granule(GO:0042588)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0005110 frizzled-2 binding(GO:0005110)
0.6 1.8 GO:0098770 FBXO family protein binding(GO:0098770)
0.1 2.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 5.5 GO:0070888 E-box binding(GO:0070888)
0.1 1.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 0.4 GO:0008494 translation activator activity(GO:0008494)
0.1 0.2 GO:0071568 UFM1 transferase activity(GO:0071568)
0.1 1.6 GO:0071837 HMG box domain binding(GO:0071837)
0.1 1.7 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 7.0 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 0.3 GO:0000150 recombinase activity(GO:0000150)
0.0 1.5 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 1.4 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.2 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 0.6 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 1.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 5.7 GO:0001047 core promoter binding(GO:0001047)
0.0 3.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.8 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.4 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 2.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.3 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.1 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.3 GO:0031489 myosin V binding(GO:0031489)
0.0 1.5 GO:0003774 motor activity(GO:0003774)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.8 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.5 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.2 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 1.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.7 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.2 4.6 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.7 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.0 1.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.8 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 1.4 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 1.5 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 2.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.8 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.6 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.3 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation