Motif ID: Barhl2

Z-value: 0.394


Transcription factors associated with Barhl2:

Gene SymbolEntrez IDGene Name
Barhl2 ENSMUSG00000034384.10 Barhl2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Barhl2mm10_v2_chr5_-_106458440_106458470-0.391.8e-02Click!


Activity profile for motif Barhl2.

activity profile for motif Barhl2


Sorted Z-values histogram for motif Barhl2

Sorted Z-values for motif Barhl2



Network of associatons between targets according to the STRING database.



First level regulatory network of Barhl2

PNG image of the network

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Top targets:


Showing 1 to 20 of 122 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_101377897 2.028 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr12_-_34528844 1.846 ENSMUST00000110819.2
 Hdac9
histone deacetylase 9
chr3_-_80802789 1.567 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr5_-_110839575 1.411 ENSMUST00000145318.1
 Hscb
HscB iron-sulfur cluster co-chaperone homolog (E. coli)
chr1_+_165788681 1.267 ENSMUST00000161971.1
ENSMUST00000178336.1
ENSMUST00000005907.5
ENSMUST00000027849.4
 Cd247



CD247 antigen



chr1_+_165788746 1.037 ENSMUST00000161559.2
 Cd247
CD247 antigen
chr3_-_49757257 1.025 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr17_-_49564262 1.013 ENSMUST00000057610.6
 Daam2
dishevelled associated activator of morphogenesis 2
chr16_-_22439719 0.994 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr5_-_110839757 0.928 ENSMUST00000056937.5
 Hscb
HscB iron-sulfur cluster co-chaperone homolog (E. coli)
chr6_+_125552948 0.923 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
 Vwf


Von Willebrand factor homolog


chr5_+_110839973 0.907 ENSMUST00000066160.1
 Chek2
checkpoint kinase 2
chr1_-_163725123 0.902 ENSMUST00000159679.1
 Mettl11b
methyltransferase like 11B
chr18_-_78206408 0.854 ENSMUST00000163367.1
 Slc14a2
solute carrier family 14 (urea transporter), member 2
chr14_+_30825580 0.849 ENSMUST00000006701.5
 Tmem110
transmembrane protein 110
chrX_+_71663665 0.842 ENSMUST00000070449.5
 Gpr50
G-protein-coupled receptor 50
chr11_+_85832551 0.756 ENSMUST00000000095.6
 Tbx2
T-box 2
chr14_-_88471396 0.706 ENSMUST00000061628.5
 Pcdh20
protocadherin 20
chr17_+_35439155 0.700 ENSMUST00000071951.6
ENSMUST00000078205.7
ENSMUST00000116598.3
ENSMUST00000076256.7
 H2-Q7



histocompatibility 2, Q region locus 7



chr18_+_61045139 0.698 ENSMUST00000025522.4
ENSMUST00000115274.1
 Pdgfrb

platelet derived growth factor receptor, beta polypeptide


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.3 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 2.3 GO:0070207 protein homotrimerization(GO:0070207)
0.0 2.0 GO:0007528 neuromuscular junction development(GO:0007528)
0.2 1.8 GO:0034983 peptidyl-lysine deacetylation(GO:0034983) regulation of skeletal muscle fiber development(GO:0048742)
0.3 1.4 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.4 1.2 GO:0002447 eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308) regulation of eosinophil activation(GO:1902566)
0.0 1.1 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 1.0 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.3 0.9 GO:0072223 metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.3 0.9 GO:0071918 urea transmembrane transport(GO:0071918)
0.2 0.9 GO:1903463 regulation of mitotic cell cycle DNA replication(GO:1903463)
0.3 0.8 GO:0007521 muscle cell fate determination(GO:0007521) mammary placode formation(GO:0060596)
0.2 0.8 GO:1902990 mitotic telomere maintenance via semi-conservative replication(GO:1902990) negative regulation of t-circle formation(GO:1904430)
0.2 0.8 GO:0015825 L-serine transport(GO:0015825)
0.0 0.8 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.0 0.7 GO:0097062 dendritic spine maintenance(GO:0097062)
0.0 0.7 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.2 0.6 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.0 0.6 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.0 0.6 GO:0034453 microtubule anchoring(GO:0034453)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.3 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 2.0 GO:0031594 neuromuscular junction(GO:0031594)
0.2 1.8 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.1 1.6 GO:0032279 asymmetric synapse(GO:0032279)
0.0 1.6 GO:0035097 histone methyltransferase complex(GO:0035097)
0.2 0.9 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.9 GO:0005882 intermediate filament(GO:0005882)
0.1 0.7 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.5 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.3 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.3 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 0.3 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 0.3 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.2 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.1 GO:0000799 nuclear condensin complex(GO:0000799)
0.0 0.1 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.0 0.1 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.1 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 0.1 GO:0005785 signal recognition particle receptor complex(GO:0005785)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.3 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.0 2.0 GO:0001671 ATPase activator activity(GO:0001671)
0.1 1.8 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.3 1.6 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.3 1.2 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.1 0.9 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.1 0.9 GO:0019865 immunoglobulin binding(GO:0019865)
0.0 0.9 GO:0008276 protein methyltransferase activity(GO:0008276)
0.3 0.8 GO:0008502 melatonin receptor activity(GO:0008502)
0.1 0.8 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) L-proline transmembrane transporter activity(GO:0015193) alanine transmembrane transporter activity(GO:0022858)
0.0 0.8 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 0.7 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.1 0.7 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.6 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.6 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.5 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.4 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 0.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.4 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.3 GO:0051011 microtubule minus-end binding(GO:0051011)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.7 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.8 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.6 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.0 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.9 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.3 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.4 2.3 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 2.2 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.6 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 0.9 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 0.9 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.9 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.8 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.6 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.5 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 0.4 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.4 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.4 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.4 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.3 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.3 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.3 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.2 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.2 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.1 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion