Motif ID: Bbx

Z-value: 0.238


Transcription factors associated with Bbx:

Gene SymbolEntrez IDGene Name
Bbx ENSMUSG00000022641.9 Bbx

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bbxmm10_v2_chr16_-_50330987_50331017-0.692.1e-06Click!


Activity profile for motif Bbx.

activity profile for motif Bbx


Sorted Z-values histogram for motif Bbx

Sorted Z-values for motif Bbx



Network of associatons between targets according to the STRING database.



First level regulatory network of Bbx

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_21111452 2.005 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr13_-_52530827 1.564 ENSMUST00000057442.6
 Diras2
DIRAS family, GTP-binding RAS-like 2
chr5_-_146585239 1.297 ENSMUST00000036211.6
 Gpr12
G-protein coupled receptor 12
chr18_+_37421418 1.105 ENSMUST00000053073.4
 Pcdhb11
protocadherin beta 11
chr13_+_49608030 0.872 ENSMUST00000021822.5
 Ogn
osteoglycin
chr10_+_86021961 0.662 ENSMUST00000130320.1
 Fbxo7
F-box protein 7
chr17_+_57358682 0.585 ENSMUST00000086763.5
ENSMUST00000004850.7
 Emr1

EGF-like module containing, mucin-like, hormone receptor-like sequence 1

chr8_+_70616816 0.533 ENSMUST00000052437.3
 Lrrc25
leucine rich repeat containing 25
chr6_+_124304646 0.504 ENSMUST00000112541.2
ENSMUST00000032234.2
 Cd163

CD163 antigen

chrX_+_140367494 0.498 ENSMUST00000141660.1
 Frmpd3
FERM and PDZ domain containing 3
chrX_-_150814265 0.285 ENSMUST00000026302.6
ENSMUST00000129768.1
ENSMUST00000112699.2
 Maged2


melanoma antigen, family D, 2


chrX_+_159708593 0.211 ENSMUST00000080394.6
 Sh3kbp1
SH3-domain kinase binding protein 1
chr7_-_127708738 0.199 ENSMUST00000106282.1
 Bcl7c
B cell CLL/lymphoma 7C
chr11_+_105146893 0.174 ENSMUST00000100338.1
 Gm10842
predicted gene 10842
chr7_-_127708886 0.142 ENSMUST00000061468.8
 Bcl7c
B cell CLL/lymphoma 7C
chr17_+_40811089 0.141 ENSMUST00000024721.7
 Rhag
Rhesus blood group-associated A glycoprotein
chr10_+_86022189 0.104 ENSMUST00000120344.1
ENSMUST00000117597.1
 Fbxo7

F-box protein 7

chr11_+_59306920 0.064 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr1_-_13660476 0.054 ENSMUST00000027071.5
 Lactb2
lactamase, beta 2
chr12_-_86079019 0.050 ENSMUST00000003687.6
 Tgfb3
transforming growth factor, beta 3
chr12_+_103388656 0.027 ENSMUST00000101094.2
ENSMUST00000021620.6
 Otub2

OTU domain, ubiquitin aldehyde binding 2

chr14_+_48670147 0.026 ENSMUST00000183522.1
ENSMUST00000184869.1
 RP23-131O4.2

RP23-131O4.2

chr1_+_180111339 0.017 ENSMUST00000145181.1
 Cdc42bpa
CDC42 binding protein kinase alpha
chr16_+_20693263 0.015 ENSMUST00000149543.1
ENSMUST00000118919.1
 Fam131a

family with sequence similarity 131, member A

chr5_-_108675569 0.007 ENSMUST00000051757.7
 Slc26a1
solute carrier family 26 (sulfate transporter), member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:1903207 neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208)
0.0 0.3 GO:0070294 renal sodium ion absorption(GO:0070294)
0.0 0.1 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.0 0.5 GO:0006953 acute-phase response(GO:0006953)
0.0 2.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.1 GO:0003032 detection of oxygen(GO:0003032)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:1990037 Lewy body core(GO:1990037)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.0 0.5 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.1 GO:0022842 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 NABA_PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.1 2.0 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions