Motif ID: Bcl6

Z-value: 0.604


Transcription factors associated with Bcl6:

Gene SymbolEntrez IDGene Name
Bcl6 ENSMUSG00000022508.5 Bcl6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bcl6mm10_v2_chr16_-_23988852_239888520.623.7e-05Click!


Activity profile for motif Bcl6.

activity profile for motif Bcl6


Sorted Z-values histogram for motif Bcl6

Sorted Z-values for motif Bcl6



Network of associatons between targets according to the STRING database.



First level regulatory network of Bcl6

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_169747634 2.742 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4

chr11_+_101245996 2.740 ENSMUST00000129680.1
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr11_-_55419898 2.306 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr4_-_64046925 2.271 ENSMUST00000107377.3
 Tnc
tenascin C
chr10_+_100015817 2.252 ENSMUST00000130190.1
ENSMUST00000020129.7
 Kitl

kit ligand

chr11_+_78499087 2.108 ENSMUST00000017488.4
 Vtn
vitronectin
chr9_+_20868628 2.022 ENSMUST00000043911.7
 A230050P20Rik
RIKEN cDNA A230050P20 gene
chr15_-_8710734 1.814 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr19_+_34217588 1.802 ENSMUST00000119603.1
 Stambpl1
STAM binding protein like 1
chr3_-_152982240 1.790 ENSMUST00000044278.5
 St6galnac5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr3_+_63295815 1.775 ENSMUST00000029400.1
 Mme
membrane metallo endopeptidase
chr1_-_175491130 1.753 ENSMUST00000027812.5
 Rgs7
regulator of G protein signaling 7
chr8_+_68880491 1.698 ENSMUST00000015712.8
 Lpl
lipoprotein lipase
chr15_-_37459327 1.652 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chr15_-_37458523 1.648 ENSMUST00000116445.2
 Ncald
neurocalcin delta
chr10_+_58813359 1.626 ENSMUST00000135526.2
ENSMUST00000153031.1
 Sh3rf3

SH3 domain containing ring finger 3

chr3_-_120886691 1.586 ENSMUST00000182099.1
ENSMUST00000183168.1
ENSMUST00000183276.1
ENSMUST00000182124.1
 6530403H02Rik



RIKEN cDNA 6530403H02 gene



chr2_+_72054598 1.577 ENSMUST00000028525.5
 Rapgef4
Rap guanine nucleotide exchange factor (GEF) 4
chr4_+_42922253 1.560 ENSMUST00000139100.1
 N28178
expressed sequence N28178
chr18_+_37484955 1.554 ENSMUST00000053856.4
 Pcdhb17
protocadherin beta 17

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 3.2 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 3.0 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.5 2.7 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.1 2.6 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.6 2.3 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.6 2.3 GO:0033024 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.1 2.3 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.0 2.3 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.3 2.2 GO:0015862 uridine transport(GO:0015862)
0.2 2.1 GO:0097421 liver regeneration(GO:0097421)
0.1 2.0 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.6 1.8 GO:0071492 cellular response to UV-A(GO:0071492)
0.1 1.8 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.4 1.7 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.2 1.7 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.2 1.7 GO:0042572 retinol metabolic process(GO:0042572)
0.4 1.6 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.3 1.6 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.1 1.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.2 1.2 GO:0048245 eosinophil chemotaxis(GO:0048245)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.5 3.1 GO:0005796 Golgi lumen(GO:0005796)
0.2 3.0 GO:0005614 interstitial matrix(GO:0005614)
0.5 2.7 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.6 2.3 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 1.8 GO:0044292 dendrite terminus(GO:0044292)
0.2 1.7 GO:0042627 chylomicron(GO:0042627)
0.3 1.6 GO:0044316 cone cell pedicle(GO:0044316)
0.0 1.5 GO:0005903 brush border(GO:0005903)
0.1 1.4 GO:0032279 asymmetric synapse(GO:0032279)
0.4 1.2 GO:0005940 septin ring(GO:0005940)
0.0 1.2 GO:0060077 inhibitory synapse(GO:0060077)
0.0 1.0 GO:0031672 A band(GO:0031672)
0.0 1.0 GO:0005811 lipid particle(GO:0005811)
0.0 1.0 GO:0072562 blood microparticle(GO:0072562)
0.2 0.9 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.2 0.9 GO:0001652 granular component(GO:0001652)
0.2 0.9 GO:0097512 cardiac myofibril(GO:0097512)
0.1 0.9 GO:0005915 zonula adherens(GO:0005915)
0.0 0.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.6 GO:0008237 metallopeptidase activity(GO:0008237)
0.1 3.3 GO:0043014 alpha-tubulin binding(GO:0043014)
0.5 3.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.5 2.7 GO:0097643 amylin receptor activity(GO:0097643)
0.1 2.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 2.6 GO:0097322 7SK snRNA binding(GO:0097322)
0.4 2.3 GO:0045545 syndecan binding(GO:0045545)
0.4 2.3 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.2 2.3 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 2.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 2.2 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 2.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.3 1.8 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.1 1.8 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.4 1.7 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.2 1.7 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 1.7 GO:0004806 triglyceride lipase activity(GO:0004806)
0.2 1.6 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 1.6 GO:0030546 receptor activator activity(GO:0030546)
0.0 1.6 GO:0030552 cAMP binding(GO:0030552)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.3 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 2.1 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 1.3 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 1.3 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.1 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 1.0 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 1.0 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.9 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.9 PID_INSULIN_PATHWAY Insulin Pathway
0.0 0.7 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.6 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.5 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 0.4 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.3 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 0.3 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.2 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 5.0 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.2 3.3 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 2.7 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.0 2.3 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES Genes involved in Transmission across Chemical Synapses
0.1 2.2 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 2.2 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.9 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 1.6 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 1.4 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 1.2 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.1 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 1.1 REACTOME_TRIGLYCERIDE_BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.1 0.9 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.9 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 0.8 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 0.7 REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.1 0.6 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.4 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.4 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix