Motif ID: Bcl6b

Z-value: 0.468


Transcription factors associated with Bcl6b:

Gene SymbolEntrez IDGene Name
Bcl6b ENSMUSG00000000317.5 Bcl6b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bcl6bmm10_v2_chr11_-_70229677_70229761-0.029.3e-01Click!


Activity profile for motif Bcl6b.

activity profile for motif Bcl6b


Sorted Z-values histogram for motif Bcl6b

Sorted Z-values for motif Bcl6b



Network of associatons between targets according to the STRING database.



First level regulatory network of Bcl6b

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_173942445 1.452 ENSMUST00000042228.8
ENSMUST00000081216.5
ENSMUST00000129829.1
ENSMUST00000123708.1
ENSMUST00000111210.2
 Ifi203



Mndal
interferon activated gene 203



myeloid nuclear differentiation antigen like
chr19_-_5797410 1.281 ENSMUST00000173314.1
 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr10_+_57794335 1.212 ENSMUST00000151623.1
ENSMUST00000020022.7
 Smpdl3a

sphingomyelin phosphodiesterase, acid-like 3A

chr9_-_90255927 1.197 ENSMUST00000144646.1
 Tbc1d2b
TBC1 domain family, member 2B
chr16_-_74411776 1.122 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chr4_-_64046925 0.978 ENSMUST00000107377.3
 Tnc
tenascin C
chr16_-_74411292 0.859 ENSMUST00000117200.1
 Robo2
roundabout homolog 2 (Drosophila)
chr13_-_98815408 0.823 ENSMUST00000040340.8
ENSMUST00000099277.4
ENSMUST00000179563.1
ENSMUST00000109403.1
 Fcho2



FCH domain only 2



chr6_+_149309391 0.801 ENSMUST00000130664.1
ENSMUST00000046689.6
 2810474O19Rik

RIKEN cDNA 2810474O19 gene

chr15_+_25752860 0.783 ENSMUST00000022882.5
ENSMUST00000135173.1
 Myo10

myosin X

chr10_-_95417099 0.773 ENSMUST00000135822.1
 Socs2
suppressor of cytokine signaling 2
chr6_+_149309444 0.770 ENSMUST00000100765.4
 2810474O19Rik
RIKEN cDNA 2810474O19 gene
chrX_+_151344171 0.768 ENSMUST00000073364.5
 Fam120c
family with sequence similarity 120, member C
chr2_+_119594288 0.738 ENSMUST00000147425.1
ENSMUST00000153581.1
 1700020I14Rik

RIKEN cDNA 1700020I14 gene

chr10_-_95416850 0.696 ENSMUST00000020215.9
 Socs2
suppressor of cytokine signaling 2
chr12_-_98577940 0.674 ENSMUST00000110113.1
 Kcnk10
potassium channel, subfamily K, member 10
chr16_-_34263179 0.667 ENSMUST00000114949.1
ENSMUST00000114954.1
 Kalrn

kalirin, RhoGEF kinase

chr16_-_34262830 0.651 ENSMUST00000114947.1
 Kalrn
kalirin, RhoGEF kinase
chr16_-_34262945 0.557 ENSMUST00000114953.1
 Kalrn
kalirin, RhoGEF kinase
chr18_-_41951187 0.545 ENSMUST00000070949.4
 Prelid2
PRELI domain containing 2
chr5_-_150665560 0.530 ENSMUST00000118316.1
 N4bp2l2
NEDD4 binding protein 2-like 2
chr1_+_82316452 0.507 ENSMUST00000027322.7
 Rhbdd1
rhomboid domain containing 1
chr10_-_86705485 0.498 ENSMUST00000020238.7
 Hsp90b1
heat shock protein 90, beta (Grp94), member 1
chr12_-_40134175 0.496 ENSMUST00000078481.7
ENSMUST00000002640.5
 Scin

scinderin

chr2_-_180824596 0.490 ENSMUST00000148700.1
 Gm14340
predicted gene 14340
chr6_+_34598500 0.456 ENSMUST00000079391.3
ENSMUST00000142512.1
 Cald1

caldesmon 1

chr8_+_13907748 0.428 ENSMUST00000043520.3
 Fbxo25
F-box protein 25
chr6_+_34598530 0.388 ENSMUST00000115027.1
ENSMUST00000115026.1
 Cald1

caldesmon 1

chr11_+_70764209 0.383 ENSMUST00000060444.5
 Zfp3
zinc finger protein 3
chr6_-_128355826 0.354 ENSMUST00000001562.6
 Tulp3
tubby-like protein 3
chr3_+_95588990 0.354 ENSMUST00000177399.1
 Golph3l
golgi phosphoprotein 3-like
chr18_+_42275353 0.353 ENSMUST00000046972.7
ENSMUST00000091920.5
 Rbm27

RNA binding motif protein 27

chr3_+_95588960 0.350 ENSMUST00000176674.1
ENSMUST00000177389.1
ENSMUST00000176755.1
 Golph3l


golgi phosphoprotein 3-like


chr1_-_136230289 0.332 ENSMUST00000150163.1
ENSMUST00000144464.1
 5730559C18Rik

RIKEN cDNA 5730559C18 gene

chr5_-_150665315 0.332 ENSMUST00000141857.1
 N4bp2l2
NEDD4 binding protein 2-like 2
chr7_+_43579577 0.324 ENSMUST00000058104.7
 Zfp719
zinc finger protein 719
chr18_+_37320374 0.322 ENSMUST00000078271.2
 Pcdhb5
protocadherin beta 5
chr1_+_139454747 0.314 ENSMUST00000053364.8
ENSMUST00000097554.3
 Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr2_-_65567505 0.307 ENSMUST00000100069.2
 Scn3a
sodium channel, voltage-gated, type III, alpha
chr3_+_95588928 0.289 ENSMUST00000177390.1
ENSMUST00000098861.4
ENSMUST00000060323.5
 Golph3l


golgi phosphoprotein 3-like


chr8_-_105568298 0.287 ENSMUST00000005849.5
 Agrp
agouti related protein
chr2_-_65567465 0.287 ENSMUST00000066432.5
 Scn3a
sodium channel, voltage-gated, type III, alpha
chr8_+_25601591 0.274 ENSMUST00000155861.1
 Whsc1l1
Wolf-Hirschhorn syndrome candidate 1-like 1 (human)
chr6_+_29361410 0.252 ENSMUST00000156163.1
 Calu
calumenin
chr11_+_58432559 0.244 ENSMUST00000108825.1
 Gm12253
predicted gene 12253
chr9_+_122923050 0.233 ENSMUST00000051667.7
ENSMUST00000148851.1
 Zfp105

zinc finger protein 105

chr17_-_45592485 0.223 ENSMUST00000166119.1
 Slc29a1
solute carrier family 29 (nucleoside transporters), member 1
chr10_+_81633694 0.222 ENSMUST00000140345.1
ENSMUST00000126323.1
 Ankrd24

ankyrin repeat domain 24

chr2_+_175283298 0.218 ENSMUST00000098998.3
 Gm14440
predicted gene 14440
chr8_+_27042555 0.197 ENSMUST00000033875.8
ENSMUST00000098851.4
 Prosc

proline synthetase co-transcribed

chr2_-_77946331 0.186 ENSMUST00000111821.2
ENSMUST00000111818.1
 Cwc22

CWC22 spliceosome-associated protein homolog (S. cerevisiae)

chrX_+_152233228 0.180 ENSMUST00000112588.2
ENSMUST00000082177.6
 Kdm5c

lysine (K)-specific demethylase 5C

chr5_-_123140135 0.170 ENSMUST00000160099.1
 AI480526
expressed sequence AI480526
chr7_+_48789003 0.154 ENSMUST00000118927.1
ENSMUST00000125280.1
 Zdhhc13

zinc finger, DHHC domain containing 13

chr2_-_28583189 0.153 ENSMUST00000113889.2
 Gtf3c5
general transcription factor IIIC, polypeptide 5
chr17_-_45592569 0.153 ENSMUST00000163492.1
 Slc29a1
solute carrier family 29 (nucleoside transporters), member 1
chr8_+_12915879 0.153 ENSMUST00000110876.2
ENSMUST00000110879.2
 Mcf2l

mcf.2 transforming sequence-like

chr11_+_95712673 0.152 ENSMUST00000107717.1
 Zfp652
zinc finger protein 652
chr2_-_77946375 0.150 ENSMUST00000065889.3
 Cwc22
CWC22 spliceosome-associated protein homolog (S. cerevisiae)
chr7_-_16221993 0.147 ENSMUST00000118795.1
ENSMUST00000119102.1
ENSMUST00000094816.2
ENSMUST00000163968.1
ENSMUST00000121123.1
 Dhx34




DEAH (Asp-Glu-Ala-His) box polypeptide 34




chrX_+_74429671 0.127 ENSMUST00000114127.1
ENSMUST00000064407.3
ENSMUST00000156707.1
 Ikbkg


inhibitor of kappaB kinase gamma


chr5_+_130079370 0.125 ENSMUST00000040721.8
 Tpst1
protein-tyrosine sulfotransferase 1
chr6_+_124916863 0.114 ENSMUST00000069553.2
 A230083G16Rik
RIKEN cDNA A230083G16 gene
chr4_+_155562348 0.114 ENSMUST00000030939.7
 Nadk
NAD kinase
chr4_+_3574872 0.101 ENSMUST00000052712.5
 Tgs1
trimethylguanosine synthase homolog (S. cerevisiae)
chr18_+_33794915 0.100 ENSMUST00000179138.1
 2410004N09Rik
RIKEN cDNA 2410004N09 gene
chr2_-_73486456 0.085 ENSMUST00000141264.1
 Wipf1
WAS/WASL interacting protein family, member 1
chr4_+_149485260 0.057 ENSMUST00000030842.7
 Lzic
leucine zipper and CTNNBIP1 domain containing
chr6_+_106769120 0.057 ENSMUST00000113247.1
ENSMUST00000113249.1
ENSMUST00000057578.9
ENSMUST00000113248.1
 Trnt1



tRNA nucleotidyl transferase, CCA-adding, 1



chr19_-_10555724 0.029 ENSMUST00000145210.1
ENSMUST00000123788.1
ENSMUST00000059582.2
ENSMUST00000154383.1
 Tmem216



transmembrane protein 216



chr18_+_33794882 0.021 ENSMUST00000146010.2
 2410004N09Rik
RIKEN cDNA 2410004N09 gene
chr9_+_121938099 0.014 ENSMUST00000063103.4
 1700048O20Rik
RIKEN cDNA 1700048O20 gene
chr15_-_103215285 0.005 ENSMUST00000122182.1
ENSMUST00000108813.3
ENSMUST00000127191.1
 Cbx5


chromobox 5


chr1_+_83159733 0.004 ENSMUST00000113436.1
ENSMUST00000065436.3
ENSMUST00000065403.6
 Daw1


dynein assembly factor with WDR repeat domains 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.3 1.3 GO:0035063 nuclear speck organization(GO:0035063)
0.2 1.0 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.2 1.9 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.2 0.9 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)
0.2 1.2 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.2 0.5 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.1 0.6 GO:0046684 response to pyrethroid(GO:0046684)
0.1 0.4 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.1 1.5 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.1 0.5 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.1 0.7 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 1.0 GO:0048194 Golgi vesicle budding(GO:0048194)
0.1 0.3 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 0.4 GO:0015862 uridine transport(GO:0015862)
0.0 0.5 GO:0071318 cellular response to ATP(GO:0071318)
0.0 1.5 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.0 0.3 GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423) nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070431)
0.0 0.3 GO:0008343 adult feeding behavior(GO:0008343)
0.0 0.1 GO:0006478 peptidyl-tyrosine sulfation(GO:0006478)
0.0 0.2 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.0 0.1 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.8 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.1 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.1 GO:0090646 mitochondrial RNA 3'-end processing(GO:0000965) mitochondrial tRNA processing(GO:0090646)
0.0 1.2 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.8 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.0 0.5 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.8 GO:0051489 regulation of filopodium assembly(GO:0051489)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0098835 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835)
0.1 0.8 GO:0030478 actin cap(GO:0030478)
0.1 0.3 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.1 0.3 GO:0036449 microtubule minus-end(GO:0036449)
0.1 1.0 GO:0005614 interstitial matrix(GO:0005614)
0.1 2.0 GO:0030673 axolemma(GO:0030673)
0.0 0.3 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.4 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.5 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.5 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 1.0 GO:0031985 Golgi cisterna(GO:0031985)
0.0 0.8 GO:0016459 myosin complex(GO:0016459)
0.0 0.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.2 2.0 GO:0008046 axon guidance receptor activity(GO:0008046)
0.2 1.0 GO:0045545 syndecan binding(GO:0045545)
0.2 0.5 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.2 1.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 0.5 GO:0046790 virion binding(GO:0046790)
0.1 0.7 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 1.9 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.2 GO:0000992 polymerase III regulatory region sequence-specific DNA binding(GO:0000992) RNA polymerase III type 1 promoter sequence-specific DNA binding(GO:0001002) RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.0 0.1 GO:1990450 linear polyubiquitin binding(GO:1990450)
0.0 0.1 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.0 1.0 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.6 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.2 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.0 0.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.8 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.4 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.8 GO:0030507 spectrin binding(GO:0030507)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 1.0 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.3 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.0 PID_IL2_1PATHWAY IL2-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 0.5 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 2.0 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.0 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.0 1.9 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 0.8 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.8 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 0.1 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.8 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions