Motif ID: Brca1

Z-value: 0.398


Transcription factors associated with Brca1:

Gene SymbolEntrez IDGene Name
Brca1 ENSMUSG00000017146.6 Brca1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Brca1mm10_v2_chr11_-_101551837_1015518930.221.9e-01Click!


Activity profile for motif Brca1.

activity profile for motif Brca1


Sorted Z-values histogram for motif Brca1

Sorted Z-values for motif Brca1



Network of associatons between targets according to the STRING database.



First level regulatory network of Brca1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_23248264 5.698 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr11_+_44617310 1.689 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
Ebf1


early B cell factor 1


chr1_-_75278345 1.336 ENSMUST00000039534.4
Resp18
regulated endocrine-specific protein 18
chr18_-_47333311 1.165 ENSMUST00000126684.1
ENSMUST00000156422.1
Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr7_-_144939823 1.116 ENSMUST00000093962.4
Ccnd1
cyclin D1
chr14_-_67715585 0.937 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
Cdca2


cell division cycle associated 2


chr11_-_106998483 0.839 ENSMUST00000124541.1
Kpna2
karyopherin (importin) alpha 2
chr6_+_14901344 0.783 ENSMUST00000115477.1
Foxp2
forkhead box P2
chr17_-_70853482 0.716 ENSMUST00000118283.1
Tgif1
TGFB-induced factor homeobox 1
chr2_-_105399286 0.694 ENSMUST00000006128.6
Rcn1
reticulocalbin 1
chr16_+_44394771 0.683 ENSMUST00000099742.2
Wdr52
WD repeat domain 52
chr8_-_47990535 0.678 ENSMUST00000057561.7
Wwc2
WW, C2 and coiled-coil domain containing 2
chr1_+_74791516 0.631 ENSMUST00000006718.8
Wnt10a
wingless related MMTV integration site 10a
chr11_-_98625661 0.587 ENSMUST00000104933.1
Gm12355
predicted gene 12355
chr11_+_97415527 0.573 ENSMUST00000121799.1
Arhgap23
Rho GTPase activating protein 23
chr19_-_24225015 0.568 ENSMUST00000099558.4
Tjp2
tight junction protein 2
chr2_-_28916668 0.565 ENSMUST00000113847.1
Barhl1
BarH-like 1 (Drosophila)
chr13_-_98891036 0.553 ENSMUST00000109399.2
Tnpo1
transportin 1
chr13_-_100775844 0.529 ENSMUST00000075550.3
Cenph
centromere protein H
chr3_+_87906321 0.522 ENSMUST00000005017.8
Hdgf
hepatoma-derived growth factor
chrX_+_169685191 0.522 ENSMUST00000112104.1
ENSMUST00000112107.1
Mid1

midline 1

chr12_+_52097737 0.500 ENSMUST00000040090.9
Nubpl
nucleotide binding protein-like
chr16_-_16829276 0.500 ENSMUST00000023468.5
Spag6
sperm associated antigen 6
chr9_-_109082372 0.491 ENSMUST00000167504.1
Tma7
translational machinery associated 7 homolog (S. cerevisiae)
chrX_-_101222426 0.490 ENSMUST00000120389.1
ENSMUST00000156473.1
ENSMUST00000077876.3
Snx12


sorting nexin 12


chr12_-_10900296 0.477 ENSMUST00000085735.2
Pgk1-rs7
phosphoglycerate kinase-1, related sequence-7
chr13_-_95891905 0.462 ENSMUST00000068603.6
Iqgap2
IQ motif containing GTPase activating protein 2
chr19_-_10203880 0.454 ENSMUST00000142241.1
ENSMUST00000116542.2
ENSMUST00000025651.5
ENSMUST00000156291.1
Fen1



flap structure specific endonuclease 1



chr11_-_101171302 0.454 ENSMUST00000164474.1
ENSMUST00000043397.7
Plekhh3

pleckstrin homology domain containing, family H (with MyTH4 domain) member 3

chr2_+_174330006 0.452 ENSMUST00000109085.1
ENSMUST00000109087.1
ENSMUST00000109084.1
Gnas


GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus


chr7_+_51878967 0.450 ENSMUST00000051912.6
Gas2
growth arrest specific 2
chr6_-_120357422 0.447 ENSMUST00000032283.5
Ccdc77
coiled-coil domain containing 77
chr13_-_98890974 0.442 ENSMUST00000179301.1
ENSMUST00000179271.1
Tnpo1

transportin 1

chr10_-_33624587 0.427 ENSMUST00000160299.1
ENSMUST00000019920.6
Clvs2

clavesin 2

chr8_-_70700070 0.426 ENSMUST00000116172.1
Gm11175
predicted gene 11175
chr9_-_37657189 0.425 ENSMUST00000117654.1
Tbrg1
transforming growth factor beta regulated gene 1
chr1_+_66386968 0.420 ENSMUST00000145419.1
Map2
microtubule-associated protein 2
chr6_-_120357440 0.411 ENSMUST00000112703.1
Ccdc77
coiled-coil domain containing 77
chr5_-_138187177 0.409 ENSMUST00000110937.1
ENSMUST00000139276.1
ENSMUST00000048698.7
ENSMUST00000123415.1
Taf6



TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor



chr1_+_192190771 0.404 ENSMUST00000078470.5
ENSMUST00000110844.1
Kcnh1

potassium voltage-gated channel, subfamily H (eag-related), member 1

chr3_-_61365951 0.381 ENSMUST00000066298.2
B430305J03Rik
RIKEN cDNA B430305J03 gene
chr5_+_15934685 0.376 ENSMUST00000078272.6
ENSMUST00000180204.1
ENSMUST00000167946.2
ENSMUST00000101581.3
ENSMUST00000039370.7
Cacna2d1




calcium channel, voltage-dependent, alpha2/delta subunit 1




chr17_-_33685386 0.359 ENSMUST00000139302.1
ENSMUST00000087582.5
ENSMUST00000114385.2
Hnrnpm


heterogeneous nuclear ribonucleoprotein M


chr6_-_120357342 0.353 ENSMUST00000163827.1
Ccdc77
coiled-coil domain containing 77
chr7_-_102100227 0.348 ENSMUST00000106937.1
Art5
ADP-ribosyltransferase 5
chr3_+_5218546 0.348 ENSMUST00000026284.6
Zfhx4
zinc finger homeodomain 4
chr3_+_5218516 0.325 ENSMUST00000175866.1
Zfhx4
zinc finger homeodomain 4
chr17_-_65613521 0.322 ENSMUST00000024897.8
Vapa
vesicle-associated membrane protein, associated protein A
chr10_-_42583628 0.320 ENSMUST00000019938.4
Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr5_+_138187485 0.318 ENSMUST00000110934.2
Cnpy4
canopy 4 homolog (zebrafish)
chr1_+_135729147 0.308 ENSMUST00000027677.7
Csrp1
cysteine and glycine-rich protein 1
chr3_-_138131356 0.301 ENSMUST00000029805.8
Mttp
microsomal triglyceride transfer protein
chr19_+_6047081 0.298 ENSMUST00000025723.8
Syvn1
synovial apoptosis inhibitor 1, synoviolin
chr7_-_133122615 0.295 ENSMUST00000167218.1
Ctbp2
C-terminal binding protein 2
chr17_-_6655939 0.289 ENSMUST00000179554.1
Dynlt1f
dynein light chain Tctex-type 1F
chr15_+_102460076 0.282 ENSMUST00000164688.1
Prr13
proline rich 13
chr13_-_49320219 0.280 ENSMUST00000110086.1
Fgd3
FYVE, RhoGEF and PH domain containing 3
chr5_-_123666682 0.267 ENSMUST00000149410.1
Clip1
CAP-GLY domain containing linker protein 1
chr13_+_100651328 0.266 ENSMUST00000084721.6
ENSMUST00000022135.8
Taf9
Taf9
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr13_-_107890059 0.262 ENSMUST00000105097.2
Zswim6
zinc finger SWIM-type containing 6
chr19_+_44562841 0.259 ENSMUST00000040455.4
Hif1an
hypoxia-inducible factor 1, alpha subunit inhibitor
chr7_-_44375006 0.250 ENSMUST00000107933.1
1700008O03Rik
RIKEN cDNA 1700008O03 gene
chr4_+_86053887 0.249 ENSMUST00000107178.2
ENSMUST00000048885.5
ENSMUST00000141889.1
ENSMUST00000120678.1
Adamtsl1



ADAMTS-like 1



chr8_+_25017211 0.243 ENSMUST00000033961.5
Tm2d2
TM2 domain containing 2
chr5_+_136953246 0.237 ENSMUST00000111094.1
ENSMUST00000111097.1
Fis1

fission 1 (mitochondrial outer membrane) homolog (yeast)

chr4_+_129058133 0.236 ENSMUST00000030584.4
ENSMUST00000168461.1
ENSMUST00000152565.1
Rnf19b


ring finger protein 19B


chr11_-_102230127 0.231 ENSMUST00000107150.1
ENSMUST00000156337.1
ENSMUST00000107151.2
ENSMUST00000107152.2
Hdac5



histone deacetylase 5



chr6_-_125191535 0.230 ENSMUST00000043848.4
Ncapd2
non-SMC condensin I complex, subunit D2
chr7_+_101896817 0.228 ENSMUST00000143835.1
Anapc15
anaphase prompoting complex C subunit 15
chr5_-_135064063 0.225 ENSMUST00000111205.1
ENSMUST00000141309.1
Wbscr22

Williams Beuren syndrome chromosome region 22

chr12_-_84617326 0.222 ENSMUST00000021666.4
Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr3_+_96172327 0.222 ENSMUST00000076372.4
Sf3b4
splicing factor 3b, subunit 4
chrX_+_150594420 0.221 ENSMUST00000112713.2
Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr11_-_102230091 0.221 ENSMUST00000008999.5
Hdac5
histone deacetylase 5
chrX_+_150589907 0.219 ENSMUST00000080884.4
Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr14_-_52305056 0.217 ENSMUST00000174853.1
ENSMUST00000022767.9
Mettl3

methyltransferase like 3

chr15_-_97020322 0.217 ENSMUST00000166223.1
Slc38a4
solute carrier family 38, member 4
chr12_-_69159109 0.213 ENSMUST00000037023.8
Rps29
ribosomal protein S29
chr3_+_5218589 0.212 ENSMUST00000177488.1
Zfhx4
zinc finger homeodomain 4
chr7_-_64872993 0.211 ENSMUST00000094331.2
Ndnl2
necdin-like 2
chr3_+_109573907 0.209 ENSMUST00000106576.2
Vav3
vav 3 oncogene
chr17_-_47611449 0.209 ENSMUST00000024783.8
Bysl
bystin-like
chr17_+_6430112 0.201 ENSMUST00000179569.1
Dynlt1b
dynein light chain Tctex-type 1B
chr5_-_21701332 0.193 ENSMUST00000115217.1
ENSMUST00000060899.8
Napepld

N-acyl phosphatidylethanolamine phospholipase D

chr19_+_45560569 0.192 ENSMUST00000047057.7
Dpcd
deleted in primary ciliary dyskinesia
chr18_-_15063560 0.189 ENSMUST00000168989.1
Kctd1
potassium channel tetramerisation domain containing 1
chr14_+_20674311 0.184 ENSMUST00000048657.8
Sec24c
Sec24 related gene family, member C (S. cerevisiae)
chr3_-_95882031 0.183 ENSMUST00000161994.1
Gm129
predicted gene 129
chrX_+_74309089 0.181 ENSMUST00000130581.1
Gdi1
guanosine diphosphate (GDP) dissociation inhibitor 1
chr11_+_93886157 0.178 ENSMUST00000063718.4
ENSMUST00000107854.2
Mbtd1

mbt domain containing 1

chr4_-_116708312 0.169 ENSMUST00000030453.4
Mmachc
methylmalonic aciduria cblC type, with homocystinuria
chr16_+_22009471 0.161 ENSMUST00000023561.7
Senp2
SUMO/sentrin specific peptidase 2
chr10_-_77902467 0.155 ENSMUST00000057608.4
Lrrc3
leucine rich repeat containing 3
chr5_+_146833106 0.155 ENSMUST00000075453.2
ENSMUST00000099272.2
Rpl21

ribosomal protein L21

chr2_-_152831665 0.154 ENSMUST00000156688.1
ENSMUST00000007803.5
Bcl2l1

BCL2-like 1

chr19_+_36083696 0.149 ENSMUST00000025714.7
Rpp30
ribonuclease P/MRP 30 subunit
chr4_+_10874498 0.147 ENSMUST00000080517.7
ENSMUST00000101504.2
2610301B20Rik

RIKEN cDNA 2610301B20 gene

chr11_+_59306920 0.147 ENSMUST00000000128.3
ENSMUST00000108783.3
Wnt9a

wingless-type MMTV integration site 9A

chr15_-_82016134 0.142 ENSMUST00000152227.1
Desi1
desumoylating isopeptidase 1
chr19_-_12765447 0.139 ENSMUST00000112933.1
Cntf
ciliary neurotrophic factor
chr3_+_87930256 0.138 ENSMUST00000055984.6
Isg20l2
interferon stimulated exonuclease gene 20-like 2
chr19_-_32466575 0.136 ENSMUST00000078034.3
Rpl9-ps6
ribosomal protein L9, pseudogene 6
chr7_-_102099932 0.135 ENSMUST00000106934.1
Art5
ADP-ribosyltransferase 5
chr18_+_7869707 0.132 ENSMUST00000166062.1
ENSMUST00000169010.1
Wac

WW domain containing adaptor with coiled-coil

chr4_-_41464816 0.131 ENSMUST00000108055.2
ENSMUST00000154535.1
ENSMUST00000030148.5
Kif24


kinesin family member 24


chr4_+_43632185 0.127 ENSMUST00000107874.2
Npr2
natriuretic peptide receptor 2
chr13_+_24943144 0.123 ENSMUST00000021773.5
Gpld1
glycosylphosphatidylinositol specific phospholipase D1
chr7_-_35056467 0.122 ENSMUST00000130491.1
Cebpg
CCAAT/enhancer binding protein (C/EBP), gamma
chr17_+_7945653 0.121 ENSMUST00000097423.2
Rsph3a
radial spoke 3A homolog (Chlamydomonas)
chr2_+_167932327 0.120 ENSMUST00000029053.7
Ptpn1
protein tyrosine phosphatase, non-receptor type 1
chrM_+_9452 0.115 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr12_+_103388656 0.111 ENSMUST00000101094.2
ENSMUST00000021620.6
Otub2

OTU domain, ubiquitin aldehyde binding 2

chr6_-_122340499 0.108 ENSMUST00000160843.1
Phc1
polyhomeotic-like 1 (Drosophila)
chr17_-_15498263 0.105 ENSMUST00000014913.9
Psmb1
proteasome (prosome, macropain) subunit, beta type 1
chr4_-_98817537 0.103 ENSMUST00000102790.3
Kank4
KN motif and ankyrin repeat domains 4
chr9_+_108392820 0.101 ENSMUST00000035234.4
1700102P08Rik
RIKEN cDNA 1700102P08 gene
chrX_-_64276937 0.097 ENSMUST00000114679.1
ENSMUST00000069926.7
Slitrk4

SLIT and NTRK-like family, member 4

chr12_-_24493656 0.097 ENSMUST00000073088.2
Gm16372
predicted pseudogene 16372
chr11_+_97703394 0.097 ENSMUST00000103147.4
Psmb3
proteasome (prosome, macropain) subunit, beta type 3
chr5_+_146832890 0.096 ENSMUST00000035983.5
Rpl21
ribosomal protein L21
chr4_+_43631935 0.095 ENSMUST00000030191.8
Npr2
natriuretic peptide receptor 2
chr7_-_4996095 0.093 ENSMUST00000108572.1
Zfp579
zinc finger protein 579
chr10_-_128923948 0.089 ENSMUST00000131271.1
Bloc1s1
biogenesis of lysosome-related organelles complex-1, subunit 1
chr5_+_72914264 0.087 ENSMUST00000144843.1
Slain2
SLAIN motif family, member 2
chr6_-_122340525 0.086 ENSMUST00000112600.2
Phc1
polyhomeotic-like 1 (Drosophila)
chr19_-_7295394 0.086 ENSMUST00000025921.8
Mark2
MAP/microtubule affinity-regulating kinase 2
chr5_-_115158169 0.084 ENSMUST00000053271.5
ENSMUST00000112121.1
Mlec

malectin

chr11_-_104550460 0.077 ENSMUST00000106961.1
ENSMUST00000093923.2
Cdc27

cell division cycle 27

chr6_+_100833606 0.076 ENSMUST00000063854.4
Ppp4r2
protein phosphatase 4, regulatory subunit 2
chr1_+_182124737 0.075 ENSMUST00000111018.1
ENSMUST00000027792.5
Srp9

signal recognition particle 9

chr3_-_95882232 0.073 ENSMUST00000161866.1
Gm129
predicted gene 129
chr11_+_6291660 0.071 ENSMUST00000101554.2
ENSMUST00000093350.3
Ogdh

oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)

chr14_-_54864055 0.070 ENSMUST00000142283.2
Homez
homeodomain leucine zipper-encoding gene
chr4_+_12906838 0.066 ENSMUST00000143186.1
ENSMUST00000183345.1
Triqk

triple QxxK/R motif containing

chr2_-_155582656 0.066 ENSMUST00000126322.1
Gss
glutathione synthetase
chr9_+_59589288 0.065 ENSMUST00000121266.1
ENSMUST00000118164.1
Celf6

CUGBP, Elav-like family member 6

chr4_+_148000722 0.065 ENSMUST00000103230.4
Nppa
natriuretic peptide type A
chrX_-_150589844 0.063 ENSMUST00000112725.1
ENSMUST00000112720.1
Apex2

apurinic/apyrimidinic endonuclease 2

chr19_+_46152505 0.061 ENSMUST00000026254.7
Gbf1
golgi-specific brefeldin A-resistance factor 1
chr7_-_126503408 0.059 ENSMUST00000040202.8
Atxn2l
ataxin 2-like
chr12_-_108894116 0.057 ENSMUST00000109848.3
Wars
tryptophanyl-tRNA synthetase
chr11_-_69920581 0.055 ENSMUST00000108610.1
Eif5a
eukaryotic translation initiation factor 5A
chr12_+_87266696 0.054 ENSMUST00000021425.6
Ahsa1
AHA1, activator of heat shock protein ATPase 1
chr10_-_128923439 0.052 ENSMUST00000153731.1
ENSMUST00000026405.3
Bloc1s1

biogenesis of lysosome-related organelles complex-1, subunit 1

chr7_-_30072801 0.047 ENSMUST00000183115.1
ENSMUST00000182919.1
ENSMUST00000183190.1
ENSMUST00000080834.8
Zfp82



zinc finger protein 82



chr17_-_6948283 0.047 ENSMUST00000024572.9
Rsph3b
radial spoke 3B homolog (Chlamydomonas)
chr2_-_9883993 0.046 ENSMUST00000114915.2
9230102O04Rik
RIKEN cDNA 9230102O04 gene
chr1_-_33814591 0.044 ENSMUST00000019861.6
Zfp451
zinc finger protein 451
chr7_-_4996044 0.043 ENSMUST00000162502.1
Zfp579
zinc finger protein 579
chr2_-_34870921 0.043 ENSMUST00000028225.5
Psmd5
proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
chr11_-_11890368 0.043 ENSMUST00000155690.1
Ddc
dopa decarboxylase
chrM_+_7759 0.041 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chrM_+_8600 0.040 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr12_-_99393010 0.040 ENSMUST00000177451.1
Foxn3
forkhead box N3
chr18_+_42275353 0.039 ENSMUST00000046972.7
ENSMUST00000091920.5
Rbm27

RNA binding motif protein 27

chr15_+_10952332 0.039 ENSMUST00000022853.8
ENSMUST00000110523.1
C1qtnf3

C1q and tumor necrosis factor related protein 3

chr2_-_91183017 0.039 ENSMUST00000066420.5
Madd
MAP-kinase activating death domain
chr11_-_104550392 0.039 ENSMUST00000106962.2
Cdc27
cell division cycle 27
chr7_+_24370255 0.038 ENSMUST00000171904.1
Kcnn4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr5_+_72914554 0.038 ENSMUST00000143829.1
Slain2
SLAIN motif family, member 2
chr11_-_30198232 0.036 ENSMUST00000102838.3
Sptbn1
spectrin beta, non-erythrocytic 1
chr6_+_48647224 0.031 ENSMUST00000078223.3
Gimap8
GTPase, IMAP family member 8
chr11_+_6291607 0.031 ENSMUST00000003461.8
Ogdh
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr8_+_26977336 0.027 ENSMUST00000154256.1
ENSMUST00000127097.1
Zfp703

zinc finger protein 703

chr13_+_100651607 0.018 ENSMUST00000167256.1
Taf9
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr6_+_116264186 0.013 ENSMUST00000036503.7
ENSMUST00000112900.3
Zfand4

zinc finger, AN1-type domain 4

chr17_+_33909481 0.012 ENSMUST00000173626.1
ENSMUST00000174541.1
Daxx

Fas death domain-associated protein

chr2_-_25224653 0.010 ENSMUST00000043584.4
Tubb4b
tubulin, beta 4B class IVB
chr2_-_91182848 0.009 ENSMUST00000111370.2
ENSMUST00000111376.1
ENSMUST00000099723.2
Madd


MAP-kinase activating death domain


chr8_+_12915879 0.009 ENSMUST00000110876.2
ENSMUST00000110879.2
Mcf2l

mcf.2 transforming sequence-like

chr19_-_10525201 0.006 ENSMUST00000025570.6
Sdhaf2
succinate dehydrogenase complex assembly factor 2
chr8_-_107263248 0.005 ENSMUST00000080443.6
Rps18-ps3
ribosomal protein S18, pseudogene 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 5.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 0.6 GO:1903011 negative regulation of bone development(GO:1903011)
0.2 0.5 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.2 1.1 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.1 0.7 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 0.4 GO:0086048 membrane depolarization during bundle of His cell action potential(GO:0086048)
0.1 1.0 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 0.5 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.1 0.3 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.1 0.2 GO:1904578 response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579)
0.1 0.5 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.1 0.4 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.1 0.3 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.1 0.8 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 0.4 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 0.5 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 0.3 GO:0021764 amygdala development(GO:0021764)
0.1 0.3 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 0.1 GO:1903898 negative regulation of PERK-mediated unfolded protein response(GO:1903898)
0.1 0.6 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.1 0.8 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.4 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 0.3 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.0 1.2 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.1 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.0 0.5 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.2 GO:1904690 adenosine to inosine editing(GO:0006382) regulation of cap-independent translational initiation(GO:1903677) positive regulation of cap-independent translational initiation(GO:1903679) regulation of cytoplasmic translational initiation(GO:1904688) positive regulation of cytoplasmic translational initiation(GO:1904690)
0.0 0.1 GO:0002430 complement receptor mediated signaling pathway(GO:0002430) GPI anchor release(GO:0006507)
0.0 0.2 GO:1903998 regulation of eating behavior(GO:1903998)
0.0 0.2 GO:0046898 response to cycloheximide(GO:0046898)
0.0 0.3 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.5 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.0 0.5 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.3 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.0 0.2 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.0 0.3 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.1 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
0.0 0.1 GO:0070973 COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.5 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.2 GO:0021678 third ventricle development(GO:0021678)
0.0 0.1 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.0 0.2 GO:0090315 negative regulation of protein targeting to membrane(GO:0090315)
0.0 0.0 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.0 0.1 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.5 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.1 GO:0061034 olfactory bulb mitral cell layer development(GO:0061034)
0.0 0.2 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.0 GO:1902277 negative regulation of pancreatic amylase secretion(GO:1902277)
0.0 0.2 GO:0072643 interferon-gamma secretion(GO:0072643)
0.0 0.0 GO:2000616 negative regulation of histone H3-K9 acetylation(GO:2000616)
0.0 0.0 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.1 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.0 0.1 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 0.3 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.0 0.1 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.4 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 0.4 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 0.2 GO:0044194 cytolytic granule(GO:0044194)
0.1 0.2 GO:0000799 nuclear condensin complex(GO:0000799)
0.1 0.3 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 0.5 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.3 GO:0000125 PCAF complex(GO:0000125)
0.0 0.4 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.4 GO:0042382 paraspeckles(GO:0042382)
0.0 0.2 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.0 0.3 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.4 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.1 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.6 GO:0005921 gap junction(GO:0005921)
0.0 0.1 GO:0097443 sorting endosome(GO:0097443)
0.0 0.2 GO:0001739 sex chromatin(GO:0001739)
0.0 1.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.1 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.0 1.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.3 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.3 GO:0097470 ribbon synapse(GO:0097470)
0.0 0.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.3 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 1.1 GO:0005643 nuclear pore(GO:0005643)
0.0 0.4 GO:0030673 axolemma(GO:0030673)
0.0 0.1 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.1 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 0.1 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.1 2.0 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.1 0.5 GO:0043515 kinetochore binding(GO:0043515)
0.1 0.5 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.1 0.5 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 0.4 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.1 0.5 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.1 0.4 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 1.8 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 1.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.2 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.1 0.2 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 0.4 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 0.4 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.0 0.2 GO:0005093 Rab GDP-dissociation inhibitor activity(GO:0005093)
0.0 0.2 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.3 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.4 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 1.1 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.5 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 7.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.3 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.4 GO:1990405 protein antigen binding(GO:1990405)
0.0 0.2 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.1 GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
0.0 0.1 GO:0034602 oxoglutarate dehydrogenase (NAD+) activity(GO:0034602)
0.0 0.1 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.8 GO:0005109 frizzled binding(GO:0005109)
0.0 0.1 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.0 0.5 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.3 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.2 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.2 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.1 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.1 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.5 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.3 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.0 GO:0036468 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
0.0 0.1 GO:0005047 signal recognition particle binding(GO:0005047) 7S RNA binding(GO:0008312)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.8 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.3 PID_MYC_PATHWAY C-MYC pathway
0.0 1.2 WNT_SIGNALING Genes related to Wnt-mediated signal transduction

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 1.0 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0 0.5 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 1.2 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.1 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 1.7 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.3 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.5 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 1.2 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.7 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.3 REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0 0.7 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.1 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.2 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.4 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.8 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes