ISMARA results: Cbfb

Motif ID: Cbfb

Z-value: 0.376

Transcription factors associated with Cbfb:

Gene Symbol	Entrez ID	Gene Name
Cbfb	ENSMUSG00000031885.7	Cbfb

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
Cbfb	mm10_v2_chr8_+_105170668_105170686	-0.56	2.9e-04	Click!

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Top targets:

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Showing 1 to 20 of 27 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr15_-_66801577	4.297	ENSMUST00000168589.1	Sla	src-like adaptor
chr14_+_101729907	2.471	ENSMUST00000100337.3	Lmo7	LIM domain only 7
chr11_-_83649349	1.443	ENSMUST00000001008.5	Ccl3	chemokine (C-C motif) ligand 3
chr12_+_95692212	1.264	ENSMUST00000057324.3	Flrt2	fibronectin leucine rich transmembrane protein 2
chr14_-_101729690	1.151	ENSMUST00000066461.3	Gm9922	predicted gene 9922
chr7_-_90129339	0.994	ENSMUST00000181189.1	2310010J17Rik	RIKEN cDNA 2310010J17 gene
chr4_-_6990774	0.991	ENSMUST00000039987.3	Tox	thymocyte selection-associated high mobility group box
chr2_+_32721055	0.835	ENSMUST00000074248.4	Sh2d3c	SH2 domain containing 3C
chr8_+_27260327	0.813	ENSMUST00000033880.5	Eif4ebp1	eukaryotic translation initiation factor 4E binding protein 1
chr5_+_104435112	0.677	ENSMUST00000031243.8 ENSMUST00000086833.6 ENSMUST00000112748.1 ENSMUST00000112746.1 ENSMUST00000145084.1 ENSMUST00000132457.1	Spp1	secreted phosphoprotein 1
chr1_-_174921813	0.526	ENSMUST00000055294.3	Grem2	gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis)
chr2_+_164948219	0.499	ENSMUST00000017881.2	Mmp9	matrix metallopeptidase 9
chr17_-_64331817	0.495	ENSMUST00000172733.1 ENSMUST00000172818.1	Pja2	praja 2, RING-H2 motif containing
chr5_+_24364804	0.423	ENSMUST00000030834.4 ENSMUST00000115090.1	Nos3	nitric oxide synthase 3, endothelial cell
chr17_+_12119274	0.343	ENSMUST00000024594.2	Agpat4	1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr10_+_69925954	0.324	ENSMUST00000181974.1 ENSMUST00000182795.1 ENSMUST00000182437.1	Ank3	ankyrin 3, epithelial
chr1_-_16656843	0.320	ENSMUST00000115352.3	Tceb1	transcription elongation factor B (SIII), polypeptide 1
chr4_+_108847827	0.293	ENSMUST00000102738.2	Kti12	KTI12 homolog, chromatin associated (S. cerevisiae)
chr15_+_99393219	0.273	ENSMUST00000159209.1	Tmbim6	transmembrane BAX inhibitor motif containing 6
chr15_+_99392948	0.268	ENSMUST00000161250.1 ENSMUST00000160635.1 ENSMUST00000161778.1	Tmbim6	transmembrane BAX inhibitor motif containing 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Showing 1 to 13 of 13 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.3	GO:0038083	peptidyl-tyrosine autophosphorylation(GO:0038083)
0.2	1.4	GO:0043615	astrocyte cell migration(GO:0043615)
0.1	1.3	GO:0061343	cell adhesion involved in heart morphogenesis(GO:0061343)
0.1	0.8	GO:1990928	response to amino acid starvation(GO:1990928)
0.2	0.7	GO:0035937	androgen catabolic process(GO:0006710) estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
0.1	0.5	GO:1904721	regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.1	0.5	GO:1900122	positive regulation of receptor binding(GO:1900122)
0.1	0.5	GO:1900116	sequestering of extracellular ligand from receptor(GO:0035581) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.5	GO:0010738	regulation of protein kinase A signaling(GO:0010738)
0.1	0.4	GO:0003100	regulation of systemic arterial blood pressure by endothelin(GO:0003100) regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.0	0.3	GO:0010650	positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0	0.2	GO:0017183	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.1	GO:0036508	protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) protein demannosylation(GO:0036507) protein alpha-1,2-demannosylation(GO:0036508) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)

Gene overrepresentation in cellular_component category:

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Showing 1 to 4 of 4 entries

Total log-likelihood	Term	Description
4.3	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
2.5	GO:0005913	cell-cell adherens junction(GO:0005913)
0.3	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.2	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)

Gene overrepresentation in molecular_function category:

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Showing 1 to 12 of 12 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.1	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.1	2.5	GO:0042805	actinin binding(GO:0042805)
0.0	1.4	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.1	1.3	GO:0045499	chemorepellent activity(GO:0045499)
0.1	0.8	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.7	GO:0050840	extracellular matrix binding(GO:0050840)
0.1	0.5	GO:0060698	endoribonuclease inhibitor activity(GO:0060698)
0.1	0.5	GO:0036122	BMP binding(GO:0036122)
0.0	0.5	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.5	GO:0001968	fibronectin binding(GO:0001968)
0.1	0.4	GO:0004517	nitric-oxide synthase activity(GO:0004517)
0.0	0.3	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)

Gene overrepresentation in C2:CP category:

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Showing 1 to 6 of 6 entries

Total log-likelihood	Term	Description
4.3	PID_PDGFRB_PATHWAY	PDGFR-beta signaling pathway
1.4	PID_IL12_2PATHWAY	IL12-mediated signaling events
1.2	PID_AVB3_OPN_PATHWAY	Osteopontin-mediated events
0.8	PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.4	PID_FRA_PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.3	PID_HIF1A_PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in C2:CP:REACTOME category:

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Showing 1 to 7 of 7 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.4	REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.1	0.8	REACTOME_MTORC1_MEDIATED_SIGNALLING	Genes involved in mTORC1-mediated signalling
0.0	0.5	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	Genes involved in Degradation of the extracellular matrix
0.0	0.5	REACTOME_SIGNALING_BY_BMP	Genes involved in Signaling by BMP
0.0	0.4	REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0	0.3	REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0	0.3	REACTOME_SYNTHESIS_OF_PA	Genes involved in Synthesis of PA