Motif ID: Cdx2

Z-value: 0.460


Transcription factors associated with Cdx2:

Gene SymbolEntrez IDGene Name
Cdx2 ENSMUSG00000029646.3 Cdx2



Activity profile for motif Cdx2.

activity profile for motif Cdx2


Sorted Z-values histogram for motif Cdx2

Sorted Z-values for motif Cdx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Cdx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 49 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_186705980 2.641 ENSMUST00000045288.8
 Tgfb2
transforming growth factor, beta 2
chr4_-_64046925 2.621 ENSMUST00000107377.3
 Tnc
tenascin C
chr4_+_144893127 2.604 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr15_+_3270767 2.377 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr12_+_85473883 2.254 ENSMUST00000021674.6
 Fos
FBJ osteosarcoma oncogene
chr16_-_44016387 1.530 ENSMUST00000036174.3
 Gramd1c
GRAM domain containing 1C
chr3_+_118433797 1.507 ENSMUST00000180593.1
ENSMUST00000181926.1
ENSMUST00000181060.1
ENSMUST00000181310.1
 Gm26871



predicted gene, 26871



chr14_+_80000292 1.376 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr6_+_17491216 1.299 ENSMUST00000080469.5
 Met
met proto-oncogene
chr4_-_24430838 1.213 ENSMUST00000183964.1
 RP23-35K5.2
RP23-35K5.2
chr2_+_4300462 1.170 ENSMUST00000175669.1
 Frmd4a
FERM domain containing 4A
chr5_+_13399309 1.061 ENSMUST00000030714.7
ENSMUST00000141968.1
 Sema3a

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A

chr13_+_63282142 0.943 ENSMUST00000159152.1
 2010111I01Rik
RIKEN cDNA 2010111I01 gene
chr2_-_59948155 0.657 ENSMUST00000153136.1
 Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr3_+_88965812 0.644 ENSMUST00000090933.4
 Ash1l
ash1 (absent, small, or homeotic)-like (Drosophila)
chrX_+_13632769 0.463 ENSMUST00000096492.3
 Gpr34
G protein-coupled receptor 34
chr11_+_87663087 0.415 ENSMUST00000165679.1
 Rnf43
ring finger protein 43
chr18_+_37755718 0.378 ENSMUST00000061279.7
 Pcdhga9
protocadherin gamma subfamily A, 9
chr3_+_40540751 0.344 ENSMUST00000091186.3
 Intu
inturned planar cell polarity effector homolog (Drosophila)
chr1_-_163289214 0.342 ENSMUST00000183691.1
 Prrx1
paired related homeobox 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 2.6 GO:1902256 endocardial cushion fusion(GO:0003274) apoptotic process involved in outflow tract morphogenesis(GO:0003275) atrial septum primum morphogenesis(GO:0003289) positive regulation of catagen(GO:0051795) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.7 2.6 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.2 2.6 GO:0042572 retinol metabolic process(GO:0042572)
0.1 2.3 GO:0035994 response to muscle stretch(GO:0035994)
0.0 1.4 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.2 1.3 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.0 1.2 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.2 1.1 GO:0021856 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.0 0.9 GO:0043171 peptide catabolic process(GO:0043171)
0.1 0.6 GO:0002674 negative regulation of acute inflammatory response(GO:0002674)
0.1 0.5 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.1 0.4 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.0 0.4 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.3 GO:0046368 GDP-L-fucose metabolic process(GO:0046368)
0.0 0.3 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.0 0.3 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0 0.3 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.0 0.3 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.3 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0 0.2 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)

Gene overrepresentation in cellular_component category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.6 GO:0005614 interstitial matrix(GO:0005614)
0.0 2.6 GO:0005604 basement membrane(GO:0005604)
0.4 2.3 GO:0035976 AP1 complex(GO:0035976)
0.0 1.8 GO:0005923 bicellular tight junction(GO:0005923)
0.1 1.4 GO:0042581 specific granule(GO:0042581)
0.0 1.3 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.2 GO:1990037 Lewy body core(GO:1990037)
0.0 0.2 GO:0061574 ASAP complex(GO:0061574)
0.0 0.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)

Gene overrepresentation in molecular_function category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 2.6 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.4 2.6 GO:0045545 syndecan binding(GO:0045545)
0.4 2.6 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 2.3 GO:0070412 R-SMAD binding(GO:0070412)
0.3 1.3 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 1.1 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.9 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 0.6 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.1 0.5 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.4 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.4 GO:0005109 frizzled binding(GO:0005109)
0.0 0.3 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 0.3 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.0 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.6 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 2.6 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 2.4 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.3 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.3 PID_ARF6_PATHWAY Arf6 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 2.6 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.3 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 1.3 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 1.1 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.3 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.3 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi