Motif ID: Cebpa_Cebpg

Z-value: 0.680

Transcription factors associated with Cebpa_Cebpg:

Gene SymbolEntrez IDGene Name
Cebpa ENSMUSG00000034957.9 Cebpa
Cebpg ENSMUSG00000056216.8 Cebpg

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cebpgmm10_v2_chr7_-_35056467_35056556-0.609.7e-05Click!
Cebpamm10_v2_chr7_+_35119285_351193010.212.1e-01Click!


Activity profile for motif Cebpa_Cebpg.

activity profile for motif Cebpa_Cebpg


Sorted Z-values histogram for motif Cebpa_Cebpg

Sorted Z-values for motif Cebpa_Cebpg



Network of associatons between targets according to the STRING database.



First level regulatory network of Cebpa_Cebpg

PNG image of the network

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Top targets:


Showing 1 to 20 of 166 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_57239310 5.187 ENSMUST00000111559.1
 Ablim1
actin-binding LIM protein 1
chr9_-_121495678 3.111 ENSMUST00000035120.4
 Cck
cholecystokinin
chr6_+_17463749 2.681 ENSMUST00000115443.1
 Met
met proto-oncogene
chrX_-_162565514 2.558 ENSMUST00000154424.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chr13_-_117025505 2.367 ENSMUST00000022239.6
 Parp8
poly (ADP-ribose) polymerase family, member 8
chr12_+_74297474 2.325 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain
chr14_+_65970610 2.215 ENSMUST00000127387.1
 Clu
clusterin
chr1_-_22315792 2.058 ENSMUST00000164877.1
 Rims1
regulating synaptic membrane exocytosis 1
chr14_+_65971049 2.012 ENSMUST00000128539.1
 Clu
clusterin
chr1_-_38821215 1.994 ENSMUST00000039612.4
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr1_-_71653162 1.963 ENSMUST00000055226.6
 Fn1
fibronectin 1
chr4_-_15149051 1.689 ENSMUST00000041606.7
 Necab1
N-terminal EF-hand calcium binding protein 1
chr13_-_49309217 1.672 ENSMUST00000110087.2
 Fgd3
FYVE, RhoGEF and PH domain containing 3
chr7_-_103813913 1.550 ENSMUST00000098192.3
 Hbb-bt
hemoglobin, beta adult t chain
chr14_+_65971164 1.460 ENSMUST00000144619.1
 Clu
clusterin
chr14_+_65970804 1.423 ENSMUST00000138191.1
 Clu
clusterin
chr4_-_15149755 1.268 ENSMUST00000108273.1
 Necab1
N-terminal EF-hand calcium binding protein 1
chr1_+_169655493 1.194 ENSMUST00000027997.3
 Rgs5
regulator of G-protein signaling 5
chr3_+_31902666 1.177 ENSMUST00000119970.1
ENSMUST00000178668.1
 Kcnmb2

potassium large conductance calcium-activated channel, subfamily M, beta member 2

chr2_-_45117349 1.097 ENSMUST00000176438.2
 Zeb2
zinc finger E-box binding homeobox 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 7.1 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.3 3.1 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.4 2.7 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.3 2.2 GO:0017085 response to insecticide(GO:0017085)
0.5 2.1 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.7 2.0 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161) transforming growth factor-beta secretion(GO:0038044)
0.5 2.0 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 2.0 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 1.9 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.3 1.4 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
0.1 1.2 GO:0005513 detection of calcium ion(GO:0005513)
0.0 1.2 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 1.2 GO:0046847 filopodium assembly(GO:0046847)
0.2 1.1 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 1.0 GO:0046688 response to copper ion(GO:0046688)
0.0 1.0 GO:0030903 notochord development(GO:0030903)
0.0 1.0 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.3 0.9 GO:0002586 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588) detection of peptidoglycan(GO:0032499)
0.2 0.9 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.2 0.9 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 7.1 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 5.3 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 3.1 GO:0043203 axon hillock(GO:0043203)
0.4 2.1 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.7 2.0 GO:0005577 fibrinogen complex(GO:0005577)
0.0 1.9 GO:0009925 basal plasma membrane(GO:0009925)
0.4 1.6 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 1.4 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 1.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 1.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 0.8 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 0.8 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 0.8 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.7 GO:0097440 apical dendrite(GO:0097440)
0.0 0.7 GO:0005720 nuclear heterochromatin(GO:0005720)
0.1 0.5 GO:0071942 XPC complex(GO:0071942)
0.1 0.4 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.4 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.4 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.1 GO:0051787 misfolded protein binding(GO:0051787)
0.2 3.1 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.7 2.7 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 2.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 2.1 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 2.1 GO:0044325 ion channel binding(GO:0044325)
0.3 2.0 GO:0045340 mercury ion binding(GO:0045340)
0.2 2.0 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.4 1.6 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.0 1.5 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 1.4 GO:0031402 sodium ion binding(GO:0031402)
0.0 1.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 1.2 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 1.1 GO:0070412 R-SMAD binding(GO:0070412)
0.2 1.0 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.2 1.0 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 1.0 GO:0005504 fatty acid binding(GO:0005504)
0.2 0.9 GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity(GO:0004066)
0.2 0.9 GO:0070891 peptidoglycan binding(GO:0042834) lipoteichoic acid binding(GO:0070891)
0.1 0.9 GO:0008429 phosphatidylethanolamine binding(GO:0008429)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.9 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 2.7 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.1 1.9 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.9 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.2 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.0 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.9 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.7 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.5 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.3 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.3 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.2 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.3 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 3.5 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 3.0 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.7 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.2 2.1 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 2.0 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 1.9 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 1.8 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 1.3 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 1.2 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 1.0 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.9 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.9 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.9 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 0.8 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.7 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.6 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.6 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 0.5 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER