Motif ID: Chd1_Pml

Z-value: 3.323

Transcription factors associated with Chd1_Pml:

Gene SymbolEntrez IDGene Name
Chd1 ENSMUSG00000023852.7 Chd1
Pml ENSMUSG00000036986.10 Pml

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pmlmm10_v2_chr9_-_58249702_58249791-0.537.7e-04Click!
Chd1mm10_v2_chr17_+_15704963_157049940.124.8e-01Click!


Activity profile for motif Chd1_Pml.

activity profile for motif Chd1_Pml


Sorted Z-values histogram for motif Chd1_Pml

Sorted Z-values for motif Chd1_Pml



Network of associatons between targets according to the STRING database.



First level regulatory network of Chd1_Pml

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_36698002 20.543 ENSMUST00000021641.6
 Tshz3
teashirt zinc finger family member 3
chr14_-_39472825 18.387 ENSMUST00000168810.2
ENSMUST00000173780.1
ENSMUST00000166968.2
 Nrg3


neuregulin 3


chr7_+_123982799 15.009 ENSMUST00000106437.1
 Hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr7_-_74554474 14.551 ENSMUST00000134539.1
ENSMUST00000026897.7
ENSMUST00000098371.2
 Slco3a1


solute carrier organic anion transporter family, member 3a1


chr6_-_148444336 12.708 ENSMUST00000060095.8
ENSMUST00000100772.3
 Tmtc1

transmembrane and tetratricopeptide repeat containing 1

chr11_-_67922136 12.574 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr2_-_163918683 12.431 ENSMUST00000044734.2
 Rims4
regulating synaptic membrane exocytosis 4
chr1_-_3671498 12.340 ENSMUST00000070533.4
 Xkr4
X Kell blood group precursor related family member 4
chr7_+_117380937 11.992 ENSMUST00000032892.5
 Xylt1
xylosyltransferase 1
chr18_-_58209926 11.937 ENSMUST00000025497.6
 Fbn2
fibrillin 2
chr10_-_43174521 11.460 ENSMUST00000040275.7
 Sobp
sine oculis-binding protein homolog (Drosophila)
chr1_+_167001457 10.760 ENSMUST00000126198.1
 Fam78b
family with sequence similarity 78, member B
chr5_+_30588078 10.594 ENSMUST00000066295.2
 Kcnk3
potassium channel, subfamily K, member 3
chr15_+_89499598 10.533 ENSMUST00000109309.1
 Shank3
SH3/ankyrin domain gene 3
chr1_+_167001417 10.436 ENSMUST00000165874.1
 Fam78b
family with sequence similarity 78, member B
chrX_-_162643575 10.348 ENSMUST00000101102.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chr8_-_48555846 10.106 ENSMUST00000110345.1
ENSMUST00000110343.1
 Tenm3

teneurin transmembrane protein 3

chr11_-_33147400 10.017 ENSMUST00000020507.7
 Fgf18
fibroblast growth factor 18
chr9_-_98033181 9.989 ENSMUST00000035027.6
 Clstn2
calsyntenin 2
chr13_-_107890059 9.643 ENSMUST00000105097.2
 Zswim6
zinc finger SWIM-type containing 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,020 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 41.7 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.3 38.2 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
1.7 32.9 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.3 31.0 GO:0016579 protein deubiquitination(GO:0016579)
1.8 24.6 GO:0015732 prostaglandin transport(GO:0015732)
1.6 24.4 GO:0048681 negative regulation of axon regeneration(GO:0048681)
1.7 23.9 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
7.9 23.8 GO:0050975 sensory perception of touch(GO:0050975)
0.9 23.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
1.2 21.7 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
1.0 21.7 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
1.8 21.0 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.7 20.9 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.3 20.4 GO:0035308 negative regulation of protein dephosphorylation(GO:0035308)
0.3 19.7 GO:0051965 positive regulation of synapse assembly(GO:0051965)
4.6 18.4 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
1.4 18.3 GO:0061000 negative regulation of dendritic spine development(GO:0061000)
4.6 18.2 GO:0097477 lateral motor column neuron migration(GO:0097477)
1.5 17.9 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
1.8 17.8 GO:0061470 T follicular helper cell differentiation(GO:0061470)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 386 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 148.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.4 89.3 GO:0098794 postsynapse(GO:0098794)
0.0 57.7 GO:0016021 integral component of membrane(GO:0016021)
1.2 57.0 GO:0048786 presynaptic active zone(GO:0048786)
1.3 52.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.7 52.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.5 52.6 GO:0043204 perikaryon(GO:0043204)
0.7 52.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 34.0 GO:0030427 site of polarized growth(GO:0030427)
0.0 32.3 GO:0005783 endoplasmic reticulum(GO:0005783)
0.8 31.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.6 28.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 26.5 GO:0005769 early endosome(GO:0005769)
0.1 26.5 GO:0000139 Golgi membrane(GO:0000139)
0.4 22.9 GO:0043195 terminal bouton(GO:0043195)
0.1 22.2 GO:0005768 endosome(GO:0005768)
1.2 21.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.5 21.4 GO:0009925 basal plasma membrane(GO:0009925)
0.6 19.9 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
3.1 18.7 GO:0005955 calcineurin complex(GO:0005955)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 597 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 50.7 GO:0061659 ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
1.4 48.8 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.4 37.0 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.7 35.6 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 35.5 GO:0005096 GTPase activator activity(GO:0005096)
0.7 30.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.2 28.3 GO:0008017 microtubule binding(GO:0008017)
0.1 28.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.2 27.3 GO:0003924 GTPase activity(GO:0003924)
0.3 26.5 GO:0044325 ion channel binding(GO:0044325)
3.5 24.2 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.5 24.2 GO:0030507 spectrin binding(GO:0030507)
1.4 23.0 GO:0045499 chemorepellent activity(GO:0045499)
1.3 21.0 GO:0043008 ATP-dependent protein binding(GO:0043008)
2.0 20.4 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.2 19.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
4.9 19.5 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.3 19.5 GO:0048365 Rac GTPase binding(GO:0048365)
0.6 19.3 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.5 19.3 GO:0005249 voltage-gated potassium channel activity(GO:0005249)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 47.8 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.7 43.8 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
2.1 36.5 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.5 29.9 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
1.8 26.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.7 25.5 PID_RAS_PATHWAY Regulation of Ras family activation
0.7 21.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
1.1 20.6 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.7 20.4 PID_ARF_3PATHWAY Arf1 pathway
0.3 18.8 PID_FGF_PATHWAY FGF signaling pathway
0.5 18.4 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.4 18.3 PID_BMP_PATHWAY BMP receptor signaling
0.5 16.5 PID_ALK1_PATHWAY ALK1 signaling events
0.5 16.5 PID_RAC1_PATHWAY RAC1 signaling pathway
0.3 15.5 PID_P53_REGULATION_PATHWAY p53 pathway
0.8 14.9 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.3 14.3 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.4 12.1 PID_SHP2_PATHWAY SHP2 signaling
0.1 11.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 11.3 PID_CERAMIDE_PATHWAY Ceramide signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 180 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 43.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
1.0 35.2 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.9 28.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
2.3 28.2 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.9 27.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.3 25.2 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
1.0 24.7 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.6 24.7 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
1.1 24.6 REACTOME_ARMS_MEDIATED_ACTIVATION Genes involved in ARMS-mediated activation
2.9 22.9 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.7 21.9 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.6 21.8 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.4 19.7 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
1.8 19.5 REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.3 19.1 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.8 18.6 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
1.4 18.2 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.5 17.8 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
1.3 17.0 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.3 16.7 REACTOME_NEURONAL_SYSTEM Genes involved in Neuronal System