Motif ID: Creb3l2

Z-value: 0.498


Transcription factors associated with Creb3l2:

Gene SymbolEntrez IDGene Name
Creb3l2 ENSMUSG00000038648.5 Creb3l2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Creb3l2mm10_v2_chr6_-_37442095_37442154-0.076.9e-01Click!


Activity profile for motif Creb3l2.

activity profile for motif Creb3l2


Sorted Z-values histogram for motif Creb3l2

Sorted Z-values for motif Creb3l2



Network of associatons between targets according to the STRING database.



First level regulatory network of Creb3l2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 147 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_148591482 2.796 ENSMUST00000006611.8
 Srm
spermidine synthase
chr13_-_92131494 2.177 ENSMUST00000099326.3
ENSMUST00000146492.1
 Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2

chr6_-_22356068 1.982 ENSMUST00000163963.1
ENSMUST00000165576.1
 Fam3c

family with sequence similarity 3, member C

chr3_+_123267445 1.968 ENSMUST00000047923.7
 Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chrX_+_8271133 1.856 ENSMUST00000127103.1
ENSMUST00000115591.1
 Slc38a5

solute carrier family 38, member 5

chr6_-_22356176 1.840 ENSMUST00000081288.7
 Fam3c
family with sequence similarity 3, member C
chr19_-_6840590 1.510 ENSMUST00000170516.2
ENSMUST00000025903.5
 Rps6ka4

ribosomal protein S6 kinase, polypeptide 4

chr6_-_8778439 1.468 ENSMUST00000115520.1
ENSMUST00000038403.5
ENSMUST00000115518.1
 Ica1


islet cell autoantigen 1


chr5_+_107331157 1.424 ENSMUST00000031215.8
ENSMUST00000112677.3
 Brdt

bromodomain, testis-specific

chr5_-_30945393 1.399 ENSMUST00000031051.6
 Cgref1
cell growth regulator with EF hand domain 1
chr6_-_8778106 1.336 ENSMUST00000151758.1
ENSMUST00000115519.1
ENSMUST00000153390.1
 Ica1


islet cell autoantigen 1


chr11_-_55033398 1.221 ENSMUST00000108883.3
ENSMUST00000102727.2
 Anxa6

annexin A6

chr18_+_75018709 1.209 ENSMUST00000039608.7
 Dym
dymeclin
chr9_+_89909775 1.189 ENSMUST00000034912.4
ENSMUST00000034909.4
 Rasgrf1

RAS protein-specific guanine nucleotide-releasing factor 1

chr6_-_13871459 1.081 ENSMUST00000155856.1
 2610001J05Rik
RIKEN cDNA 2610001J05 gene
chr15_-_102136225 1.017 ENSMUST00000154032.1
 Spryd3
SPRY domain containing 3
chr6_-_13871477 1.011 ENSMUST00000139231.1
 2610001J05Rik
RIKEN cDNA 2610001J05 gene
chr4_-_45084538 0.971 ENSMUST00000052236.6
 Fbxo10
F-box protein 10
chr15_-_75678732 0.948 ENSMUST00000000958.8
 Top1mt
DNA topoisomerase 1, mitochondrial
chr11_+_100415697 0.943 ENSMUST00000001595.3
 Fkbp10
FK506 binding protein 10

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.7 2.8 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.1 2.8 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
0.1 1.9 GO:0015816 glycine transport(GO:0015816)
0.1 1.8 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.5 1.5 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.1 1.5 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 1.4 GO:0007141 male meiosis I(GO:0007141)
0.1 1.4 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.0 1.3 GO:0007030 Golgi organization(GO:0007030)
0.0 1.2 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.1 0.9 GO:0006265 DNA topological change(GO:0006265)
0.1 0.9 GO:0051103 DNA ligation involved in DNA repair(GO:0051103)
0.1 0.9 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.0 0.9 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.9 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.1 0.8 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.0 0.8 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.8 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.2 0.6 GO:0071638 negative regulation of monocyte chemotactic protein-1 production(GO:0071638)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 GO:0030667 secretory granule membrane(GO:0030667)
0.1 1.5 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 1.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.2 1.3 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.1 1.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 1.0 GO:0014704 intercalated disc(GO:0014704)
0.2 0.9 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.9 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.8 GO:0005787 signal peptidase complex(GO:0005787)
0.2 0.6 GO:0005927 muscle tendon junction(GO:0005927)
0.1 0.5 GO:0097574 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.0 0.5 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 0.4 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.4 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.4 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 0.3 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 0.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.2 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 2.8 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.1 2.6 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 2.1 GO:0008236 serine-type peptidase activity(GO:0008236)
0.0 2.0 GO:0000149 SNARE binding(GO:0000149)
0.2 1.9 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 1.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 1.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.2 1.3 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.0 1.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 0.9 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.1 0.9 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.2 0.8 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.1 0.8 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.2 0.6 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.1 0.6 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.1 0.6 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.0 0.6 GO:0016881 acid-amino acid ligase activity(GO:0016881)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 1.5 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.3 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.2 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.6 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 0.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.2 2.5 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 1.8 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 1.5 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.1 1.4 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 1.3 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.0 1.0 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 0.8 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 0.8 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.6 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.6 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.6 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.5 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.5 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.5 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.5 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.5 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 0.4 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.4 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.3 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE