Motif ID: Crem_Jdp2
Z-value: 0.507
Transcription factors associated with Crem_Jdp2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Crem | ENSMUSG00000063889.10 | Crem |
| Jdp2 | ENSMUSG00000034271.9 | Jdp2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Jdp2 | mm10_v2_chr12_+_85599388_85599416 | -0.56 | 3.2e-04 | Click! |
| Crem | mm10_v2_chr18_-_3337539_3337600 | 0.54 | 6.1e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 6.3 | GO:0021905 | pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937) |
| 1.2 | 7.2 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 1.0 | 4.1 | GO:1902724 | positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728) |
| 1.0 | 5.9 | GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987) |
| 0.8 | 2.4 | GO:1903774 | positive regulation of viral budding via host ESCRT complex(GO:1903774) |
| 0.7 | 2.1 | GO:0003221 | right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
| 0.6 | 1.9 | GO:0072284 | cervix development(GO:0060067) metanephric S-shaped body morphogenesis(GO:0072284) anterior head development(GO:0097065) regulation of anterior head development(GO:2000742) positive regulation of anterior head development(GO:2000744) |
| 0.5 | 2.0 | GO:0042414 | epinephrine metabolic process(GO:0042414) |
| 0.5 | 1.5 | GO:0060364 | frontal suture morphogenesis(GO:0060364) |
| 0.4 | 6.0 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
| 0.4 | 2.8 | GO:2000348 | regulation of CD40 signaling pathway(GO:2000348) |
| 0.4 | 1.8 | GO:0060266 | negative regulation of respiratory burst involved in inflammatory response(GO:0060266) |
| 0.3 | 3.8 | GO:0014883 | transition between fast and slow fiber(GO:0014883) |
| 0.3 | 6.1 | GO:0031987 | locomotion involved in locomotory behavior(GO:0031987) |
| 0.3 | 3.3 | GO:1901386 | negative regulation of voltage-gated calcium channel activity(GO:1901386) |
| 0.3 | 3.0 | GO:0042487 | regulation of odontogenesis of dentin-containing tooth(GO:0042487) |
| 0.3 | 0.9 | GO:0035973 | aggrephagy(GO:0035973) |
| 0.3 | 3.3 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
| 0.2 | 3.9 | GO:0060213 | regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) |
| 0.2 | 1.2 | GO:0034162 | toll-like receptor 9 signaling pathway(GO:0034162) |
| 0.2 | 2.1 | GO:1904668 | positive regulation of ubiquitin protein ligase activity(GO:1904668) |
| 0.2 | 2.0 | GO:0030432 | peristalsis(GO:0030432) |
| 0.2 | 0.6 | GO:1902174 | positive regulation of keratinocyte apoptotic process(GO:1902174) |
| 0.2 | 3.4 | GO:0072520 | seminiferous tubule development(GO:0072520) |
| 0.2 | 1.1 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
| 0.2 | 0.9 | GO:0048245 | eosinophil chemotaxis(GO:0048245) |
| 0.2 | 1.5 | GO:0002318 | myeloid progenitor cell differentiation(GO:0002318) |
| 0.2 | 0.8 | GO:1904672 | regulation of somatic stem cell population maintenance(GO:1904672) |
| 0.2 | 0.7 | GO:0060578 | extraocular skeletal muscle development(GO:0002074) subthalamic nucleus development(GO:0021763) left lung morphogenesis(GO:0060460) pulmonary vein morphogenesis(GO:0060577) superior vena cava morphogenesis(GO:0060578) |
| 0.2 | 1.2 | GO:0000320 | re-entry into mitotic cell cycle(GO:0000320) |
| 0.2 | 0.8 | GO:0021764 | amygdala development(GO:0021764) |
| 0.2 | 0.5 | GO:0010845 | positive regulation of reciprocal meiotic recombination(GO:0010845) |
| 0.2 | 0.8 | GO:0003376 | sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520) |
| 0.2 | 0.5 | GO:2001013 | epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013) |
| 0.1 | 0.4 | GO:0021546 | rhombomere development(GO:0021546) |
| 0.1 | 1.8 | GO:0021942 | radial glia guided migration of Purkinje cell(GO:0021942) |
| 0.1 | 1.4 | GO:0036123 | histone H3-K9 dimethylation(GO:0036123) |
| 0.1 | 0.5 | GO:0001306 | age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571) |
| 0.1 | 1.6 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
| 0.1 | 0.7 | GO:1902410 | mitotic cytokinetic process(GO:1902410) |
| 0.1 | 0.7 | GO:0030643 | cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502) |
| 0.1 | 0.4 | GO:0061303 | hard palate development(GO:0060022) soft palate development(GO:0060023) cornea development in camera-type eye(GO:0061303) |
| 0.1 | 0.4 | GO:1903644 | regulation of chaperone-mediated protein folding(GO:1903644) |
| 0.1 | 1.2 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.1 | 0.7 | GO:0060040 | retinal bipolar neuron differentiation(GO:0060040) |
| 0.1 | 0.2 | GO:0070309 | lens fiber cell morphogenesis(GO:0070309) |
| 0.1 | 1.1 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 0.1 | 0.5 | GO:0006384 | transcription initiation from RNA polymerase III promoter(GO:0006384) |
| 0.1 | 0.7 | GO:0098535 | positive regulation of centriole replication(GO:0046601) de novo centriole assembly(GO:0098535) |
| 0.1 | 0.4 | GO:0032792 | negative regulation of CREB transcription factor activity(GO:0032792) |
| 0.1 | 1.0 | GO:0006824 | cobalt ion transport(GO:0006824) |
| 0.1 | 0.6 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
| 0.1 | 0.3 | GO:1900020 | regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020) |
| 0.1 | 3.1 | GO:0001709 | cell fate determination(GO:0001709) |
| 0.1 | 0.3 | GO:0035694 | mitochondrial protein catabolic process(GO:0035694) |
| 0.1 | 0.4 | GO:0032911 | negative regulation of transforming growth factor beta1 production(GO:0032911) |
| 0.1 | 0.6 | GO:0032534 | regulation of microvillus assembly(GO:0032534) |
| 0.1 | 0.8 | GO:0046602 | regulation of mitotic centrosome separation(GO:0046602) |
| 0.1 | 0.2 | GO:0045658 | eosinophil differentiation(GO:0030222) regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659) |
| 0.1 | 2.6 | GO:0016572 | histone phosphorylation(GO:0016572) |
| 0.1 | 0.4 | GO:0015842 | aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) |
| 0.1 | 0.5 | GO:0044829 | positive regulation by host of viral genome replication(GO:0044829) |
| 0.1 | 0.4 | GO:0098964 | dendritic transport of ribonucleoprotein complex(GO:0098961) dendritic transport of messenger ribonucleoprotein complex(GO:0098963) anterograde dendritic transport of messenger ribonucleoprotein complex(GO:0098964) |
| 0.1 | 0.2 | GO:1901079 | positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) positive regulation of relaxation of muscle(GO:1901079) regulation of dense core granule biogenesis(GO:2000705) |
| 0.1 | 0.2 | GO:0097278 | transforming growth factor beta activation(GO:0036363) complement-dependent cytotoxicity(GO:0097278) |
| 0.1 | 1.2 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
| 0.1 | 0.3 | GO:0090164 | asymmetric Golgi ribbon formation(GO:0090164) |
| 0.1 | 0.2 | GO:2000182 | regulation of progesterone biosynthetic process(GO:2000182) |
| 0.1 | 0.9 | GO:0046855 | inositol phosphate dephosphorylation(GO:0046855) |
| 0.1 | 0.2 | GO:0010958 | regulation of amino acid import(GO:0010958) |
| 0.1 | 0.7 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
| 0.1 | 0.1 | GO:0043622 | cortical microtubule organization(GO:0043622) |
| 0.1 | 0.7 | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162) |
| 0.1 | 0.2 | GO:0045903 | positive regulation of translational fidelity(GO:0045903) |
| 0.1 | 0.2 | GO:1900864 | mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864) |
| 0.1 | 0.9 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
| 0.1 | 0.4 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.1 | 0.2 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
| 0.1 | 0.3 | GO:0060279 | positive regulation of ovulation(GO:0060279) |
| 0.1 | 0.2 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
| 0.1 | 0.3 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.1 | 0.3 | GO:0048296 | isotype switching to IgA isotypes(GO:0048290) regulation of isotype switching to IgA isotypes(GO:0048296) |
| 0.0 | 3.2 | GO:0070527 | platelet aggregation(GO:0070527) |
| 0.0 | 0.2 | GO:0008616 | queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116) |
| 0.0 | 0.1 | GO:0097155 | fasciculation of sensory neuron axon(GO:0097155) |
| 0.0 | 0.2 | GO:0034196 | acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) |
| 0.0 | 0.4 | GO:0061072 | iris morphogenesis(GO:0061072) |
| 0.0 | 0.3 | GO:0018377 | N-terminal protein myristoylation(GO:0006499) protein myristoylation(GO:0018377) |
| 0.0 | 0.3 | GO:0035871 | protein K11-linked deubiquitination(GO:0035871) |
| 0.0 | 0.2 | GO:0042985 | negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) |
| 0.0 | 2.1 | GO:0006940 | regulation of smooth muscle contraction(GO:0006940) |
| 0.0 | 0.3 | GO:0035562 | negative regulation of chromatin binding(GO:0035562) |
| 0.0 | 0.3 | GO:2000286 | receptor internalization involved in canonical Wnt signaling pathway(GO:2000286) |
| 0.0 | 0.2 | GO:0006363 | termination of RNA polymerase I transcription(GO:0006363) |
| 0.0 | 0.3 | GO:0071557 | histone H3-K27 demethylation(GO:0071557) |
| 0.0 | 0.3 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.0 | 1.3 | GO:0003333 | amino acid transmembrane transport(GO:0003333) |
| 0.0 | 0.3 | GO:0033299 | secretion of lysosomal enzymes(GO:0033299) |
| 0.0 | 0.1 | GO:2000850 | cortisol secretion(GO:0043400) regulation of cortisol secretion(GO:0051462) negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850) |
| 0.0 | 0.1 | GO:0007066 | female meiosis sister chromatid cohesion(GO:0007066) |
| 0.0 | 0.2 | GO:0070365 | hepatocyte differentiation(GO:0070365) |
| 0.0 | 0.1 | GO:1902310 | positive regulation of peptidyl-serine dephosphorylation(GO:1902310) |
| 0.0 | 0.3 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
| 0.0 | 0.8 | GO:0010960 | magnesium ion homeostasis(GO:0010960) |
| 0.0 | 0.7 | GO:0051123 | RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123) |
| 0.0 | 0.8 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
| 0.0 | 0.2 | GO:0044375 | regulation of peroxisome size(GO:0044375) |
| 0.0 | 0.5 | GO:0038092 | nodal signaling pathway(GO:0038092) |
| 0.0 | 0.1 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.0 | 1.2 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
| 0.0 | 0.7 | GO:0070584 | mitochondrion morphogenesis(GO:0070584) |
| 0.0 | 0.0 | GO:0030049 | muscle filament sliding(GO:0030049) |
| 0.0 | 0.3 | GO:0030825 | positive regulation of cGMP metabolic process(GO:0030825) positive regulation of cGMP biosynthetic process(GO:0030828) |
| 0.0 | 0.6 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.0 | 0.1 | GO:0090063 | positive regulation of microtubule nucleation(GO:0090063) |
| 0.0 | 0.3 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.0 | 0.4 | GO:0021511 | spinal cord patterning(GO:0021511) |
| 0.0 | 0.1 | GO:1903237 | negative regulation of leukocyte tethering or rolling(GO:1903237) |
| 0.0 | 0.3 | GO:0006336 | DNA replication-independent nucleosome assembly(GO:0006336) |
| 0.0 | 0.1 | GO:0032196 | regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196) |
| 0.0 | 0.1 | GO:0008635 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635) |
| 0.0 | 0.4 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043) |
| 0.0 | 0.1 | GO:0042769 | DNA damage response, detection of DNA damage(GO:0042769) |
| 0.0 | 0.1 | GO:0010793 | regulation of mRNA export from nucleus(GO:0010793) |
| 0.0 | 0.1 | GO:0006072 | glycerol-3-phosphate metabolic process(GO:0006072) |
| 0.0 | 0.2 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
| 0.0 | 0.3 | GO:0071539 | protein localization to centrosome(GO:0071539) |
| 0.0 | 0.1 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
| 0.0 | 0.1 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 0.0 | 2.2 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
| 0.0 | 0.1 | GO:0070940 | dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940) |
| 0.0 | 0.4 | GO:2000279 | negative regulation of DNA biosynthetic process(GO:2000279) |
| 0.0 | 0.4 | GO:0048536 | spleen development(GO:0048536) |
| 0.0 | 0.1 | GO:0010815 | bradykinin catabolic process(GO:0010815) |
| 0.0 | 0.3 | GO:0045880 | positive regulation of smoothened signaling pathway(GO:0045880) |
| 0.0 | 0.1 | GO:0070935 | 3'-UTR-mediated mRNA stabilization(GO:0070935) |
| 0.0 | 0.3 | GO:0010664 | negative regulation of striated muscle cell apoptotic process(GO:0010664) |
| 0.0 | 0.8 | GO:0051225 | spindle assembly(GO:0051225) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 3.9 | GO:0071148 | TEAD-1-YAP complex(GO:0071148) |
| 0.7 | 8.6 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.7 | 2.0 | GO:0045009 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.6 | 1.8 | GO:0043224 | nuclear SCF ubiquitin ligase complex(GO:0043224) |
| 0.5 | 1.4 | GO:1990423 | RZZ complex(GO:1990423) |
| 0.3 | 3.0 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.3 | 2.0 | GO:0001940 | male pronucleus(GO:0001940) |
| 0.2 | 1.0 | GO:0000931 | gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274) |
| 0.2 | 0.7 | GO:0034274 | Atg12-Atg5-Atg16 complex(GO:0034274) |
| 0.2 | 2.1 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 1.0 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.1 | 0.7 | GO:0098536 | deuterosome(GO:0098536) |
| 0.1 | 1.9 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.1 | 2.3 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.1 | 0.7 | GO:1990726 | Lsm1-7-Pat1 complex(GO:1990726) |
| 0.1 | 0.3 | GO:0031084 | BLOC-2 complex(GO:0031084) |
| 0.1 | 1.1 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.1 | 1.3 | GO:0031045 | dense core granule(GO:0031045) |
| 0.1 | 0.5 | GO:0033503 | HULC complex(GO:0033503) |
| 0.1 | 0.2 | GO:0042025 | host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094) |
| 0.1 | 1.2 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.1 | 0.2 | GO:0038045 | large latent transforming growth factor-beta complex(GO:0038045) |
| 0.0 | 0.6 | GO:0071437 | invadopodium(GO:0071437) |
| 0.0 | 1.1 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 0.3 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.0 | 2.4 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 3.0 | GO:0005844 | polysome(GO:0005844) |
| 0.0 | 0.2 | GO:0042583 | chromaffin granule(GO:0042583) |
| 0.0 | 0.2 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
| 0.0 | 1.6 | GO:0097546 | ciliary base(GO:0097546) |
| 0.0 | 0.1 | GO:0098842 | postsynaptic early endosome(GO:0098842) |
| 0.0 | 1.2 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.0 | 1.4 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 0.2 | GO:0000125 | PCAF complex(GO:0000125) |
| 0.0 | 4.5 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 1.9 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 0.1 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.0 | 0.2 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
| 0.0 | 0.1 | GO:0033063 | Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) Holliday junction resolvase complex(GO:0048476) |
| 0.0 | 7.2 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 1.4 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.0 | 0.3 | GO:0000347 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
| 0.0 | 0.3 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.0 | 2.2 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 0.3 | GO:0030904 | retromer complex(GO:0030904) |
| 0.0 | 0.8 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 0.2 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.0 | 0.2 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.0 | 0.6 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.0 | 1.0 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 0.2 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.0 | 0.4 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 0.1 | GO:0060293 | P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293) |
| 0.0 | 3.1 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 0.2 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.0 | 0.1 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.0 | 1.0 | GO:0043235 | receptor complex(GO:0043235) |
| 0.0 | 0.1 | GO:0097610 | cell division site(GO:0032153) cleavage furrow(GO:0032154) cell division site part(GO:0032155) cell surface furrow(GO:0097610) |
| 0.0 | 1.0 | GO:0000922 | spindle pole(GO:0000922) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 5.9 | GO:0043515 | kinetochore binding(GO:0043515) |
| 1.0 | 6.1 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.7 | 2.0 | GO:0004994 | somatostatin receptor activity(GO:0004994) |
| 0.4 | 3.7 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.4 | 2.0 | GO:0035240 | dopamine binding(GO:0035240) |
| 0.4 | 6.3 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.4 | 2.5 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.3 | 1.4 | GO:1904047 | S-adenosyl-L-methionine binding(GO:1904047) |
| 0.2 | 0.7 | GO:0019776 | Atg8 ligase activity(GO:0019776) |
| 0.2 | 1.8 | GO:0019788 | NEDD8 transferase activity(GO:0019788) |
| 0.2 | 0.4 | GO:0034190 | apolipoprotein receptor binding(GO:0034190) |
| 0.2 | 3.8 | GO:0001134 | transcription factor activity, transcription factor recruiting(GO:0001134) |
| 0.2 | 3.0 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.2 | 0.7 | GO:0047389 | glycerophosphocholine phosphodiesterase activity(GO:0047389) |
| 0.2 | 1.0 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 0.2 | 1.0 | GO:0042731 | PH domain binding(GO:0042731) |
| 0.1 | 0.4 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.1 | 3.2 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.1 | 1.2 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.1 | 0.4 | GO:0008504 | monoamine transmembrane transporter activity(GO:0008504) |
| 0.1 | 1.0 | GO:0015087 | cobalt ion transmembrane transporter activity(GO:0015087) |
| 0.1 | 0.5 | GO:0008802 | betaine-aldehyde dehydrogenase activity(GO:0008802) |
| 0.1 | 1.0 | GO:0009019 | tRNA (guanine-N1-)-methyltransferase activity(GO:0009019) |
| 0.1 | 1.6 | GO:0048273 | mitogen-activated protein kinase p38 binding(GO:0048273) |
| 0.1 | 0.3 | GO:0070139 | ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139) |
| 0.1 | 2.9 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 0.1 | 0.3 | GO:0004176 | ATP-dependent peptidase activity(GO:0004176) |
| 0.1 | 0.8 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
| 0.1 | 1.1 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.1 | 18.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 0.3 | GO:0030249 | guanylate cyclase regulator activity(GO:0030249) |
| 0.1 | 0.2 | GO:0001156 | TFIIIC-class transcription factor binding(GO:0001156) |
| 0.1 | 2.6 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.1 | 0.2 | GO:0016501 | prostacyclin receptor activity(GO:0016501) |
| 0.1 | 2.8 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.1 | 0.4 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.1 | 0.7 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.1 | 0.2 | GO:0000171 | ribonuclease MRP activity(GO:0000171) |
| 0.1 | 0.1 | GO:0051021 | GDP-dissociation inhibitor binding(GO:0051021) |
| 0.1 | 1.8 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.1 | 1.6 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.1 | 0.9 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.0 | 2.0 | GO:0097472 | cyclin-dependent protein kinase activity(GO:0097472) |
| 0.0 | 2.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.2 | GO:0015093 | ferrous iron transmembrane transporter activity(GO:0015093) |
| 0.0 | 1.4 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 0.7 | GO:0042809 | vitamin D receptor binding(GO:0042809) |
| 0.0 | 0.3 | GO:0071558 | histone demethylase activity (H3-K27 specific)(GO:0071558) |
| 0.0 | 0.3 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.0 | 0.5 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.0 | 0.4 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 0.2 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.0 | 0.2 | GO:1990932 | 5.8S rRNA binding(GO:1990932) |
| 0.0 | 0.3 | GO:0071253 | connexin binding(GO:0071253) |
| 0.0 | 0.1 | GO:0000064 | L-ornithine transmembrane transporter activity(GO:0000064) |
| 0.0 | 0.4 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.0 | 0.2 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.0 | 0.6 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 1.1 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 0.1 | GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616) |
| 0.0 | 0.3 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.0 | 0.7 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 0.2 | GO:0016813 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813) |
| 0.0 | 4.3 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.0 | 1.1 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 1.1 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 0.1 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.0 | 0.1 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.0 | 0.3 | GO:0070717 | poly-purine tract binding(GO:0070717) |
| 0.0 | 0.1 | GO:0031735 | CCR10 chemokine receptor binding(GO:0031735) |
| 0.0 | 0.6 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.0 | 0.2 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 0.0 | 0.1 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.0 | 0.2 | GO:0019215 | intermediate filament binding(GO:0019215) |
| 0.0 | 1.3 | GO:0003774 | motor activity(GO:0003774) |
| 0.0 | 0.3 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.0 | 0.5 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.0 | 0.2 | GO:0034185 | apolipoprotein binding(GO:0034185) |
| 0.0 | 1.1 | GO:0015171 | amino acid transmembrane transporter activity(GO:0015171) |
| 0.0 | 0.3 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 1.1 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.0 | 0.0 | GO:1990715 | mRNA CDS binding(GO:1990715) |
| 0.0 | 0.2 | GO:0005003 | ephrin receptor activity(GO:0005003) |
| 0.0 | 0.3 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.0 | 4.1 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.0 | 0.8 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 0.2 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.0 | 0.5 | GO:0004497 | monooxygenase activity(GO:0004497) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.6 | ST_STAT3_PATHWAY | STAT3 Pathway |
| 0.2 | 3.2 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 5.3 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 6.8 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.1 | 0.8 | PID_S1P_S1P2_PATHWAY | S1P2 pathway |
| 0.1 | 2.8 | PID_BARD1_PATHWAY | BARD1 signaling events |
| 0.1 | 3.2 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
| 0.1 | 1.9 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
| 0.0 | 4.5 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 3.9 | PID_CDC42_PATHWAY | CDC42 signaling events |
| 0.0 | 1.2 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.0 | 0.3 | PID_P38_ALPHA_BETA_PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.0 | 0.8 | PID_NEPHRIN_NEPH1_PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 0.2 | PID_EPHA2_FWD_PATHWAY | EPHA2 forward signaling |
| 0.0 | 1.6 | PID_TGFBR_PATHWAY | TGF-beta receptor signaling |
| 0.0 | 0.4 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.7 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.1 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.3 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 0.4 | ST_JNK_MAPK_PATHWAY | JNK MAPK Pathway |
| 0.0 | 0.1 | PID_IL5_PATHWAY | IL5-mediated signaling events |
| 0.0 | 0.4 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.0 | 0.9 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 0.3 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.7 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 1.9 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.2 | PID_FOXO_PATHWAY | FoxO family signaling |
| 0.0 | 0.0 | SA_G1_AND_S_PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 0.5 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.0 | 0.2 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.0 | 0.2 | PID_PS1_PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 1.1 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
| 0.0 | 0.5 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 6.3 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.4 | 3.0 | REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.3 | 4.1 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.3 | 2.8 | REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 0.2 | 4.9 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.2 | 2.0 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 3.9 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.1 | 1.0 | REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.1 | 2.0 | REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.1 | 3.2 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 2.3 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 2.1 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 0.3 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.0 | 0.7 | REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 0.4 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 1.0 | REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.0 | 1.2 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 2.5 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.2 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.7 | REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.0 | 0.2 | REACTOME_THE_NLRP3_INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 0.6 | REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| 0.0 | 1.0 | REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.0 | 2.3 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 1.2 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.2 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 0.5 | REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 0.4 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 0.3 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 0.7 | REACTOME_MRNA_3_END_PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.0 | 0.5 | REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 0.4 | REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.0 | 0.8 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 0.1 | REACTOME_TRYPTOPHAN_CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 0.8 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 0.5 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.2 | REACTOME_AMYLOIDS | Genes involved in Amyloids |
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